Patrick Woster to Animals
This is a "connection" page, showing publications Patrick Woster has written about Animals.
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Inhibition of the histone demethylase KDM4B leads to activation of KDM1A, attenuates bacterial-induced pro-inflammatory cytokine release, and reduces osteoclastogenesis. Epigenetics. 2018; 13(5):557-572.
Score: 0.046
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Antibacterial Diamines Targeting Bacterial Membranes. J Med Chem. 2016 Apr 14; 59(7):3140-51.
Score: 0.039
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Design of small molecule epigenetic modulators. Bioorg Med Chem Lett. 2014 Jan 01; 24(1):21-32.
Score: 0.033
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Use of polyamine derivatives as selective histone deacetylase inhibitors. Methods Mol Biol. 2011; 720:475-91.
Score: 0.027
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Mechanism-based inhibitors of the aspartyl protease plasmepsin II as potential antimalarial agents. J Med Chem. 2010 May 27; 53(10):4234-47.
Score: 0.026
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Design of polyamine-based therapeutic agents: new targets and new directions. Essays Biochem. 2009 Nov 04; 46:77-94.
Score: 0.025
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Recent advances in the development of polyamine analogues as antitumor agents. J Med Chem. 2009 Aug 13; 52(15):4551-73.
Score: 0.025
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Metabolism of an alkyl polyamine analog by a polyamine oxidase from the microsporidian Encephalitozoon cuniculi. Antimicrob Agents Chemother. 2009 Jun; 53(6):2599-604.
Score: 0.024
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Polyamine-based analogues as biochemical probes and potential therapeutics. Biochem Soc Trans. 2007 Apr; 35(Pt 2):356-63.
Score: 0.021
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Novel alkylpolyaminoguanidines and alkylpolyaminobiguanides with potent antitrypanosomal activity. Bioorg Med Chem Lett. 2006 Jun 15; 16(12):3229-32.
Score: 0.020
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Significance of targeting polyamine metabolism as an antineoplastic strategy: unique targets for polyamine analogues. Proc West Pharmacol Soc. 2005; 48:24-30.
Score: 0.018
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New Transmission-Selective Antimalarial Agents through Hit-to-Lead Optimization of 2-([1,1'-Biphenyl]-4-carboxamido)benzoic Acid Derivatives. Chembiochem. 2022 Nov 04; 23(21):e202200427.
Score: 0.016
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Mitochondrial depolarization after acute ethanol treatment drives mitophagy in living mice. Autophagy. 2022 11; 18(11):2671-2685.
Score: 0.015
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Inhibition of Polyamine Biosynthesis Using Difluoromethylornithine Acts as a Potent Immune Modulator and Displays Therapeutic Synergy With PD-1-blockade. J Immunother. 2021 10 01; 44(8):283-291.
Score: 0.014
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Terminally alkylated polyamine analogues as chemotherapeutic agents. J Med Chem. 2001 Jan 04; 44(1):1-26.
Score: 0.014
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Spermine oxidase mediates Helicobacter pylori-induced gastric inflammation, DNA damage, and carcinogenic signaling. Oncogene. 2020 05; 39(22):4465-4474.
Score: 0.013
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Aldehyde dehydrogenase-2 activation by Alda-1 decreases necrosis and fibrosis after bile duct ligation in mice. Free Radic Biol Med. 2019 12; 145:136-145.
Score: 0.013
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Novel Synthetic Polyamines Have Potent Antimalarial Activities in vitro and in vivo by Decreasing Intracellular Spermidine and Spermine Concentrations. Front Cell Infect Microbiol. 2019; 9:9.
Score: 0.012
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Polyamine catabolism and oxidative damage. J Biol Chem. 2018 11 30; 293(48):18736-18745.
Score: 0.012
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Identification of 6',7'-dihydroxybergamottin, a cytochrome P450 inhibitor, in grapefruit juice. Drug Metab Dispos. 1996 Dec; 24(12):1287-90.
Score: 0.010
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Epigenetics: Novel Therapeutics Targeting Epigenetics. J Med Chem. 2016 Feb 25; 59(4):1247-8.
Score: 0.010
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S-(5'-deoxy-5'-adenosyl)-1-aminoxy-4-(methylsulfonio)-2-cyclopentene (AdoMao): an irreversible inhibitor of S-adenosylmethionine decarboxylase with potent in vitro antitrypanosomal activity. J Med Chem. 1995 May 12; 38(10):1770-7.
Score: 0.009
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Transcriptional activity of the islet ? cell factor Pdx1 is augmented by lysine methylation catalyzed by the methyltransferase Set7/9. J Biol Chem. 2015 Apr 10; 290(15):9812-22.
Score: 0.009
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Epigenetics: novel therapeutics targeting epigenetics. J Med Chem. 2015 Jan 22; 58(2):523-4.
Score: 0.009
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Increased Helicobacter pylori-associated gastric cancer risk in the Andean region of Colombia is mediated by spermine oxidase. Oncogene. 2015 Jun; 34(26):3429-40.
Score: 0.009
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Elevated ornithine decarboxylase activity promotes skin tumorigenesis by stimulating the recruitment of bulge stem cells but not via toxic polyamine catabolic metabolites. Amino Acids. 2014 Mar; 46(3):543-52.
Score: 0.008
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Polyamines and cancer: implications for chemotherapy and chemoprevention. Expert Rev Mol Med. 2013 Feb 22; 15:e3.
Score: 0.008
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Loss of LSD1 (lysine-specific demethylase 1) suppresses growth and alters gene expression of human colon cancer cells in a p53- and DNMT1(DNA methyltransferase 1)-independent manner. Biochem J. 2013 Jan 15; 449(2):459-68.
Score: 0.008
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Inhibition of the LSD1 (KDM1A) demethylase reactivates the all-trans-retinoic acid differentiation pathway in acute myeloid leukemia. Nat Med. 2012 Mar 11; 18(4):605-11.
Score: 0.007
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Polyamine catabolism contributes to enterotoxigenic Bacteroides fragilis-induced colon tumorigenesis. Proc Natl Acad Sci U S A. 2011 Sep 13; 108(37):15354-9.
Score: 0.007
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Spermine oxidase (SMO) activity in breast tumor tissues and biochemical analysis of the anticancer spermine analogues BENSpm and CPENSpm. BMC Cancer. 2010 Oct 14; 10:555.
Score: 0.007
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Novel oligoamine analogues inhibit lysine-specific demethylase 1 and induce reexpression of epigenetically silenced genes. Clin Cancer Res. 2009 Dec 01; 15(23):7217-28.
Score: 0.006
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Polyamine analogues targeting epigenetic gene regulation. Essays Biochem. 2009 Nov 04; 46:95-110.
Score: 0.006
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A small molecule polyamine oxidase inhibitor blocks androgen-induced oxidative stress and delays prostate cancer progression in the transgenic adenocarcinoma of the mouse prostate model. Cancer Res. 2009 Oct 01; 69(19):7689-95.
Score: 0.006
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The role of the polyamine catabolic enzymes SSAT and SMO in the synergistic effects of standard chemotherapeutic agents with a polyamine analogue in human breast cancer cell lines. Cancer Chemother Pharmacol. 2010 May; 65(6):1067-81.
Score: 0.006
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A novel histone deacetylase inhibitor prevents IL-1beta induced metabolic dysfunction in pancreatic beta-cells. J Cell Mol Med. 2009 Aug; 13(8B):1877-85.
Score: 0.006
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Spermine analogue-regulated expression of spermidine/spermine N1-acetyltransferase and its effects on depletion of intracellular polyamine pools in mouse fetal fibroblasts. Biochem J. 2009 Jul 29; 422(1):101-9.
Score: 0.006
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Synthesis and biological evaluation of S-adenosyl-1,12-diamino-3-thio-9-azadodecane, a multisubstrate adduct inhibitor of spermine synthase. J Med Chem. 1989 Jun; 32(6):1300-7.
Score: 0.006
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Elevated ornithine decarboxylase levels activate ataxia telangiectasia mutated-DNA damage signaling in normal keratinocytes. Cancer Res. 2008 Apr 01; 68(7):2214-22.
Score: 0.006
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Studies of the mechanism by which increased spermidine/spermine N1-acetyltransferase activity increases susceptibility to skin carcinogenesis. Carcinogenesis. 2007 Nov; 28(11):2404-11.
Score: 0.005
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Spermine and spermidine mediate protection against oxidative damage caused by hydrogen peroxide. Amino Acids. 2007 Aug; 33(2):231-40.
Score: 0.005
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Synthesis and biological evaluation of cyclic analogues of 1-carnitine as potential agents in the treatment of myocardial ischemia. J Med Chem. 1986 May; 29(5):865-8.
Score: 0.005
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Polyamine metabolism in a member of the phylum Microspora (Encephalitozoon cuniculi): effects of polyamine analogues. Microbiology (Reading). 2004 May; 150(Pt 5):1215-1224.
Score: 0.004
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The activator-binding site of Onchocerca volvulus S-adenosylmethionine decarboxylase, a potential drug target. Biol Chem. 2003 Aug; 384(8):1195-201.
Score: 0.004
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Detoxification of the polyamine analogue N1-ethyl-N11-[(cycloheptyl)methy]-4,8-diazaundecane (CHENSpm) by polyamine oxidase. Clin Cancer Res. 2002 May; 8(5):1241-7.
Score: 0.004
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Novel alkylpolyamine analogues that possess both antitrypanosomal and antimicrosporidial activity. Bioorg Med Chem Lett. 2001 Jun 18; 11(12):1613-7.
Score: 0.004
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Photoaffinity labeling of a cell surface polyamine binding protein. J Biol Chem. 1995 Dec 01; 270(48):28705-11.
Score: 0.002
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Dapsone-induced hematologic toxicity: comparison of the methemoglobin-forming ability of hydroxylamine metabolites of dapsone in rat and human blood. Toxicol Appl Pharmacol. 1994 Dec; 129(2):309-16.
Score: 0.002
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Effect of S-adenosyl-1,12-diamino-3-thio-9-azadodecane, a multisubstrate adduct inhibitor of spermine synthase, on polyamine metabolism in mammalian cells. Biochemistry. 1989 Oct 17; 28(21):8446-53.
Score: 0.002