Charles Smith to Humans
This is a "connection" page, showing publications Charles Smith has written about Humans.
Connection Strength
0.455
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Suppression of c-Myc and RRM2 expression in pancreatic cancer cells by the sphingosine kinase-2 inhibitor ABC294640. Oncotarget. 2016 Sep 13; 7(37):60181-60192.
Score: 0.021
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Downregulation of Critical Oncogenes by the Selective SK2 Inhibitor ABC294640 Hinders Prostate Cancer Progression. Mol Cancer Res. 2015 Dec; 13(12):1591-601.
Score: 0.020
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Characterization of isoenzyme-selective inhibitors of human sphingosine kinases. PLoS One. 2012; 7(9):e44543.
Score: 0.016
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Ablation of sphingosine kinase-2 inhibits tumor cell proliferation and migration. Mol Cancer Res. 2011 Nov; 9(11):1509-19.
Score: 0.015
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Discovery and evaluation of inhibitors of human ceramidase. Mol Cancer Ther. 2011 Nov; 10(11):2052-61.
Score: 0.015
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2-Amino-4-methyl-5-phenylethyl substituted-7-N-benzyl-pyrrolo[2,3-d]pyrimidines as novel antitumor antimitotic agents that also reverse tumor resistance. Bioorg Med Chem. 2011 Jul 15; 19(14):4355-65.
Score: 0.015
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Antitumor activity of sphingosine kinase 2 inhibitor ABC294640 and sorafenib in hepatocellular carcinoma xenografts. Cancer Biol Ther. 2011 Mar 01; 11(5):524-34.
Score: 0.015
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Combined anticancer effects of sphingosine kinase inhibitors and sorafenib. Invest New Drugs. 2011 Dec; 29(6):1132-42.
Score: 0.014
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DHHC20: a human palmitoyl acyltransferase that causes cellular transformation. Mol Membr Biol. 2010 Apr; 27(2-3):123-36.
Score: 0.014
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A novel sphingosine kinase inhibitor induces autophagy in tumor cells. J Pharmacol Exp Ther. 2010 May; 333(2):454-64.
Score: 0.014
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Pharmacology and antitumor activity of ABC294640, a selective inhibitor of sphingosine kinase-2. J Pharmacol Exp Ther. 2010 Apr; 333(1):129-39.
Score: 0.013
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Improved synthesis of a fluorogenic ceramidase substrate. Bioorg Med Chem. 2010 Feb; 18(3):1003-9.
Score: 0.013
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Palmitoyl acyltransferase assays and inhibitors (Review). Mol Membr Biol. 2009 Jan; 26(1):5-13.
Score: 0.013
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Synthesis and evaluation of novel inhibitors of Pim-1 and Pim-2 protein kinases. J Med Chem. 2009 Jan 08; 52(1):74-86.
Score: 0.013
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Removal of embedded central venous catheters. J Pediatr Surg. 2008 Jun; 43(6):1030-4.
Score: 0.012
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Discovery of novel antitumor antimitotic agents that also reverse tumor resistance. J Med Chem. 2007 Jul 12; 50(14):3290-301.
Score: 0.011
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Cellular palmitoylation and trafficking of lipidated peptides. J Lipid Res. 2007 Aug; 48(8):1873-84.
Score: 0.011
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Discovery and characterization of inhibitors of human palmitoyl acyltransferases. Mol Cancer Ther. 2006 Jul; 5(7):1647-59.
Score: 0.010
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Two N-myristoyltransferase isozymes play unique roles in protein myristoylation, proliferation, and apoptosis. Mol Cancer Res. 2005 Aug; 3(8):463-76.
Score: 0.010
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Synthesis and evaluation of dihydropyrroloquinolines that selectively antagonize P-glycoprotein. J Med Chem. 2004 Mar 11; 47(6):1413-22.
Score: 0.009
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Cyclohexyl-octahydro-pyrrolo[1,2-a]pyrazine-based inhibitors of human N-myristoyltransferase-1. J Pharmacol Exp Ther. 2004 Apr; 309(1):340-7.
Score: 0.009
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Discovery and evaluation of inhibitors of human sphingosine kinase. Cancer Res. 2003 Sep 15; 63(18):5962-9.
Score: 0.009
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Characterization of human palmitoyl-acyl transferase activity using peptides that mimic distinct palmitoylation motifs. Biochem J. 2003 Jul 01; 373(Pt 1):91-9.
Score: 0.009
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Success factors and hurdles in quality improvement in a children's hospital. Semin Pediatr Surg. 2002 Feb; 11(1):12-9.
Score: 0.008
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Analysis of selective target engagement by small-molecule sphingosine kinase inhibitors using the Cellular Thermal Shift Assay (CETSA). Cancer Biol Ther. 2020 09 01; 21(9):841-852.
Score: 0.007
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ABC294640, A Novel Sphingosine Kinase 2 Inhibitor, Induces Oncogenic Virus-Infected Cell Autophagic Death and Represses Tumor Growth. Mol Cancer Ther. 2017 Dec; 16(12):2724-2734.
Score: 0.006
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A Phase I Study of ABC294640, a First-in-Class Sphingosine Kinase-2 Inhibitor, in Patients with Advanced Solid Tumors. Clin Cancer Res. 2017 Aug 15; 23(16):4642-4650.
Score: 0.006
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Applying a high-throughput fluorescence polarization assay for the discovery of chemical probes blocking La:RNA interactions in vitro and in cells. PLoS One. 2017; 12(3):e0173246.
Score: 0.006
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Antitumor effect of the novel sphingosine kinase 2 inhibitor ABC294640 is enhanced by inhibition of autophagy and by sorafenib in human cholangiocarcinoma cells. Oncotarget. 2016 Apr 12; 7(15):20080-92.
Score: 0.005
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Esophageal foreign bodies in children: diagnosis, treatment, and complications. AJR Am J Roentgenol. 1996 Apr; 166(4):919-24.
Score: 0.005
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Aortoesophageal fistula and double aortic arch: two important points in management. J Pediatr Surg. 1996 Apr; 31(4):594-5.
Score: 0.005
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Tissue biomarkers of drug efficacy: case studies using a MALDI-MSI workflow. Bioanalysis. 2015; 7(20):2611-9.
Score: 0.005
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The Sphingosine Kinase 2 Inhibitor ABC294640 Reduces the Growth of Prostate Cancer Cells and Results in Accumulation of Dihydroceramides In Vitro and In Vivo. Mol Cancer Ther. 2015 Dec; 14(12):2744-52.
Score: 0.005
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Binding of the sphingolipid S1P to hTERT stabilizes telomerase at the nuclear periphery by allosterically mimicking protein phosphorylation. Sci Signal. 2015 Jun 16; 8(381):ra58.
Score: 0.005
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Targeting sphingosine kinase induces apoptosis and tumor regression for KSHV-associated primary effusion lymphoma. Mol Cancer Ther. 2014 Jan; 13(1):154-64.
Score: 0.004
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Clinical practice guidelines for pediatric appendicitis evaluation can decrease computed tomography utilization while maintaining diagnostic accuracy. Pediatr Emerg Care. 2013 May; 29(5):568-73.
Score: 0.004
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Perinatal ovarian cyst: a nonsurgical approach. J Pediatr Surg. 1992 Dec; 27(12):1618-9.
Score: 0.004
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Nissen fundoplication in children with profound neurologic disability. High risks and unmet goals. Ann Surg. 1992 Jun; 215(6):654-8; discussion 658-9.
Score: 0.004
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Rapid histamine-induced neutrophil recruitment is sphingosine kinase-1 dependent. Am J Pathol. 2012 Apr; 180(4):1740-50.
Score: 0.004
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Quinacrine sensitizes hepatocellular carcinoma cells to TRAIL and chemotherapeutic agents. Cancer Biol Ther. 2011 Aug 01; 12(3):229-38.
Score: 0.004
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Quinacrine synergizes with 5-fluorouracil and other therapies in colorectal cancer. Cancer Biol Ther. 2011 Aug 01; 12(3):239-51.
Score: 0.004
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Targeting NF?B mediated breast cancer chemoresistance through selective inhibition of sphingosine kinase-2. Cancer Biol Ther. 2011 Apr 01; 11(7):678-89.
Score: 0.004
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The Pim protein kinases regulate energy metabolism and cell growth. Proc Natl Acad Sci U S A. 2011 Jan 11; 108(2):528-33.
Score: 0.004
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Relief of tracheal compression by aortopexy. Ann Thorac Surg. 1990 Oct; 50(4):524-8; discussion 529.
Score: 0.004
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Giant fibrous hamartoma of infancy: a report of two cases and review of the literature. J Am Acad Dermatol. 2011 Mar; 64(3):579-86.
Score: 0.003
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Sorafenib inhibits ERK1/2 and MCL-1(L) phosphorylation levels resulting in caspase-independent cell death in malignant pleural mesothelioma. Cancer Biol Ther. 2009 Dec; 8(24):2406-16.
Score: 0.003
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A small molecule inhibitor of Pim protein kinases blocks the growth of precursor T-cell lymphoblastic leukemia/lymphoma. Blood. 2010 Jan 28; 115(4):824-33.
Score: 0.003
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Malrotation of the intestines in children: the effect of age on presentation and therapy. J Pediatr Surg. 1989 Aug; 24(8):777-80.
Score: 0.003
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Novel benzylidene-thiazolidine-2,4-diones inhibit Pim protein kinase activity and induce cell cycle arrest in leukemia and prostate cancer cells. Mol Cancer Ther. 2009 Jun; 8(6):1473-83.
Score: 0.003
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PIM1 protein kinase regulates PRAS40 phosphorylation and mTOR activity in FDCP1 cells. Cancer Biol Ther. 2009 May; 8(9):846-53.
Score: 0.003
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Traumatic pancreatitis and pseudocyst in children: current management. J Trauma. 1989 May; 29(5):597-601.
Score: 0.003
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Combining nanoliposomal ceramide with sorafenib synergistically inhibits melanoma and breast cancer cell survival to decrease tumor development. Clin Cancer Res. 2008 Jun 01; 14(11):3571-81.
Score: 0.003
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The surgical management of esophageal stricture in children. A century of progress. Ann Surg. 1988 May; 207(5):590-7.
Score: 0.003
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Reduction of TRAIL-induced Mcl-1 and cIAP2 by c-Myc or sorafenib sensitizes resistant human cancer cells to TRAIL-induced death. Cancer Cell. 2007 Jul; 12(1):66-80.
Score: 0.003
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Pneumatic reduction bag for treatment of gastroschisis and omphalocele. A 10-year experience. Ann Surg. 1986 May; 203(5):512-6.
Score: 0.003
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Diaphragmatic paralysis and eventration in infants. J Thorac Cardiovasc Surg. 1986 Apr; 91(4):490-7.
Score: 0.003
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Mutant V599EB-Raf regulates growth and vascular development of malignant melanoma tumors. Cancer Res. 2005 Mar 15; 65(6):2412-21.
Score: 0.002
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Thermal injury in children. J S C Med Assoc. 2004 Dec; 100(12):342-6.
Score: 0.002
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Effects of a weaning protocol on ventilated pediatric intensive care unit (PICU) patients. Top Health Inf Manage. 2001 Nov; 22(2):35-43.
Score: 0.002
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Cancer in children at the medical university hospital: update 1980. J S C Med Assoc. 1980 Mar; 76(3):103-7.
Score: 0.002
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The role of the physician's assistant in a university-based pediatric surgical service. J Pediatr Surg. 1979 Dec; 14(6):789-93.
Score: 0.002
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Save the child's esophagus, Part II: Colic patch repair. J Pediatr Surg. 1997 Feb; 32(2):328-33.
Score: 0.001
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Paired box gene expression in Wilms' tumor. J Pediatr Surg. 1994 Feb; 29(2):134-41.
Score: 0.001
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Impact of laparoscopic cholecystectomy on the management of cholelithiasis in children with sickle cell disease. J Pediatr Surg. 1994 Feb; 29(2):209-12; discussion 212-3.
Score: 0.001
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Tracheoesophageal compression from aortic arch anomalies: analysis of 30 operatively treated children. J Pediatr Surg. 1994 Feb; 29(2):334-7; discussion 337-8.
Score: 0.001
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Barrett's esophagus in children. Diagnosis and management. Ann Surg. 1993 Jun; 217(6):676-80; discussion 680-1.
Score: 0.001
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Balloon tracheoplasty in children: results of a 15-year experience. J Pediatr Surg. 1991 Aug; 26(8):957-61.
Score: 0.001
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The state of the art in pediatric surgery and pediatric oncology at MUSC Children's Hospital. J S C Med Assoc. 1990 May; 86(5):290-3.
Score: 0.001
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Necrotizing fasciitis of the abdominal wall as a complication of chickenpox. Pediatr Infect Dis. 1985 Jul-Aug; 4(4):420-1.
Score: 0.001
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Skeletal muscle differentiation in Wilms' tumor. Antibody identification and explant culture. Arch Pathol Lab Med. 1984 Jan; 108(1):58-62.
Score: 0.001