Yusuf Hannun to Humans
This is a "connection" page, showing publications Yusuf Hannun has written about Humans.
Connection Strength
2.787
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Upregulation of sphingosine kinase 1 in response to doxorubicin generates an angiogenic response via stabilization of Snail. FASEB J. 2023 03; 37(3):e22787.
Score: 0.033
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Sublethal doxorubicin promotes migration and invasion of breast cancer cells: role of Src Family non-receptor tyrosine kinases. Breast Cancer Res. 2021 07 27; 23(1):76.
Score: 0.029
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Protein Kinase C as a Therapeutic Target in Non-Small Cell Lung Cancer. Int J Mol Sci. 2021 May 24; 22(11).
Score: 0.029
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The doxorubicin-induced cell motility network is under the control of the ceramide-activated protein phosphatase 1 alpha. FASEB J. 2021 03; 35(3):e21396.
Score: 0.028
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Synthesis of erythro- B13 enantiomers and stereospecific action of full set of B13-isomers in MCF7 breast carcinoma cells: Cellular metabolism and effects on sphingolipids. Bioorg Med Chem. 2021 02 15; 32:116011.
Score: 0.028
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Transcriptional Regulation of Sphingosine Kinase 1. Cells. 2020 11 08; 9(11).
Score: 0.028
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Ceramide launches an acute anti-adhesion pro-migration cell signaling program in response to chemotherapy. FASEB J. 2020 06; 34(6):7610-7630.
Score: 0.027
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Exploring the Therapeutic Landscape of Sphingomyelinases. Handb Exp Pharmacol. 2020; 259:19-47.
Score: 0.026
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PKCa is required for Akt-mTORC1 activation in non-small cell lung carcinoma (NSCLC) with EGFR mutation. Oncogene. 2019 11; 38(48):7311-7328.
Score: 0.025
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Probing compartment-specific sphingolipids with targeted bacterial sphingomyelinases and ceramidases. J Lipid Res. 2019 11; 60(11):1841-1850.
Score: 0.025
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Bioactive sphingolipid profile in a xenograft mouse model of head and neck squamous cell carcinoma. PLoS One. 2019; 14(4):e0215770.
Score: 0.025
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The juxtamembrane linker in neutral sphingomyelinase-2 functions as an intramolecular allosteric switch that activates the enzyme. J Biol Chem. 2019 05 03; 294(18):7488-7502.
Score: 0.025
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Multiple actions of doxorubicin on the sphingolipid network revealed by flux analysis. J Lipid Res. 2019 04; 60(4):819-831.
Score: 0.024
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Dose dependent actions of LCL521 on acid ceramidase and key sphingolipid metabolites. Bioorg Med Chem. 2018 12 15; 26(23-24):6067-6075.
Score: 0.024
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Neutral ceramidase: Advances in mechanisms, cell regulation, and roles in cancer. Adv Biol Regul. 2019 01; 71:141-146.
Score: 0.024
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Visualizing bioactive ceramides. Chem Phys Lipids. 2018 11; 216:142-151.
Score: 0.024
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Functions of neutral ceramidase in the Golgi apparatus. J Lipid Res. 2018 11; 59(11):2116-2125.
Score: 0.024
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Evaluating intrinsic and non-intrinsic cancer risk factors. Nat Commun. 2018 08 28; 9(1):3490.
Score: 0.024
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Identification of an acid sphingomyelinase ceramide kinase pathway in the regulation of the chemokine CCL5. J Lipid Res. 2018 07; 59(7):1219-1229.
Score: 0.023
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AKT as a key target for growth promoting functions of neutral ceramidase in colon cancer cells. Oncogene. 2018 07; 37(28):3852-3863.
Score: 0.023
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Probing de novo sphingolipid metabolism in mammalian cells utilizing mass spectrometry. J Lipid Res. 2018 06; 59(6):1046-1057.
Score: 0.023
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Sphingolipids and their metabolism in physiology and disease. Nat Rev Mol Cell Biol. 2018 03; 19(3):175-191.
Score: 0.023
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Contributions of the Intrinsic Mutation Process to Cancer Mutation and Risk Burdens. EBioMedicine. 2017 10; 24:5-6.
Score: 0.022
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Co-ordinated activation of classical and novel PKC isoforms is required for PMA-induced mTORC1 activation. PLoS One. 2017; 12(9):e0184818.
Score: 0.022
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P38 delta MAPK promotes breast cancer progression and lung metastasis by enhancing cell proliferation and cell detachment. Oncogene. 2017 11 23; 36(47):6649-6657.
Score: 0.022
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Structure of human nSMase2 reveals an interdomain allosteric activation mechanism for ceramide generation. Proc Natl Acad Sci U S A. 2017 07 11; 114(28):E5549-E5558.
Score: 0.022
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Anticancer actions of lysosomally targeted inhibitor, LCL521, of acid ceramidase. PLoS One. 2017; 12(6):e0177805.
Score: 0.022
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Ceramidases, roles in sphingolipid metabolism and in health and disease. Adv Biol Regul. 2017 Jan; 63:122-131.
Score: 0.021
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Role of neutral ceramidase in colon cancer. FASEB J. 2016 12; 30(12):4159-4171.
Score: 0.021
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ATRA transcriptionally induces nSMase2 through CBP/p300-mediated histone acetylation. J Lipid Res. 2016 05; 57(5):868-81.
Score: 0.020
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Murine Model for Colitis-Associated Cancer of the Colon. Methods Mol Biol. 2016; 1438:245-54.
Score: 0.020
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Substantial contribution of extrinsic risk factors to cancer development. Nature. 2016 Jan 07; 529(7584):43-7.
Score: 0.020
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P53-dependent upregulation of neutral sphingomyelinase-2: role in doxorubicin-induced growth arrest. Cell Death Dis. 2015 Oct 29; 6:e1947.
Score: 0.020
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Activation of p38 Mitogen-Activated Protein Kinase in Gaucher's Disease. PLoS One. 2015; 10(8):e0136633.
Score: 0.019
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Structural Basis for Ceramide Recognition and Hydrolysis by Human Neutral Ceramidase. Structure. 2015 Aug 04; 23(8):1482-1491.
Score: 0.019
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Critical determinants of mitochondria-associated neutral sphingomyelinase (MA-nSMase) for mitochondrial localization. Biochim Biophys Acta. 2015 Apr; 1850(4):628-39.
Score: 0.018
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Roles and regulation of neutral sphingomyelinase-2 in cellular and pathological processes. Adv Biol Regul. 2015 Jan; 57:24-41.
Score: 0.018
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Identification and biochemical characterization of an acid sphingomyelinase-like protein from the bacterial plant pathogen Ralstonia solanacearum that hydrolyzes ATP to AMP but not sphingomyelin to ceramide. PLoS One. 2014; 9(8):e105830.
Score: 0.018
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Defining a role for acid sphingomyelinase in the p38/interleukin-6 pathway. J Biol Chem. 2014 Aug 08; 289(32):22401-12.
Score: 0.018
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Evolving concepts in cancer therapy through targeting sphingolipid metabolism. Biochim Biophys Acta. 2014 Aug; 1841(8):1174-88.
Score: 0.017
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Sustained activation of protein kinase C induces delayed phosphorylation and regulates the fate of epidermal growth factor receptor. PLoS One. 2013; 8(11):e80721.
Score: 0.017
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The yeast sphingolipid signaling landscape. Chem Phys Lipids. 2014 Jan; 177:26-40.
Score: 0.017
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Sustained PKC?II activity confers oncogenic properties in a phospholipase D- and mTOR-dependent manner. FASEB J. 2014 Jan; 28(1):495-505.
Score: 0.017
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Sphingolipids in colon cancer. Biochim Biophys Acta. 2014 May; 1841(5):773-82.
Score: 0.017
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Sphingolipid metabolism and neutral sphingomyelinases. Handb Exp Pharmacol. 2013; (215):57-76.
Score: 0.016
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Novel chemotherapeutic drugs in sphingolipid cancer research. Handb Exp Pharmacol. 2013; (215):211-38.
Score: 0.016
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Protein phosphatase 1a mediates ceramide-induced ERM protein dephosphorylation: a novel mechanism independent of phosphatidylinositol 4, 5-biphosphate (PIP2) and myosin/ERM phosphatase. J Biol Chem. 2012 Mar 23; 287(13):10145-10155.
Score: 0.015
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The roles of neutral sphingomyelinases in neurological pathologies. Neurochem Res. 2012 Jun; 37(6):1137-49.
Score: 0.015
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Many ceramides. J Biol Chem. 2011 Aug 12; 286(32):27855-62.
Score: 0.014
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Drug targeting of sphingolipid metabolism: sphingomyelinases and ceramidases. Br J Pharmacol. 2011 Jun; 163(4):694-712.
Score: 0.014
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Identification of novel anionic phospholipid binding domains in neutral sphingomyelinase 2 with selective binding preference. J Biol Chem. 2011 Jun 24; 286(25):22362-71.
Score: 0.014
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Neutral sphingomyelinase-2 mediates growth arrest by retinoic acid through modulation of ribosomal S6 kinase. J Biol Chem. 2011 Jun 17; 286(24):21565-76.
Score: 0.014
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Neutral sphingomyelinase 2 (nSMase2) is the primary neutral sphingomyelinase isoform activated by tumour necrosis factor-a in MCF-7 cells. Biochem J. 2011 Apr 15; 435(2):381-90.
Score: 0.014
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Delayed phosphorylation of classical protein kinase C (PKC) substrates requires PKC internalization and formation of the pericentrion in a phospholipase D (PLD)-dependent manner. J Biol Chem. 2011 Jun 03; 286(22):19340-53.
Score: 0.014
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Regulation of CC ligand 5/RANTES by acid sphingomyelinase and acid ceramidase. J Biol Chem. 2011 Apr 15; 286(15):13292-303.
Score: 0.014
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A novel mechanism of lysosomal acid sphingomyelinase maturation: requirement for carboxyl-terminal proteolytic processing. J Biol Chem. 2011 Feb 04; 286(5):3777-88.
Score: 0.014
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The neutral sphingomyelinase family: identifying biochemical connections. Adv Enzyme Regul. 2011; 51(1):51-8.
Score: 0.014
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Regulated secretion of acid sphingomyelinase: implications for selectivity of ceramide formation. J Biol Chem. 2010 Nov 12; 285(46):35706-18.
Score: 0.014
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Anterograde and retrograde transport of neutral sphingomyelinase-2 between the Golgi and the plasma membrane. Biochim Biophys Acta. 2010 Dec; 1801(12):1361-74.
Score: 0.014
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Differential effects of ceramide and sphingosine 1-phosphate on ERM phosphorylation: probing sphingolipid signaling at the outer plasma membrane. J Biol Chem. 2010 Oct 15; 285(42):32476-85.
Score: 0.014
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The acid sphingomyelinase/ceramide pathway: biomedical significance and mechanisms of regulation. Curr Mol Med. 2010 Jul; 10(5):454-66.
Score: 0.014
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Mammalian neutral sphingomyelinases: regulation and roles in cell signaling responses. Neuromolecular Med. 2010 Dec; 12(4):320-30.
Score: 0.013
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Identification and characterization of murine mitochondria-associated neutral sphingomyelinase (MA-nSMase), the mammalian sphingomyelin phosphodiesterase 5. J Biol Chem. 2010 Jun 04; 285(23):17993-8002.
Score: 0.013
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Dihydroceramide desaturase activity is modulated by oxidative stress. Biochem J. 2010 Mar 29; 427(2):265-74.
Score: 0.013
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An overview of sphingolipid metabolism: from synthesis to breakdown. Adv Exp Med Biol. 2010; 688:1-23.
Score: 0.013
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Sphingomyelin metabolism at the plasma membrane: implications for bioactive sphingolipids. FEBS Lett. 2010 May 03; 584(9):1887-94.
Score: 0.013
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Sustained receptor stimulation leads to sequestration of recycling endosomes in a classical protein kinase C- and phospholipase D-dependent manner. J Biol Chem. 2009 Aug 14; 284(33):22322-22331.
Score: 0.013
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Roles and regulation of secretory and lysosomal acid sphingomyelinase. Cell Signal. 2009 Jun; 21(6):836-46.
Score: 0.013
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Acid beta-glucosidase 1 counteracts p38delta-dependent induction of interleukin-6: possible role for ceramide as an anti-inflammatory lipid. J Biol Chem. 2009 May 08; 284(19):12979-88.
Score: 0.012
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Involvement of acid beta-glucosidase 1 in the salvage pathway of ceramide formation. J Biol Chem. 2009 May 08; 284(19):12972-8.
Score: 0.012
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Bioactive sphingolipids: metabolism and function. J Lipid Res. 2009 Apr; 50 Suppl:S91-6.
Score: 0.012
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Molecular targeting of acid ceramidase: implications to cancer therapy. Curr Drug Targets. 2008 Aug; 9(8):653-61.
Score: 0.012
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Regulation of neutral sphingomyelinase-2 (nSMase2) by tumor necrosis factor-alpha involves protein kinase C-delta in lung epithelial cells. Mol Pharmacol. 2008 Oct; 74(4):1022-32.
Score: 0.012
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Remodeling of cellular cytoskeleton by the acid sphingomyelinase/ceramide pathway. J Cell Biol. 2008 Apr 21; 181(2):335-50.
Score: 0.012
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Principles of bioactive lipid signalling: lessons from sphingolipids. Nat Rev Mol Cell Biol. 2008 Feb; 9(2):139-50.
Score: 0.011
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Confluence induced threonine41/serine45 phospho-beta-catenin dephosphorylation via ceramide-mediated activation of PP1cgamma. Biochim Biophys Acta. 2007 Dec; 1771(12):1418-28.
Score: 0.011
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Novel analogs of D-e-MAPP and B13. Part 2: signature effects on bioactive sphingolipids. Bioorg Med Chem. 2008 Jan 15; 16(2):1032-45.
Score: 0.011
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A novel role for protein kinase Cdelta-mediated phosphorylation of acid sphingomyelinase in UV light-induced mitochondrial injury. FASEB J. 2008 Jan; 22(1):183-93.
Score: 0.011
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Translational aspects of sphingolipid metabolism. Trends Mol Med. 2007 Aug; 13(8):327-36.
Score: 0.011
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Mechanism of inhibition of sequestration of protein kinase C alpha/betaII by ceramide. Roles of ceramide-activated protein phosphatases and phosphorylation/dephosphorylation of protein kinase C alpha/betaII on threonine 638/641. J Biol Chem. 2007 Jul 13; 282(28):20647-56.
Score: 0.011
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Analysis of membrane topology of neutral sphingomyelinase 2. FEBS Lett. 2007 Apr 03; 581(7):1323-8.
Score: 0.011
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Activation of acid sphingomyelinase by protein kinase Cdelta-mediated phosphorylation. J Biol Chem. 2007 Apr 13; 282(15):11549-61.
Score: 0.011
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Regulation of membrane trafficking and endocytosis by protein kinase C: emerging role of the pericentrion, a novel protein kinase C-dependent subset of recycling endosomes. Cell Mol Life Sci. 2007 Feb; 64(3):263-70.
Score: 0.011
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Neutral sphingomyelinase 2 is palmitoylated on multiple cysteine residues. Role of palmitoylation in subcellular localization. J Biol Chem. 2007 Mar 30; 282(13):10047-10056.
Score: 0.011
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Redox regulation of neutral sphingomyelinase-1 activity in HEK293 cells through a GSH-dependent mechanism. Arch Biochem Biophys. 2007 Mar 15; 459(2):295-300.
Score: 0.011
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Role for neutral sphingomyelinase-2 in tumor necrosis factor alpha-stimulated expression of vascular cell adhesion molecule-1 (VCAM) and intercellular adhesion molecule-1 (ICAM) in lung epithelial cells: p38 MAPK is an upstream regulator of nSMase2. J Biol Chem. 2007 Jan 12; 282(2):1384-96.
Score: 0.010
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Protein kinase C-induced activation of a ceramide/protein phosphatase 1 pathway leading to dephosphorylation of p38 MAPK. J Biol Chem. 2006 Dec 01; 281(48):36793-802.
Score: 0.010
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The extended family of neutral sphingomyelinases. Biochemistry. 2006 Sep 26; 45(38):11247-56.
Score: 0.010
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Sphingolipid-binding proteins. Biochim Biophys Acta. 2006 Aug; 1761(8):927-46.
Score: 0.010
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Bioactive sphingolipids in the modulation of the inflammatory response. Pharmacol Ther. 2006 Oct; 112(1):171-83.
Score: 0.010
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Dynamic sequestration of the recycling compartment by classical protein kinase C. J Biol Chem. 2006 Aug 04; 281(31):22321-22331.
Score: 0.010
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Identification of a novel amidase motif in neutral ceramidase. Biochem J. 2006 Feb 01; 393(Pt 3):687-95.
Score: 0.010
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Identification of a novel phosphatidic acid binding domain in protein phosphatase-1. Biochemistry. 2005 Oct 11; 44(40):13235-45.
Score: 0.010
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Protein kinase C and phospholipase D: intimate interactions in intracellular signaling. Cell Mol Life Sci. 2005 Jul; 62(13):1448-61.
Score: 0.010
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The coordination of prostaglandin E2 production by sphingosine-1-phosphate and ceramide-1-phosphate. Mol Pharmacol. 2005 Aug; 68(2):330-5.
Score: 0.009
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Selective inhibition of juxtanuclear translocation of protein kinase C betaII by a negative feedback mechanism involving ceramide formed from the salvage pathway. J Biol Chem. 2005 Jan 28; 280(4):2606-12.
Score: 0.009
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Biologically active sphingolipids in cancer pathogenesis and treatment. Nat Rev Cancer. 2004 Aug; 4(8):604-16.
Score: 0.009
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Isoenzyme-specific translocation of protein kinase C (PKC)betaII and not PKCbetaI to a juxtanuclear subset of recycling endosomes: involvement of phospholipase D. J Biol Chem. 2004 Jul 02; 279(27):28251-6.
Score: 0.009
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Role for mammalian neutral sphingomyelinase 2 in confluence-induced growth arrest of MCF7 cells. J Biol Chem. 2004 Jun 11; 279(24):25101-11.
Score: 0.009
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Acid and neutral sphingomyelinases: roles and mechanisms of regulation. Biochem Cell Biol. 2004 Feb; 82(1):27-44.
Score: 0.009
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The structural requirements for ceramide activation of serine-threonine protein phosphatases. J Lipid Res. 2004 Mar; 45(3):496-506.
Score: 0.009
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cPKC-dependent sequestration of membrane-recycling components in a subset of recycling endosomes. J Biol Chem. 2003 Dec 26; 278(52):52747-54.
Score: 0.008
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Ceramide, stress, and a "LAG" in aging. Sci Aging Knowledge Environ. 2003 Oct 01; 2003(39):PE27.
Score: 0.008
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The sphingosine kinase 1/sphingosine-1-phosphate pathway mediates COX-2 induction and PGE2 production in response to TNF-alpha. FASEB J. 2003 Aug; 17(11):1411-21.
Score: 0.008
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Biochemical properties of mammalian neutral sphingomyelinase 2 and its role in sphingolipid metabolism. J Biol Chem. 2003 Apr 18; 278(16):13775-83.
Score: 0.008
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Ceramide in apoptosis: an overview and current perspectives. Biochim Biophys Acta. 2002 Dec 30; 1585(2-3):114-25.
Score: 0.008
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Alkaline ceramidase catalyzes the hydrolysis of ceramides via a catalytic mechanism shared by Zn2+-dependent amidases. PLoS One. 2022; 17(9):e0271540.
Score: 0.008
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Tight binding inhibition of protein phosphatase-1 by phosphatidic acid. Specificity of inhibition by the phospholipid. J Biol Chem. 2002 May 03; 277(18):15530-8.
Score: 0.008
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Neutral ceramidase deficiency protects against cisplatin-induced acute kidney injury. J Lipid Res. 2022 03; 63(3):100179.
Score: 0.008
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Biochemical mechanisms of the generation of endogenous long chain ceramide in response to exogenous short chain ceramide in the A549 human lung adenocarcinoma cell line. Role for endogenous ceramide in mediating the action of exogenous ceramide. J Biol Chem. 2002 Apr 12; 277(15):12960-9.
Score: 0.008
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De novo ceramide regulates the alternative splicing of caspase 9 and Bcl-x in A549 lung adenocarcinoma cells. Dependence on protein phosphatase-1. J Biol Chem. 2002 Apr 12; 277(15):12587-95.
Score: 0.008
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Substrate specificity of rat brain ceramidase. J Lipid Res. 2002 Jan; 43(1):141-8.
Score: 0.008
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Mitochondria and ceramide: intertwined roles in regulation of apoptosis. Adv Enzyme Regul. 2002; 42:113-29.
Score: 0.008
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Sphingolipids in vascular biology. Adv Exp Med Biol. 2002; 507:439-44.
Score: 0.008
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Updates on functions of ceramide in chemotherapy-induced cell death and in multidrug resistance. Drug Resist Updat. 2001 Dec; 4(6):368-77.
Score: 0.007
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Determination of ceramides and diglycerides by the diglyceride kinase assay. Anal Biochem. 2001 Nov 15; 298(2):141-50.
Score: 0.007
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Group IIA secreted phospholipase A2 is associated with the pathobiology leading to COVID-19 mortality. J Clin Invest. 2021 10 01; 131(19).
Score: 0.007
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GRASP55 regulates intra-Golgi localization of glycosylation enzymes to control glycosphingolipid biosynthesis. EMBO J. 2021 10 18; 40(20):e107766.
Score: 0.007
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Enzymes of sphingolipid metabolism: from modular to integrative signaling. Biochemistry. 2001 Apr 24; 40(16):4893-903.
Score: 0.007
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Ceramide kinase regulates TNF-a-induced immune responses in human monocytic cells. Sci Rep. 2021 04 15; 11(1):8259.
Score: 0.007
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Golgi maturation-dependent glycoenzyme recycling controls glycosphingolipid biosynthesis and cell growth via GOLPH3. EMBO J. 2021 04 15; 40(8):e107238.
Score: 0.007
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Neutral Sphingomyelinase 2 Heightens Anti-Melanoma Immune Responses and Anti-PD-1 Therapy Efficacy. Cancer Immunol Res. 2021 05; 9(5):568-582.
Score: 0.007
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Biochemical characterization of the reverse activity of rat brain ceramidase. A CoA-independent and fumonisin B1-insensitive ceramide synthase. J Biol Chem. 2001 May 18; 276(20):16758-66.
Score: 0.007
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Asah2 Represses the p53-Hmox1 Axis to Protect Myeloid-Derived Suppressor Cells from Ferroptosis. J Immunol. 2021 03 15; 206(6):1395-1404.
Score: 0.007
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Ceramide synthase 2-C24:1 -ceramide axis limits the metastatic potential of ovarian cancer cells. FASEB J. 2021 02; 35(2):e21287.
Score: 0.007
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Sphingosine kinase 1 downregulation is required for adaptation to serine deprivation. FASEB J. 2021 02; 35(2):e21284.
Score: 0.007
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Induction of apoptosis through B-cell receptor cross-linking occurs via de novo generated C16-ceramide and involves mitochondria. J Biol Chem. 2001 Apr 27; 276(17):13606-14.
Score: 0.007
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Acid sphingomyelinase-dependent autophagic degradation of GPX4 is critical for the execution of ferroptosis. Cell Death Dis. 2021 01 07; 12(1):26.
Score: 0.007
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Targeting sphingosine kinase 1 (SK1) enhances oncogene-induced senescence through ceramide synthase 2 (CerS2)-mediated generation of very-long-chain ceramides. Cell Death Dis. 2021 01 04; 12(1):27.
Score: 0.007
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Bioactive sphingolipids: Advancements and contributions from the laboratory of Dr. Lina M. Obeid. Cell Signal. 2021 03; 79:109875.
Score: 0.007
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Sphingosine-1-phosphate receptor 3 potentiates inflammatory programs in normal and leukemia stem cells to promote differentiation. Blood Cancer Discov. 2021 01 01; 2(1):32-53.
Score: 0.007
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Neutral sphingomyelinase 2 regulates inflammatory responses in monocytes/macrophages induced by TNF-a. Sci Rep. 2020 10 08; 10(1):16802.
Score: 0.007
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Targeting acid ceramidase inhibits YAP/TAZ signaling to reduce fibrosis in mice. Sci Transl Med. 2020 08 19; 12(557).
Score: 0.007
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Identification of Small-Molecule Inhibitors of Neutral Ceramidase (nCDase) via Target-Based High-Throughput Screening. SLAS Discov. 2021 01; 26(1):113-121.
Score: 0.007
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Inhibition of acid ceramidase regulates MHC class II antigen presentation and suppression of autoimmune arthritis. Cytokine. 2020 11; 135:155219.
Score: 0.007
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Molecular cloning and characterization of a human mitochondrial ceramidase. J Biol Chem. 2000 Jul 14; 275(28):21508-13.
Score: 0.007
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Regulation of receptor-mediated protein kinase C membrane trafficking by autophosphorylation. J Biol Chem. 2000 Jun 02; 275(22):17024-34.
Score: 0.007
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Differential effects of sphingomyelin hydrolysis and resynthesis on the activation of NF-kappa B in normal and SV40-transformed human fibroblasts. J Biol Chem. 2000 May 12; 275(19):14760-6.
Score: 0.007
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Serine palmitoyltransferase regulates de novo ceramide generation during etoposide-induced apoptosis. J Biol Chem. 2000 Mar 24; 275(12):9078-84.
Score: 0.007
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Ceramide in the eukaryotic stress response. Trends Cell Biol. 2000 Feb; 10(2):73-80.
Score: 0.007
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Use of short-chain ceramides. Methods Enzymol. 2000; 312:407-20.
Score: 0.007
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Function of the cloned putative neutral sphingomyelinase as lyso-platelet activating factor-phospholipase C. J Biol Chem. 1999 Dec 31; 274(53):38131-9.
Score: 0.007
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Ceramide and sphingomyelinases in the regulation of stress responses. Chem Phys Lipids. 1999 Nov; 102(1-2):141-7.
Score: 0.006
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Phosphatidic acid is a potent and selective inhibitor of protein phosphatase 1 and an inhibitor of ceramide-mediated responses. J Biol Chem. 1999 Jul 23; 274(30):21335-41.
Score: 0.006
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Ceramide and apoptosis. Trends Biochem Sci. 1999 Jun; 24(6):224-5; author reply 227.
Score: 0.006
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RPGRIP1L is required for stabilizing epidermal keratinocyte adhesion through regulating desmoglein endocytosis. PLoS Genet. 2019 01; 15(1):e1007914.
Score: 0.006
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Emergence of membrane sphingolipids as a potential therapeutic target. Biochimie. 2019 Mar; 158:257-264.
Score: 0.006
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Sphingolipid metabolism in the regulation of bioactive molecules. Lipids. 1999; 34 Suppl:S5-11.
Score: 0.006
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The role of ceramide in cell signaling. Biochim Biophys Acta. 1998 Dec 08; 1436(1-2):233-43.
Score: 0.006
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An essential role for autophosphorylation in the dissociation of activated protein kinase C from the plasma membrane. J Biol Chem. 1998 Oct 09; 273(41):26870-4.
Score: 0.006
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p53-dependent ceramide response to genotoxic stress. J Clin Invest. 1998 Jul 15; 102(2):329-39.
Score: 0.006
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Role of sphingolipids in senescence: implication in aging and age-related diseases. J Clin Invest. 2018 07 02; 128(7):2702-2712.
Score: 0.006
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Sphingomyelin synthase, a potential regulator of intracellular levels of ceramide and diacylglycerol during SV40 transformation. Does sphingomyelin synthase account for the putative phosphatidylcholine-specific phospholipase C? J Biol Chem. 1998 Jun 05; 273(23):14550-9.
Score: 0.006
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Glutathione regulation of neutral sphingomyelinase in tumor necrosis factor-alpha-induced cell death. J Biol Chem. 1998 May 01; 273(18):11313-20.
Score: 0.006
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Visualization of dynamic trafficking of a protein kinase C betaII/green fluorescent protein conjugate reveals differences in G protein-coupled receptor activation and desensitization. J Biol Chem. 1998 Apr 24; 273(17):10755-62.
Score: 0.006
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The Synergy between Palmitate and TNF-a for CCL2 Production Is Dependent on the TRIF/IRF3 Pathway: Implications for Metabolic Inflammation. J Immunol. 2018 05 15; 200(10):3599-3611.
Score: 0.006
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Alkaline ceramidase 2 is essential for the homeostasis of plasma sphingoid bases and their phosphates. FASEB J. 2018 06; 32(6):3058-3069.
Score: 0.006
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An intrinsic lipid-binding interface controls sphingosine kinase 1 function. J Lipid Res. 2018 03; 59(3):462-474.
Score: 0.006
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Decreased ceramide underlies mitochondrial dysfunction in Charcot-Marie-Tooth 2F. FASEB J. 2018 03; 32(3):1716-1728.
Score: 0.006
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Loss of acid ceramidase in myeloid cells suppresses intestinal neutrophil recruitment. FASEB J. 2018 05; 32(5):2339-2353.
Score: 0.006
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Tumor suppressor p53 links ceramide metabolism to DNA damage response through alkaline ceramidase 2. Cell Death Differ. 2018 05; 25(5):841-856.
Score: 0.006
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Ceramide and the eukaryotic stress response. Biochem Soc Trans. 1997 Nov; 25(4):1171-5.
Score: 0.006
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The ceramide activated protein phosphatase Sit4 impairs sphingolipid dynamics, mitochondrial function and lifespan in a yeast model of Niemann-Pick type C1. Biochim Biophys Acta Mol Basis Dis. 2018 Jan; 1864(1):79-88.
Score: 0.006
-
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Loss of sphingosine kinase-1 activates the intrinsic pathway of programmed cell death: modulation of sphingolipid levels and the induction of apoptosis. FASEB J. 2006 Mar; 20(3):482-4.
Score: 0.002
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Sphingosine kinase 1 is up-regulated in colon carcinogenesis. FASEB J. 2006 Feb; 20(2):386-8.
Score: 0.002
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Dihydrosphingosine 1-phosphate stimulates MMP1 gene expression via activation of ERK1/2-Ets1 pathway in human fibroblasts. FASEB J. 2006 Jan; 20(1):184-6.
Score: 0.002
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Resistance to TRAIL is associated with defects in ceramide signaling that can be overcome by exogenous C6-ceramide without requiring down-regulation of cellular FLICE inhibitory protein. Mol Cancer Ther. 2005 Sep; 4(9):1320-7.
Score: 0.002
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Roles for C16-ceramide and sphingosine 1-phosphate in regulating hepatocyte apoptosis in response to tumor necrosis factor-alpha. J Biol Chem. 2005 Jul 29; 280(30):27879-87.
Score: 0.002
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A mitochondrial pool of sphingomyelin is involved in TNFalpha-induced Bax translocation to mitochondria. Biochem J. 2005 Mar 15; 386(Pt 3):445-51.
Score: 0.002
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Tumor necrosis factor induces the loss of sphingosine kinase-1 by a cathepsin B-dependent mechanism. J Biol Chem. 2005 Apr 29; 280(17):17196-202.
Score: 0.002
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Golgi fragmentation is associated with ceramide-induced cellular effects. Mol Biol Cell. 2005 Mar; 16(3):1555-67.
Score: 0.002
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Inhibition of growth and telomerase activity by novel cationic ceramide analogs with high solubility in human head and neck squamous cell carcinoma cells. Otolaryngol Head Neck Surg. 2005 Jan; 132(1):55-62.
Score: 0.002
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Sphingosine kinase 1 (SPHK1) is induced by transforming growth factor-beta and mediates TIMP-1 up-regulation. J Biol Chem. 2004 Dec 24; 279(52):53994-4001.
Score: 0.002
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Defects in cell growth regulation by C18:0-ceramide and longevity assurance gene 1 in human head and neck squamous cell carcinomas. J Biol Chem. 2004 Oct 22; 279(43):44311-9.
Score: 0.002
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EpCAM is overexpressed in breast cancer and is a potential target for breast cancer gene therapy. Cancer Res. 2004 Aug 15; 64(16):5818-24.
Score: 0.002
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Down-regulation of sphingosine kinase-1 by DNA damage: dependence on proteases and p53. J Biol Chem. 2004 May 07; 279(19):20546-54.
Score: 0.002
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Prodrug modification increases potassium tricyclo[5.2.1.0(2,6)]-decan-8-yl dithiocarbonate (D609) chemical stability and cytotoxicity against U937 leukemia cells. J Pharmacol Exp Ther. 2004 Jun; 309(3):1051-9.
Score: 0.002
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Sphingomyelin synthase as a potential target for D609-induced apoptosis in U937 human monocytic leukemia cells. Exp Cell Res. 2004 Jan 15; 292(2):385-92.
Score: 0.002
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Quantitative measurement of different ceramide species from crude cellular extracts by normal-phase high-performance liquid chromatography coupled to atmospheric pressure ionization mass spectrometry. Rapid Commun Mass Spectrom. 2004; 18(5):577-83.
Score: 0.002
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Mass spectrometric analysis of ceramide perturbations in brain and fibroblasts of mice and human patients with peroxisomal disorders. Rapid Commun Mass Spectrom. 2004; 18(14):1569-74.
Score: 0.002
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Ceramide 1-phosphate is a direct activator of cytosolic phospholipase A2. J Biol Chem. 2004 Mar 19; 279(12):11320-6.
Score: 0.002
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Rapid shortening of telomere length in response to ceramide involves the inhibition of telomere binding activity of nuclear glyceraldehyde-3-phosphate dehydrogenase. J Biol Chem. 2004 Feb 13; 279(7):6152-62.
Score: 0.002
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Ceramide kinase mediates cytokine- and calcium ionophore-induced arachidonic acid release. J Biol Chem. 2003 Oct 03; 278(40):38206-13.
Score: 0.002
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Quantification and characterization of the bystander effect in prostate cancer cells following adenovirus-mediated FasL expression. Cancer Gene Ther. 2003 Apr; 10(4):330-9.
Score: 0.002
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BcR-induced apoptosis involves differential regulation of C16 and C24-ceramide formation and sphingolipid-dependent activation of the proteasome. J Biol Chem. 2003 Apr 25; 278(17):14723-31.
Score: 0.002
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Modulation of transforming growth factor-beta (TGF-beta) signaling by endogenous sphingolipid mediators. J Biol Chem. 2003 Mar 14; 278(11):9276-82.
Score: 0.002
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Inhibition of tumor necrosis factor-induced cell death in MCF7 by a novel inhibitor of neutral sphingomyelinase. J Biol Chem. 2002 Oct 25; 277(43):41128-39.
Score: 0.002
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PKC-dependent activation of sphingosine kinase 1 and translocation to the plasma membrane. Extracellular release of sphingosine-1-phosphate induced by phorbol 12-myristate 13-acetate (PMA). J Biol Chem. 2002 Sep 20; 277(38):35257-62.
Score: 0.002
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Selective hydrolysis of a mitochondrial pool of sphingomyelin induces apoptosis. FASEB J. 2001 Dec; 15(14):2669-79.
Score: 0.002
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Cystic fibrosis transmembrane regulator regulates uptake of sphingoid base phosphates and lysophosphatidic acid: modulation of cellular activity of sphingosine 1-phosphate. J Biol Chem. 2001 Sep 21; 276(38):35258-64.
Score: 0.002
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Molecular mechanisms of ceramide-mediated telomerase inhibition in the A549 human lung adenocarcinoma cell line. J Biol Chem. 2001 Aug 31; 276(35):32506-14.
Score: 0.002
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Role of ceramide in mediating the inhibition of telomerase activity in A549 human lung adenocarcinoma cells. J Biol Chem. 2001 Jul 06; 276(27):24901-10.
Score: 0.002
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Roles for inositol-phosphoryl ceramide synthase 1 (IPC1) in pathogenesis of C. neoformans. Genes Dev. 2001 Jan 15; 15(2):201-12.
Score: 0.002
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FADD is required for multiple signaling events downstream of the receptor Fas. Cell Growth Differ. 1999 Dec; 10(12):797-804.
Score: 0.002
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A novel assay for apoptotic body formation and membrane release during apoptosis. Cell Death Differ. 1999 Jul; 6(7):596-8.
Score: 0.002
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Regulation of membrane release in apoptosis. Biochem J. 1998 Sep 01; 334 ( Pt 2):479-85.
Score: 0.001
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Platelet-activating factor receptor activation. An initiator step in HIV-1 neuropathogenesis. J Biol Chem. 1998 Jul 10; 273(28):17660-4.
Score: 0.001
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Increases in neutral, Mg2+-dependent and acidic, Mg2+-independent sphingomyelinase activities precede commitment to apoptosis and are not a consequence of caspase 3-like activity in Molt-4 cells in response to thymidylate synthase inhibition by GW1843. Blood. 1998 Jun 01; 91(11):4350-60.
Score: 0.001
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Dual role of ceramide in the control of apoptosis following IL-2 withdrawal. J Immunol. 1998 Apr 01; 160(7):3528-33.
Score: 0.001
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Sphingosylphosphocholine reduces the calcium ion requirement for activating tissue transglutaminase. J Biol Chem. 1997 Jun 27; 272(26):16295-300.
Score: 0.001
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Cytosolic Ca2+ and protein kinase Calpha couple cellular metabolism to membrane K+ permeability in a human biliary cell line. J Clin Invest. 1997 Jun 15; 99(12):2890-7.
Score: 0.001
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Upregulation of Bcl-2 and elevation of ceramide in Batten disease. Neuropediatrics. 1997 Feb; 28(1):37-41.
Score: 0.001
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12(S)-HETE increases the motility of prostate tumor cells through selective activation of PKC alpha. Adv Exp Med Biol. 1997; 400B:707-18.
Score: 0.001
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Ceramide inactivates cellular protein kinase Calpha. J Biol Chem. 1996 May 31; 271(22):13169-74.
Score: 0.001
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prICE: a downstream target for ceramide-induced apoptosis and for the inhibitory action of Bcl-2. Biochem J. 1996 May 15; 316 ( Pt 1):25-8.
Score: 0.001
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Role of ceramide in stimulation of the transcription of cytosolic phospholipase A2 and cyclooxygenase 2. Biochem Biophys Res Commun. 1996 Mar 27; 220(3):681-6.
Score: 0.001
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Ceramide activates the stress-activated protein kinases. J Biol Chem. 1995 Sep 29; 270(39):22689-92.
Score: 0.001
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Ceramide induces interleukin 6 gene expression in human fibroblasts. J Exp Med. 1995 Aug 01; 182(2):599-604.
Score: 0.001
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Regulation of protein kinase C (PKC) expression by iron: effect of different iron compounds on PKC-beta and PKC-alpha gene expression and role of the 5'-flanking region of the PKC-beta gene in the response to ferric transferrin. Blood. 1994 Nov 15; 84(10):3510-7.
Score: 0.001
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Specific role for protein kinase C beta in cell differentiation. Cell Growth Differ. 1994 Apr; 5(4):405-9.
Score: 0.001
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Introduction: sphingolipids and their metabolites in cell regulation. Adv Lipid Res. 1993; 25:1-24.
Score: 0.001
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The novel second messenger ceramide: identification, mechanism of action, and cellular activity. Adv Lipid Res. 1993; 25:43-64.
Score: 0.001
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15-Hydroxyeicosatetraenoic acid-mediated potentiation of thrombin-induced platelet functions occurs via enhanced production of phosphoinositide-derived second messengers--sn-1,2-diacylglycerol and inositol-1,4,5-trisphosphate. Blood. 1992 Dec 01; 80(11):2765-73.
Score: 0.001
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Sphingosine inhibits monocyte tissue factor-initiated coagulation by altering factor VII binding. J Biol Chem. 1989 Nov 05; 264(31):18440-4.
Score: 0.001
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Structural requirements for long-chain (sphingoid) base inhibition of protein kinase C in vitro and for the cellular effects of these compounds. Biochemistry. 1989 Apr 18; 28(8):3138-45.
Score: 0.001
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Regulation of the epidermal growth factor receptor phosphorylation state by sphingosine in A431 human epidermoid carcinoma cells. J Biol Chem. 1988 Apr 15; 263(11):5319-27.
Score: 0.001
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Inhibition of phorbol ester-dependent differentiation of human promyelocytic leukemic (HL-60) cells by sphinganine and other long-chain bases. J Biol Chem. 1986 Sep 25; 261(27):12610-5.
Score: 0.001