Yusuf Hannun to Protein Kinase C
This is a "connection" page, showing publications Yusuf Hannun has written about Protein Kinase C.
Connection Strength
8.428
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Protein Kinase C as a Therapeutic Target in Non-Small Cell Lung Cancer. Int J Mol Sci. 2021 May 24; 22(11).
Score: 0.670
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Co-ordinated activation of classical and novel PKC isoforms is required for PMA-induced mTORC1 activation. PLoS One. 2017; 12(9):e0184818.
Score: 0.519
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Sustained activation of protein kinase C induces delayed phosphorylation and regulates the fate of epidermal growth factor receptor. PLoS One. 2013; 8(11):e80721.
Score: 0.397
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Sustained PKC?II activity confers oncogenic properties in a phospholipase D- and mTOR-dependent manner. FASEB J. 2014 Jan; 28(1):495-505.
Score: 0.395
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Delayed phosphorylation of classical protein kinase C (PKC) substrates requires PKC internalization and formation of the pericentrion in a phospholipase D (PLD)-dependent manner. J Biol Chem. 2011 Jun 03; 286(22):19340-53.
Score: 0.332
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Sustained receptor stimulation leads to sequestration of recycling endosomes in a classical protein kinase C- and phospholipase D-dependent manner. J Biol Chem. 2009 Aug 14; 284(33):22322-22331.
Score: 0.293
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Mechanism of inhibition of sequestration of protein kinase C alpha/betaII by ceramide. Roles of ceramide-activated protein phosphatases and phosphorylation/dephosphorylation of protein kinase C alpha/betaII on threonine 638/641. J Biol Chem. 2007 Jul 13; 282(28):20647-56.
Score: 0.253
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Regulation of membrane trafficking and endocytosis by protein kinase C: emerging role of the pericentrion, a novel protein kinase C-dependent subset of recycling endosomes. Cell Mol Life Sci. 2007 Feb; 64(3):263-70.
Score: 0.248
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Protein kinase C-induced activation of a ceramide/protein phosphatase 1 pathway leading to dephosphorylation of p38 MAPK. J Biol Chem. 2006 Dec 01; 281(48):36793-802.
Score: 0.243
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Protein kinase C and phospholipase D: intimate interactions in intracellular signaling. Cell Mol Life Sci. 2005 Jul; 62(13):1448-61.
Score: 0.223
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Selective inhibition of juxtanuclear translocation of protein kinase C betaII by a negative feedback mechanism involving ceramide formed from the salvage pathway. J Biol Chem. 2005 Jan 28; 280(4):2606-12.
Score: 0.213
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Isoenzyme-specific translocation of protein kinase C (PKC)betaII and not PKCbetaI to a juxtanuclear subset of recycling endosomes: involvement of phospholipase D. J Biol Chem. 2004 Jul 02; 279(27):28251-6.
Score: 0.204
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cPKC-dependent sequestration of membrane-recycling components in a subset of recycling endosomes. J Biol Chem. 2003 Dec 26; 278(52):52747-54.
Score: 0.197
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Regulation of receptor-mediated protein kinase C membrane trafficking by autophosphorylation. J Biol Chem. 2000 Jun 02; 275(22):17024-34.
Score: 0.157
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Effects of sphingosine and other sphingolipids on protein kinase C. Methods Enzymol. 2000; 312:361-73.
Score: 0.152
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An essential role for autophosphorylation in the dissociation of activated protein kinase C from the plasma membrane. J Biol Chem. 1998 Oct 09; 273(41):26870-4.
Score: 0.140
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Visualization of dynamic trafficking of a protein kinase C betaII/green fluorescent protein conjugate reveals differences in G protein-coupled receptor activation and desensitization. J Biol Chem. 1998 Apr 24; 273(17):10755-62.
Score: 0.135
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Protein kinase C beta II specifically binds to and is activated by F-actin. J Biol Chem. 1996 Jun 28; 271(26):15823-30.
Score: 0.119
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Protein kinase C isoenzymes: regulation and function. Cancer Surv. 1996; 27:213-48.
Score: 0.115
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Arachidonic acid and free fatty acids as second messengers and the role of protein kinase C. Cell Signal. 1995 Mar; 7(3):171-84.
Score: 0.109
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Protein kinase C: cellular target of the second messenger arachidonic acid? Prostaglandins Leukot Essent Fatty Acids. 1995 Feb-Mar; 52(2-3):129-35.
Score: 0.108
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Regulation of protein kinase C and role in cancer biology. Cancer Metastasis Rev. 1994 Dec; 13(3-4):411-31.
Score: 0.107
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Selective regulation of expression of protein kinase C beta isoenzymes occurs via alternative splicing. J Biol Chem. 1993 May 15; 268(14):10627-35.
Score: 0.096
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Selective regulation of protein kinase C isoenzymes by oleic acid in human platelets. J Biol Chem. 1993 Mar 05; 268(7):5063-8.
Score: 0.095
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Selective regulation of expression of protein kinase C (PKC) isoenzymes in multidrug-resistant MCF-7 cells. Functional significance of enhanced expression of PKC alpha. J Biol Chem. 1993 Jan 05; 268(1):658-64.
Score: 0.094
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Cloning and characterization of the major promoter of the human protein kinase C beta gene. Regulation by phorbol esters. J Biol Chem. 1992 Oct 15; 267(29):20804-10.
Score: 0.092
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Tissue and cellular distribution of the extended family of protein kinase C isoenzymes. J Cell Biol. 1992 Apr; 117(1):121-33.
Score: 0.089
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Activation of protein kinase C by oleic acid. Determination and analysis of inhibition by detergent micelles and physiologic membranes: requirement for free oleate. J Biol Chem. 1992 Feb 25; 267(6):3605-12.
Score: 0.088
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Selective changes in protein kinase C isoenzymes in rat liver nuclei during liver regeneration. Biochem Biophys Res Commun. 1992 Feb 14; 182(3):1333-9.
Score: 0.088
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Network of signal transduction pathways involving lipids: protein kinase C-dependent and -independent pathways. Adv Exp Med Biol. 1992; 318:275-84.
Score: 0.087
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Arachidonic and cis-unsaturated fatty acids induce selective platelet substrate phosphorylation through activation of cytosolic protein kinase C. FEBS Lett. 1991 Nov 04; 292(1-2):98-102.
Score: 0.086
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Use of D-erythro-sphingosine as a pharmacological inhibitor of protein kinase C in human platelets. Biochem J. 1991 Sep 01; 278 ( Pt 2):387-92.
Score: 0.085
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Use of sphingosine as inhibitor of protein kinase C. Methods Enzymol. 1991; 201:316-28.
Score: 0.081
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Protein kinase C and platelet inhibition by D-erythro-sphingosine: comparison with N,N-dimethylsphingosine and commercial preparation. Biochem Biophys Res Commun. 1990 Oct 30; 172(2):683-91.
Score: 0.081
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Regulation of platelet protein kinase C by oleic acid. Kinetic analysis of allosteric regulation and effects on autophosphorylation, phorbol ester binding, and susceptibility to inhibition. J Biol Chem. 1990 Sep 25; 265(27):16437-43.
Score: 0.080
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Rat brain protein kinase C. Kinetic analysis of substrate dependence, allosteric regulation, and autophosphorylation. J Biol Chem. 1990 Feb 15; 265(5):2962-72.
Score: 0.077
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Transcriptional regulation of protein kinase C by 1,25-dihydroxyvitamin D3 in HL-60 cells. J Biol Chem. 1990 Feb 05; 265(4):2370-4.
Score: 0.077
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Regulation of protein kinase C by sphingosine and lysosphingolipids. Clin Chim Acta. 1989 Dec 15; 185(3):333-45.
Score: 0.076
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The adriamycin-iron(III) complex is a potent inhibitor of protein kinase C. J Biol Chem. 1989 Jun 15; 264(17):9960-6.
Score: 0.073
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Acid beta-glucosidase 1 counteracts p38delta-dependent induction of interleukin-6: possible role for ceramide as an anti-inflammatory lipid. J Biol Chem. 2009 May 08; 284(19):12979-88.
Score: 0.072
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Involvement of acid beta-glucosidase 1 in the salvage pathway of ceramide formation. J Biol Chem. 2009 May 08; 284(19):12972-8.
Score: 0.072
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Remodeling of cellular cytoskeleton by the acid sphingomyelinase/ceramide pathway. J Cell Biol. 2008 Apr 21; 181(2):335-50.
Score: 0.068
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Aminoacridines, potent inhibitors of protein kinase C. J Biol Chem. 1988 Apr 15; 263(11):5124-31.
Score: 0.068
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Protein kinase C regulation by sphingosine/lysosphingolipids. Cold Spring Harb Symp Quant Biol. 1988; 53 Pt 1:103-10.
Score: 0.066
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Sphingosine inhibition of agonist-dependent secretion and activation of human platelets implies that protein kinase C is a necessary and common event of the signal transduction pathways. J Biol Chem. 1987 Oct 05; 262(28):13620-6.
Score: 0.065
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Lysosphingolipids inhibit protein kinase C: implications for the sphingolipidoses. Science. 1987 Feb 06; 235(4789):670-4.
Score: 0.062
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Mixed micellar assay for phorbol ester binding. Methods Enzymol. 1987; 141:287-93.
Score: 0.062
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Mechanism of activation of protein kinase C: role of diacylglycerol and calcium second messengers. Soc Gen Physiol Ser. 1987; 42:229-40.
Score: 0.062
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Sphingosine inhibition of protein kinase C activity and of phorbol dibutyrate binding in vitro and in human platelets. J Biol Chem. 1986 Sep 25; 261(27):12604-9.
Score: 0.061
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Phorbol ester binding and activation of protein kinase C on triton X-100 mixed micelles containing phosphatidylserine. J Biol Chem. 1986 Jul 15; 261(20):9341-7.
Score: 0.060
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Protein kinase C activation in mixed micelles. Mechanistic implications of phospholipid, diacylglycerol, and calcium interdependencies. J Biol Chem. 1986 Jun 05; 261(16):7184-90.
Score: 0.059
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Dynamic sequestration of the recycling compartment by classical protein kinase C. J Biol Chem. 2006 Aug 04; 281(31):22321-22331.
Score: 0.059
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The sphingolipid pathway regulates Pkc1 through the formation of diacylglycerol in Cryptococcus neoformans. J Biol Chem. 2004 May 14; 279(20):21144-53.
Score: 0.051
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PKC alpha mediates maternal touch regulation of growth-related gene expression in infant rats. Neuropsychopharmacology. 2003 Jun; 28(6):1026-30.
Score: 0.048
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PKC-dependent activation of sphingosine kinase 1 and translocation to the plasma membrane. Extracellular release of sphingosine-1-phosphate induced by phorbol 12-myristate 13-acetate (PMA). J Biol Chem. 2002 Sep 20; 277(38):35257-62.
Score: 0.045
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Functional dichotomy of protein kinase C (PKC) in tumor necrosis factor-alpha (TNF-alpha ) signal transduction in L929 cells. Translocation and inactivation of PKC by TNF-alpha. J Biol Chem. 2000 Sep 22; 275(38):29290-8.
Score: 0.040
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Phorbol myristate acetate-dependent association of protein kinase C alpha with phospholipase D1 in intact cells. Biochim Biophys Acta. 1997 Aug 16; 1347(2-3):199-204.
Score: 0.032
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Cytosolic Ca2+ and protein kinase Calpha couple cellular metabolism to membrane K+ permeability in a human biliary cell line. J Clin Invest. 1997 Jun 15; 99(12):2890-7.
Score: 0.032
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Mechanisms of ceramide-mediated apoptosis. Adv Exp Med Biol. 1997; 407:145-9.
Score: 0.031
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12(S)-HETE increases the motility of prostate tumor cells through selective activation of PKC alpha. Adv Exp Med Biol. 1997; 400B:707-18.
Score: 0.031
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Phosphorylation specificities of protein kinase C isozymes for bovine cardiac troponin I and troponin T and sites within these proteins and regulation of myofilament properties. J Biol Chem. 1996 Sep 20; 271(38):23277-83.
Score: 0.030
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Metabolic stress opens K+ channels in hepatoma cells through a Ca2+- and protein kinase calpha-dependent mechanism. J Biol Chem. 1996 Jul 26; 271(30):18107-13.
Score: 0.030
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Picomole scale stereochemical analysis of sphingosines and dihydrosphingosines. Bioorg Med Chem. 1996 Jul; 4(7):1035-43.
Score: 0.030
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Ceramide inactivates cellular protein kinase Calpha. J Biol Chem. 1996 May 31; 271(22):13169-74.
Score: 0.030
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12(S)-hydroxyeicosatetraenoic acid and 13(S)-hydroxyoctadecadienoic acid regulation of protein kinase C-alpha in melanoma cells: role of receptor-mediated hydrolysis of inositol phospholipids. Proc Natl Acad Sci U S A. 1995 Sep 26; 92(20):9323-7.
Score: 0.028
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Regulation of protein kinase C (PKC) expression by iron: effect of different iron compounds on PKC-beta and PKC-alpha gene expression and role of the 5'-flanking region of the PKC-beta gene in the response to ferric transferrin. Blood. 1994 Nov 15; 84(10):3510-7.
Score: 0.027
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12(S)-HETE enhancement of prostate tumor cell invasion: selective role of PKC alpha. J Natl Cancer Inst. 1994 Aug 03; 86(15):1145-51.
Score: 0.026
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Specific role for protein kinase C beta in cell differentiation. Cell Growth Differ. 1994 Apr; 5(4):405-9.
Score: 0.026
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Immunolocalization of PKC zeta in rat photoreceptor inner segments. Curr Eye Res. 1994 Feb; 13(2):145-50.
Score: 0.025
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Heterogeneity of protein kinase C-mediated rapid regulation of Na/K-ATPase in kidney epithelial cells. J Biol Chem. 1993 Jul 25; 268(21):15958-64.
Score: 0.024
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Programmed cell death induced by ceramide. Science. 1993 Mar 19; 259(5102):1769-71.
Score: 0.024
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Retinoblastoma protein dephosphorylation induced by D-erythro-sphingosine. J Biol Chem. 1992 Nov 25; 267(33):23459-62.
Score: 0.023
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Quantitative analysis of diacylglycerol second messengers in human platelets: correlation with aggregation and secretion. Mol Pharmacol. 1992 Feb; 41(2):382-6.
Score: 0.022
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Delayed accumulation of diacylglycerol in platelets as a mechanism for regulation of onset of aggregation and secretion. Blood. 1991 Jul 15; 78(2):435-44.
Score: 0.021
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Diacylglycerol overcomes aspirin inhibition of platelets: evidence for a necessary role for diacylglycerol accumulation in platelet activation. Mol Pharmacol. 1991 Apr; 39(4):547-56.
Score: 0.021
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Structural requirements for long-chain (sphingoid) base inhibition of protein kinase C in vitro and for the cellular effects of these compounds. Biochemistry. 1989 Apr 18; 28(8):3138-45.
Score: 0.018
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Functions of sphingolipids and sphingolipid breakdown products in cellular regulation. Science. 1989 Jan 27; 243(4890):500-7.
Score: 0.018
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Specificity and mechanism of protein kinase C activation by sn-1,2-diacylglycerols. Proc Natl Acad Sci U S A. 1986 Mar; 83(5):1184-8.
Score: 0.015
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Mechanism of regulation of protein kinase C by lipid second messengers. Symp Fundam Cancer Res. 1986; 39:145-56.
Score: 0.014
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Mixed micelle assay of protein kinase C. Methods Enzymol. 1986; 124:353-9.
Score: 0.014
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Activation of protein kinase C by Triton X-100 mixed micelles containing diacylglycerol and phosphatidylserine. J Biol Chem. 1985 Aug 25; 260(18):10039-43.
Score: 0.014
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Sphingomyelin synthase as a potential target for D609-induced apoptosis in U937 human monocytic leukemia cells. Exp Cell Res. 2004 Jan 15; 292(2):385-92.
Score: 0.013
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Role for ceramide as an endogenous mediator of Fas-induced cytotoxicity. Proc Natl Acad Sci U S A. 1995 Aug 29; 92(18):8443-7.
Score: 0.007
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Regulation of the epidermal growth factor receptor phosphorylation state by sphingosine in A431 human epidermoid carcinoma cells. J Biol Chem. 1988 Apr 15; 263(11):5319-27.
Score: 0.004
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Inhibition of phorbol ester-dependent differentiation of human promyelocytic leukemic (HL-60) cells by sphinganine and other long-chain bases. J Biol Chem. 1986 Sep 25; 261(27):12610-5.
Score: 0.004