Patrick Woster to Structure-Activity Relationship
This is a "connection" page, showing publications Patrick Woster has written about Structure-Activity Relationship.
Connection Strength
0.862
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Structure-activity study for (bis)ureidopropyl- and (bis)thioureidopropyldiamine LSD1 inhibitors with 3-5-3 and 3-6-3 carbon backbone architectures. Bioorg Med Chem. 2015 Apr 01; 23(7):1601-12.
Score: 0.110
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Design of small molecule epigenetic modulators. Bioorg Med Chem Lett. 2014 Jan 01; 24(1):21-32.
Score: 0.101
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(Bis)urea and (bis)thiourea inhibitors of lysine-specific demethylase 1 as epigenetic modulators. J Med Chem. 2010 Jul 22; 53(14):5197-212.
Score: 0.080
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Mechanism-based inhibitors of the aspartyl protease plasmepsin II as potential antimalarial agents. J Med Chem. 2010 May 27; 53(10):4234-47.
Score: 0.079
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Recent advances in the development of polyamine analogues as antitumor agents. J Med Chem. 2009 Aug 13; 52(15):4551-73.
Score: 0.075
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Polyamine-based analogues as biochemical probes and potential therapeutics. Biochem Soc Trans. 2007 Apr; 35(Pt 2):356-63.
Score: 0.064
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Novel alkylpolyaminoguanidines and alkylpolyaminobiguanides with potent antitrypanosomal activity. Bioorg Med Chem Lett. 2006 Jun 15; 16(12):3229-32.
Score: 0.060
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Alkyl-substituted polyaminohydroxamic acids: a novel class of targeted histone deacetylase inhibitors. J Med Chem. 2005 Oct 06; 48(20):6350-65.
Score: 0.058
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Terminally alkylated polyamine analogues as chemotherapeutic agents. J Med Chem. 2001 Jan 04; 44(1):1-26.
Score: 0.041
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Interrogating alkyl and arylalkylpolyamino (bis)urea and (bis)thiourea isosteres as potent antimalarial chemotypes against multiple lifecycle forms of Plasmodium falciparum parasites. Bioorg Med Chem. 2015 Aug 15; 23(16):5131-43.
Score: 0.027
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Growth and biochemical effects of unsymmetrically substituted polyamine analogues in human lung tumor cells 1. Cancer Chemother Pharmacol. 1995; 36(1):69-74.
Score: 0.027
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P1 and P1' para-fluoro phenyl groups show enhanced binding and favorable predicted pharmacological properties: structure-based virtual screening of extended lopinavir analogs against multi-drug resistant HIV-1 protease. J Mol Graph Model. 2014 Feb; 47:18-24.
Score: 0.025
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Synthesis and evaluation of unsymmetrically substituted polyamine analogues as modulators of human spermidine/spermine-N1-acetyltransferase (SSAT) and as potential antitumor agents. J Med Chem. 1993 Oct 01; 36(20):2998-3004.
Score: 0.025
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Elevated ornithine decarboxylase activity promotes skin tumorigenesis by stimulating the recruitment of bulge stem cells but not via toxic polyamine catabolic metabolites. Amino Acids. 2014 Mar; 46(3):543-52.
Score: 0.025
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The re-expression of the epigenetically silenced e-cadherin gene by a polyamine analogue lysine-specific demethylase-1 (LSD1) inhibitor in human acute myeloid leukemia cell lines. Amino Acids. 2014 Mar; 46(3):585-94.
Score: 0.024
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Discovery of novel alkylated (bis)urea and (bis)thiourea polyamine analogues with potent antimalarial activities. J Med Chem. 2011 Oct 13; 54(19):6624-33.
Score: 0.022
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Novel alkylpolyamine analogues that possess both antitrypanosomal and antimicrosporidial activity. Bioorg Med Chem Lett. 2001 Jun 18; 11(12):1613-7.
Score: 0.011
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Structural specificity of polyamines and polyamine analogues in the protection of DNA from strand breaks induced by reactive oxygen species. Biochem Biophys Res Commun. 1998 Mar 06; 244(1):298-303.
Score: 0.009