Yusuf Hannun to Mice
This is a "connection" page, showing publications Yusuf Hannun has written about Mice.
Connection Strength
1.638
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AKT as a key target for growth promoting functions of neutral ceramidase in colon cancer cells. Oncogene. 2018 07; 37(28):3852-3863.
Score: 0.064
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P38 delta MAPK promotes breast cancer progression and lung metastasis by enhancing cell proliferation and cell detachment. Oncogene. 2017 11 23; 36(47):6649-6657.
Score: 0.061
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Murine Model for Colitis-Associated Cancer of the Colon. Methods Mol Biol. 2016; 1438:245-54.
Score: 0.055
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Activation of p38 Mitogen-Activated Protein Kinase in Gaucher's Disease. PLoS One. 2015; 10(8):e0136633.
Score: 0.054
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Critical determinants of mitochondria-associated neutral sphingomyelinase (MA-nSMase) for mitochondrial localization. Biochim Biophys Acta. 2015 Apr; 1850(4):628-39.
Score: 0.051
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The roles of neutral sphingomyelinases in neurological pathologies. Neurochem Res. 2012 Jun; 37(6):1137-49.
Score: 0.042
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Identification of novel anionic phospholipid binding domains in neutral sphingomyelinase 2 with selective binding preference. J Biol Chem. 2011 Jun 24; 286(25):22362-71.
Score: 0.040
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Regulation of CC ligand 5/RANTES by acid sphingomyelinase and acid ceramidase. J Biol Chem. 2011 Apr 15; 286(15):13292-303.
Score: 0.039
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Mammalian neutral sphingomyelinases: regulation and roles in cell signaling responses. Neuromolecular Med. 2010 Dec; 12(4):320-30.
Score: 0.037
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Identification and characterization of murine mitochondria-associated neutral sphingomyelinase (MA-nSMase), the mammalian sphingomyelin phosphodiesterase 5. J Biol Chem. 2010 Jun 04; 285(23):17993-8002.
Score: 0.037
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Downregulation of neutral ceramidase by gemcitabine: Implications for cell cycle regulation. Biochim Biophys Acta. 2009 Aug; 1791(8):730-9.
Score: 0.034
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Neutral sphingomyelinases and nSMase2: bridging the gaps. Biochim Biophys Acta. 2006 Dec; 1758(12):1893-901.
Score: 0.029
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Acid ceramidase but not acid sphingomyelinase is required for tumor necrosis factor-{alpha}-induced PGE2 production. J Biol Chem. 2006 Aug 25; 281(34):24695-703.
Score: 0.028
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The sphingosine kinase 1/sphingosine-1-phosphate pathway mediates COX-2 induction and PGE2 production in response to TNF-alpha. FASEB J. 2003 Aug; 17(11):1411-21.
Score: 0.023
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Biochemical properties of mammalian neutral sphingomyelinase 2 and its role in sphingolipid metabolism. J Biol Chem. 2003 Apr 18; 278(16):13775-83.
Score: 0.022
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Neutral ceramidase deficiency protects against cisplatin-induced acute kidney injury. J Lipid Res. 2022 03; 63(3):100179.
Score: 0.021
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Loss of sphingosine kinase 1 increases lung metastases in the MMTV-PyMT mouse model of breast cancer. PLoS One. 2021; 16(5):e0252311.
Score: 0.020
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Neutral Sphingomyelinase 2 Heightens Anti-Melanoma Immune Responses and Anti-PD-1 Therapy Efficacy. Cancer Immunol Res. 2021 05; 9(5):568-582.
Score: 0.020
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Asah2 Represses the p53-Hmox1 Axis to Protect Myeloid-Derived Suppressor Cells from Ferroptosis. J Immunol. 2021 03 15; 206(6):1395-1404.
Score: 0.020
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Ceramide synthase 2-C24:1 -ceramide axis limits the metastatic potential of ovarian cancer cells. FASEB J. 2021 02; 35(2):e21287.
Score: 0.020
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Acid sphingomyelinase-dependent autophagic degradation of GPX4 is critical for the execution of ferroptosis. Cell Death Dis. 2021 01 07; 12(1):26.
Score: 0.019
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Maternal and fetal alkaline ceramidase 2 is required for placental vascular integrity in mice. FASEB J. 2020 11; 34(11):15252-15268.
Score: 0.019
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Targeting acid ceramidase inhibits YAP/TAZ signaling to reduce fibrosis in mice. Sci Transl Med. 2020 08 19; 12(557).
Score: 0.019
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Inhibition of acid ceramidase regulates MHC class II antigen presentation and suppression of autoimmune arthritis. Cytokine. 2020 11; 135:155219.
Score: 0.019
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Effects of sphingosine and other sphingolipids on protein kinase C. Methods Enzymol. 2000; 312:361-73.
Score: 0.018
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Quantifying 1-deoxydihydroceramides and 1-deoxyceramides in mouse nervous system tissue. Prostaglandins Other Lipid Mediat. 2019 04; 141:40-48.
Score: 0.017
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RPGRIP1L is required for stabilizing epidermal keratinocyte adhesion through regulating desmoglein endocytosis. PLoS Genet. 2019 01; 15(1):e1007914.
Score: 0.017
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p53-dependent ceramide response to genotoxic stress. J Clin Invest. 1998 Jul 15; 102(2):329-39.
Score: 0.016
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The Synergy between Palmitate and TNF-a for CCL2 Production Is Dependent on the TRIF/IRF3 Pathway: Implications for Metabolic Inflammation. J Immunol. 2018 05 15; 200(10):3599-3611.
Score: 0.016
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Alkaline ceramidase 2 is essential for the homeostasis of plasma sphingoid bases and their phosphates. FASEB J. 2018 06; 32(6):3058-3069.
Score: 0.016
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Loss of acid ceramidase in myeloid cells suppresses intestinal neutrophil recruitment. FASEB J. 2018 05; 32(5):2339-2353.
Score: 0.016
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Sphingosine Kinase 1 expression in peritoneal macrophages is required for colon carcinogenesis. Carcinogenesis. 2017 12 07; 38(12):1218-1227.
Score: 0.016
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Alkaline Ceramidase 1 Protects Mice from Premature Hair Loss by Maintaining the Homeostasis of Hair Follicle Stem Cells. Stem Cell Reports. 2017 11 14; 9(5):1488-1500.
Score: 0.016
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Phospholipase A2 is necessary for tumor necrosis factor alpha-induced ceramide generation in L929 cells. J Biol Chem. 1997 Jul 04; 272(27):17196-203.
Score: 0.015
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Inhibiting glucosylceramide synthase exacerbates cisplatin-induced acute kidney injury. J Lipid Res. 2017 07; 58(7):1439-1452.
Score: 0.015
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CHK1 regulates NF-?B signaling upon DNA damage in p53- deficient cells and associated tumor-derived microvesicles. Oncotarget. 2016 Apr 05; 7(14):18159-70.
Score: 0.014
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Alkaline ceramidase 3 deficiency aggravates colitis and colitis-associated tumorigenesis in mice by hyperactivating the innate immune system. Cell Death Dis. 2016 Mar 03; 7:e2124.
Score: 0.014
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Loss of neutral ceramidase protects cells from nutrient- and energy -deprivation-induced cell death. Biochem J. 2016 Mar 15; 473(6):743-55.
Score: 0.014
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Alkaline Ceramidase 3 Deficiency Results in Purkinje Cell Degeneration and Cerebellar Ataxia Due to Dyshomeostasis of Sphingolipids in the Brain. PLoS Genet. 2015 Oct; 11(10):e1005591.
Score: 0.014
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Elevation of 20-carbon long chain bases due to a mutation in serine palmitoyltransferase small subunit b results in neurodegeneration. Proc Natl Acad Sci U S A. 2015 Oct 20; 112(42):12962-7.
Score: 0.014
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Neurotrophins induce sphingomyelin hydrolysis. Modulation by co-expression of p75NTR with Trk receptors. J Biol Chem. 1995 Sep 22; 270(38):22135-42.
Score: 0.013
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Ceramide limits phosphatidylinositol-3-kinase C2?-controlled cell motility in ovarian cancer: potential of ceramide as a metastasis-suppressor lipid. Oncogene. 2016 05; 35(21):2801-12.
Score: 0.013
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Activity of neutral and alkaline ceramidases on fluorogenic N-acylated coumarin-containing aminodiols. J Lipid Res. 2015 Oct; 56(10):2019-28.
Score: 0.013
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Lack of Acid Sphingomyelinase Induces Age-Related Retinal Degeneration. PLoS One. 2015; 10(7):e0133032.
Score: 0.013
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Distinct roles for hematopoietic and extra-hematopoietic sphingosine kinase-1 in inflammatory bowel disease. PLoS One. 2014; 9(12):e113998.
Score: 0.013
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Endoplasmic reticulum heat shock protein gp96 maintains liver homeostasis and promotes hepatocellular carcinogenesis. J Hepatol. 2015 Apr; 62(4):879-88.
Score: 0.013
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Go-6976 reverses hyperglycemia-induced insulin resistance independently of cPKC inhibition in adipocytes. PLoS One. 2014; 9(10):e108963.
Score: 0.013
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Activation of the sphingomyelin cycle through the low-affinity neurotrophin receptor. Science. 1994 Sep 09; 265(5178):1596-9.
Score: 0.013
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On-tissue localization of ceramides and other sphingolipids by MALDI mass spectrometry imaging. Anal Chem. 2014 Aug 19; 86(16):8303-11.
Score: 0.012
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Ceramide and sphingosine-1-phosphate act as photodynamic therapy-elicited damage-associated molecular patterns: cell surface exposure. Int Immunopharmacol. 2014 Jun; 20(2):359-65.
Score: 0.012
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Essential roles of neutral ceramidase and sphingosine in mitochondrial dysfunction due to traumatic brain injury. J Biol Chem. 2014 May 09; 289(19):13142-54.
Score: 0.012
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Bone-specific insulin resistance disrupts whole-body glucose homeostasis via decreased osteocalcin activation. J Clin Invest. 2014 Apr; 124(4):1-13.
Score: 0.012
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Sphingosine kinase 1 regulates tumor necrosis factor-mediated RANTES induction through p38 mitogen-activated protein kinase but independently of nuclear factor ?B activation. J Biol Chem. 2013 Sep 20; 288(38):27667-27679.
Score: 0.012
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Acid sphingomyelinase plays a key role in palmitic acid-amplified inflammatory signaling triggered by lipopolysaccharide at low concentrations in macrophages. Am J Physiol Endocrinol Metab. 2013 Oct 01; 305(7):E853-67.
Score: 0.012
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Adiponectin regulates bone mass via opposite central and peripheral mechanisms through FoxO1. Cell Metab. 2013 Jun 04; 17(6):901-915.
Score: 0.011
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A signaling cascade mediated by ceramide, src and PDGFR? coordinates the activation of the redox-sensitive neutral sphingomyelinase-2 and sphingosine kinase-1. Biochim Biophys Acta. 2013 Aug; 1831(8):1344-56.
Score: 0.011
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Sphingosine 1-phosphate induces filopodia formation through S1PR2 activation of ERM proteins. Biochem J. 2013 Feb 01; 449(3):661-72.
Score: 0.011
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Effect of sphingosine kinase 1 inhibition on blood pressure. FASEB J. 2013 Feb; 27(2):656-64.
Score: 0.011
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Loss of neutral ceramidase increases inflammation in a mouse model of inflammatory bowel disease. Prostaglandins Other Lipid Mediat. 2012 Dec; 99(3-4):124-30.
Score: 0.011
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Oncogenic K-Ras regulates bioactive sphingolipids in a sphingosine kinase 1-dependent manner. J Biol Chem. 2012 Sep 14; 287(38):31794-803.
Score: 0.011
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Differential regulation of acid sphingomyelinase in macrophages stimulated with oxidized low-density lipoprotein (LDL) and oxidized LDL immune complexes: role in phagocytosis and cytokine release. Immunology. 2012 May; 136(1):30-45.
Score: 0.011
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Off-target function of the Sonic hedgehog inhibitor cyclopamine in mediating apoptosis via nitric oxide-dependent neutral sphingomyelinase 2/ceramide induction. Mol Cancer Ther. 2012 May; 11(5):1092-102.
Score: 0.011
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A cell-autonomous requirement for neutral sphingomyelinase 2 in bone mineralization. J Cell Biol. 2011 Jul 25; 194(2):277-89.
Score: 0.010
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Defining a role for sphingosine kinase 1 in p53-dependent tumors. Oncogene. 2012 Mar 01; 31(9):1166-75.
Score: 0.010
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Accumulation of long-chain glycosphingolipids during aging is prevented by caloric restriction. PLoS One. 2011; 6(6):e20411.
Score: 0.010
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Novel pathway of ceramide production in mitochondria: thioesterase and neutral ceramidase produce ceramide from sphingosine and acyl-CoA. J Biol Chem. 2011 Jul 15; 286(28):25352-62.
Score: 0.010
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A deficiency of ceramide biosynthesis causes cerebellar purkinje cell neurodegeneration and lipofuscin accumulation. PLoS Genet. 2011 May; 7(5):e1002063.
Score: 0.010
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Isofagomine in vivo effects in a neuronopathic Gaucher disease mouse. PLoS One. 2011 Apr 20; 6(4):e19037.
Score: 0.010
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A role of sphingosine kinase 1 in head and neck carcinogenesis. Cancer Prev Res (Phila). 2011 Mar; 4(3):454-62.
Score: 0.010
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Stress-induced sphingolipid signaling: role of type-2 neutral sphingomyelinase in murine cell apoptosis and proliferation. PLoS One. 2010 Mar 23; 5(3):e9826.
Score: 0.009
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Neuronopathic Gaucher disease in the mouse: viable combined selective saposin C deficiency and mutant glucocerebrosidase (V394L) mice with glucosylsphingosine and glucosylceramide accumulation and progressive neurological deficits. Hum Mol Genet. 2010 Mar 15; 19(6):1088-97.
Score: 0.009
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Specific saposin C deficiency: CNS impairment and acid beta-glucosidase effects in the mouse. Hum Mol Genet. 2010 Feb 15; 19(4):634-47.
Score: 0.009
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Central role of ceramide biosynthesis in body weight regulation, energy metabolism, and the metabolic syndrome. Am J Physiol Endocrinol Metab. 2009 Jul; 297(1):E211-24.
Score: 0.009
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Defective acid sphingomyelinase pathway with Pseudomonas aeruginosa infection in cystic fibrosis. Am J Respir Cell Mol Biol. 2009 Sep; 41(3):367-75.
Score: 0.008
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Acid ceramidase upregulation in prostate cancer cells confers resistance to radiation: AC inhibition, a potential radiosensitizer. Mol Ther. 2009 Mar; 17(3):430-8.
Score: 0.008
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Role for sphingosine kinase 1 in colon carcinogenesis. FASEB J. 2009 Feb; 23(2):405-14.
Score: 0.008
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A role for sphingosine kinase 1 in dextran sulfate sodium-induced colitis. FASEB J. 2009 Jan; 23(1):143-52.
Score: 0.008
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Integrin-associated Lyn kinase promotes cell survival by suppressing acid sphingomyelinase activity. J Biol Chem. 2008 Oct 24; 283(43):28806-16.
Score: 0.008
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Protection from high fat diet-induced increase in ceramide in mice lacking plasminogen activator inhibitor 1. J Biol Chem. 2008 May 16; 283(20):13538-48.
Score: 0.008
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Mitochondrially targeted ceramide LCL-30 inhibits colorectal cancer in mice. Br J Cancer. 2008 Jan 15; 98(1):98-105.
Score: 0.008
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The functional effects of acid ceramidase overexpression in prostate cancer progression and resistance to chemotherapy. Cancer Biol Ther. 2007 Sep; 6(9):1455-60.
Score: 0.008
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Role of acid ceramidase in resistance to FasL: therapeutic approaches based on acid ceramidase inhibitors and FasL gene therapy. Mol Ther. 2007 Jul; 15(7):1259-63.
Score: 0.008
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MAO-A-induced mitogenic signaling is mediated by reactive oxygen species, MMP-2, and the sphingolipid pathway. Free Radic Biol Med. 2007 Jul 01; 43(1):80-9.
Score: 0.008
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Role for furin in tumor necrosis factor alpha-induced activation of the matrix metalloproteinase/sphingolipid mitogenic pathway. Mol Cell Biol. 2007 Apr; 27(8):2997-3007.
Score: 0.007
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Role of human longevity assurance gene 1 and C18-ceramide in chemotherapy-induced cell death in human head and neck squamous cell carcinomas. Mol Cancer Ther. 2007 Feb; 6(2):712-22.
Score: 0.007
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Distribution and dynamic changes of sphingolipids in blood in response to platelet activation. J Thromb Haemost. 2006 Dec; 4(12):2704-9.
Score: 0.007
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Altered adipose and plasma sphingolipid metabolism in obesity: a potential mechanism for cardiovascular and metabolic risk. Diabetes. 2006 Sep; 55(9):2579-87.
Score: 0.007
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Necessary role for the Lag1p motif in (dihydro)ceramide synthase activity. J Biol Chem. 2006 Nov 10; 281(45):33931-8.
Score: 0.007
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Modulation of ceramide metabolism enhances viral protein apoptin's cytotoxicity in prostate cancer. Mol Ther. 2006 Nov; 14(5):637-46.
Score: 0.007
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Potent antitumor activity of a novel cationic pyridinium-ceramide alone or in combination with gemcitabine against human head and neck squamous cell carcinomas in vitro and in vivo. J Pharmacol Exp Ther. 2006 Jun; 317(3):1188-99.
Score: 0.007
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Neutral ceramidase encoded by the Asah2 gene is essential for the intestinal degradation of sphingolipids. J Biol Chem. 2006 Mar 17; 281(11):7324-31.
Score: 0.007
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Roles of AKT and sphingosine kinase in the antiapoptotic effects of bile duct ligation in mouse liver. Hepatology. 2005 Dec; 42(6):1320-8.
Score: 0.007
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Sphingosine kinase 1 is up-regulated in colon carcinogenesis. FASEB J. 2006 Feb; 20(2):386-8.
Score: 0.007
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Roles for C16-ceramide and sphingosine 1-phosphate in regulating hepatocyte apoptosis in response to tumor necrosis factor-alpha. J Biol Chem. 2005 Jul 29; 280(30):27879-87.
Score: 0.007
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Local correlation of expression profiles with gene annotations--proof of concept for a general conciliatory method. Bioinformatics. 2005 Apr 01; 21(7):1037-45.
Score: 0.006
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Defects in cell growth regulation by C18:0-ceramide and longevity assurance gene 1 in human head and neck squamous cell carcinomas. J Biol Chem. 2004 Oct 22; 279(43):44311-9.
Score: 0.006
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Mass spectrometric analysis of ceramide perturbations in brain and fibroblasts of mice and human patients with peroxisomal disorders. Rapid Commun Mass Spectrom. 2004; 18(14):1569-74.
Score: 0.006
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Identification of App1 as a regulator of phagocytosis and virulence of Cryptococcus neoformans. J Clin Invest. 2003 Oct; 112(7):1080-94.
Score: 0.006
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Cystic fibrosis transmembrane regulator regulates uptake of sphingoid base phosphates and lysophosphatidic acid: modulation of cellular activity of sphingosine 1-phosphate. J Biol Chem. 2001 Sep 21; 276(38):35258-64.
Score: 0.005
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Roles for inositol-phosphoryl ceramide synthase 1 (IPC1) in pathogenesis of C. neoformans. Genes Dev. 2001 Jan 15; 15(2):201-12.
Score: 0.005
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Functional dichotomy of protein kinase C (PKC) in tumor necrosis factor-alpha (TNF-alpha ) signal transduction in L929 cells. Translocation and inactivation of PKC by TNF-alpha. J Biol Chem. 2000 Sep 22; 275(38):29290-8.
Score: 0.005
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Proteolytic cleavage of phospholipase C-gamma1 during apoptosis in Molt-4 cells. FASEB J. 2000 Jun; 14(9):1083-92.
Score: 0.005
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Rapid replenishment of sphingomyelin in the plasma membrane upon degradation by sphingomyelinase in NIH3T3 cells overexpressing the phosphatidylinositol transfer protein beta. Biochem J. 2000 Mar 01; 346 Pt 2:537-43.
Score: 0.005
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Dual role of ceramide in the control of apoptosis following IL-2 withdrawal. J Immunol. 1998 Apr 01; 160(7):3528-33.
Score: 0.004
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Phorbol myristate acetate-dependent association of protein kinase C alpha with phospholipase D1 in intact cells. Biochim Biophys Acta. 1997 Aug 16; 1347(2-3):199-204.
Score: 0.004
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Role of ceramide in stimulation of the transcription of cytosolic phospholipase A2 and cyclooxygenase 2. Biochem Biophys Res Commun. 1996 Mar 27; 220(3):681-6.
Score: 0.003
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Ceramide activates the stress-activated protein kinases. J Biol Chem. 1995 Sep 29; 270(39):22689-92.
Score: 0.003
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12(S)-hydroxyeicosatetraenoic acid and 13(S)-hydroxyoctadecadienoic acid regulation of protein kinase C-alpha in melanoma cells: role of receptor-mediated hydrolysis of inositol phospholipids. Proc Natl Acad Sci U S A. 1995 Sep 26; 92(20):9323-7.
Score: 0.003
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12(S)-HETE enhancement of prostate tumor cell invasion: selective role of PKC alpha. J Natl Cancer Inst. 1994 Aug 03; 86(15):1145-51.
Score: 0.003