Kumar Sambamurti to Animals
This is a "connection" page, showing publications Kumar Sambamurti has written about Animals.
Connection Strength
0.827
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Melatonin Treatment Enhances A? Lymphatic Clearance in a Transgenic Mouse Model of Amyloidosis. Curr Alzheimer Res. 2018; 15(7):637-642.
Score: 0.046
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Amyloid-beta protein clearance and degradation (ABCD) pathways and their role in Alzheimer's disease. Curr Alzheimer Res. 2015; 12(1):32-46.
Score: 0.037
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Major carboxyl terminal fragments generated by ?-secretase processing of the Alzheimer amyloid precursor are 50 and 51 amino acids long. Am J Geriatr Psychiatry. 2013 May; 21(5):474-83.
Score: 0.033
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Targets for AD treatment: conflicting messages from ?-secretase inhibitors. J Neurochem. 2011 May; 117(3):359-74.
Score: 0.029
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Differential accumulation of secreted AbetaPP metabolites in ocular fluids. J Alzheimers Dis. 2010; 20(4):1243-53.
Score: 0.026
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Pigment epithelium-derived factor maintains retinal pigment epithelium function by inhibiting vascular endothelial growth factor-R2 signaling through gamma-secretase. J Biol Chem. 2009 Oct 30; 284(44):30177-86.
Score: 0.026
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Effects of a saturated fat and high cholesterol diet on memory and hippocampal morphology in the middle-aged rat. J Alzheimers Dis. 2008 Jun; 14(2):133-45.
Score: 0.024
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Value in development of a TAPIR-like mouse monoclonal antibody to Abeta. J Alzheimers Dis. 2008 Jun; 14(2):175-7.
Score: 0.024
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Beta-secretase: structure, function, and evolution. CNS Neurol Disord Drug Targets. 2008 Jun; 7(3):278-94.
Score: 0.024
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Insulysin cleaves the APP cytoplasmic fragment at multiple sites. Neurochem Res. 2007 Dec; 32(12):2225-34.
Score: 0.022
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Geranylgeranyl pyrophosphate stimulates gamma-secretase to increase the generation of Abeta and APP-CTFgamma. FASEB J. 2008 Jan; 22(1):47-54.
Score: 0.022
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Age-dependent loss of NGF signaling in the rat basal forebrain is due to disrupted MAPK activation. Neurosci Lett. 2007 Feb 14; 413(2):110-4.
Score: 0.021
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Genotoxicity in Alzheimer's disease: role of amyloid. Curr Alzheimer Res. 2006 Sep; 3(4):365-75.
Score: 0.021
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A partial failure of membrane protein turnover may cause Alzheimer's disease: a new hypothesis. Curr Alzheimer Res. 2006 Feb; 3(1):81-90.
Score: 0.020
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Cholesterol and Alzheimer's disease: clinical and experimental models suggest interactions of different genetic, dietary and environmental risk factors. Curr Drug Targets. 2004 Aug; 5(6):517-28.
Score: 0.018
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Gene structure and organization of the human beta-secretase (BACE) promoter. FASEB J. 2004 Jun; 18(9):1034-6.
Score: 0.018
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Rationale for the development of cholinesterase inhibitors as anti-Alzheimer agents. Curr Pharm Des. 2004; 10(25):3111-9.
Score: 0.017
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APH1, PEN2, and Nicastrin increase Abeta levels and gamma-secretase activity. Biochem Biophys Res Commun. 2003 Jun 06; 305(3):502-9.
Score: 0.017
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Beta-secretase processing of the Alzheimer's amyloid protein precursor (APP). J Mol Neurosci. 2003; 20(3):233-9.
Score: 0.016
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The role of the carboxyl-terminal fragments of amyloid precursor protein in Alzheimer's disease. Ann N Y Acad Sci. 2002 Nov; 973:334-9.
Score: 0.016
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Current Advances in Adeno-Associated Virus-Mediated Gene Therapy to Prevent Acquired Hearing Loss. J Assoc Res Otolaryngol. 2022 10; 23(5):569-578.
Score: 0.016
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Lipid rafts play an important role in A beta biogenesis by regulating the beta-secretase pathway. J Mol Neurosci. 2002 Aug-Oct; 19(1-2):31-5.
Score: 0.016
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Sex-Specific Regulation of ?-Secretase: A Novel Estrogen Response Element (ERE)-Dependent Mechanism in Alzheimer's Disease. J Neurosci. 2022 02 09; 42(6):1154-1165.
Score: 0.015
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Indoles as essential mediators in the gut-brain axis. Their role in Alzheimer's disease. Neurobiol Dis. 2021 08; 156:105403.
Score: 0.015
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A novel gamma -secretase assay based on detection of the putative C-terminal fragment-gamma of amyloid beta protein precursor. J Biol Chem. 2001 Jan 05; 276(1):481-7.
Score: 0.014
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Rivastigmine modifies the a-secretase pathway and potentially early Alzheimer's disease. Transl Psychiatry. 2020 02 03; 10(1):47.
Score: 0.013
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Glycosylphosphatidylinositol-anchored proteins play an important role in the biogenesis of the Alzheimer's amyloid beta-protein. J Biol Chem. 1999 Sep 17; 274(38):26810-4.
Score: 0.013
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ERAB contains a putative noncleavable signal peptide. Biochem Biophys Res Commun. 1998 Aug 19; 249(2):546-9.
Score: 0.012
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The heat shock/oxidative stress connection. Relevance to Alzheimer disease. Mol Chem Neuropathol. 1996 May-Aug; 28(1-3):21-34.
Score: 0.010
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Beta-Amyloid Precursor Protein (?APP) Processing in Alzheimer's Disease (AD) and Age-Related Macular Degeneration (AMD). Mol Neurobiol. 2015 Aug; 52(1):533-44.
Score: 0.009
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Amyloid-? precursor protein synthesis inhibitors for Alzheimer's disease treatment. Ann Neurol. 2014 Oct; 76(4):629-30.
Score: 0.009
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Evidence for lymphatic A? clearance in Alzheimer's transgenic mice. Neurobiol Dis. 2014 Nov; 71:215-9.
Score: 0.009
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Incretin mimetics as pharmacologic tools to elucidate and as a new drug strategy to treat traumatic brain injury. Alzheimers Dement. 2014 Feb; 10(1 Suppl):S62-75.
Score: 0.009
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The Alzheimer's amyloid precursor is cleaved intracellularly in the trans-Golgi network or in a post-Golgi compartment. Ann N Y Acad Sci. 1992 Dec 31; 674:118-28.
Score: 0.008
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Evidence for intracellular cleavage of the Alzheimer's amyloid precursor in PC12 cells. J Neurosci Res. 1992 Oct; 33(2):319-29.
Score: 0.008
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The Psen1-L166P-knock-in mutation leads to amyloid deposition in human wild-type amyloid precursor protein YAC transgenic mice. FASEB J. 2012 Jul; 26(7):2899-910.
Score: 0.008
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Vitamin D3-enriched diet correlates with a decrease of amyloid plaques in the brain of A?PP transgenic mice. J Alzheimers Dis. 2011; 25(2):295-307.
Score: 0.007
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A novel endogenous indole protects rodent mitochondria and extends rotifer lifespan. PLoS One. 2010 Apr 21; 5(4):e10206.
Score: 0.007
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GLP-1 receptor stimulation reduces amyloid-beta peptide accumulation and cytotoxicity in cellular and animal models of Alzheimer's disease. J Alzheimers Dis. 2010; 19(4):1205-19.
Score: 0.007
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GLP-1 receptor stimulation preserves primary cortical and dopaminergic neurons in cellular and rodent models of stroke and Parkinsonism. Proc Natl Acad Sci U S A. 2009 Jan 27; 106(4):1285-90.
Score: 0.006
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Challenges associated with metal chelation therapy in Alzheimer's disease. J Alzheimers Dis. 2009; 17(3):457-68.
Score: 0.006
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Cholinergic degeneration and memory loss delayed by vitamin E in a Down syndrome mouse model. Exp Neurol. 2009 Apr; 216(2):278-89.
Score: 0.006
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Molecular toxicity of aluminium in relation to neurodegeneration. Indian J Med Res. 2008 Oct; 128(4):545-56.
Score: 0.006
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An increase in Abeta42 in the prefrontal cortex is associated with a reversal-learning impairment in Alzheimer's disease model Tg2576 APPsw mice. Curr Alzheimer Res. 2008 Aug; 5(4):385-91.
Score: 0.006
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High cholesterol-induced neuroinflammation and amyloid precursor protein processing correlate with loss of working memory in mice. J Neurochem. 2008 Jul; 106(1):475-85.
Score: 0.006
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Role of DNA dynamics in Alzheimer's disease. Brain Res Rev. 2008 Jun; 58(1):136-48.
Score: 0.006
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TNF-alpha inhibition as a treatment strategy for neurodegenerative disorders: new drug candidates and targets. Curr Alzheimer Res. 2007 Sep; 4(4):378-85.
Score: 0.006
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Taking down the unindicted co-conspirators of amyloid beta-peptide-mediated neuronal death: shared gene regulation of BACE1 and APP genes interacting with CREB, Fe65 and YY1 transcription factors. Curr Alzheimer Res. 2006 Dec; 3(5):475-83.
Score: 0.005
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The experimental Alzheimer's disease drug posiphen [(+)-phenserine] lowers amyloid-beta peptide levels in cell culture and mice. J Pharmacol Exp Ther. 2007 Jan; 320(1):386-96.
Score: 0.005
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Increased App expression in a mouse model of Down's syndrome disrupts NGF transport and causes cholinergic neuron degeneration. Neuron. 2006 Jul 06; 51(1):29-42.
Score: 0.005
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Identification of novel small molecule inhibitors of amyloid precursor protein synthesis as a route to lower Alzheimer's disease amyloid-beta peptide. J Pharmacol Exp Ther. 2006 Aug; 318(2):855-62.
Score: 0.005
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Hyperhomocysteinemic Alzheimer's mouse model of amyloidosis shows increased brain amyloid beta peptide levels. Neurobiol Dis. 2006 Jun; 22(3):651-6.
Score: 0.005
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Selective butyrylcholinesterase inhibition elevates brain acetylcholine, augments learning and lowers Alzheimer beta-amyloid peptide in rodent. Proc Natl Acad Sci U S A. 2005 Nov 22; 102(47):17213-8.
Score: 0.005
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An overview of phenserine tartrate, a novel acetylcholinesterase inhibitor for the treatment of Alzheimer's disease. Curr Alzheimer Res. 2005 Jul; 2(3):281-90.
Score: 0.005
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New therapeutic strategies and drug candidates for neurodegenerative diseases: p53 and TNF-alpha inhibitors, and GLP-1 receptor agonists. Ann N Y Acad Sci. 2004 Dec; 1035:290-315.
Score: 0.005
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Differential expression of cholesterol hydroxylases in Alzheimer's disease. J Biol Chem. 2004 Aug 13; 279(33):34674-81.
Score: 0.004
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Functional characterization of the 5' flanking region of the BACE gene: identification of a 91 bp fragment involved in basal level of BACE promoter expression. FASEB J. 2004 Jun; 18(9):1037-9.
Score: 0.004
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Glucagon-like peptide-1 decreases endogenous amyloid-beta peptide (Abeta) levels and protects hippocampal neurons from death induced by Abeta and iron. J Neurosci Res. 2003 Jun 01; 72(5):603-12.
Score: 0.004
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Amyloid-beta peptide levels in brain are inversely correlated with insulysin activity levels in vivo. Proc Natl Acad Sci U S A. 2003 May 13; 100(10):6221-6.
Score: 0.004
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A critical analysis of new molecular targets and strategies for drug developments in Alzheimer's disease. Curr Drug Targets. 2003 Feb; 4(2):97-112.
Score: 0.004
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Alzheimer's disease beta-amyloid peptide is increased in mice deficient in endothelin-converting enzyme. J Biol Chem. 2003 Jan 24; 278(4):2081-4.
Score: 0.004
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Characterization of recombinant, soluble beta-secretase from an insect cell expression system. Mol Pharmacol. 2001 Mar; 59(3):619-26.
Score: 0.004
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Cell-free assays for gamma-secretase activity. FASEB J. 2000 Dec; 14(15):2383-6.
Score: 0.004
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Reduction of Abeta accumulation in the Tg2576 animal model of Alzheimer's disease after oral administration of the phosphatidyl-inositol kinase inhibitor wortmannin. FASEB J. 2001 Jan; 15(1):16-18.
Score: 0.004
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Hypercholesterolemia accelerates the Alzheimer's amyloid pathology in a transgenic mouse model. Neurobiol Dis. 2000 Aug; 7(4):321-31.
Score: 0.003
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Glycosylphosphatidylinositol-anchor intermediates associate with triton-insoluble membranes in subcellular compartments that include the endoplasmic reticulum. Biochem J. 1999 Nov 01; 343 Pt 3:627-35.
Score: 0.003
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Release of nontransmembrane full-length Alzheimer's amyloid precursor protein from the lumenar surface of chromaffin granule membranes. Biochemistry. 1998 Feb 03; 37(5):1274-82.
Score: 0.003
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Evidence that secretase cleavage of cell surface Alzheimer amyloid precursor occurs after normal endocytic internalization. J Neurosci Res. 1995 Apr 01; 40(5):694-706.
Score: 0.002
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Study of the phorbol ester effect on Alzheimer amyloid precursor processing: sequence requirements and involvement of a cholera toxin sensitive protein. J Neurosci Res. 1994 May 01; 38(1):81-90.
Score: 0.002
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Cellular processing and proteoglycan nature of amyloid precursor proteins. Ann N Y Acad Sci. 1993 Sep 24; 695:132-8.
Score: 0.002
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Exact cleavage site of Alzheimer amyloid precursor in neuronal PC-12 cells. Neurosci Lett. 1991 Jul 08; 128(1):126-8.
Score: 0.002
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Increased biosynthesis of Alzheimer amyloid precursor protein in the cerebral cortex of rats with lesions of the nucleus basalis of Meynert. Brain Res Mol Brain Res. 1991 May; 10(2):173-8.
Score: 0.002