Yusuf Hannun to Lysophospholipids
This is a "connection" page, showing publications Yusuf Hannun has written about Lysophospholipids.
Connection Strength
5.312
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Neutral ceramidase: Advances in mechanisms, cell regulation, and roles in cancer. Adv Biol Regul. 2019 01; 71:141-146.
Score: 0.553
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Structural Basis for Ceramide Recognition and Hydrolysis by Human Neutral Ceramidase. Structure. 2015 Aug 04; 23(8):1482-1491.
Score: 0.440
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Differential effects of ceramide and sphingosine 1-phosphate on ERM phosphorylation: probing sphingolipid signaling at the outer plasma membrane. J Biol Chem. 2010 Oct 15; 285(42):32476-85.
Score: 0.312
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The coordination of prostaglandin E2 production by sphingosine-1-phosphate and ceramide-1-phosphate. Mol Pharmacol. 2005 Aug; 68(2):330-5.
Score: 0.218
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Biologically active sphingolipids in cancer pathogenesis and treatment. Nat Rev Cancer. 2004 Aug; 4(8):604-16.
Score: 0.206
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The sphingosine kinase 1/sphingosine-1-phosphate pathway mediates COX-2 induction and PGE2 production in response to TNF-alpha. FASEB J. 2003 Aug; 17(11):1411-21.
Score: 0.192
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Upregulation of sphingosine kinase 1 in response to doxorubicin generates an angiogenic response via stabilization of Snail. FASEB J. 2023 03; 37(3):e22787.
Score: 0.187
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Mitochondria and ceramide: intertwined roles in regulation of apoptosis. Adv Enzyme Regul. 2002; 42:113-29.
Score: 0.172
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Bioactive sphingolipids: Advancements and contributions from the laboratory of Dr. Lina M. Obeid. Cell Signal. 2021 03; 79:109875.
Score: 0.160
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Maternal and fetal alkaline ceramidase 2 is required for placental vascular integrity in mice. FASEB J. 2020 11; 34(11):15252-15268.
Score: 0.158
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Bioactive sphingolipid profile in a xenograft mouse model of head and neck squamous cell carcinoma. PLoS One. 2019; 14(4):e0215770.
Score: 0.143
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AKT as a key target for growth promoting functions of neutral ceramidase in colon cancer cells. Oncogene. 2018 07; 37(28):3852-3863.
Score: 0.133
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Alkaline ceramidase 2 is essential for the homeostasis of plasma sphingoid bases and their phosphates. FASEB J. 2018 06; 32(6):3058-3069.
Score: 0.131
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An intrinsic lipid-binding interface controls sphingosine kinase 1 function. J Lipid Res. 2018 03; 59(3):462-474.
Score: 0.131
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Tumor suppressor p53 links ceramide metabolism to DNA damage response through alkaline ceramidase 2. Cell Death Differ. 2018 05; 25(5):841-856.
Score: 0.130
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Sphingosine 1-phosphate activation of ERM contributes to vascular calcification. J Lipid Res. 2018 01; 59(1):69-78.
Score: 0.130
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The BST1 gene of Saccharomyces cerevisiae is the sphingosine-1-phosphate lyase. J Biol Chem. 1997 Oct 17; 272(42):26087-90.
Score: 0.129
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Intracellular sphingosine kinase 2-derived sphingosine-1-phosphate mediates epidermal growth factor-induced ezrin-radixin-moesin phosphorylation and cancer cell invasion. FASEB J. 2015 Nov; 29(11):4654-69.
Score: 0.110
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Stereoselectivity of induction of the retinoblastoma gene product (pRb) dephosphorylation by D-erythro-sphingosine supports a role for pRb in growth suppression by sphingosine. Biochemistry. 1995 Feb 14; 34(6):1885-92.
Score: 0.107
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Ceramide and sphingosine-1-phosphate act as photodynamic therapy-elicited damage-associated molecular patterns: cell surface exposure. Int Immunopharmacol. 2014 Jun; 20(2):359-65.
Score: 0.101
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Sphingosine-1-phosphate receptor 2. FEBS J. 2013 Dec; 280(24):6354-66.
Score: 0.096
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Epidermal growth factor-induced cellular invasion requires sphingosine-1-phosphate/sphingosine-1-phosphate 2 receptor-mediated ezrin activation. FASEB J. 2013 Aug; 27(8):3155-66.
Score: 0.094
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Sphingosine 1-phosphate induces filopodia formation through S1PR2 activation of ERM proteins. Biochem J. 2013 Feb 01; 449(3):661-72.
Score: 0.093
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Loss of neutral ceramidase increases inflammation in a mouse model of inflammatory bowel disease. Prostaglandins Other Lipid Mediat. 2012 Dec; 99(3-4):124-30.
Score: 0.090
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Acid ceramidase-mediated production of sphingosine 1-phosphate promotes prostate cancer invasion through upregulation of cathepsin B. Int J Cancer. 2012 Nov 01; 131(9):2034-43.
Score: 0.088
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Protein phosphatase 1a mediates ceramide-induced ERM protein dephosphorylation: a novel mechanism independent of phosphatidylinositol 4, 5-biphosphate (PIP2) and myosin/ERM phosphatase. J Biol Chem. 2012 Mar 23; 287(13):10145-10155.
Score: 0.087
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Regulation of CC ligand 5/RANTES by acid sphingomyelinase and acid ceramidase. J Biol Chem. 2011 Apr 15; 286(15):13292-303.
Score: 0.081
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Molecular targeting of acid ceramidase: implications to cancer therapy. Curr Drug Targets. 2008 Aug; 9(8):653-61.
Score: 0.068
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Principles of bioactive lipid signalling: lessons from sphingolipids. Nat Rev Mol Cell Biol. 2008 Feb; 9(2):139-50.
Score: 0.066
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Protein kinase C regulation by sphingosine/lysosphingolipids. Cold Spring Harb Symp Quant Biol. 1988; 53 Pt 1:103-10.
Score: 0.065
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Acid ceramidase but not acid sphingomyelinase is required for tumor necrosis factor-{alpha}-induced PGE2 production. J Biol Chem. 2006 Aug 25; 281(34):24695-703.
Score: 0.059
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Roles for C16-ceramide and sphingosine 1-phosphate in regulating hepatocyte apoptosis in response to tumor necrosis factor-alpha. J Biol Chem. 2005 Jul 29; 280(30):27879-87.
Score: 0.055
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A simple, highly sensitive, and facile method to quantify ceramide at the plasma membrane. J Lipid Res. 2023 02; 64(2):100322.
Score: 0.046
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PKC-dependent activation of sphingosine kinase 1 and translocation to the plasma membrane. Extracellular release of sphingosine-1-phosphate induced by phorbol 12-myristate 13-acetate (PMA). J Biol Chem. 2002 Sep 20; 277(38):35257-62.
Score: 0.045
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Tight binding inhibition of protein phosphatase-1 by phosphatidic acid. Specificity of inhibition by the phospholipid. J Biol Chem. 2002 May 03; 277(18):15530-8.
Score: 0.043
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Cystic fibrosis transmembrane regulator regulates uptake of sphingoid base phosphates and lysophosphatidic acid: modulation of cellular activity of sphingosine 1-phosphate. J Biol Chem. 2001 Sep 21; 276(38):35258-64.
Score: 0.042
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Role of sphingolipids in senescence: implication in aging and age-related diseases. J Clin Invest. 2018 07 02; 128(7):2702-2712.
Score: 0.034
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Loss of neutral ceramidase protects cells from nutrient- and energy -deprivation-induced cell death. Biochem J. 2016 Mar 15; 473(6):743-55.
Score: 0.028
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Alkaline Ceramidase 3 Deficiency Results in Purkinje Cell Degeneration and Cerebellar Ataxia Due to Dyshomeostasis of Sphingolipids in the Brain. PLoS Genet. 2015 Oct; 11(10):e1005591.
Score: 0.028
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A novel role of sphingosine kinase-1 in the invasion and angiogenesis of VHL mutant clear cell renal cell carcinoma. FASEB J. 2015 Jul; 29(7):2803-13.
Score: 0.027
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Distinct roles for hematopoietic and extra-hematopoietic sphingosine kinase-1 in inflammatory bowel disease. PLoS One. 2014; 9(12):e113998.
Score: 0.026
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A signaling cascade mediated by ceramide, src and PDGFR? coordinates the activation of the redox-sensitive neutral sphingomyelinase-2 and sphingosine kinase-1. Biochim Biophys Acta. 2013 Aug; 1831(8):1344-56.
Score: 0.024
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Central role of ceramide biosynthesis in body weight regulation, energy metabolism, and the metabolic syndrome. Am J Physiol Endocrinol Metab. 2009 Jul; 297(1):E211-24.
Score: 0.018
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Role for sphingosine kinase 1 in colon carcinogenesis. FASEB J. 2009 Feb; 23(2):405-14.
Score: 0.017
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A role for sphingosine kinase 1 in dextran sulfate sodium-induced colitis. FASEB J. 2009 Jan; 23(1):143-52.
Score: 0.017
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Clinical relevance of ceramide metabolism in the pathogenesis of human head and neck squamous cell carcinoma (HNSCC): attenuation of C(18)-ceramide in HNSCC tumors correlates with lymphovascular invasion and nodal metastasis. Cancer Lett. 2007 Oct 18; 256(1):101-11.
Score: 0.016
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Role for furin in tumor necrosis factor alpha-induced activation of the matrix metalloproteinase/sphingolipid mitogenic pathway. Mol Cell Biol. 2007 Apr; 27(8):2997-3007.
Score: 0.015
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Distribution and dynamic changes of sphingolipids in blood in response to platelet activation. J Thromb Haemost. 2006 Dec; 4(12):2704-9.
Score: 0.015
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Cationic long-chain ceramide LCL-30 induces cell death by mitochondrial targeting in SW403 cells. Mol Cancer Ther. 2006 Jun; 5(6):1520-9.
Score: 0.015
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Sphingosine kinase: biochemical and cellular regulation and role in disease. J Biochem Mol Biol. 2006 Mar 31; 39(2):113-31.
Score: 0.014
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Neutral ceramidase encoded by the Asah2 gene is essential for the intestinal degradation of sphingolipids. J Biol Chem. 2006 Mar 17; 281(11):7324-31.
Score: 0.014
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Sphingosine kinase 1 is up-regulated in colon carcinogenesis. FASEB J. 2006 Feb; 20(2):386-8.
Score: 0.014
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Dihydrosphingosine 1-phosphate stimulates MMP1 gene expression via activation of ERK1/2-Ets1 pathway in human fibroblasts. FASEB J. 2006 Jan; 20(1):184-6.
Score: 0.014
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Sphingosine kinase 1 (SPHK1) is induced by transforming growth factor-beta and mediates TIMP-1 up-regulation. J Biol Chem. 2004 Dec 24; 279(52):53994-4001.
Score: 0.013