Yusuf Hannun to Ceramides
This is a "connection" page, showing publications Yusuf Hannun has written about Ceramides.
Connection Strength
21.162
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The doxorubicin-induced cell motility network is under the control of the ceramide-activated protein phosphatase 1 alpha. FASEB J. 2021 03; 35(3):e21396.
Score: 0.551
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Ceramide launches an acute anti-adhesion pro-migration cell signaling program in response to chemotherapy. FASEB J. 2020 06; 34(6):7610-7630.
Score: 0.519
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Exploring the Therapeutic Landscape of Sphingomyelinases. Handb Exp Pharmacol. 2020; 259:19-47.
Score: 0.509
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Visualizing bioactive ceramides. Chem Phys Lipids. 2018 11; 216:142-151.
Score: 0.466
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Tsc3 regulates SPT amino acid choice in Saccharomyces cerevisiae by promoting alanine in the sphingolipid pathway. J Lipid Res. 2018 11; 59(11):2126-2139.
Score: 0.463
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Structure of human nSMase2 reveals an interdomain allosteric activation mechanism for ceramide generation. Proc Natl Acad Sci U S A. 2017 07 11; 114(28):E5549-E5558.
Score: 0.427
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Role of neutral ceramidase in colon cancer. FASEB J. 2016 12; 30(12):4159-4171.
Score: 0.404
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Structural Basis for Ceramide Recognition and Hydrolysis by Human Neutral Ceramidase. Structure. 2015 Aug 04; 23(8):1482-1491.
Score: 0.373
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Identification of C18:1-phytoceramide as the candidate lipid mediator for hydroxyurea resistance in yeast. J Biol Chem. 2013 Jun 14; 288(24):17272-84.
Score: 0.320
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Identification and characterization of protein phosphatase 2C activation by ceramide. J Lipid Res. 2012 Aug; 53(8):1513-21.
Score: 0.300
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Protein phosphatase 1a mediates ceramide-induced ERM protein dephosphorylation: a novel mechanism independent of phosphatidylinositol 4, 5-biphosphate (PIP2) and myosin/ERM phosphatase. J Biol Chem. 2012 Mar 23; 287(13):10145-10155.
Score: 0.294
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Many ceramides. J Biol Chem. 2011 Aug 12; 286(32):27855-62.
Score: 0.282
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Regulated secretion of acid sphingomyelinase: implications for selectivity of ceramide formation. J Biol Chem. 2010 Nov 12; 285(46):35706-18.
Score: 0.266
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Differential effects of ceramide and sphingosine 1-phosphate on ERM phosphorylation: probing sphingolipid signaling at the outer plasma membrane. J Biol Chem. 2010 Oct 15; 285(42):32476-85.
Score: 0.265
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The acid sphingomyelinase/ceramide pathway: biomedical significance and mechanisms of regulation. Curr Mol Med. 2010 Jul; 10(5):454-66.
Score: 0.263
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Mammalian neutral sphingomyelinases: regulation and roles in cell signaling responses. Neuromolecular Med. 2010 Dec; 12(4):320-30.
Score: 0.262
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Acid beta-glucosidase 1 counteracts p38delta-dependent induction of interleukin-6: possible role for ceramide as an anti-inflammatory lipid. J Biol Chem. 2009 May 08; 284(19):12979-88.
Score: 0.240
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Involvement of acid beta-glucosidase 1 in the salvage pathway of ceramide formation. J Biol Chem. 2009 May 08; 284(19):12972-8.
Score: 0.240
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Remodeling of cellular cytoskeleton by the acid sphingomyelinase/ceramide pathway. J Cell Biol. 2008 Apr 21; 181(2):335-50.
Score: 0.226
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The sphingolipid salvage pathway in ceramide metabolism and signaling. Cell Signal. 2008 Jun; 20(6):1010-8.
Score: 0.221
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Confluence induced threonine41/serine45 phospho-beta-catenin dephosphorylation via ceramide-mediated activation of PP1cgamma. Biochim Biophys Acta. 2007 Dec; 1771(12):1418-28.
Score: 0.219
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Mechanism of inhibition of sequestration of protein kinase C alpha/betaII by ceramide. Roles of ceramide-activated protein phosphatases and phosphorylation/dephosphorylation of protein kinase C alpha/betaII on threonine 638/641. J Biol Chem. 2007 Jul 13; 282(28):20647-56.
Score: 0.212
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The coordination of prostaglandin E2 production by sphingosine-1-phosphate and ceramide-1-phosphate. Mol Pharmacol. 2005 Aug; 68(2):330-5.
Score: 0.185
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Selective inhibition of juxtanuclear translocation of protein kinase C betaII by a negative feedback mechanism involving ceramide formed from the salvage pathway. J Biol Chem. 2005 Jan 28; 280(4):2606-12.
Score: 0.178
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Biologically active sphingolipids in cancer pathogenesis and treatment. Nat Rev Cancer. 2004 Aug; 4(8):604-16.
Score: 0.175
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Lipid metabolism: ceramide transfer protein adds a new dimension. Curr Biol. 2004 Feb 17; 14(4):R163-5.
Score: 0.169
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The structural requirements for ceramide activation of serine-threonine protein phosphatases. J Lipid Res. 2004 Mar; 45(3):496-506.
Score: 0.167
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Ceramide, stress, and a "LAG" in aging. Sci Aging Knowledge Environ. 2003 Oct 01; 2003(39):PE27.
Score: 0.165
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Ceramide in apoptosis: an overview and current perspectives. Biochim Biophys Acta. 2002 Dec 30; 1585(2-3):114-25.
Score: 0.156
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A simple, highly sensitive, and facile method to quantify ceramide at the plasma membrane. J Lipid Res. 2023 02; 64(2):100322.
Score: 0.156
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Alkaline ceramidase catalyzes the hydrolysis of ceramides via a catalytic mechanism shared by Zn2+-dependent amidases. PLoS One. 2022; 17(9):e0271540.
Score: 0.153
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The Ceramide-centric universe of lipid-mediated cell regulation: stress encounters of the lipid kind. J Biol Chem. 2002 Jul 19; 277(29):25847-50.
Score: 0.150
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Biochemical mechanisms of the generation of endogenous long chain ceramide in response to exogenous short chain ceramide in the A549 human lung adenocarcinoma cell line. Role for endogenous ceramide in mediating the action of exogenous ceramide. J Biol Chem. 2002 Apr 12; 277(15):12960-9.
Score: 0.147
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De novo ceramide regulates the alternative splicing of caspase 9 and Bcl-x in A549 lung adenocarcinoma cells. Dependence on protein phosphatase-1. J Biol Chem. 2002 Apr 12; 277(15):12587-95.
Score: 0.147
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Substrate specificity of rat brain ceramidase. J Lipid Res. 2002 Jan; 43(1):141-8.
Score: 0.146
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Mitochondria and ceramide: intertwined roles in regulation of apoptosis. Adv Enzyme Regul. 2002; 42:113-29.
Score: 0.146
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Sphingolipids in vascular biology. Adv Exp Med Biol. 2002; 507:439-44.
Score: 0.146
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Updates on functions of ceramide in chemotherapy-induced cell death and in multidrug resistance. Drug Resist Updat. 2001 Dec; 4(6):368-77.
Score: 0.145
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Determination of ceramides and diglycerides by the diglyceride kinase assay. Anal Biochem. 2001 Nov 15; 298(2):141-50.
Score: 0.145
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Ceramide synthase 2-C24:1 -ceramide axis limits the metastatic potential of ovarian cancer cells. FASEB J. 2021 02; 35(2):e21287.
Score: 0.137
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Induction of apoptosis through B-cell receptor cross-linking occurs via de novo generated C16-ceramide and involves mitochondria. J Biol Chem. 2001 Apr 27; 276(17):13606-14.
Score: 0.137
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Acid sphingomyelinase-dependent autophagic degradation of GPX4 is critical for the execution of ferroptosis. Cell Death Dis. 2021 01 07; 12(1):26.
Score: 0.136
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Targeting sphingosine kinase 1 (SK1) enhances oncogene-induced senescence through ceramide synthase 2 (CerS2)-mediated generation of very-long-chain ceramides. Cell Death Dis. 2021 01 04; 12(1):27.
Score: 0.136
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Serine palmitoyltransferase regulates de novo ceramide generation during etoposide-induced apoptosis. J Biol Chem. 2000 Mar 24; 275(12):9078-84.
Score: 0.129
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Ceramide in the eukaryotic stress response. Trends Cell Biol. 2000 Feb; 10(2):73-80.
Score: 0.128
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Preparation of radiolabeled ceramides and phosphosphingolipids. Methods Enzymol. 2000; 311:499-518.
Score: 0.127
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Synthesis of key precursors of radiolabeled sphingolipids. Methods Enzymol. 2000; 311:518-35.
Score: 0.127
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Quantitative determination of ceramide using diglyceride kinase. Methods Enzymol. 2000; 312:22-31.
Score: 0.127
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Use of short-chain ceramides. Methods Enzymol. 2000; 312:407-20.
Score: 0.127
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Ceramide and sphingomyelinases in the regulation of stress responses. Chem Phys Lipids. 1999 Nov; 102(1-2):141-7.
Score: 0.126
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Long chain ceramides activate protein phosphatase-1 and protein phosphatase-2A. Activation is stereospecific and regulated by phosphatidic acid. J Biol Chem. 1999 Jul 16; 274(29):20313-7.
Score: 0.123
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Probing compartment-specific sphingolipids with targeted bacterial sphingomyelinases and ceramidases. J Lipid Res. 2019 11; 60(11):1841-1850.
Score: 0.123
-
Ceramide and apoptosis. Trends Biochem Sci. 1999 Jun; 24(6):224-5; author reply 227.
Score: 0.122
-
The use of diglyceride kinase for quantifying ceramide. Trends Biochem Sci. 1999 Jun; 24(6):226-7.
Score: 0.122
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Bioactive sphingolipid profile in a xenograft mouse model of head and neck squamous cell carcinoma. PLoS One. 2019; 14(4):e0215770.
Score: 0.121
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Quantifying 1-deoxydihydroceramides and 1-deoxyceramides in mouse nervous system tissue. Prostaglandins Other Lipid Mediat. 2019 04; 141:40-48.
Score: 0.120
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The role of ceramide in cell signaling. Biochim Biophys Acta. 1998 Dec 08; 1436(1-2):233-43.
Score: 0.118
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Purification and characterization of ceramide-activated protein phosphatases. Biochemistry. 1998 Aug 11; 37(32):11232-8.
Score: 0.115
-
p53-dependent ceramide response to genotoxic stress. J Clin Invest. 1998 Jul 15; 102(2):329-39.
Score: 0.115
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Sphingomyelin synthase, a potential regulator of intracellular levels of ceramide and diacylglycerol during SV40 transformation. Does sphingomyelin synthase account for the putative phosphatidylcholine-specific phospholipase C? J Biol Chem. 1998 Jun 05; 273(23):14550-9.
Score: 0.114
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Identification of an acid sphingomyelinase ceramide kinase pathway in the regulation of the chemokine CCL5. J Lipid Res. 2018 07; 59(7):1219-1229.
Score: 0.113
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Decreased ceramide underlies mitochondrial dysfunction in Charcot-Marie-Tooth 2F. FASEB J. 2018 03; 32(3):1716-1728.
Score: 0.111
-
Tumor suppressor p53 links ceramide metabolism to DNA damage response through alkaline ceramidase 2. Cell Death Differ. 2018 05; 25(5):841-856.
Score: 0.110
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Ceramide and the eukaryotic stress response. Biochem Soc Trans. 1997 Nov; 25(4):1171-5.
Score: 0.109
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Bcl-2 antagonizes apoptotic cell death induced by two new ceramide analogues. FEBS Lett. 1997 Jul 14; 411(2-3):260-4.
Score: 0.107
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Phospholipase A2 is necessary for tumor necrosis factor alpha-induced ceramide generation in L929 cells. J Biol Chem. 1997 Jul 04; 272(27):17196-203.
Score: 0.107
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Selective involvement of ceramide in cytokine-induced apoptosis. Ceramide inhibits phorbol ester activation of nuclear factor kappaB. J Biol Chem. 1997 Jun 27; 272(26):16474-81.
Score: 0.107
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Tricyclic Antidepressants Promote Ceramide Accumulation to Regulate Collagen Production in Human Hepatic Stellate Cells. Sci Rep. 2017 03 21; 7:44867.
Score: 0.105
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Ceramide Is Metabolized to Acylceramide and Stored in Lipid Droplets. Cell Metab. 2017 03 07; 25(3):686-697.
Score: 0.105
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Cytokine response modifier A (CrmA) inhibits ceramide formation in response to tumor necrosis factor (TNF)-alpha: CrmA and Bcl-2 target distinct components in the apoptotic pathway. J Exp Med. 1997 Feb 03; 185(3):481-90.
Score: 0.104
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Ceramide: a novel lipid mediator of apoptosis. Adv Pharmacol. 1997; 41:133-54.
Score: 0.103
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Mechanisms of ceramide-mediated apoptosis. Adv Exp Med Biol. 1997; 407:145-9.
Score: 0.103
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Sphingolipid second messengers: tumor suppressor lipids. Adv Exp Med Biol. 1997; 400A:305-12.
Score: 0.103
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Functions of ceramide in coordinating cellular responses to stress. Science. 1996 Dec 13; 274(5294):1855-9.
Score: 0.103
-
Ceramide: role in growth inhibitory cascades. J Lipid Mediat Cell Signal. 1996 Sep; 14(1-3):295-301.
Score: 0.101
-
Activation of the sphingomyelin cycle by brefeldin A: effects of brefeldin A on differentiation and implications for a role for ceramide in regulation of protein trafficking. Cell Growth Differ. 1996 Jun; 7(6):765-74.
Score: 0.099
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Bcl-2 interrupts the ceramide-mediated pathway of cell death. Proc Natl Acad Sci U S A. 1996 May 28; 93(11):5325-8.
Score: 0.099
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Ceramide: an intracellular mediator of apoptosis and growth suppression. Philos Trans R Soc Lond B Biol Sci. 1996 Feb 29; 351(1336):233-40; discussion 240-1.
Score: 0.097
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Analysis of the Involvement of Different Ceramide Variants in the Response to Hydroxyurea Stress in Baker's Yeast. PLoS One. 2016; 11(1):e0146839.
Score: 0.097
-
Ceramide limits phosphatidylinositol-3-kinase C2?-controlled cell motility in ovarian cancer: potential of ceramide as a metastasis-suppressor lipid. Oncogene. 2016 05; 35(21):2801-12.
Score: 0.094
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Tumor Necrosis Factor-a (TNFa)-induced Ceramide Generation via Ceramide Synthases Regulates Loss of Focal Adhesion Kinase (FAK) and Programmed Cell Death. J Biol Chem. 2015 Oct 16; 290(42):25356-73.
Score: 0.094
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Activity of neutral and alkaline ceramidases on fluorogenic N-acylated coumarin-containing aminodiols. J Lipid Res. 2015 Oct; 56(10):2019-28.
Score: 0.094
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Dynamics of the Heat Stress Response of Ceramides with Different Fatty-Acyl Chain Lengths in Baker's Yeast. PLoS Comput Biol. 2015 Aug; 11(8):e1004373.
Score: 0.094
-
Ceramide: an endogenous regulator of apoptosis and growth suppression. Immunol Today. 1995 Jun; 16(6):294-7.
Score: 0.093
-
Ceramide: a stress signal and mediator of growth suppression and apoptosis. J Cell Biochem. 1995 Jun; 58(2):191-8.
Score: 0.093
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Retinoblastoma gene product as a downstream target for a ceramide-dependent pathway of growth arrest. Proc Natl Acad Sci U S A. 1995 Feb 28; 92(5):1347-51.
Score: 0.091
-
Role for ceramide in cell cycle arrest. J Biol Chem. 1995 Feb 03; 270(5):2047-52.
Score: 0.090
-
Ceramide: an intracellular signal for apoptosis. Trends Biochem Sci. 1995 Feb; 20(2):73-7.
Score: 0.090
-
Roles and regulation of neutral sphingomyelinase-2 in cellular and pathological processes. Adv Biol Regul. 2015 Jan; 57:24-41.
Score: 0.089
-
On-tissue localization of ceramides and other sphingolipids by MALDI mass spectrometry imaging. Anal Chem. 2014 Aug 19; 86(16):8303-11.
Score: 0.087
-
Role of ceramide-activated protein phosphatase in ceramide-mediated signal transduction. J Biol Chem. 1994 Jul 29; 269(30):19605-9.
Score: 0.087
-
Ceramide and sphingosine-1-phosphate act as photodynamic therapy-elicited damage-associated molecular patterns: cell surface exposure. Int Immunopharmacol. 2014 Jun; 20(2):359-65.
Score: 0.085
-
The sphingomyelin cycle and the second messenger function of ceramide. J Biol Chem. 1994 Feb 04; 269(5):3125-8.
Score: 0.084
-
Selectivity of ceramide-mediated biology. Lack of activity of erythro-dihydroceramide. J Biol Chem. 1993 Dec 15; 268(35):26226-32.
Score: 0.084
-
The protein kinase Sch9 is a key regulator of sphingolipid metabolism in Saccharomyces cerevisiae. Mol Biol Cell. 2014 Jan; 25(1):196-211.
Score: 0.083
-
Distinct signaling roles of ceramide species in yeast revealed through systematic perturbation and systems biology analyses. Sci Signal. 2013 Oct 29; 6(299):rs14.
Score: 0.083
-
Tumor necrosis factor-alpha (TNF-alpha) signal transduction through ceramide. Dissociation of growth inhibitory effects of TNF-alpha from activation of nuclear factor-kappa B. J Biol Chem. 1993 Aug 25; 268(24):17762-6.
Score: 0.082
-
Ceramide activates heterotrimeric protein phosphatase 2A. J Biol Chem. 1993 Jul 25; 268(21):15523-30.
Score: 0.081
-
Ceramide-mediated growth inhibition and CAPP are conserved in Saccharomyces cerevisiae. J Biol Chem. 1993 May 05; 268(13):9255-61.
Score: 0.080
-
A signaling cascade mediated by ceramide, src and PDGFR? coordinates the activation of the redox-sensitive neutral sphingomyelinase-2 and sphingosine kinase-1. Biochim Biophys Acta. 2013 Aug; 1831(8):1344-56.
Score: 0.080
-
Programmed cell death induced by ceramide. Science. 1993 Mar 19; 259(5102):1769-71.
Score: 0.079
-
Ceramide-activated protein phosphatase: partial purification and relationship to protein phosphatase 2A. Adv Lipid Res. 1993; 25:91-104.
Score: 0.078
-
Modulation of mitochondrial outer membrane permeabilization and apoptosis by ceramide metabolism. PLoS One. 2012; 7(11):e48571.
Score: 0.078
-
Ceramide-mediated biology. Determination of structural and stereospecific requirements through the use of N-acyl-phenylaminoalcohol analogs. J Biol Chem. 1992 Sep 15; 267(26):18493-7.
Score: 0.077
-
Modulation of cell growth and differentiation by ceramide. FEBS Lett. 1992 Jul 28; 307(2):211-4.
Score: 0.076
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Lipidomic profiling in Crohn's disease: abnormalities in phosphatidylinositols, with preservation of ceramide, phosphatidylcholine and phosphatidylserine composition. Int J Biochem Cell Biol. 2012 Nov; 44(11):1839-46.
Score: 0.075
-
Dihydroceramide accumulation and reactive oxygen species are distinct and nonessential events in 4-HPR-mediated leukemia cell death. Biochem Cell Biol. 2012 Apr; 90(2):209-23.
Score: 0.074
-
Ceramide stimulates a cytosolic protein phosphatase. J Biol Chem. 1992 Mar 15; 267(8):5048-51.
Score: 0.074
-
The roles of neutral sphingomyelinases in neurological pathologies. Neurochem Res. 2012 Jun; 37(6):1137-49.
Score: 0.073
-
Results of a phase II trial of gemcitabine plus doxorubicin in patients with recurrent head and neck cancers: serum C18-ceramide as a novel biomarker for monitoring response. Clin Cancer Res. 2011 Sep 15; 17(18):6097-105.
Score: 0.071
-
Novel pathway of ceramide production in mitochondria: thioesterase and neutral ceramidase produce ceramide from sphingosine and acyl-CoA. J Biol Chem. 2011 Jul 15; 286(28):25352-62.
Score: 0.070
-
A deficiency of ceramide biosynthesis causes cerebellar purkinje cell neurodegeneration and lipofuscin accumulation. PLoS Genet. 2011 May; 7(5):e1002063.
Score: 0.070
-
Neutral sphingomyelinase-2 mediates growth arrest by retinoic acid through modulation of ribosomal S6 kinase. J Biol Chem. 2011 Jun 17; 286(24):21565-76.
Score: 0.070
-
Ceramide synthase-dependent ceramide generation and programmed cell death: involvement of salvage pathway in regulating postmitochondrial events. J Biol Chem. 2011 May 06; 286(18):15929-42.
Score: 0.069
-
Mitochondrially targeted ceramides preferentially promote autophagy, retard cell growth, and induce apoptosis. J Lipid Res. 2011 Feb; 52(2):278-88.
Score: 0.068
-
Synthesis, NMR characterization and divergent biological actions of 2'-hydroxy-ceramide/dihydroceramide stereoisomers in MCF7 cells. Bioorg Med Chem. 2010 Nov 01; 18(21):7565-79.
Score: 0.067
-
Role of ceramide as a lipid mediator of 1 alpha,25-dihydroxyvitamin D3-induced HL-60 cell differentiation. J Biol Chem. 1990 Sep 15; 265(26):15823-31.
Score: 0.067
-
Dihydroceramide desaturase activity is modulated by oxidative stress. Biochem J. 2010 Mar 29; 427(2):265-74.
Score: 0.065
-
An overview of sphingolipid metabolism: from synthesis to breakdown. Adv Exp Med Biol. 2010; 688:1-23.
Score: 0.064
-
Antiapoptotic roles of ceramide-synthase-6-generated C16-ceramide via selective regulation of the ATF6/CHOP arm of ER-stress-response pathways. FASEB J. 2010 Jan; 24(1):296-308.
Score: 0.062
-
Potentiation of cannabinoid-induced cytotoxicity in mantle cell lymphoma through modulation of ceramide metabolism. Mol Cancer Res. 2009 Jul; 7(7):1086-98.
Score: 0.061
-
AMPK inhibitor Compound C stimulates ceramide production and promotes Bax redistribution and apoptosis in MCF7 breast carcinoma cells. J Lipid Res. 2009 Dec; 50(12):2389-97.
Score: 0.061
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Central role of ceramide biosynthesis in body weight regulation, energy metabolism, and the metabolic syndrome. Am J Physiol Endocrinol Metab. 2009 Jul; 297(1):E211-24.
Score: 0.061
-
Downregulation of neutral ceramidase by gemcitabine: Implications for cell cycle regulation. Biochim Biophys Acta. 2009 Aug; 1791(8):730-9.
Score: 0.060
-
Direct interaction between the inhibitor 2 and ceramide via sphingolipid-protein binding is involved in the regulation of protein phosphatase 2A activity and signaling. FASEB J. 2009 Mar; 23(3):751-63.
Score: 0.059
-
Ceramide-enriched membrane domains in red blood cells and the mechanism of sphingomyelinase-induced hot-cold hemolysis. Biochemistry. 2008 Oct 28; 47(43):11222-30.
Score: 0.058
-
Anti-ceramidase LCL385 acutely reduces BCL-2 expression in the hippocampus but is not associated with an increase of learned helplessness in rats. Behav Brain Res. 2009 Jan 30; 197(1):41-4.
Score: 0.058
-
Ceramide generated by sphingomyelin hydrolysis and the salvage pathway is involved in hypoxia/reoxygenation-induced Bax redistribution to mitochondria in NT-2 cells. J Biol Chem. 2008 Sep 26; 283(39):26509-17.
Score: 0.058
-
Molecular targeting of acid ceramidase: implications to cancer therapy. Curr Drug Targets. 2008 Aug; 9(8):653-61.
Score: 0.058
-
Protection from high fat diet-induced increase in ceramide in mice lacking plasminogen activator inhibitor 1. J Biol Chem. 2008 May 16; 283(20):13538-48.
Score: 0.056
-
De novo N-palmitoylsphingosine synthesis is the major biochemical mechanism of ceramide accumulation following p53 up-regulation. Prostaglandins Other Lipid Mediat. 2008 Jun; 86(1-4):41-8.
Score: 0.056
-
Thematic review series: sphingolipids. ISC1 (inositol phosphosphingolipid-phospholipase C), the yeast homologue of neutral sphingomyelinases. J Lipid Res. 2008 May; 49(5):922-8.
Score: 0.056
-
Mitochondrially targeted ceramide LCL-30 inhibits colorectal cancer in mice. Br J Cancer. 2008 Jan 15; 98(1):98-105.
Score: 0.055
-
A novel role for protein kinase Cdelta-mediated phosphorylation of acid sphingomyelinase in UV light-induced mitochondrial injury. FASEB J. 2008 Jan; 22(1):183-93.
Score: 0.054
-
Clinical relevance of ceramide metabolism in the pathogenesis of human head and neck squamous cell carcinoma (HNSCC): attenuation of C(18)-ceramide in HNSCC tumors correlates with lymphovascular invasion and nodal metastasis. Cancer Lett. 2007 Oct 18; 256(1):101-11.
Score: 0.054
-
Activation of acid sphingomyelinase by protein kinase Cdelta-mediated phosphorylation. J Biol Chem. 2007 Apr 13; 282(15):11549-61.
Score: 0.052
-
Role of human longevity assurance gene 1 and C18-ceramide in chemotherapy-induced cell death in human head and neck squamous cell carcinomas. Mol Cancer Ther. 2007 Feb; 6(2):712-22.
Score: 0.052
-
Large-scale purification and characterization of recombinant Pseudomonas ceramidase: regulation by calcium. J Lipid Res. 2007 Mar; 48(3):600-8.
Score: 0.051
-
Necessary role for the Lag1p motif in (dihydro)ceramide synthase activity. J Biol Chem. 2006 Nov 10; 281(45):33931-8.
Score: 0.050
-
Tailoring structure-function and targeting properties of ceramides by site-specific cationization. Bioorg Med Chem. 2006 Nov 01; 14(21):7083-104.
Score: 0.050
-
Modulation of ceramide metabolism enhances viral protein apoptin's cytotoxicity in prostate cancer. Mol Ther. 2006 Nov; 14(5):637-46.
Score: 0.050
-
Sphingolipid-binding proteins. Biochim Biophys Acta. 2006 Aug; 1761(8):927-46.
Score: 0.050
-
Combined therapeutic use of AdGFPFasL and small molecule inhibitors of ceramide metabolism in prostate and head and neck cancers: a status report. Cancer Gene Ther. 2006 Dec; 13(12):1045-51.
Score: 0.050
-
Cationic long-chain ceramide LCL-30 induces cell death by mitochondrial targeting in SW403 cells. Mol Cancer Ther. 2006 Jun; 5(6):1520-9.
Score: 0.050
-
Regulation of the sphingosine-recycling pathway for ceramide generation by oxidative stress, and its role in controlling c-Myc/Max function. Biochem J. 2006 Jan 15; 393(Pt 2):513-21.
Score: 0.048
-
Resistance to TRAIL is associated with defects in ceramide signaling that can be overcome by exogenous C6-ceramide without requiring down-regulation of cellular FLICE inhibitory protein. Mol Cancer Ther. 2005 Sep; 4(9):1320-7.
Score: 0.047
-
Protein kinase C and phospholipase D: intimate interactions in intracellular signaling. Cell Mol Life Sci. 2005 Jul; 62(13):1448-61.
Score: 0.047
-
Roles for C16-ceramide and sphingosine 1-phosphate in regulating hepatocyte apoptosis in response to tumor necrosis factor-alpha. J Biol Chem. 2005 Jul 29; 280(30):27879-87.
Score: 0.046
-
Positively charged ceramide is a potent inducer of mitochondrial permeabilization. J Biol Chem. 2005 Apr 22; 280(16):16096-105.
Score: 0.045
-
Golgi fragmentation is associated with ceramide-induced cellular effects. Mol Biol Cell. 2005 Mar; 16(3):1555-67.
Score: 0.045
-
Inhibition of growth and telomerase activity by novel cationic ceramide analogs with high solubility in human head and neck squamous cell carcinoma cells. Otolaryngol Head Neck Surg. 2005 Jan; 132(1):55-62.
Score: 0.045
-
Defects in cell growth regulation by C18:0-ceramide and longevity assurance gene 1 in human head and neck squamous cell carcinomas. J Biol Chem. 2004 Oct 22; 279(43):44311-9.
Score: 0.044
-
Sphingolipids in inflammation: roles and implications. Curr Mol Med. 2004 Jun; 4(4):405-18.
Score: 0.043
-
Role for mammalian neutral sphingomyelinase 2 in confluence-induced growth arrest of MCF7 cells. J Biol Chem. 2004 Jun 11; 279(24):25101-11.
Score: 0.043
-
Acid and neutral sphingomyelinases: roles and mechanisms of regulation. Biochem Cell Biol. 2004 Feb; 82(1):27-44.
Score: 0.042
-
Quantitative measurement of different ceramide species from crude cellular extracts by normal-phase high-performance liquid chromatography coupled to atmospheric pressure ionization mass spectrometry. Rapid Commun Mass Spectrom. 2004; 18(5):577-83.
Score: 0.042
-
Mass spectrometric analysis of ceramide perturbations in brain and fibroblasts of mice and human patients with peroxisomal disorders. Rapid Commun Mass Spectrom. 2004; 18(14):1569-74.
Score: 0.042
-
Ceramide 1-phosphate is a direct activator of cytosolic phospholipase A2. J Biol Chem. 2004 Mar 19; 279(12):11320-6.
Score: 0.042
-
Rapid shortening of telomere length in response to ceramide involves the inhibition of telomere binding activity of nuclear glyceraldehyde-3-phosphate dehydrogenase. J Biol Chem. 2004 Feb 13; 279(7):6152-62.
Score: 0.042
-
BcR-induced apoptosis involves differential regulation of C16 and C24-ceramide formation and sphingolipid-dependent activation of the proteasome. J Biol Chem. 2003 Apr 25; 278(17):14723-31.
Score: 0.039
-
Biochemical properties of mammalian neutral sphingomyelinase 2 and its role in sphingolipid metabolism. J Biol Chem. 2003 Apr 18; 278(16):13775-83.
Score: 0.039
-
Observation of different ceramide species from crude cellular extracts by normal-phase high-performance liquid chromatography coupled to atmospheric pressure chemical ionization mass spectrometry. Rapid Commun Mass Spectrom. 2003; 17(11):1203-11.
Score: 0.039
-
GRASP55 regulates intra-Golgi localization of glycosylation enzymes to control glycosphingolipid biosynthesis. EMBO J. 2021 10 18; 40(20):e107766.
Score: 0.036
-
Molecular mechanisms of ceramide-mediated telomerase inhibition in the A549 human lung adenocarcinoma cell line. J Biol Chem. 2001 Aug 31; 276(35):32506-14.
Score: 0.035
-
Role of ceramide in mediating the inhibition of telomerase activity in A549 human lung adenocarcinoma cells. J Biol Chem. 2001 Jul 06; 276(27):24901-10.
Score: 0.035
-
Ceramide kinase regulates TNF-a-induced immune responses in human monocytic cells. Sci Rep. 2021 04 15; 11(1):8259.
Score: 0.035
-
Biochemical characterization of the reverse activity of rat brain ceramidase. A CoA-independent and fumonisin B1-insensitive ceramide synthase. J Biol Chem. 2001 May 18; 276(20):16758-66.
Score: 0.034
-
Function of the cloned putative neutral sphingomyelinase as lyso-platelet activating factor-phospholipase C. J Biol Chem. 1999 Dec 31; 274(53):38131-9.
Score: 0.032
-
Phosphatidic acid is a potent and selective inhibitor of protein phosphatase 1 and an inhibitor of ceramide-mediated responses. J Biol Chem. 1999 Jul 23; 274(30):21335-41.
Score: 0.031
-
Role of sphingolipids in senescence: implication in aging and age-related diseases. J Clin Invest. 2018 07 02; 128(7):2702-2712.
Score: 0.029
-
Ceramide is involved in triggering of cardiomyocyte apoptosis induced by ischemia and reperfusion. Am J Pathol. 1997 Nov; 151(5):1257-63.
Score: 0.027
-
Alkaline Ceramidase 1 Protects Mice from Premature Hair Loss by Maintaining the Homeostasis of Hair Follicle Stem Cells. Stem Cell Reports. 2017 11 14; 9(5):1488-1500.
Score: 0.027
-
Inhibiting glucosylceramide synthase exacerbates cisplatin-induced acute kidney injury. J Lipid Res. 2017 07; 58(7):1439-1452.
Score: 0.026
-
Upregulation of Bcl-2 and elevation of ceramide in Batten disease. Neuropediatrics. 1997 Feb; 28(1):37-41.
Score: 0.026
-
Ceramide inactivates cellular protein kinase Calpha. J Biol Chem. 1996 May 31; 271(22):13169-74.
Score: 0.025
-
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Score: 0.025
-
Aging-related elevation of sphingoid bases shortens yeast chronological life span by compromising mitochondrial function. Oncotarget. 2016 Apr 19; 7(16):21124-44.
Score: 0.025
-
Role of ceramide in stimulation of the transcription of cytosolic phospholipase A2 and cyclooxygenase 2. Biochem Biophys Res Commun. 1996 Mar 27; 220(3):681-6.
Score: 0.024
-
Alkaline ceramidase 3 deficiency aggravates colitis and colitis-associated tumorigenesis in mice by hyperactivating the innate immune system. Cell Death Dis. 2016 Mar 03; 7:e2124.
Score: 0.024
-
Alkaline Ceramidase 3 Deficiency Results in Purkinje Cell Degeneration and Cerebellar Ataxia Due to Dyshomeostasis of Sphingolipids in the Brain. PLoS Genet. 2015 Oct; 11(10):e1005591.
Score: 0.024
-
Ceramide activates the stress-activated protein kinases. J Biol Chem. 1995 Sep 29; 270(39):22689-92.
Score: 0.024
-
Role for ceramide as an endogenous mediator of Fas-induced cytotoxicity. Proc Natl Acad Sci U S A. 1995 Aug 29; 92(18):8443-7.
Score: 0.024
-
Ceramide induces interleukin 6 gene expression in human fibroblasts. J Exp Med. 1995 Aug 01; 182(2):599-604.
Score: 0.023
-
Activation of the sphingomyelin cycle through the low-affinity neurotrophin receptor. Science. 1994 Sep 09; 265(5178):1596-9.
Score: 0.022
-
Evaluation of the role of secretory sphingomyelinase and bioactive sphingolipids as biomarkers in hemophagocytic lymphohistiocytosis. Am J Hematol. 2013 Nov; 88(11):E265-72.
Score: 0.020
-
The sphingomyelin cycle: a prototypic sphingolipid signaling pathway. Adv Lipid Res. 1993; 25:27-41.
Score: 0.020
-
The novel second messenger ceramide: identification, mechanism of action, and cellular activity. Adv Lipid Res. 1993; 25:43-64.
Score: 0.020
-
Retinoblastoma protein dephosphorylation induced by D-erythro-sphingosine. J Biol Chem. 1992 Nov 25; 267(33):23459-62.
Score: 0.019
-
Off-target function of the Sonic hedgehog inhibitor cyclopamine in mediating apoptosis via nitric oxide-dependent neutral sphingomyelinase 2/ceramide induction. Mol Cancer Ther. 2012 May; 11(5):1092-102.
Score: 0.019
-
Ceramide synthases at the centre of sphingolipid metabolism and biology. Biochem J. 2012 Feb 01; 441(3):789-802.
Score: 0.018
-
Accumulation of long-chain glycosphingolipids during aging is prevented by caloric restriction. PLoS One. 2011; 6(6):e20411.
Score: 0.018
-
Identification of sphingomyelin turnover as an effector mechanism for the action of tumor necrosis factor alpha and gamma-interferon. Specific role in cell differentiation. J Biol Chem. 1991 Jan 05; 266(1):484-9.
Score: 0.017
-
Selective knockdown of ceramide synthases reveals complex interregulation of sphingolipid metabolism. J Lipid Res. 2011 Jan; 52(1):68-77.
Score: 0.017
-
Blood sphingolipidomics in healthy humans: impact of sample collection methodology. J Lipid Res. 2010 Oct; 51(10):3074-87.
Score: 0.017
-
Hydrolytic pathway protects against ceramide-induced apoptosis in keratinocytes exposed to UVB. J Invest Dermatol. 2010 Oct; 130(10):2472-80.
Score: 0.016
-
Plant sphingolipids: decoding the enigma of the Sphinx. New Phytol. 2010 Feb; 185(3):611-30.
Score: 0.016
-
Acid ceramidase upregulation in prostate cancer: role in tumor development and implications for therapy. Expert Opin Ther Targets. 2009 Dec; 13(12):1449-58.
Score: 0.016
-
Acid ceramidase upregulation in prostate cancer cells confers resistance to radiation: AC inhibition, a potential radiosensitizer. Mol Ther. 2009 Mar; 17(3):430-8.
Score: 0.015
-
Sphingolipids function as downstream effectors of a fungal PAQR. Mol Pharmacol. 2009 Apr; 75(4):866-75.
Score: 0.015
-
Molecular cloning and characterization of OsCDase, a ceramidase enzyme from rice. Plant J. 2008 Sep; 55(6):1000-9.
Score: 0.014
-
Glycosphingolipid synthesis requires FAPP2 transfer of glucosylceramide. Nature. 2007 Sep 06; 449(7158):62-7.
Score: 0.013
-
The functional effects of acid ceramidase overexpression in prostate cancer progression and resistance to chemotherapy. Cancer Biol Ther. 2007 Sep; 6(9):1455-60.
Score: 0.013
-
Lysosomotropic acid ceramidase inhibitor induces apoptosis in prostate cancer cells. Cancer Chemother Pharmacol. 2008 Feb; 61(2):231-42.
Score: 0.013
-
Role of acid ceramidase in resistance to FasL: therapeutic approaches based on acid ceramidase inhibitors and FasL gene therapy. Mol Ther. 2007 Jul; 15(7):1259-63.
Score: 0.013
-
Role for furin in tumor necrosis factor alpha-induced activation of the matrix metalloproteinase/sphingolipid mitogenic pathway. Mol Cell Biol. 2007 Apr; 27(8):2997-3007.
Score: 0.013
-
Involvement of dihydroceramide desaturase in cell cycle progression in human neuroblastoma cells. J Biol Chem. 2007 Jun 08; 282(23):16718-28.
Score: 0.013
-
Distribution and dynamic changes of sphingolipids in blood in response to platelet activation. J Thromb Haemost. 2006 Dec; 4(12):2704-9.
Score: 0.013
-
Altered adipose and plasma sphingolipid metabolism in obesity: a potential mechanism for cardiovascular and metabolic risk. Diabetes. 2006 Sep; 55(9):2579-87.
Score: 0.013
-
Involvement of sphingolipids in apoptin-induced cell killing. Mol Ther. 2006 Nov; 14(5):627-36.
Score: 0.013
-
Sphingosine kinase: biochemical and cellular regulation and role in disease. J Biochem Mol Biol. 2006 Mar 31; 39(2):113-31.
Score: 0.012
-
Potent antitumor activity of a novel cationic pyridinium-ceramide alone or in combination with gemcitabine against human head and neck squamous cell carcinomas in vitro and in vivo. J Pharmacol Exp Ther. 2006 Jun; 317(3):1188-99.
Score: 0.012
-
Loss of sphingosine kinase-1 activates the intrinsic pathway of programmed cell death: modulation of sphingolipid levels and the induction of apoptosis. FASEB J. 2006 Mar; 20(3):482-4.
Score: 0.012
-
Neutral ceramidase encoded by the Asah2 gene is essential for the intestinal degradation of sphingolipids. J Biol Chem. 2006 Mar 17; 281(11):7324-31.
Score: 0.012
-
Dihydrosphingosine 1-phosphate stimulates MMP1 gene expression via activation of ERK1/2-Ets1 pathway in human fibroblasts. FASEB J. 2006 Jan; 20(1):184-6.
Score: 0.012
-
A mitochondrial pool of sphingomyelin is involved in TNFalpha-induced Bax translocation to mitochondria. Biochem J. 2005 Mar 15; 386(Pt 3):445-51.
Score: 0.011
-
Sphingosine kinase 1 (SPHK1) is induced by transforming growth factor-beta and mediates TIMP-1 up-regulation. J Biol Chem. 2004 Dec 24; 279(52):53994-4001.
Score: 0.011
-
Prodrug modification increases potassium tricyclo[5.2.1.0(2,6)]-decan-8-yl dithiocarbonate (D609) chemical stability and cytotoxicity against U937 leukemia cells. J Pharmacol Exp Ther. 2004 Jun; 309(3):1051-9.
Score: 0.011
-
Sphingomyelin synthase as a potential target for D609-induced apoptosis in U937 human monocytic leukemia cells. Exp Cell Res. 2004 Jan 15; 292(2):385-92.
Score: 0.011
-
Ceramide kinase mediates cytokine- and calcium ionophore-induced arachidonic acid release. J Biol Chem. 2003 Oct 03; 278(40):38206-13.
Score: 0.010
-
Modulation of transforming growth factor-beta (TGF-beta) signaling by endogenous sphingolipid mediators. J Biol Chem. 2003 Mar 14; 278(11):9276-82.
Score: 0.010
-
Selective hydrolysis of a mitochondrial pool of sphingomyelin induces apoptosis. FASEB J. 2001 Dec; 15(14):2669-79.
Score: 0.009
-
Proteolytic cleavage of phospholipase C-gamma1 during apoptosis in Molt-4 cells. FASEB J. 2000 Jun; 14(9):1083-92.
Score: 0.008
-
FADD is required for multiple signaling events downstream of the receptor Fas. Cell Growth Differ. 1999 Dec; 10(12):797-804.
Score: 0.008
-
Platelet-activating factor receptor activation. An initiator step in HIV-1 neuropathogenesis. J Biol Chem. 1998 Jul 10; 273(28):17660-4.
Score: 0.007
-
Increases in neutral, Mg2+-dependent and acidic, Mg2+-independent sphingomyelinase activities precede commitment to apoptosis and are not a consequence of caspase 3-like activity in Molt-4 cells in response to thymidylate synthase inhibition by GW1843. Blood. 1998 Jun 01; 91(11):4350-60.
Score: 0.007
-
Expression of neutral sphingomyelinase identifies a distinct pool of sphingomyelin involved in apoptosis. J Biol Chem. 1997 Apr 11; 272(15):9609-12.
Score: 0.007
-
Sphingosine inhibits monocyte tissue factor-initiated coagulation by altering factor VII binding. J Biol Chem. 1989 Nov 05; 264(31):18440-4.
Score: 0.004