Yusuf Hannun to Tumor Cells, Cultured
This is a "connection" page, showing publications Yusuf Hannun has written about Tumor Cells, Cultured.
Connection Strength
2.100
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Synthesis of erythro- B13 enantiomers and stereospecific action of full set of B13-isomers in MCF7 breast carcinoma cells: Cellular metabolism and effects on sphingolipids. Bioorg Med Chem. 2021 02 15; 32:116011.
Score: 0.159
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PKCa is required for Akt-mTORC1 activation in non-small cell lung carcinoma (NSCLC) with EGFR mutation. Oncogene. 2019 11; 38(48):7311-7328.
Score: 0.145
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Multiple actions of doxorubicin on the sphingolipid network revealed by flux analysis. J Lipid Res. 2019 04; 60(4):819-831.
Score: 0.138
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Dose dependent actions of LCL521 on acid ceramidase and key sphingolipid metabolites. Bioorg Med Chem. 2018 12 15; 26(23-24):6067-6075.
Score: 0.137
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Sphingomyelin turnover induced by vitamin D3 in HL-60 cells. Role in cell differentiation. J Biol Chem. 1989 Nov 15; 264(32):19076-80.
Score: 0.074
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Analysis of membrane topology of neutral sphingomyelinase 2. FEBS Lett. 2007 Apr 03; 581(7):1323-8.
Score: 0.061
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The sphingosine kinase 1/sphingosine-1-phosphate pathway mediates COX-2 induction and PGE2 production in response to TNF-alpha. FASEB J. 2003 Aug; 17(11):1411-21.
Score: 0.048
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Biochemical properties of mammalian neutral sphingomyelinase 2 and its role in sphingolipid metabolism. J Biol Chem. 2003 Apr 18; 278(16):13775-83.
Score: 0.046
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Biochemical mechanisms of the generation of endogenous long chain ceramide in response to exogenous short chain ceramide in the A549 human lung adenocarcinoma cell line. Role for endogenous ceramide in mediating the action of exogenous ceramide. J Biol Chem. 2002 Apr 12; 277(15):12960-9.
Score: 0.043
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De novo ceramide regulates the alternative splicing of caspase 9 and Bcl-x in A549 lung adenocarcinoma cells. Dependence on protein phosphatase-1. J Biol Chem. 2002 Apr 12; 277(15):12587-95.
Score: 0.043
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Molecular cloning and characterization of a human mitochondrial ceramidase. J Biol Chem. 2000 Jul 14; 275(28):21508-13.
Score: 0.039
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Serine palmitoyltransferase regulates de novo ceramide generation during etoposide-induced apoptosis. J Biol Chem. 2000 Mar 24; 275(12):9078-84.
Score: 0.038
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Effects of sphingosine and other sphingolipids on protein kinase C. Methods Enzymol. 2000; 312:361-73.
Score: 0.037
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Function of the cloned putative neutral sphingomyelinase as lyso-platelet activating factor-phospholipase C. J Biol Chem. 1999 Dec 31; 274(53):38131-9.
Score: 0.037
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p53-dependent ceramide response to genotoxic stress. J Clin Invest. 1998 Jul 15; 102(2):329-39.
Score: 0.034
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Glutathione regulation of neutral sphingomyelinase in tumor necrosis factor-alpha-induced cell death. J Biol Chem. 1998 May 01; 273(18):11313-20.
Score: 0.033
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Zinc is a potent inhibitor of the apoptotic protease, caspase-3. A novel target for zinc in the inhibition of apoptosis. J Biol Chem. 1997 Jul 25; 272(30):18530-3.
Score: 0.031
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Bcl-2 antagonizes apoptotic cell death induced by two new ceramide analogues. FEBS Lett. 1997 Jul 14; 411(2-3):260-4.
Score: 0.031
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Phospholipase A2 is necessary for tumor necrosis factor alpha-induced ceramide generation in L929 cells. J Biol Chem. 1997 Jul 04; 272(27):17196-203.
Score: 0.031
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Inhibition of the neutral magnesium-dependent sphingomyelinase by glutathione. J Biol Chem. 1997 Jun 27; 272(26):16281-7.
Score: 0.031
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Cytokine response modifier A (CrmA) inhibits ceramide formation in response to tumor necrosis factor (TNF)-alpha: CrmA and Bcl-2 target distinct components in the apoptotic pathway. J Exp Med. 1997 Feb 03; 185(3):481-90.
Score: 0.030
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Activation of the sphingomyelin cycle by brefeldin A: effects of brefeldin A on differentiation and implications for a role for ceramide in regulation of protein trafficking. Cell Growth Differ. 1996 Jun; 7(6):765-74.
Score: 0.029
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Bcl-2 interrupts the ceramide-mediated pathway of cell death. Proc Natl Acad Sci U S A. 1996 May 28; 93(11):5325-8.
Score: 0.029
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(1S,2R)-D-erythro-2-(N-myristoylamino)-1-phenyl-1-propanol as an inhibitor of ceramidase. J Biol Chem. 1996 May 24; 271(21):12646-54.
Score: 0.029
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Activation of a retinoblastoma-protein-dependent pathway by sphingosine. Biochem J. 1995 Sep 01; 310 ( Pt 2):453-9.
Score: 0.027
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Ceramide: an endogenous regulator of apoptosis and growth suppression. Immunol Today. 1995 Jun; 16(6):294-7.
Score: 0.027
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Retinoblastoma gene product as a downstream target for a ceramide-dependent pathway of growth arrest. Proc Natl Acad Sci U S A. 1995 Feb 28; 92(5):1347-51.
Score: 0.027
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Stereoselectivity of induction of the retinoblastoma gene product (pRb) dephosphorylation by D-erythro-sphingosine supports a role for pRb in growth suppression by sphingosine. Biochemistry. 1995 Feb 14; 34(6):1885-92.
Score: 0.026
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Activation of the sphingomyelin cycle through the low-affinity neurotrophin receptor. Science. 1994 Sep 09; 265(5178):1596-9.
Score: 0.026
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Role of ceramide-activated protein phosphatase in ceramide-mediated signal transduction. J Biol Chem. 1994 Jul 29; 269(30):19605-9.
Score: 0.025
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Modulation of cytosolic protein phosphorylation by sphingosylphosphorylcholine. Biochim Biophys Acta. 1994 Mar 10; 1221(1):54-60.
Score: 0.025
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Identification of arachidonic acid as a mediator of sphingomyelin hydrolysis in response to tumor necrosis factor alpha. J Biol Chem. 1994 Feb 25; 269(8):5757-63.
Score: 0.025
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Characteristics and partial purification of a novel cytosolic, magnesium-independent, neutral sphingomyelinase activated in the early signal transduction of 1 alpha,25-dihydroxyvitamin D3-induced HL-60 cell differentiation. J Biol Chem. 1994 Feb 11; 269(6):4070-7.
Score: 0.025
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Selectivity of ceramide-mediated biology. Lack of activity of erythro-dihydroceramide. J Biol Chem. 1993 Dec 15; 268(35):26226-32.
Score: 0.024
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Regulation of sphingosine-activated protein kinases: selectivity of activation by sphingoid bases and inhibition by non-esterified fatty acids. Biochem J. 1993 Sep 15; 294 ( Pt 3):699-703.
Score: 0.024
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Tumor necrosis factor-alpha (TNF-alpha) signal transduction through ceramide. Dissociation of growth inhibitory effects of TNF-alpha from activation of nuclear factor-kappa B. J Biol Chem. 1993 Aug 25; 268(24):17762-6.
Score: 0.024
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Ceramide activates heterotrimeric protein phosphatase 2A. J Biol Chem. 1993 Jul 25; 268(21):15523-30.
Score: 0.024
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Programmed cell death induced by ceramide. Science. 1993 Mar 19; 259(5102):1769-71.
Score: 0.023
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Selective regulation of expression of protein kinase C (PKC) isoenzymes in multidrug-resistant MCF-7 cells. Functional significance of enhanced expression of PKC alpha. J Biol Chem. 1993 Jan 05; 268(1):658-64.
Score: 0.023
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Cloning and characterization of the major promoter of the human protein kinase C beta gene. Regulation by phorbol esters. J Biol Chem. 1992 Oct 15; 267(29):20804-10.
Score: 0.023
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Modulation of cell growth and differentiation by ceramide. FEBS Lett. 1992 Jul 28; 307(2):211-4.
Score: 0.022
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Brefeldin A promotes hydrolysis of sphingomyelin. J Biol Chem. 1992 Jul 25; 267(21):14909-11.
Score: 0.022
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Evaluation of bioactive sphingolipids in 4-HPR-resistant leukemia cells. BMC Cancer. 2011 Nov 07; 11:477.
Score: 0.021
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Transcriptional regulation of protein kinase C by 1,25-dihydroxyvitamin D3 in HL-60 cells. J Biol Chem. 1990 Feb 05; 265(4):2370-4.
Score: 0.019
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Mitochondrially targeted ceramide LCL-30 inhibits colorectal cancer in mice. Br J Cancer. 2008 Jan 15; 98(1):98-105.
Score: 0.016
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Cationic long-chain ceramide LCL-30 induces cell death by mitochondrial targeting in SW403 cells. Mol Cancer Ther. 2006 Jun; 5(6):1520-9.
Score: 0.014
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Resistance to TRAIL is associated with defects in ceramide signaling that can be overcome by exogenous C6-ceramide without requiring down-regulation of cellular FLICE inhibitory protein. Mol Cancer Ther. 2005 Sep; 4(9):1320-7.
Score: 0.014
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Inhibition of growth and telomerase activity by novel cationic ceramide analogs with high solubility in human head and neck squamous cell carcinoma cells. Otolaryngol Head Neck Surg. 2005 Jan; 132(1):55-62.
Score: 0.013
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Prodrug modification increases potassium tricyclo[5.2.1.0(2,6)]-decan-8-yl dithiocarbonate (D609) chemical stability and cytotoxicity against U937 leukemia cells. J Pharmacol Exp Ther. 2004 Jun; 309(3):1051-9.
Score: 0.012
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Ceramide kinase mediates cytokine- and calcium ionophore-induced arachidonic acid release. J Biol Chem. 2003 Oct 03; 278(40):38206-13.
Score: 0.012
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BcR-induced apoptosis involves differential regulation of C16 and C24-ceramide formation and sphingolipid-dependent activation of the proteasome. J Biol Chem. 2003 Apr 25; 278(17):14723-31.
Score: 0.012
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Observation of different ceramide species from crude cellular extracts by normal-phase high-performance liquid chromatography coupled to atmospheric pressure chemical ionization mass spectrometry. Rapid Commun Mass Spectrom. 2003; 17(11):1203-11.
Score: 0.011
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Inhibition of tumor necrosis factor-induced cell death in MCF7 by a novel inhibitor of neutral sphingomyelinase. J Biol Chem. 2002 Oct 25; 277(43):41128-39.
Score: 0.011
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Selective hydrolysis of a mitochondrial pool of sphingomyelin induces apoptosis. FASEB J. 2001 Dec; 15(14):2669-79.
Score: 0.011
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Molecular mechanisms of ceramide-mediated telomerase inhibition in the A549 human lung adenocarcinoma cell line. J Biol Chem. 2001 Aug 31; 276(35):32506-14.
Score: 0.010
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Role of ceramide in mediating the inhibition of telomerase activity in A549 human lung adenocarcinoma cells. J Biol Chem. 2001 Jul 06; 276(27):24901-10.
Score: 0.010
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Proteolytic cleavage of phospholipase C-gamma1 during apoptosis in Molt-4 cells. FASEB J. 2000 Jun; 14(9):1083-92.
Score: 0.010
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Inhibition of caspases inhibits the release of apoptotic bodies: Bcl-2 inhibits the initiation of formation of apoptotic bodies in chemotherapeutic agent-induced apoptosis. J Cell Biol. 1999 Apr 05; 145(1):99-108.
Score: 0.009
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Regulation of membrane release in apoptosis. Biochem J. 1998 Sep 01; 334 ( Pt 2):479-85.
Score: 0.008
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Platelet-activating factor receptor activation. An initiator step in HIV-1 neuropathogenesis. J Biol Chem. 1998 Jul 10; 273(28):17660-4.
Score: 0.008
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Increases in neutral, Mg2+-dependent and acidic, Mg2+-independent sphingomyelinase activities precede commitment to apoptosis and are not a consequence of caspase 3-like activity in Molt-4 cells in response to thymidylate synthase inhibition by GW1843. Blood. 1998 Jun 01; 91(11):4350-60.
Score: 0.008
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Cytosolic Ca2+ and protein kinase Calpha couple cellular metabolism to membrane K+ permeability in a human biliary cell line. J Clin Invest. 1997 Jun 15; 99(12):2890-7.
Score: 0.008
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Expression of neutral sphingomyelinase identifies a distinct pool of sphingomyelin involved in apoptosis. J Biol Chem. 1997 Apr 11; 272(15):9609-12.
Score: 0.008
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12(S)-HETE increases the motility of prostate tumor cells through selective activation of PKC alpha. Adv Exp Med Biol. 1997; 400B:707-18.
Score: 0.008
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Metabolic stress opens K+ channels in hepatoma cells through a Ca2+- and protein kinase calpha-dependent mechanism. J Biol Chem. 1996 Jul 26; 271(30):18107-13.
Score: 0.007
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Ceramide inactivates cellular protein kinase Calpha. J Biol Chem. 1996 May 31; 271(22):13169-74.
Score: 0.007
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prICE: a downstream target for ceramide-induced apoptosis and for the inhibitory action of Bcl-2. Biochem J. 1996 May 15; 316 ( Pt 1):25-8.
Score: 0.007
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12(S)-hydroxyeicosatetraenoic acid and 13(S)-hydroxyoctadecadienoic acid regulation of protein kinase C-alpha in melanoma cells: role of receptor-mediated hydrolysis of inositol phospholipids. Proc Natl Acad Sci U S A. 1995 Sep 26; 92(20):9323-7.
Score: 0.007
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Regulation of protein kinase C (PKC) expression by iron: effect of different iron compounds on PKC-beta and PKC-alpha gene expression and role of the 5'-flanking region of the PKC-beta gene in the response to ferric transferrin. Blood. 1994 Nov 15; 84(10):3510-7.
Score: 0.007
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12(S)-HETE enhancement of prostate tumor cell invasion: selective role of PKC alpha. J Natl Cancer Inst. 1994 Aug 03; 86(15):1145-51.
Score: 0.006
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Specific role for protein kinase C beta in cell differentiation. Cell Growth Differ. 1994 Apr; 5(4):405-9.
Score: 0.006
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Regulation of the epidermal growth factor receptor phosphorylation state by sphingosine in A431 human epidermoid carcinoma cells. J Biol Chem. 1988 Apr 15; 263(11):5319-27.
Score: 0.004