Yusuf Hannun to Animals
This is a "connection" page, showing publications Yusuf Hannun has written about Animals.
Connection Strength
3.127
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Bioactive sphingolipid profile in a xenograft mouse model of head and neck squamous cell carcinoma. PLoS One. 2019; 14(4):e0215770.
Score: 0.048
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Approaches for probing and evaluating mammalian sphingolipid metabolism. Anal Biochem. 2019 06 15; 575:70-86.
Score: 0.048
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Neutral ceramidase: Advances in mechanisms, cell regulation, and roles in cancer. Adv Biol Regul. 2019 01; 71:141-146.
Score: 0.046
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Visualizing bioactive ceramides. Chem Phys Lipids. 2018 11; 216:142-151.
Score: 0.046
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Evaluating intrinsic and non-intrinsic cancer risk factors. Nat Commun. 2018 08 28; 9(1):3490.
Score: 0.046
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AKT as a key target for growth promoting functions of neutral ceramidase in colon cancer cells. Oncogene. 2018 07; 37(28):3852-3863.
Score: 0.045
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Sphingolipids and their metabolism in physiology and disease. Nat Rev Mol Cell Biol. 2018 03; 19(3):175-191.
Score: 0.044
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P38 delta MAPK promotes breast cancer progression and lung metastasis by enhancing cell proliferation and cell detachment. Oncogene. 2017 11 23; 36(47):6649-6657.
Score: 0.043
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Ceramidases, roles in sphingolipid metabolism and in health and disease. Adv Biol Regul. 2017 Jan; 63:122-131.
Score: 0.040
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Role of neutral ceramidase in colon cancer. FASEB J. 2016 12; 30(12):4159-4171.
Score: 0.040
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Murine Model for Colitis-Associated Cancer of the Colon. Methods Mol Biol. 2016; 1438:245-54.
Score: 0.038
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Activation of p38 Mitogen-Activated Protein Kinase in Gaucher's Disease. PLoS One. 2015; 10(8):e0136633.
Score: 0.037
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Structural Basis for Ceramide Recognition and Hydrolysis by Human Neutral Ceramidase. Structure. 2015 Aug 04; 23(8):1482-1491.
Score: 0.037
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A new twist to the emerging functions of ceramides in cancer: novel role for platelet acid sphingomyelinase in cancer metastasis. EMBO Mol Med. 2015 Jun; 7(6):692-4.
Score: 0.037
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Critical determinants of mitochondria-associated neutral sphingomyelinase (MA-nSMase) for mitochondrial localization. Biochim Biophys Acta. 2015 Apr; 1850(4):628-39.
Score: 0.035
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Roles and regulation of neutral sphingomyelinase-2 in cellular and pathological processes. Adv Biol Regul. 2015 Jan; 57:24-41.
Score: 0.035
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Sphingolipids in colon cancer. Biochim Biophys Acta. 2014 May; 1841(5):773-82.
Score: 0.033
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Sphingolipid metabolism and neutral sphingomyelinases. Handb Exp Pharmacol. 2013; (215):57-76.
Score: 0.031
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Novel chemotherapeutic drugs in sphingolipid cancer research. Handb Exp Pharmacol. 2013; (215):211-38.
Score: 0.031
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Identification and characterization of protein phosphatase 2C activation by ceramide. J Lipid Res. 2012 Aug; 53(8):1513-21.
Score: 0.030
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The roles of neutral sphingomyelinases in neurological pathologies. Neurochem Res. 2012 Jun; 37(6):1137-49.
Score: 0.029
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Many ceramides. J Biol Chem. 2011 Aug 12; 286(32):27855-62.
Score: 0.028
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Drug targeting of sphingolipid metabolism: sphingomyelinases and ceramidases. Br J Pharmacol. 2011 Jun; 163(4):694-712.
Score: 0.028
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Identification of novel anionic phospholipid binding domains in neutral sphingomyelinase 2 with selective binding preference. J Biol Chem. 2011 Jun 24; 286(25):22362-71.
Score: 0.028
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Regulation of CC ligand 5/RANTES by acid sphingomyelinase and acid ceramidase. J Biol Chem. 2011 Apr 15; 286(15):13292-303.
Score: 0.027
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The neutral sphingomyelinase family: identifying biochemical connections. Adv Enzyme Regul. 2011; 51(1):51-8.
Score: 0.027
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Differential effects of ceramide and sphingosine 1-phosphate on ERM phosphorylation: probing sphingolipid signaling at the outer plasma membrane. J Biol Chem. 2010 Oct 15; 285(42):32476-85.
Score: 0.026
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The acid sphingomyelinase/ceramide pathway: biomedical significance and mechanisms of regulation. Curr Mol Med. 2010 Jul; 10(5):454-66.
Score: 0.026
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Mammalian neutral sphingomyelinases: regulation and roles in cell signaling responses. Neuromolecular Med. 2010 Dec; 12(4):320-30.
Score: 0.026
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Identification and characterization of murine mitochondria-associated neutral sphingomyelinase (MA-nSMase), the mammalian sphingomyelin phosphodiesterase 5. J Biol Chem. 2010 Jun 04; 285(23):17993-8002.
Score: 0.026
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An overview of sphingolipid metabolism: from synthesis to breakdown. Adv Exp Med Biol. 2010; 688:1-23.
Score: 0.025
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Sphingomyelin metabolism at the plasma membrane: implications for bioactive sphingolipids. FEBS Lett. 2010 May 03; 584(9):1887-94.
Score: 0.025
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Roles and regulation of secretory and lysosomal acid sphingomyelinase. Cell Signal. 2009 Jun; 21(6):836-46.
Score: 0.024
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Downregulation of neutral ceramidase by gemcitabine: Implications for cell cycle regulation. Biochim Biophys Acta. 2009 Aug; 1791(8):730-9.
Score: 0.024
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ISC1-dependent metabolic adaptation reveals an indispensable role for mitochondria in induction of nuclear genes during the diauxic shift in Saccharomyces cerevisiae. J Biol Chem. 2009 Apr 17; 284(16):10818-30.
Score: 0.024
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Bioactive sphingolipids: metabolism and function. J Lipid Res. 2009 Apr; 50 Suppl:S91-6.
Score: 0.023
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Anti-ceramidase LCL385 acutely reduces BCL-2 expression in the hippocampus but is not associated with an increase of learned helplessness in rats. Behav Brain Res. 2009 Jan 30; 197(1):41-4.
Score: 0.023
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Molecular targeting of acid ceramidase: implications to cancer therapy. Curr Drug Targets. 2008 Aug; 9(8):653-61.
Score: 0.023
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Thematic review series: sphingolipids. ISC1 (inositol phosphosphingolipid-phospholipase C), the yeast homologue of neutral sphingomyelinases. J Lipid Res. 2008 May; 49(5):922-8.
Score: 0.022
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Principles of bioactive lipid signalling: lessons from sphingolipids. Nat Rev Mol Cell Biol. 2008 Feb; 9(2):139-50.
Score: 0.022
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The sphingolipid salvage pathway in ceramide metabolism and signaling. Cell Signal. 2008 Jun; 20(6):1010-8.
Score: 0.022
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Translational aspects of sphingolipid metabolism. Trends Mol Med. 2007 Aug; 13(8):327-36.
Score: 0.021
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Activation of acid sphingomyelinase by protein kinase Cdelta-mediated phosphorylation. J Biol Chem. 2007 Apr 13; 282(15):11549-61.
Score: 0.021
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Regulation of membrane trafficking and endocytosis by protein kinase C: emerging role of the pericentrion, a novel protein kinase C-dependent subset of recycling endosomes. Cell Mol Life Sci. 2007 Feb; 64(3):263-70.
Score: 0.021
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The extended family of neutral sphingomyelinases. Biochemistry. 2006 Sep 26; 45(38):11247-56.
Score: 0.020
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Neutral sphingomyelinases and nSMase2: bridging the gaps. Biochim Biophys Acta. 2006 Dec; 1758(12):1893-901.
Score: 0.020
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Sphingolipid-binding proteins. Biochim Biophys Acta. 2006 Aug; 1761(8):927-46.
Score: 0.020
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Acid ceramidase but not acid sphingomyelinase is required for tumor necrosis factor-{alpha}-induced PGE2 production. J Biol Chem. 2006 Aug 25; 281(34):24695-703.
Score: 0.020
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Bioactive sphingolipids in the modulation of the inflammatory response. Pharmacol Ther. 2006 Oct; 112(1):171-83.
Score: 0.020
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Identification of a novel amidase motif in neutral ceramidase. Biochem J. 2006 Feb 01; 393(Pt 3):687-95.
Score: 0.019
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Protein kinase C and phospholipase D: intimate interactions in intracellular signaling. Cell Mol Life Sci. 2005 Jul; 62(13):1448-61.
Score: 0.018
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The complex life of simple sphingolipids. EMBO Rep. 2004 Aug; 5(8):777-82.
Score: 0.017
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Acid and neutral sphingomyelinases: roles and mechanisms of regulation. Biochem Cell Biol. 2004 Feb; 82(1):27-44.
Score: 0.017
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cPKC-dependent sequestration of membrane-recycling components in a subset of recycling endosomes. J Biol Chem. 2003 Dec 26; 278(52):52747-54.
Score: 0.016
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Ceramide, stress, and a "LAG" in aging. Sci Aging Knowledge Environ. 2003 Oct 01; 2003(39):PE27.
Score: 0.016
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The sphingosine kinase 1/sphingosine-1-phosphate pathway mediates COX-2 induction and PGE2 production in response to TNF-alpha. FASEB J. 2003 Aug; 17(11):1411-21.
Score: 0.016
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Biochemical properties of mammalian neutral sphingomyelinase 2 and its role in sphingolipid metabolism. J Biol Chem. 2003 Apr 18; 278(16):13775-83.
Score: 0.016
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Ceramide in apoptosis: an overview and current perspectives. Biochim Biophys Acta. 2002 Dec 30; 1585(2-3):114-25.
Score: 0.015
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Neutral ceramidase deficiency protects against cisplatin-induced acute kidney injury. J Lipid Res. 2022 03; 63(3):100179.
Score: 0.015
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Substrate specificity of rat brain ceramidase. J Lipid Res. 2002 Jan; 43(1):141-8.
Score: 0.014
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Mitochondria and ceramide: intertwined roles in regulation of apoptosis. Adv Enzyme Regul. 2002; 42:113-29.
Score: 0.014
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Sphingolipids in vascular biology. Adv Exp Med Biol. 2002; 507:439-44.
Score: 0.014
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Determination of ceramides and diglycerides by the diglyceride kinase assay. Anal Biochem. 2001 Nov 15; 298(2):141-50.
Score: 0.014
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A Milk-Fat Based Diet Increases Metastasis in the MMTV-PyMT Mouse Model of Breast Cancer. Nutrients. 2021 Jul 15; 13(7).
Score: 0.014
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Loss of sphingosine kinase 1 increases lung metastases in the MMTV-PyMT mouse model of breast cancer. PLoS One. 2021; 16(5):e0252311.
Score: 0.014
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Enzymes of sphingolipid metabolism: from modular to integrative signaling. Biochemistry. 2001 Apr 24; 40(16):4893-903.
Score: 0.014
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Neutral Sphingomyelinase 2 Heightens Anti-Melanoma Immune Responses and Anti-PD-1 Therapy Efficacy. Cancer Immunol Res. 2021 05; 9(5):568-582.
Score: 0.014
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Biochemical characterization of the reverse activity of rat brain ceramidase. A CoA-independent and fumonisin B1-insensitive ceramide synthase. J Biol Chem. 2001 May 18; 276(20):16758-66.
Score: 0.014
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Asah2 Represses the p53-Hmox1 Axis to Protect Myeloid-Derived Suppressor Cells from Ferroptosis. J Immunol. 2021 03 15; 206(6):1395-1404.
Score: 0.014
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Ceramide synthase 2-C24:1 -ceramide axis limits the metastatic potential of ovarian cancer cells. FASEB J. 2021 02; 35(2):e21287.
Score: 0.014
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Acid sphingomyelinase-dependent autophagic degradation of GPX4 is critical for the execution of ferroptosis. Cell Death Dis. 2021 01 07; 12(1):26.
Score: 0.014
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Bioactive sphingolipids: Advancements and contributions from the laboratory of Dr. Lina M. Obeid. Cell Signal. 2021 03; 79:109875.
Score: 0.013
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Maternal and fetal alkaline ceramidase 2 is required for placental vascular integrity in mice. FASEB J. 2020 11; 34(11):15252-15268.
Score: 0.013
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Targeting acid ceramidase inhibits YAP/TAZ signaling to reduce fibrosis in mice. Sci Transl Med. 2020 08 19; 12(557).
Score: 0.013
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Identification of Small-Molecule Inhibitors of Neutral Ceramidase (nCDase) via Target-Based High-Throughput Screening. SLAS Discov. 2021 01; 26(1):113-121.
Score: 0.013
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Inhibition of acid ceramidase regulates MHC class II antigen presentation and suppression of autoimmune arthritis. Cytokine. 2020 11; 135:155219.
Score: 0.013
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Molecular cloning and characterization of a human mitochondrial ceramidase. J Biol Chem. 2000 Jul 14; 275(28):21508-13.
Score: 0.013
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Ceramide in the eukaryotic stress response. Trends Cell Biol. 2000 Feb; 10(2):73-80.
Score: 0.013
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Purification of rat brain membrane neutral sphingomyelinase. Methods Enzymol. 2000; 311:156-64.
Score: 0.013
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Quantitative determination of ceramide using diglyceride kinase. Methods Enzymol. 2000; 312:22-31.
Score: 0.013
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Effects of sphingosine and other sphingolipids on protein kinase C. Methods Enzymol. 2000; 312:361-73.
Score: 0.013
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Use of short-chain ceramides. Methods Enzymol. 2000; 312:407-20.
Score: 0.013
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Analysis of ceramide-activated protein phosphatases. Methods Enzymol. 2000; 312:420-8.
Score: 0.013
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Function of the cloned putative neutral sphingomyelinase as lyso-platelet activating factor-phospholipase C. J Biol Chem. 1999 Dec 31; 274(53):38131-9.
Score: 0.013
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Ceramide and sphingomyelinases in the regulation of stress responses. Chem Phys Lipids. 1999 Nov; 102(1-2):141-7.
Score: 0.012
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Purification and characterization of a membrane-bound nonlysosomal ceramidase from rat brain. J Biol Chem. 1999 Sep 24; 274(39):27948-55.
Score: 0.012
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Phosphatidic acid is a potent and selective inhibitor of protein phosphatase 1 and an inhibitor of ceramide-mediated responses. J Biol Chem. 1999 Jul 23; 274(30):21335-41.
Score: 0.012
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Ceramide and apoptosis. Trends Biochem Sci. 1999 Jun; 24(6):224-5; author reply 227.
Score: 0.012
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Quantifying 1-deoxydihydroceramides and 1-deoxyceramides in mouse nervous system tissue. Prostaglandins Other Lipid Mediat. 2019 04; 141:40-48.
Score: 0.012
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RPGRIP1L is required for stabilizing epidermal keratinocyte adhesion through regulating desmoglein endocytosis. PLoS Genet. 2019 01; 15(1):e1007914.
Score: 0.012
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Emergence of membrane sphingolipids as a potential therapeutic target. Biochimie. 2019 Mar; 158:257-264.
Score: 0.012
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Sphingolipid metabolism in the regulation of bioactive molecules. Lipids. 1999; 34 Suppl:S5-11.
Score: 0.012
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Purification and characterization of a membrane bound neutral pH optimum magnesium-dependent and phosphatidylserine-stimulated sphingomyelinase from rat brain. J Biol Chem. 1998 Dec 18; 273(51):34472-9.
Score: 0.012
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The role of ceramide in cell signaling. Biochim Biophys Acta. 1998 Dec 08; 1436(1-2):233-43.
Score: 0.012
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Purification and characterization of ceramide-activated protein phosphatases. Biochemistry. 1998 Aug 11; 37(32):11232-8.
Score: 0.011
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p53-dependent ceramide response to genotoxic stress. J Clin Invest. 1998 Jul 15; 102(2):329-39.
Score: 0.011
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Role of sphingolipids in senescence: implication in aging and age-related diseases. J Clin Invest. 2018 07 02; 128(7):2702-2712.
Score: 0.011
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The Synergy between Palmitate and TNF-a for CCL2 Production Is Dependent on the TRIF/IRF3 Pathway: Implications for Metabolic Inflammation. J Immunol. 2018 05 15; 200(10):3599-3611.
Score: 0.011
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Alkaline ceramidase 2 is essential for the homeostasis of plasma sphingoid bases and their phosphates. FASEB J. 2018 06; 32(6):3058-3069.
Score: 0.011
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Loss of acid ceramidase in myeloid cells suppresses intestinal neutrophil recruitment. FASEB J. 2018 05; 32(5):2339-2353.
Score: 0.011
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Tumor suppressor p53 links ceramide metabolism to DNA damage response through alkaline ceramidase 2. Cell Death Differ. 2018 05; 25(5):841-856.
Score: 0.011
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Sphingosine Kinase 1 expression in peritoneal macrophages is required for colon carcinogenesis. Carcinogenesis. 2017 12 07; 38(12):1218-1227.
Score: 0.011
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Sphingosine 1-phosphate activation of ERM contributes to vascular calcification. J Lipid Res. 2018 01; 59(1):69-78.
Score: 0.011
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Ceramide and the eukaryotic stress response. Biochem Soc Trans. 1997 Nov; 25(4):1171-5.
Score: 0.011
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Alkaline Ceramidase 1 Protects Mice from Premature Hair Loss by Maintaining the Homeostasis of Hair Follicle Stem Cells. Stem Cell Reports. 2017 11 14; 9(5):1488-1500.
Score: 0.011
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Zinc is a potent inhibitor of the apoptotic protease, caspase-3. A novel target for zinc in the inhibition of apoptosis. J Biol Chem. 1997 Jul 25; 272(30):18530-3.
Score: 0.011
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Phospholipase A2 is necessary for tumor necrosis factor alpha-induced ceramide generation in L929 cells. J Biol Chem. 1997 Jul 04; 272(27):17196-203.
Score: 0.011
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Inhibiting glucosylceramide synthase exacerbates cisplatin-induced acute kidney injury. J Lipid Res. 2017 07; 58(7):1439-1452.
Score: 0.010
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Ceramide Is Metabolized to Acylceramide and Stored in Lipid Droplets. Cell Metab. 2017 03 07; 25(3):686-697.
Score: 0.010
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Ceramide: a novel lipid mediator of apoptosis. Adv Pharmacol. 1997; 41:133-54.
Score: 0.010
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Mechanisms of ceramide-mediated apoptosis. Adv Exp Med Biol. 1997; 407:145-9.
Score: 0.010
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Sphingolipid second messengers: tumor suppressor lipids. Adv Exp Med Biol. 1997; 400A:305-12.
Score: 0.010
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Functions of ceramide in coordinating cellular responses to stress. Science. 1996 Dec 13; 274(5294):1855-9.
Score: 0.010
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Ceramide: role in growth inhibitory cascades. J Lipid Mediat Cell Signal. 1996 Sep; 14(1-3):295-301.
Score: 0.010
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Protein kinase C beta II specifically binds to and is activated by F-actin. J Biol Chem. 1996 Jun 28; 271(26):15823-30.
Score: 0.010
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CHK1 regulates NF-?B signaling upon DNA damage in p53- deficient cells and associated tumor-derived microvesicles. Oncotarget. 2016 Apr 05; 7(14):18159-70.
Score: 0.010
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Alkaline ceramidase 3 deficiency aggravates colitis and colitis-associated tumorigenesis in mice by hyperactivating the innate immune system. Cell Death Dis. 2016 Mar 03; 7:e2124.
Score: 0.010
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Ceramide: an intracellular mediator of apoptosis and growth suppression. Philos Trans R Soc Lond B Biol Sci. 1996 Feb 29; 351(1336):233-40; discussion 240-1.
Score: 0.010
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Loss of neutral ceramidase protects cells from nutrient- and energy -deprivation-induced cell death. Biochem J. 2016 Mar 15; 473(6):743-55.
Score: 0.010
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Protein kinase C isoenzymes: regulation and function. Cancer Surv. 1996; 27:213-48.
Score: 0.010
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Alkaline Ceramidase 3 Deficiency Results in Purkinje Cell Degeneration and Cerebellar Ataxia Due to Dyshomeostasis of Sphingolipids in the Brain. PLoS Genet. 2015 Oct; 11(10):e1005591.
Score: 0.009
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Elevation of 20-carbon long chain bases due to a mutation in serine palmitoyltransferase small subunit b results in neurodegeneration. Proc Natl Acad Sci U S A. 2015 Oct 20; 112(42):12962-7.
Score: 0.009
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Neurotrophins induce sphingomyelin hydrolysis. Modulation by co-expression of p75NTR with Trk receptors. J Biol Chem. 1995 Sep 22; 270(38):22135-42.
Score: 0.009
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Ceramide limits phosphatidylinositol-3-kinase C2?-controlled cell motility in ovarian cancer: potential of ceramide as a metastasis-suppressor lipid. Oncogene. 2016 05; 35(21):2801-12.
Score: 0.009
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Activation of a retinoblastoma-protein-dependent pathway by sphingosine. Biochem J. 1995 Sep 01; 310 ( Pt 2):453-9.
Score: 0.009
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Activity of neutral and alkaline ceramidases on fluorogenic N-acylated coumarin-containing aminodiols. J Lipid Res. 2015 Oct; 56(10):2019-28.
Score: 0.009
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Lack of Acid Sphingomyelinase Induces Age-Related Retinal Degeneration. PLoS One. 2015; 10(7):e0133032.
Score: 0.009
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IQ Motif-Containing GTPase-Activating Protein 2 (IQGAP2) Is a Novel Regulator of Colonic Inflammation in Mice. PLoS One. 2015; 10(6):e0129314.
Score: 0.009
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Ceramide: an endogenous regulator of apoptosis and growth suppression. Immunol Today. 1995 Jun; 16(6):294-7.
Score: 0.009
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Ceramide: a stress signal and mediator of growth suppression and apoptosis. J Cell Biochem. 1995 Jun; 58(2):191-8.
Score: 0.009
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Arachidonic acid and free fatty acids as second messengers and the role of protein kinase C. Cell Signal. 1995 Mar; 7(3):171-84.
Score: 0.009
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Distinct roles for hematopoietic and extra-hematopoietic sphingosine kinase-1 in inflammatory bowel disease. PLoS One. 2014; 9(12):e113998.
Score: 0.009
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Regulation of protein kinase C and role in cancer biology. Cancer Metastasis Rev. 1994 Dec; 13(3-4):411-31.
Score: 0.009
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Endoplasmic reticulum heat shock protein gp96 maintains liver homeostasis and promotes hepatocellular carcinogenesis. J Hepatol. 2015 Apr; 62(4):879-88.
Score: 0.009
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Go-6976 reverses hyperglycemia-induced insulin resistance independently of cPKC inhibition in adipocytes. PLoS One. 2014; 9(10):e108963.
Score: 0.009
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Activation of the sphingomyelin cycle through the low-affinity neurotrophin receptor. Science. 1994 Sep 09; 265(5178):1596-9.
Score: 0.009
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On-tissue localization of ceramides and other sphingolipids by MALDI mass spectrometry imaging. Anal Chem. 2014 Aug 19; 86(16):8303-11.
Score: 0.009
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Ceramide and sphingosine-1-phosphate act as photodynamic therapy-elicited damage-associated molecular patterns: cell surface exposure. Int Immunopharmacol. 2014 Jun; 20(2):359-65.
Score: 0.008
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Essential roles of neutral ceramidase and sphingosine in mitochondrial dysfunction due to traumatic brain injury. J Biol Chem. 2014 May 09; 289(19):13142-54.
Score: 0.008
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Bone-specific insulin resistance disrupts whole-body glucose homeostasis via decreased osteocalcin activation. J Clin Invest. 2014 Apr; 124(4):1-13.
Score: 0.008
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The sphingomyelin cycle and the second messenger function of ceramide. J Biol Chem. 1994 Feb 04; 269(5):3125-8.
Score: 0.008
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Sphingolipid breakdown products: anti-proliferative and tumor-suppressor lipids. Biochim Biophys Acta. 1993 Dec 21; 1154(3-4):223-36.
Score: 0.008
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Sphingosine-1-phosphate receptor 2. FEBS J. 2013 Dec; 280(24):6354-66.
Score: 0.008
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Sphingosine kinase 1 regulates tumor necrosis factor-mediated RANTES induction through p38 mitogen-activated protein kinase but independently of nuclear factor ?B activation. J Biol Chem. 2013 Sep 20; 288(38):27667-27679.
Score: 0.008
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Acid sphingomyelinase plays a key role in palmitic acid-amplified inflammatory signaling triggered by lipopolysaccharide at low concentrations in macrophages. Am J Physiol Endocrinol Metab. 2013 Oct 01; 305(7):E853-67.
Score: 0.008
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Ceramide activates heterotrimeric protein phosphatase 2A. J Biol Chem. 1993 Jul 25; 268(21):15523-30.
Score: 0.008
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Sphingolipid regulation of ezrin, radixin, and moesin proteins family: implications for cell dynamics. Biochim Biophys Acta. 2014 May; 1841(5):727-37.
Score: 0.008
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Adiponectin regulates bone mass via opposite central and peripheral mechanisms through FoxO1. Cell Metab. 2013 Jun 04; 17(6):901-915.
Score: 0.008
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A signaling cascade mediated by ceramide, src and PDGFR? coordinates the activation of the redox-sensitive neutral sphingomyelinase-2 and sphingosine kinase-1. Biochim Biophys Acta. 2013 Aug; 1831(8):1344-56.
Score: 0.008
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Sphingosine 1-phosphate induces filopodia formation through S1PR2 activation of ERM proteins. Biochem J. 2013 Feb 01; 449(3):661-72.
Score: 0.008
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Ceramide-activated protein phosphatase: partial purification and relationship to protein phosphatase 2A. Adv Lipid Res. 1993; 25:91-104.
Score: 0.008
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Modulation of mitochondrial outer membrane permeabilization and apoptosis by ceramide metabolism. PLoS One. 2012; 7(11):e48571.
Score: 0.008
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Effect of sphingosine kinase 1 inhibition on blood pressure. FASEB J. 2013 Feb; 27(2):656-64.
Score: 0.008
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Cloning and characterization of the major promoter of the human protein kinase C beta gene. Regulation by phorbol esters. J Biol Chem. 1992 Oct 15; 267(29):20804-10.
Score: 0.008
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Ceramide-mediated biology. Determination of structural and stereospecific requirements through the use of N-acyl-phenylaminoalcohol analogs. J Biol Chem. 1992 Sep 15; 267(26):18493-7.
Score: 0.008
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Loss of neutral ceramidase increases inflammation in a mouse model of inflammatory bowel disease. Prostaglandins Other Lipid Mediat. 2012 Dec; 99(3-4):124-30.
Score: 0.008
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Safety study of adeno-associated virus serotype 2-mediated human acid sphingomyelinase expression in the nonhuman primate brain. Hum Gene Ther. 2012 Aug; 23(8):891-902.
Score: 0.008
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Oncogenic K-Ras regulates bioactive sphingolipids in a sphingosine kinase 1-dependent manner. J Biol Chem. 2012 Sep 14; 287(38):31794-803.
Score: 0.008
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Differential regulation of acid sphingomyelinase in macrophages stimulated with oxidized low-density lipoprotein (LDL) and oxidized LDL immune complexes: role in phagocytosis and cytokine release. Immunology. 2012 May; 136(1):30-45.
Score: 0.007
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Tissue and cellular distribution of the extended family of protein kinase C isoenzymes. J Cell Biol. 1992 Apr; 117(1):121-33.
Score: 0.007
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Off-target function of the Sonic hedgehog inhibitor cyclopamine in mediating apoptosis via nitric oxide-dependent neutral sphingomyelinase 2/ceramide induction. Mol Cancer Ther. 2012 May; 11(5):1092-102.
Score: 0.007
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Selective changes in protein kinase C isoenzymes in rat liver nuclei during liver regeneration. Biochem Biophys Res Commun. 1992 Feb 14; 182(3):1333-9.
Score: 0.007
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Ceramide synthases at the centre of sphingolipid metabolism and biology. Biochem J. 2012 Feb 01; 441(3):789-802.
Score: 0.007
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Network of signal transduction pathways involving lipids: protein kinase C-dependent and -independent pathways. Adv Exp Med Biol. 1992; 318:275-84.
Score: 0.007
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A cell-autonomous requirement for neutral sphingomyelinase 2 in bone mineralization. J Cell Biol. 2011 Jul 25; 194(2):277-89.
Score: 0.007
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Defining a role for sphingosine kinase 1 in p53-dependent tumors. Oncogene. 2012 Mar 01; 31(9):1166-75.
Score: 0.007
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Accumulation of long-chain glycosphingolipids during aging is prevented by caloric restriction. PLoS One. 2011; 6(6):e20411.
Score: 0.007
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Novel pathway of ceramide production in mitochondria: thioesterase and neutral ceramidase produce ceramide from sphingosine and acyl-CoA. J Biol Chem. 2011 Jul 15; 286(28):25352-62.
Score: 0.007
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A deficiency of ceramide biosynthesis causes cerebellar purkinje cell neurodegeneration and lipofuscin accumulation. PLoS Genet. 2011 May; 7(5):e1002063.
Score: 0.007
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Identification of dihydroceramide desaturase as a direct in vitro target for fenretinide. J Biol Chem. 2011 Jul 15; 286(28):24754-64.
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