Emil Alexov to Humans
This is a "connection" page, showing publications Emil Alexov has written about Humans.
Connection Strength
0.745
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Opioid Addiction and Opioid Receptor Dimerization: Structural Modeling of the OPRD1 and OPRM1 Heterodimer and Its Signaling Pathways. Int J Mol Sci. 2021 Sep 24; 22(19).
Score: 0.030
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Computational Investigation of the pH Dependence of Stability of Melanosome Proteins: Implication for Melanosome formation and Disease. Int J Mol Sci. 2021 Jul 31; 22(15).
Score: 0.030
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SAAMBE-SEQ: a sequence-based method for predicting mutation effect on protein-protein binding affinity. Bioinformatics. 2021 05 17; 37(7):992-999.
Score: 0.029
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SAAFEC-SEQ: A Sequence-Based Method for Predicting the Effect of Single Point Mutations on Protein Thermodynamic Stability. Int J Mol Sci. 2021 Jan 09; 22(2).
Score: 0.029
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An Ensemble Approach to Predict the Pathogenicity of Synonymous Variants. Genes (Basel). 2020 09 21; 11(9).
Score: 0.028
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SAAMBE-3D: Predicting Effect of Mutations on Protein-Protein Interactions. Int J Mol Sci. 2020 Apr 07; 21(7).
Score: 0.027
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Novel Genetic Markers for Early Detection of Elevated Breast Cancer Risk in Women. Int J Mol Sci. 2019 Sep 28; 20(19).
Score: 0.026
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Computational Investigation of the Missense Mutations in DHCR7 Gene Associated with Smith-Lemli-Opitz Syndrome. Int J Mol Sci. 2018 Jan 04; 19(1).
Score: 0.023
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Forces and Disease: Electrostatic force differences caused by mutations in kinesin motor domains can distinguish between disease-causing and non-disease-causing mutations. Sci Rep. 2017 08 15; 7(1):8237.
Score: 0.023
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Cofactors-loaded quaternary structure of lysine-specific demethylase 5C (KDM5C) protein: Computational model. Proteins. 2016 12; 84(12):1797-1809.
Score: 0.021
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SAAMBE: Webserver to Predict the Charge of Binding Free Energy Caused by Amino Acids Mutations. Int J Mol Sci. 2016 Apr 12; 17(4):547.
Score: 0.021
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Investigating the linkage between disease-causing amino acid variants and their effect on protein stability and binding. Proteins. 2016 Feb; 84(2):232-9.
Score: 0.020
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Revealing the Effects of Missense Mutations Causing Snyder-Robinson Syndrome on the Stability and Dimerization of Spermine Synthase. Int J Mol Sci. 2016 Jan 08; 17(1).
Score: 0.020
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Mutations in the KDM5C ARID Domain and Their Plausible Association with Syndromic Claes-Jensen-Type Disease. Int J Mol Sci. 2015 Nov 13; 16(11):27270-87.
Score: 0.020
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Impact of Rett Syndrome Mutations on MeCP2 MBD Stability. Biochemistry. 2015 Oct 20; 54(41):6357-68.
Score: 0.020
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On human disease-causing amino acid variants: statistical study of sequence and structural patterns. Hum Mutat. 2015 May; 36(5):524-534.
Score: 0.019
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Structural, Dynamical, and Energetical Consequences of Rett Syndrome Mutation R133C in MeCP2. Comput Math Methods Med. 2015; 2015:746157.
Score: 0.019
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Structural and physico-chemical effects of disease and non-disease nsSNPs on proteins. Curr Opin Struct Biol. 2015 Jun; 32:18-24.
Score: 0.019
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Chronic Beryllium Disease: revealing the role of beryllium ion and small peptides binding to HLA-DP2. PLoS One. 2014; 9(11):e111604.
Score: 0.019
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ProBLM web server: protein and membrane placement and orientation package. Comput Math Methods Med. 2014; 2014:838259.
Score: 0.018
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Computational and experimental approaches to reveal the effects of single nucleotide polymorphisms with respect to disease diagnostics. Int J Mol Sci. 2014 May 30; 15(6):9670-717.
Score: 0.018
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Understanding molecular effects of naturally occurring genetic differences. J Mol Biol. 2013 Nov 01; 425(21):3911-3.
Score: 0.017
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Molecular mechanisms of disease-causing missense mutations. J Mol Biol. 2013 Nov 01; 425(21):3919-36.
Score: 0.017
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Protonation and pK changes in protein-ligand binding. Q Rev Biophys. 2013 May; 46(2):181-209.
Score: 0.017
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Enhancing human spermine synthase activity by engineered mutations. PLoS Comput Biol. 2013; 9(2):e1002924.
Score: 0.017
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A rational free energy-based approach to understanding and targeting disease-causing missense mutations. J Am Med Inform Assoc. 2013 Jul-Aug; 20(4):643-51.
Score: 0.017
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Analyzing effects of naturally occurring missense mutations. Comput Math Methods Med. 2012; 2012:805827.
Score: 0.016
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Predicting folding free energy changes upon single point mutations. Bioinformatics. 2012 Mar 01; 28(5):664-71.
Score: 0.015
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A missense mutation in CLIC2 associated with intellectual disability is predicted by in silico modeling to affect protein stability and dynamics. Proteins. 2011 Aug; 79(8):2444-54.
Score: 0.015
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In silico and in vitro investigations of the mutability of disease-causing missense mutation sites in spermine synthase. PLoS One. 2011; 6(5):e20373.
Score: 0.015
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On the role of electrostatics in protein-protein interactions. Phys Biol. 2011 Jun; 8(3):035001.
Score: 0.015
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Computational analysis of missense mutations causing Snyder-Robinson syndrome. Hum Mutat. 2010 Sep; 31(9):1043-9.
Score: 0.014
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Modeling effects of human single nucleotide polymorphisms on protein-protein interactions. Biophys J. 2009 Mar 18; 96(6):2178-88.
Score: 0.013
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Increased p53 signaling impairs neural differentiation in HUWE1-promoted intellectual disabilities. Cell Rep Med. 2021 04 20; 2(4):100240.
Score: 0.007
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Mutations in FAM50A suggest that Armfield XLID syndrome is a spliceosomopathy. Nat Commun. 2020 07 23; 11(1):3698.
Score: 0.007
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Three additional patients with EED-associated overgrowth: potential mutation hotspots identified? J Hum Genet. 2019 Jun; 64(6):561-572.
Score: 0.006
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Structural Perspective on Revealing and Altering Molecular Functions of Genetic Variants Linked with Diseases. Int J Mol Sci. 2019 Jan 28; 20(3).
Score: 0.006
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Key apoptotic genes APAF1 and CASP9 implicated in recurrent folate-resistant neural tube defects. Eur J Hum Genet. 2018 03; 26(3):420-427.
Score: 0.006
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Identification and characterization of a missense mutation in the O-linked ?-N-acetylglucosamine (O-GlcNAc) transferase gene that segregates with X-linked intellectual disability. J Biol Chem. 2017 05 26; 292(21):8948-8963.
Score: 0.005
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Binding Analysis of Methyl-CpG Binding Domain of MeCP2 and Rett Syndrome Mutations. ACS Chem Biol. 2016 10 21; 11(10):2706-2715.
Score: 0.005
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ZC4H2, an XLID gene, is required for the generation of a specific subset of CNS interneurons. Hum Mol Genet. 2015 Sep 01; 24(17):4848-61.
Score: 0.005
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Rational design of small-molecule stabilizers of spermine synthase dimer by virtual screening and free energy-based approach. PLoS One. 2014; 9(10):e110884.
Score: 0.005
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A novel p.Leu(381)Phe mutation in presenilin 1 is associated with very early onset and unusually fast progressing dementia as well as lysosomal inclusions typically seen in Kufs disease. J Alzheimers Dis. 2014; 39(1):23-7.
Score: 0.004
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A mutation in a ganglioside biosynthetic enzyme, ST3GAL5, results in salt & pepper syndrome, a neurocutaneous disorder with altered glycolipid and glycoprotein glycosylation. Hum Mol Genet. 2014 Jan 15; 23(2):418-33.
Score: 0.004
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Cancer missense mutations alter binding properties of proteins and their interaction networks. PLoS One. 2013; 8(6):e66273.
Score: 0.004
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A Y328C missense mutation in spermine synthase causes a mild form of Snyder-Robinson syndrome. Hum Mol Genet. 2013 Sep 15; 22(18):3789-97.
Score: 0.004
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An X-linked channelopathy with cardiomegaly due to a CLIC2 mutation enhancing ryanodine receptor channel activity. Hum Mol Genet. 2012 Oct 15; 21(20):4497-507.
Score: 0.004
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Structural assessment of the effects of amino acid substitutions on protein stability and protein protein interaction. Int J Comput Biol Drug Des. 2010; 3(4):334-49.
Score: 0.004
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Electrostatic and lipid anchor contributions to the interaction of transducin with membranes: mechanistic implications for activation and translocation. J Biol Chem. 2008 Nov 07; 283(45):31197-207.
Score: 0.003