Kumar Sambamurti to Amyloid Precursor Protein Secretases
This is a "connection" page, showing publications Kumar Sambamurti has written about Amyloid Precursor Protein Secretases.
Connection Strength
3.739
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Amyloid-beta protein clearance and degradation (ABCD) pathways and their role in Alzheimer's disease. Curr Alzheimer Res. 2015; 12(1):32-46.
Score: 0.479
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Evidence of a novel mechanism for partial ?-secretase inhibition induced paradoxical increase in secreted amyloid ? protein. PLoS One. 2014; 9(3):e91531.
Score: 0.454
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Major carboxyl terminal fragments generated by ?-secretase processing of the Alzheimer amyloid precursor are 50 and 51 amino acids long. Am J Geriatr Psychiatry. 2013 May; 21(5):474-83.
Score: 0.427
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Targets for AD treatment: conflicting messages from ?-secretase inhibitors. J Neurochem. 2011 May; 117(3):359-74.
Score: 0.368
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Pigment epithelium-derived factor maintains retinal pigment epithelium function by inhibiting vascular endothelial growth factor-R2 signaling through gamma-secretase. J Biol Chem. 2009 Oct 30; 284(44):30177-86.
Score: 0.331
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Beta-secretase: structure, function, and evolution. CNS Neurol Disord Drug Targets. 2008 Jun; 7(3):278-94.
Score: 0.303
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Geranylgeranyl pyrophosphate stimulates gamma-secretase to increase the generation of Abeta and APP-CTFgamma. FASEB J. 2008 Jan; 22(1):47-54.
Score: 0.286
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Sex-Specific Regulation of ?-Secretase: A Novel Estrogen Response Element (ERE)-Dependent Mechanism in Alzheimer's Disease. J Neurosci. 2022 02 09; 42(6):1154-1165.
Score: 0.194
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Rivastigmine modifies the a-secretase pathway and potentially early Alzheimer's disease. Transl Psychiatry. 2020 02 03; 10(1):47.
Score: 0.170
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Differential accumulation of secreted AbetaPP metabolites in ocular fluids. J Alzheimers Dis. 2010; 20(4):1243-53.
Score: 0.085
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Taking down the unindicted co-conspirators of amyloid beta-peptide-mediated neuronal death: shared gene regulation of BACE1 and APP genes interacting with CREB, Fe65 and YY1 transcription factors. Curr Alzheimer Res. 2006 Dec; 3(5):475-83.
Score: 0.068
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A partial failure of membrane protein turnover may cause Alzheimer's disease: a new hypothesis. Curr Alzheimer Res. 2006 Feb; 3(1):81-90.
Score: 0.065
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Gene structure and organization of the human beta-secretase (BACE) promoter. FASEB J. 2004 Jun; 18(9):1034-6.
Score: 0.057
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Amyloid precursor protein compartmentalization restricts beta-amyloid production: therapeutic targets based on BACE compartmentalization. J Mol Neurosci. 2004; 24(1):137-43.
Score: 0.056
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APH1, PEN2, and Nicastrin increase Abeta levels and gamma-secretase activity. Biochem Biophys Res Commun. 2003 Jun 06; 305(3):502-9.
Score: 0.054
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Beta-secretase processing of the Alzheimer's amyloid protein precursor (APP). J Mol Neurosci. 2003; 20(3):233-9.
Score: 0.052
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Lipid rafts play an important role in A beta biogenesis by regulating the beta-secretase pathway. J Mol Neurosci. 2002 Aug-Oct; 19(1-2):31-5.
Score: 0.051
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A novel gamma -secretase assay based on detection of the putative C-terminal fragment-gamma of amyloid beta protein precursor. J Biol Chem. 2001 Jan 05; 276(1):481-7.
Score: 0.045
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Glycosylphosphatidylinositol-anchored proteins play an important role in the biogenesis of the Alzheimer's amyloid beta-protein. J Biol Chem. 1999 Sep 17; 274(38):26810-4.
Score: 0.041
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The secretion of amyloid beta-peptides is inhibited in the tacrine-treated human neuroblastoma cells. Brain Res Mol Brain Res. 1998 Nov 20; 62(2):131-40.
Score: 0.039
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The Alzheimer's amyloid precursor is cleaved intracellularly in the trans-Golgi network or in a post-Golgi compartment. Ann N Y Acad Sci. 1992 Dec 31; 674:118-28.
Score: 0.026
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High cholesterol-induced neuroinflammation and amyloid precursor protein processing correlate with loss of working memory in mice. J Neurochem. 2008 Jul; 106(1):475-85.
Score: 0.019
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The experimental Alzheimer's disease drug posiphen [(+)-phenserine] lowers amyloid-beta peptide levels in cell culture and mice. J Pharmacol Exp Ther. 2007 Jan; 320(1):386-96.
Score: 0.017
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Functional characterization of the 5' flanking region of the BACE gene: identification of a 91 bp fragment involved in basal level of BACE promoter expression. FASEB J. 2004 Jun; 18(9):1037-9.
Score: 0.014
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Characterization of recombinant, soluble beta-secretase from an insect cell expression system. Mol Pharmacol. 2001 Mar; 59(3):619-26.
Score: 0.011
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Cell-free assays for gamma-secretase activity. FASEB J. 2000 Dec; 14(15):2383-6.
Score: 0.011
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Evidence that secretase cleavage of cell surface Alzheimer amyloid precursor occurs after normal endocytic internalization. J Neurosci Res. 1995 Apr 01; 40(5):694-706.
Score: 0.008
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Cellular processing and proteoglycan nature of amyloid precursor proteins. Ann N Y Acad Sci. 1993 Sep 24; 695:132-8.
Score: 0.007