Yusuf Hannun to Sphingolipids
This is a "connection" page, showing publications Yusuf Hannun has written about Sphingolipids.
Connection Strength
19.316
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Synthesis of erythro- B13 enantiomers and stereospecific action of full set of B13-isomers in MCF7 breast carcinoma cells: Cellular metabolism and effects on sphingolipids. Bioorg Med Chem. 2021 02 15; 32:116011.
Score: 0.568
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Exploring the Therapeutic Landscape of Sphingomyelinases. Handb Exp Pharmacol. 2020; 259:19-47.
Score: 0.529
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Probing compartment-specific sphingolipids with targeted bacterial sphingomyelinases and ceramidases. J Lipid Res. 2019 11; 60(11):1841-1850.
Score: 0.511
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Bioactive sphingolipid profile in a xenograft mouse model of head and neck squamous cell carcinoma. PLoS One. 2019; 14(4):e0215770.
Score: 0.504
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Approaches for probing and evaluating mammalian sphingolipid metabolism. Anal Biochem. 2019 06 15; 575:70-86.
Score: 0.502
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Multiple actions of doxorubicin on the sphingolipid network revealed by flux analysis. J Lipid Res. 2019 04; 60(4):819-831.
Score: 0.493
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Dose dependent actions of LCL521 on acid ceramidase and key sphingolipid metabolites. Bioorg Med Chem. 2018 12 15; 26(23-24):6067-6075.
Score: 0.489
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Tsc3 regulates SPT amino acid choice in Saccharomyces cerevisiae by promoting alanine in the sphingolipid pathway. J Lipid Res. 2018 11; 59(11):2126-2139.
Score: 0.482
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Probing de novo sphingolipid metabolism in mammalian cells utilizing mass spectrometry. J Lipid Res. 2018 06; 59(6):1046-1057.
Score: 0.469
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Sphingolipids and their metabolism in physiology and disease. Nat Rev Mol Cell Biol. 2018 03; 19(3):175-191.
Score: 0.457
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Ceramidases, roles in sphingolipid metabolism and in health and disease. Adv Biol Regul. 2017 Jan; 63:122-131.
Score: 0.423
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Evolving concepts in cancer therapy through targeting sphingolipid metabolism. Biochim Biophys Acta. 2014 Aug; 1841(8):1174-88.
Score: 0.349
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The yeast sphingolipid signaling landscape. Chem Phys Lipids. 2014 Jan; 177:26-40.
Score: 0.346
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Sphingolipids in colon cancer. Biochim Biophys Acta. 2014 May; 1841(5):773-82.
Score: 0.343
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Sphingolipid metabolism and neutral sphingomyelinases. Handb Exp Pharmacol. 2013; (215):57-76.
Score: 0.326
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Novel chemotherapeutic drugs in sphingolipid cancer research. Handb Exp Pharmacol. 2013; (215):211-38.
Score: 0.326
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Sphingoid bases and the serine catabolic enzyme CHA1 define a novel feedforward/feedback mechanism in the response to serine availability. J Biol Chem. 2012 Mar 16; 287(12):9280-9.
Score: 0.305
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Drug targeting of sphingolipid metabolism: sphingomyelinases and ceramidases. Br J Pharmacol. 2011 Jun; 163(4):694-712.
Score: 0.292
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Sphingolipids mediate formation of mRNA processing bodies during the heat-stress response of Saccharomyces cerevisiae. Biochem J. 2010 Oct 01; 431(1):31-8.
Score: 0.279
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Differential effects of ceramide and sphingosine 1-phosphate on ERM phosphorylation: probing sphingolipid signaling at the outer plasma membrane. J Biol Chem. 2010 Oct 15; 285(42):32476-85.
Score: 0.276
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An overview of sphingolipid metabolism: from synthesis to breakdown. Adv Exp Med Biol. 2010; 688:1-23.
Score: 0.265
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Computational analysis of sphingolipid pathway systems. Adv Exp Med Biol. 2010; 688:264-75.
Score: 0.265
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Sphingomyelin metabolism at the plasma membrane: implications for bioactive sphingolipids. FEBS Lett. 2010 May 03; 584(9):1887-94.
Score: 0.261
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Bioactive sphingolipids: metabolism and function. J Lipid Res. 2009 Apr; 50 Suppl:S91-6.
Score: 0.245
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Thematic review series: sphingolipids. ISC1 (inositol phosphosphingolipid-phospholipase C), the yeast homologue of neutral sphingomyelinases. J Lipid Res. 2008 May; 49(5):922-8.
Score: 0.233
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Principles of bioactive lipid signalling: lessons from sphingolipids. Nat Rev Mol Cell Biol. 2008 Feb; 9(2):139-50.
Score: 0.232
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The sphingolipid salvage pathway in ceramide metabolism and signaling. Cell Signal. 2008 Jun; 20(6):1010-8.
Score: 0.230
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Coordination of the dynamics of yeast sphingolipid metabolism during the diauxic shift. Theor Biol Med Model. 2007 Oct 31; 4:42.
Score: 0.228
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Novel analogs of D-e-MAPP and B13. Part 2: signature effects on bioactive sphingolipids. Bioorg Med Chem. 2008 Jan 15; 16(2):1032-45.
Score: 0.225
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Isc1 regulates sphingolipid metabolism in yeast mitochondria. Biochim Biophys Acta. 2007 Nov; 1768(11):2849-61.
Score: 0.224
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Translational aspects of sphingolipid metabolism. Trends Mol Med. 2007 Aug; 13(8):327-36.
Score: 0.222
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Selective substrate supply in the regulation of yeast de novo sphingolipid synthesis. J Biol Chem. 2007 Apr 20; 282(16):12330-40.
Score: 0.217
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A guide to biochemical systems modeling of sphingolipids for the biochemist. Methods Enzymol. 2007; 432:319-50.
Score: 0.215
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Sphingolipid-binding proteins. Biochim Biophys Acta. 2006 Aug; 1761(8):927-46.
Score: 0.208
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Bioactive sphingolipids in the modulation of the inflammatory response. Pharmacol Ther. 2006 Oct; 112(1):171-83.
Score: 0.207
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Distinct roles for de novo versus hydrolytic pathways of sphingolipid biosynthesis in Saccharomyces cerevisiae. Biochem J. 2006 Feb 01; 393(Pt 3):733-40.
Score: 0.202
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Using genomic and lipidomic strategies to investigate sphingolipid function in the yeast heat-stress response. Biochem Soc Trans. 2005 Nov; 33(Pt 5):1166-9.
Score: 0.198
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Simulation and validation of modelled sphingolipid metabolism in Saccharomyces cerevisiae. Nature. 2005 Jan 27; 433(7024):425-30.
Score: 0.188
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Biologically active sphingolipids in cancer pathogenesis and treatment. Nat Rev Cancer. 2004 Aug; 4(8):604-16.
Score: 0.182
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The complex life of simple sphingolipids. EMBO Rep. 2004 Aug; 5(8):777-82.
Score: 0.182
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Sphingolipids in inflammation: roles and implications. Curr Mol Med. 2004 Jun; 4(4):405-18.
Score: 0.180
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Roles for sphingolipid biosynthesis in mediation of specific programs of the heat stress response determined through gene expression profiling. J Biol Chem. 2003 Aug 08; 278(32):30328-38.
Score: 0.167
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Upregulation of sphingosine kinase 1 in response to doxorubicin generates an angiogenic response via stabilization of Snail. FASEB J. 2023 03; 37(3):e22787.
Score: 0.165
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Biochemical properties of mammalian neutral sphingomyelinase 2 and its role in sphingolipid metabolism. J Biol Chem. 2003 Apr 18; 278(16):13775-83.
Score: 0.164
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Sphingolipids in vascular biology. Adv Exp Med Biol. 2002; 507:439-44.
Score: 0.152
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Enzymes of sphingolipid metabolism: from modular to integrative signaling. Biochemistry. 2001 Apr 24; 40(16):4893-903.
Score: 0.145
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Identification of ISC1 (YER019w) as inositol phosphosphingolipid phospholipase C in Saccharomyces cerevisiae. J Biol Chem. 2000 Dec 15; 275(50):39793-8.
Score: 0.141
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Bioactive sphingolipids: Advancements and contributions from the laboratory of Dr. Lina M. Obeid. Cell Signal. 2021 03; 79:109875.
Score: 0.141
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Role for de novo sphingoid base biosynthesis in the heat-induced transient cell cycle arrest of Saccharomyces cerevisiae. J Biol Chem. 2001 Mar 16; 276(11):8574-81.
Score: 0.140
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Maternal and fetal alkaline ceramidase 2 is required for placental vascular integrity in mice. FASEB J. 2020 11; 34(11):15252-15268.
Score: 0.139
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Preparation of radiolabeled ceramides and phosphosphingolipids. Methods Enzymol. 2000; 311:499-518.
Score: 0.132
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Synthesis of key precursors of radiolabeled sphingolipids. Methods Enzymol. 2000; 311:518-35.
Score: 0.132
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Effects of sphingosine and other sphingolipids on protein kinase C. Methods Enzymol. 2000; 312:361-73.
Score: 0.132
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Emergence of membrane sphingolipids as a potential therapeutic target. Biochimie. 2019 Mar; 158:257-264.
Score: 0.124
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Sphingolipid metabolism in the regulation of bioactive molecules. Lipids. 1999; 34 Suppl:S5-11.
Score: 0.123
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Functions of neutral ceramidase in the Golgi apparatus. J Lipid Res. 2018 11; 59(11):2116-2125.
Score: 0.121
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Role of sphingolipids in senescence: implication in aging and age-related diseases. J Clin Invest. 2018 07 02; 128(7):2702-2712.
Score: 0.119
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AKT as a key target for growth promoting functions of neutral ceramidase in colon cancer cells. Oncogene. 2018 07; 37(28):3852-3863.
Score: 0.118
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Alkaline ceramidase 2 is essential for the homeostasis of plasma sphingoid bases and their phosphates. FASEB J. 2018 06; 32(6):3058-3069.
Score: 0.116
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Involvement of yeast sphingolipids in the heat stress response of Saccharomyces cerevisiae. J Biol Chem. 1997 Dec 19; 272(51):32566-72.
Score: 0.115
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Ceramide and the eukaryotic stress response. Biochem Soc Trans. 1997 Nov; 25(4):1171-5.
Score: 0.114
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The ceramide activated protein phosphatase Sit4 impairs sphingolipid dynamics, mitochondrial function and lifespan in a yeast model of Niemann-Pick type C1. Biochim Biophys Acta Mol Basis Dis. 2018 Jan; 1864(1):79-88.
Score: 0.113
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Bladder cancer cell growth and motility implicate cannabinoid 2 receptor-mediated modifications of sphingolipids metabolism. Sci Rep. 2017 02 13; 7:42157.
Score: 0.108
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Sphingolipid second messengers: tumor suppressor lipids. Adv Exp Med Biol. 1997; 400A:305-12.
Score: 0.108
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Role of neutral ceramidase in colon cancer. FASEB J. 2016 12; 30(12):4159-4171.
Score: 0.105
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Aging-related elevation of sphingoid bases shortens yeast chronological life span by compromising mitochondrial function. Oncotarget. 2016 Apr 19; 7(16):21124-44.
Score: 0.102
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Dynamics of the Heat Stress Response of Ceramides with Different Fatty-Acyl Chain Lengths in Baker's Yeast. PLoS Comput Biol. 2015 Aug; 11(8):e1004373.
Score: 0.097
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On-tissue localization of ceramides and other sphingolipids by MALDI mass spectrometry imaging. Anal Chem. 2014 Aug 19; 86(16):8303-11.
Score: 0.091
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Sphingolipids and mitochondrial function in budding yeast. Biochim Biophys Acta. 2014 Oct; 1840(10):3131-7.
Score: 0.090
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The plant decapeptide OSIP108 prevents copper-induced apoptosis in yeast and human cells. Biochim Biophys Acta. 2014 Jun; 1843(6):1207-1215.
Score: 0.089
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Sphingolipid breakdown products: anti-proliferative and tumor-suppressor lipids. Biochim Biophys Acta. 1993 Dec 21; 1154(3-4):223-36.
Score: 0.087
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Sphingolipid signalling mediates mitochondrial dysfunctions and reduced chronological lifespan in the yeast model of Niemann-Pick type C1. Mol Microbiol. 2014 Feb; 91(3):438-51.
Score: 0.087
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Evaluation of the role of secretory sphingomyelinase and bioactive sphingolipids as biomarkers in hemophagocytic lymphohistiocytosis. Am J Hematol. 2013 Nov; 88(11):E265-72.
Score: 0.085
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Sphingolipid regulation of ezrin, radixin, and moesin proteins family: implications for cell dynamics. Biochim Biophys Acta. 2014 May; 1841(5):727-37.
Score: 0.085
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Coordination of rapid sphingolipid responses to heat stress in yeast. PLoS Comput Biol. 2013; 9(5):e1003078.
Score: 0.084
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The sphingomyelin cycle: a prototypic sphingolipid signaling pathway. Adv Lipid Res. 1993; 25:27-41.
Score: 0.081
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Oncogenic K-Ras regulates bioactive sphingolipids in a sphingosine kinase 1-dependent manner. J Biol Chem. 2012 Sep 14; 287(38):31794-803.
Score: 0.079
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Ceramide synthases at the centre of sphingolipid metabolism and biology. Biochem J. 2012 Feb 01; 441(3):789-802.
Score: 0.076
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The roles of neutral sphingomyelinases in neurological pathologies. Neurochem Res. 2012 Jun; 37(6):1137-49.
Score: 0.076
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Evaluation of bioactive sphingolipids in 4-HPR-resistant leukemia cells. BMC Cancer. 2011 Nov 07; 11:477.
Score: 0.075
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Neutral sphingomyelinase-2 mediates growth arrest by retinoic acid through modulation of ribosomal S6 kinase. J Biol Chem. 2011 Jun 17; 286(24):21565-76.
Score: 0.073
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Neutral sphingomyelinase 2 (nSMase2) is the primary neutral sphingomyelinase isoform activated by tumour necrosis factor-a in MCF-7 cells. Biochem J. 2011 Apr 15; 435(2):381-90.
Score: 0.072
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Selective knockdown of ceramide synthases reveals complex interregulation of sphingolipid metabolism. J Lipid Res. 2011 Jan; 52(1):68-77.
Score: 0.070
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Membrane sphingolipids as essential molecular signals for Bacteroides survival in the intestine. Proc Natl Acad Sci U S A. 2011 Mar 15; 108 Suppl 1:4666-71.
Score: 0.070
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Blood sphingolipidomics in healthy humans: impact of sample collection methodology. J Lipid Res. 2010 Oct; 51(10):3074-87.
Score: 0.069
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Stress-induced sphingolipid signaling: role of type-2 neutral sphingomyelinase in murine cell apoptosis and proliferation. PLoS One. 2010 Mar 23; 5(3):e9826.
Score: 0.067
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Plant sphingolipids: decoding the enigma of the Sphinx. New Phytol. 2010 Feb; 185(3):611-30.
Score: 0.066
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Regulation of protein kinase C by sphingosine and lysosphingolipids. Clin Chim Acta. 1989 Dec 15; 185(3):333-45.
Score: 0.066
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Functions of sphingolipids and sphingolipid breakdown products in cellular regulation. Science. 1989 Jan 27; 243(4890):500-7.
Score: 0.062
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Sphingolipids function as downstream effectors of a fungal PAQR. Mol Pharmacol. 2009 Apr; 75(4):866-75.
Score: 0.061
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Protein kinase C regulation by sphingosine/lysosphingolipids. Cold Spring Harb Symp Quant Biol. 1988; 53 Pt 1:103-10.
Score: 0.058
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Involvement of sphingoid bases in mediating reactive oxygen intermediate production and programmed cell death in Arabidopsis. Cell Res. 2007 Dec; 17(12):1030-40.
Score: 0.057
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Lysosphingolipids inhibit protein kinase C: implications for the sphingolipidoses. Science. 1987 Feb 06; 235(4789):670-4.
Score: 0.054
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Role for furin in tumor necrosis factor alpha-induced activation of the matrix metalloproteinase/sphingolipid mitogenic pathway. Mol Cell Biol. 2007 Apr; 27(8):2997-3007.
Score: 0.054
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Distribution and dynamic changes of sphingolipids in blood in response to platelet activation. J Thromb Haemost. 2006 Dec; 4(12):2704-9.
Score: 0.053
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Altered adipose and plasma sphingolipid metabolism in obesity: a potential mechanism for cardiovascular and metabolic risk. Diabetes. 2006 Sep; 55(9):2579-87.
Score: 0.053
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Involvement of sphingolipids in apoptin-induced cell killing. Mol Ther. 2006 Nov; 14(5):627-36.
Score: 0.052
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Simultaneous quantitative analysis of bioactive sphingolipids by high-performance liquid chromatography-tandem mass spectrometry. Methods. 2006 Jun; 39(2):82-91.
Score: 0.052
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Loss of sphingosine kinase-1 activates the intrinsic pathway of programmed cell death: modulation of sphingolipid levels and the induction of apoptosis. FASEB J. 2006 Mar; 20(3):482-4.
Score: 0.050
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The sphingolipid pathway regulates Pkc1 through the formation of diacylglycerol in Cryptococcus neoformans. J Biol Chem. 2004 May 14; 279(20):21144-53.
Score: 0.044
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Lipid metabolism: ceramide transfer protein adds a new dimension. Curr Biol. 2004 Feb 17; 14(4):R163-5.
Score: 0.044
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Integration of kinetic information on yeast sphingolipid metabolism in dynamical pathway models. J Theor Biol. 2004 Feb 07; 226(3):265-91.
Score: 0.044
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Modulation of transforming growth factor-beta (TGF-beta) signaling by endogenous sphingolipid mediators. J Biol Chem. 2003 Mar 14; 278(11):9276-82.
Score: 0.041
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A simple, highly sensitive, and facile method to quantify ceramide at the plasma membrane. J Lipid Res. 2023 02; 64(2):100322.
Score: 0.041
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De novo ceramide regulates the alternative splicing of caspase 9 and Bcl-x in A549 lung adenocarcinoma cells. Dependence on protein phosphatase-1. J Biol Chem. 2002 Apr 12; 277(15):12587-95.
Score: 0.038
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Mitochondria and ceramide: intertwined roles in regulation of apoptosis. Adv Enzyme Regul. 2002; 42:113-29.
Score: 0.038
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Use of short-chain ceramides. Methods Enzymol. 2000; 312:407-20.
Score: 0.033
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Glutathione regulation of neutral sphingomyelinase in tumor necrosis factor-alpha-induced cell death. J Biol Chem. 1998 May 01; 273(18):11313-20.
Score: 0.029
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Alkaline Ceramidase 3 Deficiency Results in Purkinje Cell Degeneration and Cerebellar Ataxia Due to Dyshomeostasis of Sphingolipids in the Brain. PLoS Genet. 2015 Oct; 11(10):e1005591.
Score: 0.025
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Activity of neutral and alkaline ceramidases on fluorogenic N-acylated coumarin-containing aminodiols. J Lipid Res. 2015 Oct; 56(10):2019-28.
Score: 0.024
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Finding pathway-modulating genes from a novel Ontology Fingerprint-derived gene network. Nucleic Acids Res. 2014 Oct; 42(18):e138.
Score: 0.023
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The protein kinase Sch9 is a key regulator of sphingolipid metabolism in Saccharomyces cerevisiae. Mol Biol Cell. 2014 Jan; 25(1):196-211.
Score: 0.022
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Distinct signaling roles of ceramide species in yeast revealed through systematic perturbation and systems biology analyses. Sci Signal. 2013 Oct 29; 6(299):rs14.
Score: 0.022
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Introduction: sphingolipids and their metabolites in cell regulation. Adv Lipid Res. 1993; 25:1-24.
Score: 0.020
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Lipidomic profiling in Crohn's disease: abnormalities in phosphatidylinositols, with preservation of ceramide, phosphatidylcholine and phosphatidylserine composition. Int J Biochem Cell Biol. 2012 Nov; 44(11):1839-46.
Score: 0.020
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Dihydroceramide accumulation and reactive oxygen species are distinct and nonessential events in 4-HPR-mediated leukemia cell death. Biochem Cell Biol. 2012 Apr; 90(2):209-23.
Score: 0.019
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Network of signal transduction pathways involving lipids: protein kinase C-dependent and -independent pathways. Adv Exp Med Biol. 1992; 318:275-84.
Score: 0.019
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Mathematical modeling and validation of the ergosterol pathway in Saccharomyces cerevisiae. PLoS One. 2011; 6(12):e28344.
Score: 0.019
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Cellular morphogenesis under stress is influenced by the sphingolipid pathway gene ISC1 and DNA integrity checkpoint genes in Saccharomyces cerevisiae. Genetics. 2011 Oct; 189(2):533-47.
Score: 0.018
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Role for Sit4p-dependent mitochondrial dysfunction in mediating the shortened chronological lifespan and oxidative stress sensitivity of Isc1p-deficient cells. Mol Microbiol. 2011 Jul; 81(2):515-27.
Score: 0.018
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Role of phospholipase in generating lipid second messengers in signal transduction. FASEB J. 1991 Apr; 5(7):2068-77.
Score: 0.018
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Purification and characterization of a second type of neutral ceramidase from rat brain: a second more hydrophobic form of rat brain ceramidase. Biochim Biophys Acta. 2011 Apr; 1811(4):242-52.
Score: 0.018
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Synthesis, NMR characterization and divergent biological actions of 2'-hydroxy-ceramide/dihydroceramide stereoisomers in MCF7 cells. Bioorg Med Chem. 2010 Nov 01; 18(21):7565-79.
Score: 0.017
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Revealing a signaling role of phytosphingosine-1-phosphate in yeast. Mol Syst Biol. 2010; 6:349.
Score: 0.017
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Acid ceramidase upregulation in prostate cancer: role in tumor development and implications for therapy. Expert Opin Ther Targets. 2009 Dec; 13(12):1449-58.
Score: 0.016
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Central role of ceramide biosynthesis in body weight regulation, energy metabolism, and the metabolic syndrome. Am J Physiol Endocrinol Metab. 2009 Jul; 297(1):E211-24.
Score: 0.016
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Defective acid sphingomyelinase pathway with Pseudomonas aeruginosa infection in cystic fibrosis. Am J Respir Cell Mol Biol. 2009 Sep; 41(3):367-75.
Score: 0.016
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Direct interaction between the inhibitor 2 and ceramide via sphingolipid-protein binding is involved in the regulation of protein phosphatase 2A activity and signaling. FASEB J. 2009 Mar; 23(3):751-63.
Score: 0.015
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Molecular cloning and characterization of OsCDase, a ceramidase enzyme from rice. Plant J. 2008 Sep; 55(6):1000-9.
Score: 0.015
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Mitochondrially targeted ceramide LCL-30 inhibits colorectal cancer in mice. Br J Cancer. 2008 Jan 15; 98(1):98-105.
Score: 0.014
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Lysosomotropic acid ceramidase inhibitor induces apoptosis in prostate cancer cells. Cancer Chemother Pharmacol. 2008 Feb; 61(2):231-42.
Score: 0.014
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MAO-A-induced mitogenic signaling is mediated by reactive oxygen species, MMP-2, and the sphingolipid pathway. Free Radic Biol Med. 2007 Jul 01; 43(1):80-9.
Score: 0.014
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New insights on the use of desipramine as an inhibitor for acid ceramidase. FEBS Lett. 2006 Aug 21; 580(19):4751-6.
Score: 0.013
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Modulation of ceramide metabolism enhances viral protein apoptin's cytotoxicity in prostate cancer. Mol Ther. 2006 Nov; 14(5):637-46.
Score: 0.013
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Neutral ceramidase encoded by the Asah2 gene is essential for the intestinal degradation of sphingolipids. J Biol Chem. 2006 Mar 17; 281(11):7324-31.
Score: 0.013
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Roles for C16-ceramide and sphingosine 1-phosphate in regulating hepatocyte apoptosis in response to tumor necrosis factor-alpha. J Biol Chem. 2005 Jul 29; 280(30):27879-87.
Score: 0.012
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BcR-induced apoptosis involves differential regulation of C16 and C24-ceramide formation and sphingolipid-dependent activation of the proteasome. J Biol Chem. 2003 Apr 25; 278(17):14723-31.
Score: 0.010
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Identification and characterization of Saccharomyces cerevisiae dihydrosphingosine-1-phosphate phosphatase. J Biol Chem. 1997 Nov 07; 272(45):28690-4.
Score: 0.007