Kumar Sambamurti to Amyloid beta-Peptides
This is a "connection" page, showing publications Kumar Sambamurti has written about Amyloid beta-Peptides.
Connection Strength
5.319
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Melatonin Treatment Enhances A? Lymphatic Clearance in a Transgenic Mouse Model of Amyloidosis. Curr Alzheimer Res. 2018; 15(7):637-642.
Score: 0.560
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Amyloid-beta protein clearance and degradation (ABCD) pathways and their role in Alzheimer's disease. Curr Alzheimer Res. 2015; 12(1):32-46.
Score: 0.455
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Evidence of a novel mechanism for partial ?-secretase inhibition induced paradoxical increase in secreted amyloid ? protein. PLoS One. 2014; 9(3):e91531.
Score: 0.431
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Value in development of a TAPIR-like mouse monoclonal antibody to Abeta. J Alzheimers Dis. 2008 Jun; 14(2):175-7.
Score: 0.288
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Geranylgeranyl pyrophosphate stimulates gamma-secretase to increase the generation of Abeta and APP-CTFgamma. FASEB J. 2008 Jan; 22(1):47-54.
Score: 0.272
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Genotoxicity in Alzheimer's disease: role of amyloid. Curr Alzheimer Res. 2006 Sep; 3(4):365-75.
Score: 0.255
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Amyloid precursor protein compartmentalization restricts beta-amyloid production: therapeutic targets based on BACE compartmentalization. J Mol Neurosci. 2004; 24(1):137-43.
Score: 0.212
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APH1, PEN2, and Nicastrin increase Abeta levels and gamma-secretase activity. Biochem Biophys Res Commun. 2003 Jun 06; 305(3):502-9.
Score: 0.204
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Beta-secretase processing of the Alzheimer's amyloid protein precursor (APP). J Mol Neurosci. 2003; 20(3):233-9.
Score: 0.198
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Lipid rafts play an important role in A beta biogenesis by regulating the beta-secretase pathway. J Mol Neurosci. 2002 Aug-Oct; 19(1-2):31-5.
Score: 0.192
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Advances in the cellular and molecular biology of the beta-amyloid protein in Alzheimer's disease. Neuromolecular Med. 2002; 1(1):1-31.
Score: 0.185
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A novel gamma -secretase assay based on detection of the putative C-terminal fragment-gamma of amyloid beta protein precursor. J Biol Chem. 2001 Jan 05; 276(1):481-7.
Score: 0.173
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Glycosylphosphatidylinositol-anchored proteins play an important role in the biogenesis of the Alzheimer's amyloid beta-protein. J Biol Chem. 1999 Sep 17; 274(38):26810-4.
Score: 0.158
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The secretion of amyloid beta-peptides is inhibited in the tacrine-treated human neuroblastoma cells. Brain Res Mol Brain Res. 1998 Nov 20; 62(2):131-40.
Score: 0.149
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Beta-Amyloid Precursor Protein (?APP) Processing in Alzheimer's Disease (AD) and Age-Related Macular Degeneration (AMD). Mol Neurobiol. 2015 Aug; 52(1):533-44.
Score: 0.111
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Evidence for lymphatic A? clearance in Alzheimer's transgenic mice. Neurobiol Dis. 2014 Nov; 71:215-9.
Score: 0.111
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Major carboxyl terminal fragments generated by ?-secretase processing of the Alzheimer amyloid precursor are 50 and 51 amino acids long. Am J Geriatr Psychiatry. 2013 May; 21(5):474-83.
Score: 0.101
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GLP-1 receptor stimulation reduces amyloid-beta peptide accumulation and cytotoxicity in cellular and animal models of Alzheimer's disease. J Alzheimers Dis. 2010; 19(4):1205-19.
Score: 0.080
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An increase in Abeta42 in the prefrontal cortex is associated with a reversal-learning impairment in Alzheimer's disease model Tg2576 APPsw mice. Curr Alzheimer Res. 2008 Aug; 5(4):385-91.
Score: 0.073
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Beta-secretase: structure, function, and evolution. CNS Neurol Disord Drug Targets. 2008 Jun; 7(3):278-94.
Score: 0.072
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Role of DNA dynamics in Alzheimer's disease. Brain Res Rev. 2008 Jun; 58(1):136-48.
Score: 0.070
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Taking down the unindicted co-conspirators of amyloid beta-peptide-mediated neuronal death: shared gene regulation of BACE1 and APP genes interacting with CREB, Fe65 and YY1 transcription factors. Curr Alzheimer Res. 2006 Dec; 3(5):475-83.
Score: 0.065
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The experimental Alzheimer's disease drug posiphen [(+)-phenserine] lowers amyloid-beta peptide levels in cell culture and mice. J Pharmacol Exp Ther. 2007 Jan; 320(1):386-96.
Score: 0.064
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Neurine, an acetylcholine autolysis product, elevates secreted amyloid-beta protein precursor and amyloid-beta peptide levels, and lowers neuronal cell viability in culture: a role in Alzheimer's disease? J Alzheimers Dis. 2006 Sep; 10(1):9-16.
Score: 0.064
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Identification of novel small molecule inhibitors of amyloid precursor protein synthesis as a route to lower Alzheimer's disease amyloid-beta peptide. J Pharmacol Exp Ther. 2006 Aug; 318(2):855-62.
Score: 0.063
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Hyperhomocysteinemic Alzheimer's mouse model of amyloidosis shows increased brain amyloid beta peptide levels. Neurobiol Dis. 2006 Jun; 22(3):651-6.
Score: 0.062
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Selective butyrylcholinesterase inhibition elevates brain acetylcholine, augments learning and lowers Alzheimer beta-amyloid peptide in rodent. Proc Natl Acad Sci U S A. 2005 Nov 22; 102(47):17213-8.
Score: 0.060
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Rationale for the development of cholinesterase inhibitors as anti-Alzheimer agents. Curr Pharm Des. 2004; 10(25):3111-9.
Score: 0.053
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Amyloid-beta peptide levels in brain are inversely correlated with insulysin activity levels in vivo. Proc Natl Acad Sci U S A. 2003 May 13; 100(10):6221-6.
Score: 0.051
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17beta-estradiol reduces plasma Abeta40 for HRT-na?ve postmenopausal women with Alzheimer disease: a preliminary study. Am J Geriatr Psychiatry. 2003 Mar-Apr; 11(2):239-44.
Score: 0.050
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Alzheimer's disease beta-amyloid peptide is increased in mice deficient in endothelin-converting enzyme. J Biol Chem. 2003 Jan 24; 278(4):2081-4.
Score: 0.049
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Cell-free assays for gamma-secretase activity. FASEB J. 2000 Dec; 14(15):2383-6.
Score: 0.043
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Reduction of Abeta accumulation in the Tg2576 animal model of Alzheimer's disease after oral administration of the phosphatidyl-inositol kinase inhibitor wortmannin. FASEB J. 2001 Jan; 15(1):16-18.
Score: 0.043
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Hypercholesterolemia accelerates the Alzheimer's amyloid pathology in a transgenic mouse model. Neurobiol Dis. 2000 Aug; 7(4):321-31.
Score: 0.042
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Rivastigmine modifies the a-secretase pathway and potentially early Alzheimer's disease. Transl Psychiatry. 2020 02 03; 10(1):47.
Score: 0.040
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Antisense-induced reduction of presenilin 1 expression selectively increases the production of amyloid beta42 in transfected cells. J Neurochem. 1999 Dec; 73(6):2383-8.
Score: 0.040
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ERAB contains a putative noncleavable signal peptide. Biochem Biophys Res Commun. 1998 Aug 19; 249(2):546-9.
Score: 0.037
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Resolution of inflammation is altered in Alzheimer's disease. Alzheimers Dement. 2015 Jan; 11(1):40-50.e1-2.
Score: 0.027
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The genesis of the senile plaque. Further evidence in support of its neuronal origin. Am J Pathol. 1992 Nov; 141(5):1151-9.
Score: 0.024
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Increased biosynthesis of Alzheimer amyloid precursor protein in the cerebral cortex of rats with lesions of the nucleus basalis of Meynert. Brain Res Mol Brain Res. 1991 May; 10(2):173-8.
Score: 0.022
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Neuronutrition and Alzheimer's disease. J Alzheimers Dis. 2010; 19(4):1123-39.
Score: 0.020
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High cholesterol-induced neuroinflammation and amyloid precursor protein processing correlate with loss of working memory in mice. J Neurochem. 2008 Jul; 106(1):475-85.
Score: 0.018
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Increased App expression in a mouse model of Down's syndrome disrupts NGF transport and causes cholinergic neuron degeneration. Neuron. 2006 Jul 06; 51(1):29-42.
Score: 0.016
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Glucagon-like peptide-1 decreases endogenous amyloid-beta peptide (Abeta) levels and protects hippocampal neurons from death induced by Abeta and iron. J Neurosci Res. 2003 Jun 01; 72(5):603-12.
Score: 0.013