Kumar Sambamurti to Amyloid beta-Protein Precursor
This is a "connection" page, showing publications Kumar Sambamurti has written about Amyloid beta-Protein Precursor.
Connection Strength
3.773
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Major carboxyl terminal fragments generated by ?-secretase processing of the Alzheimer amyloid precursor are 50 and 51 amino acids long. Am J Geriatr Psychiatry. 2013 May; 21(5):474-83.
Score: 0.422
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Differential accumulation of secreted AbetaPP metabolites in ocular fluids. J Alzheimers Dis. 2010; 20(4):1243-53.
Score: 0.335
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Insulysin cleaves the APP cytoplasmic fragment at multiple sites. Neurochem Res. 2007 Dec; 32(12):2225-34.
Score: 0.284
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Geranylgeranyl pyrophosphate stimulates gamma-secretase to increase the generation of Abeta and APP-CTFgamma. FASEB J. 2008 Jan; 22(1):47-54.
Score: 0.283
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Amyloid precursor protein compartmentalization restricts beta-amyloid production: therapeutic targets based on BACE compartmentalization. J Mol Neurosci. 2004; 24(1):137-43.
Score: 0.221
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Beta-secretase processing of the Alzheimer's amyloid protein precursor (APP). J Mol Neurosci. 2003; 20(3):233-9.
Score: 0.206
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The role of the carboxyl-terminal fragments of amyloid precursor protein in Alzheimer's disease. Ann N Y Acad Sci. 2002 Nov; 973:334-9.
Score: 0.204
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Lipid rafts play an important role in A beta biogenesis by regulating the beta-secretase pathway. J Mol Neurosci. 2002 Aug-Oct; 19(1-2):31-5.
Score: 0.200
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A novel gamma -secretase assay based on detection of the putative C-terminal fragment-gamma of amyloid beta protein precursor. J Biol Chem. 2001 Jan 05; 276(1):481-7.
Score: 0.179
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Amyloid-? precursor protein synthesis inhibitors for Alzheimer's disease treatment. Ann Neurol. 2014 Oct; 76(4):629-30.
Score: 0.116
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The Alzheimer's amyloid precursor is cleaved intracellularly in the trans-Golgi network or in a post-Golgi compartment. Ann N Y Acad Sci. 1992 Dec 31; 674:118-28.
Score: 0.103
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Evidence for intracellular cleavage of the Alzheimer's amyloid precursor in PC12 cells. J Neurosci Res. 1992 Oct; 33(2):319-29.
Score: 0.101
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The Psen1-L166P-knock-in mutation leads to amyloid deposition in human wild-type amyloid precursor protein YAC transgenic mice. FASEB J. 2012 Jul; 26(7):2899-910.
Score: 0.098
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High cholesterol-induced neuroinflammation and amyloid precursor protein processing correlate with loss of working memory in mice. J Neurochem. 2008 Jul; 106(1):475-85.
Score: 0.075
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Beta-secretase: structure, function, and evolution. CNS Neurol Disord Drug Targets. 2008 Jun; 7(3):278-94.
Score: 0.075
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Role of DNA dynamics in Alzheimer's disease. Brain Res Rev. 2008 Jun; 58(1):136-48.
Score: 0.073
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Neurine, an acetylcholine autolysis product, elevates secreted amyloid-beta protein precursor and amyloid-beta peptide levels, and lowers neuronal cell viability in culture: a role in Alzheimer's disease? J Alzheimers Dis. 2006 Sep; 10(1):9-16.
Score: 0.066
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Increased App expression in a mouse model of Down's syndrome disrupts NGF transport and causes cholinergic neuron degeneration. Neuron. 2006 Jul 06; 51(1):29-42.
Score: 0.066
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Identification of novel small molecule inhibitors of amyloid precursor protein synthesis as a route to lower Alzheimer's disease amyloid-beta peptide. J Pharmacol Exp Ther. 2006 Aug; 318(2):855-62.
Score: 0.065
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APH1, PEN2, and Nicastrin increase Abeta levels and gamma-secretase activity. Biochem Biophys Res Commun. 2003 Jun 06; 305(3):502-9.
Score: 0.053
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Advances in the cellular and molecular biology of the beta-amyloid protein in Alzheimer's disease. Neuromolecular Med. 2002; 1(1):1-31.
Score: 0.048
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Cell-free assays for gamma-secretase activity. FASEB J. 2000 Dec; 14(15):2383-6.
Score: 0.045
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Rivastigmine modifies the a-secretase pathway and potentially early Alzheimer's disease. Transl Psychiatry. 2020 02 03; 10(1):47.
Score: 0.042
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Release of nontransmembrane full-length Alzheimer's amyloid precursor protein from the lumenar surface of chromaffin granule membranes. Biochemistry. 1998 Feb 03; 37(5):1274-82.
Score: 0.037
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The effect of tacrine and leupeptin on the secretion of the beta-amyloid precursor protein in HeLa cells. Life Sci. 1997; 61(20):1985-92.
Score: 0.034
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Heat-shock induces abnormalities in the cellular distribution of amyloid precursor protein (APP) and APP fusion proteins. Neurosci Lett. 1995 Jun 09; 192(2):105-8.
Score: 0.030
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Evidence that secretase cleavage of cell surface Alzheimer amyloid precursor occurs after normal endocytic internalization. J Neurosci Res. 1995 Apr 01; 40(5):694-706.
Score: 0.030
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Evidence for lymphatic A? clearance in Alzheimer's transgenic mice. Neurobiol Dis. 2014 Nov; 71:215-9.
Score: 0.029
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Study of the phorbol ester effect on Alzheimer amyloid precursor processing: sequence requirements and involvement of a cholera toxin sensitive protein. J Neurosci Res. 1994 May 01; 38(1):81-90.
Score: 0.028
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Cellular processing and proteoglycan nature of amyloid precursor proteins. Ann N Y Acad Sci. 1993 Sep 24; 695:132-8.
Score: 0.027
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Synthesis of the Alzheimer drug Posiphen into its primary metabolic products (+)-N1-norPosiphen, (+)-N8-norPosiphen and (+)-N1, N8-bisnorPosiphen, their inhibition of amyloid precursor protein, a-Synuclein synthesis, interleukin-1? release, and cholinergic action. Antiinflamm Antiallergy Agents Med Chem. 2013; 12(2):117-28.
Score: 0.026
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Exact cleavage site of Alzheimer amyloid precursor in neuronal PC-12 cells. Neurosci Lett. 1991 Jul 08; 128(1):126-8.
Score: 0.023
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Vitamin D3-enriched diet correlates with a decrease of amyloid plaques in the brain of A?PP transgenic mice. J Alzheimers Dis. 2011; 25(2):295-307.
Score: 0.022
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Cholinergic degeneration and memory loss delayed by vitamin E in a Down syndrome mouse model. Exp Neurol. 2009 Apr; 216(2):278-89.
Score: 0.019
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An increase in Abeta42 in the prefrontal cortex is associated with a reversal-learning impairment in Alzheimer's disease model Tg2576 APPsw mice. Curr Alzheimer Res. 2008 Aug; 5(4):385-91.
Score: 0.019
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The experimental Alzheimer's disease drug posiphen [(+)-phenserine] lowers amyloid-beta peptide levels in cell culture and mice. J Pharmacol Exp Ther. 2007 Jan; 320(1):386-96.
Score: 0.017
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Selective butyrylcholinesterase inhibition elevates brain acetylcholine, augments learning and lowers Alzheimer beta-amyloid peptide in rodent. Proc Natl Acad Sci U S A. 2005 Nov 22; 102(47):17213-8.
Score: 0.016
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Differential expression of cholesterol hydroxylases in Alzheimer's disease. J Biol Chem. 2004 Aug 13; 279(33):34674-81.
Score: 0.014
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Glucagon-like peptide-1 decreases endogenous amyloid-beta peptide (Abeta) levels and protects hippocampal neurons from death induced by Abeta and iron. J Neurosci Res. 2003 Jun 01; 72(5):603-12.
Score: 0.013
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Alzheimer's disease beta-amyloid peptide is increased in mice deficient in endothelin-converting enzyme. J Biol Chem. 2003 Jan 24; 278(4):2081-4.
Score: 0.013
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Reduction of Abeta accumulation in the Tg2576 animal model of Alzheimer's disease after oral administration of the phosphatidyl-inositol kinase inhibitor wortmannin. FASEB J. 2001 Jan; 15(1):16-18.
Score: 0.011
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Increased biosynthesis of Alzheimer amyloid precursor protein in the cerebral cortex of rats with lesions of the nucleus basalis of Meynert. Brain Res Mol Brain Res. 1991 May; 10(2):173-8.
Score: 0.006