Richard Drake to Thymidine Kinase
This is a "connection" page, showing publications Richard Drake has written about Thymidine Kinase.
Connection Strength
1.648
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Mutation of herpesvirus thymidine kinase to generate ganciclovir-specific kinases for use in cancer gene therapies. Protein Eng. 2002 Nov; 15(11):903-11.
Score: 0.204
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Connexin-independent ganciclovir-mediated killing conferred on bystander effect-resistant cell lines by a herpes simplex virus-thymidine kinase-expressing colon cell line. Mol Ther. 2000 Nov; 2(5):515-23.
Score: 0.178
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Conservative mutations of glutamine-125 in herpes simplex virus type 1 thymidine kinase result in a ganciclovir kinase with minimal deoxypyrimidine kinase activities. Biochemistry. 2000 Apr 11; 39(14):4105-11.
Score: 0.171
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Two-drug combinations that increase apoptosis and modulate bak and bcl-X(L) expression in human colon tumor cell lines transduced with herpes simplex virus thymidine kinase. Cancer Gene Ther. 2000 Apr; 7(4):563-73.
Score: 0.171
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Differential ganciclovir-mediated cell killing by glutamine 125 mutants of herpes simplex virus type 1 thymidine kinase. J Biol Chem. 1999 Dec 24; 274(52):37186-92.
Score: 0.167
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Lack of bystander killing in herpes simplex virus thymidine kinase-transduced colon cell lines due to deficient connexin43 gap junction formation. Hum Gene Ther. 1998 Oct 10; 9(15):2253-61.
Score: 0.154
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Metabolism and activities of 3'-azido-2',3'-dideoxythymidine and 2',3'-didehydro-2',3'-dideoxythymidine in herpesvirus thymidine kinase transduced T-lymphocytes. Antiviral Res. 1997 Aug; 35(3):177-85.
Score: 0.142
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Proteolytic mapping of the thymidine/thymidylate binding site of herpes simplex virus type 1 thymidine kinase: a general photoaffinity labeling method for identifying active-site peptides. Anal Biochem. 1996 May 15; 237(1):135-40.
Score: 0.130
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Synthesis of a photoaffinity analog of 3'-azidothymidine, 5-azido-3'-azido-2',3'-dideoxyuridine. Interactions with herpesvirus thymidine kinase and cellular enzymes. J Biol Chem. 1995 Jun 09; 270(23):13660-4.
Score: 0.122
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Purification and photoaffinity labeling of herpes simplex virus type-1 thymidine kinase. J Biol Chem. 1995 Mar 31; 270(13):7055-60.
Score: 0.121
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Ganciclovir-mediated cell killing and bystander effect is enhanced in cells with two copies of the herpes simplex virus thymidine kinase gene. Cancer Gene Ther. 2000 Feb; 7(2):240-6.
Score: 0.042
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Thymidine kinase (TK) gene-transduced human lymphocytes can be highly purified, remain fully functional, and are killed efficiently with ganciclovir. Blood. 1997 Feb 15; 89(4):1334-40.
Score: 0.034
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Expression of MRP4 confers resistance to ganciclovir and compromises bystander cell killing. J Biol Chem. 2002 Oct 11; 277(41):38998-9004.
Score: 0.012