Yusuf Hannun to Cell Line, Tumor
This is a "connection" page, showing publications Yusuf Hannun has written about Cell Line, Tumor.
Connection Strength
2.394
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Sublethal doxorubicin promotes migration and invasion of breast cancer cells: role of Src Family non-receptor tyrosine kinases. Breast Cancer Res. 2021 07 27; 23(1):76.
Score: 0.132
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Ceramide launches an acute anti-adhesion pro-migration cell signaling program in response to chemotherapy. FASEB J. 2020 06; 34(6):7610-7630.
Score: 0.121
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Bioactive sphingolipid profile in a xenograft mouse model of head and neck squamous cell carcinoma. PLoS One. 2019; 14(4):e0215770.
Score: 0.113
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AKT as a key target for growth promoting functions of neutral ceramidase in colon cancer cells. Oncogene. 2018 07; 37(28):3852-3863.
Score: 0.105
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Defining a role for acid sphingomyelinase in the p38/interleukin-6 pathway. J Biol Chem. 2014 Aug 08; 289(32):22401-12.
Score: 0.081
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Neutral sphingomyelinase-2 mediates growth arrest by retinoic acid through modulation of ribosomal S6 kinase. J Biol Chem. 2011 Jun 17; 286(24):21565-76.
Score: 0.065
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Neutral sphingomyelinase 2 (nSMase2) is the primary neutral sphingomyelinase isoform activated by tumour necrosis factor-a in MCF-7 cells. Biochem J. 2011 Apr 15; 435(2):381-90.
Score: 0.065
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Regulation of CC ligand 5/RANTES by acid sphingomyelinase and acid ceramidase. J Biol Chem. 2011 Apr 15; 286(15):13292-303.
Score: 0.064
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A novel mechanism of lysosomal acid sphingomyelinase maturation: requirement for carboxyl-terminal proteolytic processing. J Biol Chem. 2011 Feb 04; 286(5):3777-88.
Score: 0.063
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Regulated secretion of acid sphingomyelinase: implications for selectivity of ceramide formation. J Biol Chem. 2010 Nov 12; 285(46):35706-18.
Score: 0.062
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Identification and characterization of murine mitochondria-associated neutral sphingomyelinase (MA-nSMase), the mammalian sphingomyelin phosphodiesterase 5. J Biol Chem. 2010 Jun 04; 285(23):17993-8002.
Score: 0.060
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Acid beta-glucosidase 1 counteracts p38delta-dependent induction of interleukin-6: possible role for ceramide as an anti-inflammatory lipid. J Biol Chem. 2009 May 08; 284(19):12979-88.
Score: 0.056
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Involvement of acid beta-glucosidase 1 in the salvage pathway of ceramide formation. J Biol Chem. 2009 May 08; 284(19):12972-8.
Score: 0.056
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Regulation of neutral sphingomyelinase-2 (nSMase2) by tumor necrosis factor-alpha involves protein kinase C-delta in lung epithelial cells. Mol Pharmacol. 2008 Oct; 74(4):1022-32.
Score: 0.053
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Remodeling of cellular cytoskeleton by the acid sphingomyelinase/ceramide pathway. J Cell Biol. 2008 Apr 21; 181(2):335-50.
Score: 0.053
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Confluence induced threonine41/serine45 phospho-beta-catenin dephosphorylation via ceramide-mediated activation of PP1cgamma. Biochim Biophys Acta. 2007 Dec; 1771(12):1418-28.
Score: 0.051
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A novel role for protein kinase Cdelta-mediated phosphorylation of acid sphingomyelinase in UV light-induced mitochondrial injury. FASEB J. 2008 Jan; 22(1):183-93.
Score: 0.050
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Mechanism of inhibition of sequestration of protein kinase C alpha/betaII by ceramide. Roles of ceramide-activated protein phosphatases and phosphorylation/dephosphorylation of protein kinase C alpha/betaII on threonine 638/641. J Biol Chem. 2007 Jul 13; 282(28):20647-56.
Score: 0.049
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Activation of acid sphingomyelinase by protein kinase Cdelta-mediated phosphorylation. J Biol Chem. 2007 Apr 13; 282(15):11549-61.
Score: 0.048
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Neutral sphingomyelinase 2 is palmitoylated on multiple cysteine residues. Role of palmitoylation in subcellular localization. J Biol Chem. 2007 Mar 30; 282(13):10047-10056.
Score: 0.048
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Role for neutral sphingomyelinase-2 in tumor necrosis factor alpha-stimulated expression of vascular cell adhesion molecule-1 (VCAM) and intercellular adhesion molecule-1 (ICAM) in lung epithelial cells: p38 MAPK is an upstream regulator of nSMase2. J Biol Chem. 2007 Jan 12; 282(2):1384-96.
Score: 0.047
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Protein kinase C-induced activation of a ceramide/protein phosphatase 1 pathway leading to dephosphorylation of p38 MAPK. J Biol Chem. 2006 Dec 01; 281(48):36793-802.
Score: 0.047
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The coordination of prostaglandin E2 production by sphingosine-1-phosphate and ceramide-1-phosphate. Mol Pharmacol. 2005 Aug; 68(2):330-5.
Score: 0.043
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Selective inhibition of juxtanuclear translocation of protein kinase C betaII by a negative feedback mechanism involving ceramide formed from the salvage pathway. J Biol Chem. 2005 Jan 28; 280(4):2606-12.
Score: 0.041
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Role for mammalian neutral sphingomyelinase 2 in confluence-induced growth arrest of MCF7 cells. J Biol Chem. 2004 Jun 11; 279(24):25101-11.
Score: 0.040
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cPKC-dependent sequestration of membrane-recycling components in a subset of recycling endosomes. J Biol Chem. 2003 Dec 26; 278(52):52747-54.
Score: 0.038
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Neutral Sphingomyelinase 2 Heightens Anti-Melanoma Immune Responses and Anti-PD-1 Therapy Efficacy. Cancer Immunol Res. 2021 05; 9(5):568-582.
Score: 0.032
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Asah2 Represses the p53-Hmox1 Axis to Protect Myeloid-Derived Suppressor Cells from Ferroptosis. J Immunol. 2021 03 15; 206(6):1395-1404.
Score: 0.032
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Ceramide synthase 2-C24:1 -ceramide axis limits the metastatic potential of ovarian cancer cells. FASEB J. 2021 02; 35(2):e21287.
Score: 0.032
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Bladder cancer cell growth and motility implicate cannabinoid 2 receptor-mediated modifications of sphingolipids metabolism. Sci Rep. 2017 02 13; 7:42157.
Score: 0.024
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CHK1 regulates NF-?B signaling upon DNA damage in p53- deficient cells and associated tumor-derived microvesicles. Oncotarget. 2016 Apr 05; 7(14):18159-70.
Score: 0.023
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Alkaline ceramidase 2 and its bioactive product sphingosine are novel regulators of the DNA damage response. Oncotarget. 2016 Apr 05; 7(14):18440-57.
Score: 0.023
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Ceramide limits phosphatidylinositol-3-kinase C2?-controlled cell motility in ovarian cancer: potential of ceramide as a metastasis-suppressor lipid. Oncogene. 2016 05; 35(21):2801-12.
Score: 0.022
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A novel role of sphingosine kinase-1 in the invasion and angiogenesis of VHL mutant clear cell renal cell carcinoma. FASEB J. 2015 Jul; 29(7):2803-13.
Score: 0.021
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Endoplasmic reticulum heat shock protein gp96 maintains liver homeostasis and promotes hepatocellular carcinogenesis. J Hepatol. 2015 Apr; 62(4):879-88.
Score: 0.021
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On-tissue localization of ceramides and other sphingolipids by MALDI mass spectrometry imaging. Anal Chem. 2014 Aug 19; 86(16):8303-11.
Score: 0.020
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Ceramide and sphingosine-1-phosphate act as photodynamic therapy-elicited damage-associated molecular patterns: cell surface exposure. Int Immunopharmacol. 2014 Jun; 20(2):359-65.
Score: 0.020
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Sphingosine 1-phosphate induces filopodia formation through S1PR2 activation of ERM proteins. Biochem J. 2013 Feb 01; 449(3):661-72.
Score: 0.018
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Acid ceramidase-mediated production of sphingosine 1-phosphate promotes prostate cancer invasion through upregulation of cathepsin B. Int J Cancer. 2012 Nov 01; 131(9):2034-43.
Score: 0.017
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Off-target function of the Sonic hedgehog inhibitor cyclopamine in mediating apoptosis via nitric oxide-dependent neutral sphingomyelinase 2/ceramide induction. Mol Cancer Ther. 2012 May; 11(5):1092-102.
Score: 0.017
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Dihydroceramide accumulation and reactive oxygen species are distinct and nonessential events in 4-HPR-mediated leukemia cell death. Biochem Cell Biol. 2012 Apr; 90(2):209-23.
Score: 0.017
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Identification of dihydroceramide desaturase as a direct in vitro target for fenretinide. J Biol Chem. 2011 Jul 15; 286(28):24754-64.
Score: 0.016
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Ceramide synthase-dependent ceramide generation and programmed cell death: involvement of salvage pathway in regulating postmitochondrial events. J Biol Chem. 2011 May 06; 286(18):15929-42.
Score: 0.016
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Selective knockdown of ceramide synthases reveals complex interregulation of sphingolipid metabolism. J Lipid Res. 2011 Jan; 52(1):68-77.
Score: 0.016
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Synthesis, NMR characterization and divergent biological actions of 2'-hydroxy-ceramide/dihydroceramide stereoisomers in MCF7 cells. Bioorg Med Chem. 2010 Nov 01; 18(21):7565-79.
Score: 0.016
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Antiapoptotic roles of ceramide-synthase-6-generated C16-ceramide via selective regulation of the ATF6/CHOP arm of ER-stress-response pathways. FASEB J. 2010 Jan; 24(1):296-308.
Score: 0.014
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Potentiation of cannabinoid-induced cytotoxicity in mantle cell lymphoma through modulation of ceramide metabolism. Mol Cancer Res. 2009 Jul; 7(7):1086-98.
Score: 0.014
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AMPK inhibitor Compound C stimulates ceramide production and promotes Bax redistribution and apoptosis in MCF7 breast carcinoma cells. J Lipid Res. 2009 Dec; 50(12):2389-97.
Score: 0.014
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Synthesis and bioevaluation of omega-N-amino analogs of B13. Bioorg Med Chem. 2009 Mar 01; 17(5):1840-8.
Score: 0.014
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Acid ceramidase upregulation in prostate cancer cells confers resistance to radiation: AC inhibition, a potential radiosensitizer. Mol Ther. 2009 Mar; 17(3):430-8.
Score: 0.014
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Direct interaction between the inhibitor 2 and ceramide via sphingolipid-protein binding is involved in the regulation of protein phosphatase 2A activity and signaling. FASEB J. 2009 Mar; 23(3):751-63.
Score: 0.014
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De novo N-palmitoylsphingosine synthesis is the major biochemical mechanism of ceramide accumulation following p53 up-regulation. Prostaglandins Other Lipid Mediat. 2008 Jun; 86(1-4):41-8.
Score: 0.013
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The functional effects of acid ceramidase overexpression in prostate cancer progression and resistance to chemotherapy. Cancer Biol Ther. 2007 Sep; 6(9):1455-60.
Score: 0.012
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Lysosomotropic acid ceramidase inhibitor induces apoptosis in prostate cancer cells. Cancer Chemother Pharmacol. 2008 Feb; 61(2):231-42.
Score: 0.012
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Role of acid ceramidase in resistance to FasL: therapeutic approaches based on acid ceramidase inhibitors and FasL gene therapy. Mol Ther. 2007 Jul; 15(7):1259-63.
Score: 0.012
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Involvement of dihydroceramide desaturase in cell cycle progression in human neuroblastoma cells. J Biol Chem. 2007 Jun 08; 282(23):16718-28.
Score: 0.012
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Role of human longevity assurance gene 1 and C18-ceramide in chemotherapy-induced cell death in human head and neck squamous cell carcinomas. Mol Cancer Ther. 2007 Feb; 6(2):712-22.
Score: 0.012
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Sphingosine kinase-1 is cleaved by cathepsin B in vitro: identification of the initial cleavage sites for the protease. FEBS Lett. 2006 Nov 13; 580(26):6047-54.
Score: 0.012
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Involvement of sphingolipids in apoptin-induced cell killing. Mol Ther. 2006 Nov; 14(5):627-36.
Score: 0.012
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Tailoring structure-function and targeting properties of ceramides by site-specific cationization. Bioorg Med Chem. 2006 Nov 01; 14(21):7083-104.
Score: 0.012
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New insights on the use of desipramine as an inhibitor for acid ceramidase. FEBS Lett. 2006 Aug 21; 580(19):4751-6.
Score: 0.012
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Modulation of ceramide metabolism enhances viral protein apoptin's cytotoxicity in prostate cancer. Mol Ther. 2006 Nov; 14(5):637-46.
Score: 0.012
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Potent antitumor activity of a novel cationic pyridinium-ceramide alone or in combination with gemcitabine against human head and neck squamous cell carcinomas in vitro and in vivo. J Pharmacol Exp Ther. 2006 Jun; 317(3):1188-99.
Score: 0.011
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Regulation of the sphingosine-recycling pathway for ceramide generation by oxidative stress, and its role in controlling c-Myc/Max function. Biochem J. 2006 Jan 15; 393(Pt 2):513-21.
Score: 0.011
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Loss of sphingosine kinase-1 activates the intrinsic pathway of programmed cell death: modulation of sphingolipid levels and the induction of apoptosis. FASEB J. 2006 Mar; 20(3):482-4.
Score: 0.011
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Sphingosine kinase 1 is up-regulated in colon carcinogenesis. FASEB J. 2006 Feb; 20(2):386-8.
Score: 0.011
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A mitochondrial pool of sphingomyelin is involved in TNFalpha-induced Bax translocation to mitochondria. Biochem J. 2005 Mar 15; 386(Pt 3):445-51.
Score: 0.011
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Tumor necrosis factor induces the loss of sphingosine kinase-1 by a cathepsin B-dependent mechanism. J Biol Chem. 2005 Apr 29; 280(17):17196-202.
Score: 0.011
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Defects in cell growth regulation by C18:0-ceramide and longevity assurance gene 1 in human head and neck squamous cell carcinomas. J Biol Chem. 2004 Oct 22; 279(43):44311-9.
Score: 0.010
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EpCAM is overexpressed in breast cancer and is a potential target for breast cancer gene therapy. Cancer Res. 2004 Aug 15; 64(16):5818-24.
Score: 0.010
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Down-regulation of sphingosine kinase-1 by DNA damage: dependence on proteases and p53. J Biol Chem. 2004 May 07; 279(19):20546-54.
Score: 0.010
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Ceramide 1-phosphate is a direct activator of cytosolic phospholipase A2. J Biol Chem. 2004 Mar 19; 279(12):11320-6.
Score: 0.010
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Rapid shortening of telomere length in response to ceramide involves the inhibition of telomere binding activity of nuclear glyceraldehyde-3-phosphate dehydrogenase. J Biol Chem. 2004 Feb 13; 279(7):6152-62.
Score: 0.010
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Quantification and characterization of the bystander effect in prostate cancer cells following adenovirus-mediated FasL expression. Cancer Gene Ther. 2003 Apr; 10(4):330-9.
Score: 0.009