Connection

John O'Bryan to Signal Transduction

This is a "connection" page, showing publications John O'Bryan has written about Signal Transduction.
Connection Strength

2.252
  1. Targeting the a4-a5 interface of RAS results in multiple levels of inhibition. Small GTPases. 2019 09; 10(5):378-387.
    View in: PubMed
    Score: 0.303
  2. Intersectin scaffold proteins and their role in cell signaling and endocytosis. Biochim Biophys Acta Mol Cell Res. 2017 Jan; 1864(1):23-30.
    View in: PubMed
    Score: 0.278
  3. Emerging roles for intersectin (ITSN) in regulating signaling and disease pathways. Int J Mol Sci. 2013 Apr 10; 14(4):7829-52.
    View in: PubMed
    Score: 0.218
  4. Intersecting pathways in cell biology. Sci Signal. 2010 Dec 14; 3(152):re10.
    View in: PubMed
    Score: 0.186
  5. Regulation of neuron survival through an intersectin-phosphoinositide 3'-kinase C2beta-AKT pathway. Mol Cell Biol. 2007 Nov; 27(22):7906-17.
    View in: PubMed
    Score: 0.148
  6. Intersectin regulates epidermal growth factor receptor endocytosis, ubiquitylation, and signaling. Mol Pharmacol. 2006 Nov; 70(5):1643-53.
    View in: PubMed
    Score: 0.138
  7. Identification of the nucleotide-free state as a therapeutic vulnerability for inhibition of selected oncogenic RAS mutants. Cell Rep. 2022 02 08; 38(6):110322.
    View in: PubMed
    Score: 0.101
  8. Mitogenesis and endocytosis: What's at the INTERSECTIoN? Oncogene. 2001 Oct 01; 20(44):6300-8.
    View in: PubMed
    Score: 0.098
  9. Inhibition of RAS: proven and potential vulnerabilities. Biochem Soc Trans. 2020 10 30; 48(5):1831-1841.
    View in: PubMed
    Score: 0.092
  10. Intersectin, an adaptor protein involved in clathrin-mediated endocytosis, activates mitogenic signaling pathways. J Biol Chem. 2000 Sep 01; 275(35):27414-20.
    View in: PubMed
    Score: 0.091
  11. Biology, pathology, and therapeutic targeting of RAS. Adv Cancer Res. 2020; 148:69-146.
    View in: PubMed
    Score: 0.090
  12. Direct inhibition of RAS: Quest for the Holy Grail? Semin Cancer Biol. 2019 02; 54:138-148.
    View in: PubMed
    Score: 0.075
  13. Intersectin (ITSN) family of scaffolds function as molecular hubs in protein interaction networks. PLoS One. 2012; 7(4):e36023.
    View in: PubMed
    Score: 0.051
  14. Intersectin 1 is required for neuroblastoma tumorigenesis. Oncogene. 2012 Nov 15; 31(46):4828-34.
    View in: PubMed
    Score: 0.050
  15. Intersectin enhances huntingtin aggregation and neurodegeneration through activation of c-Jun-NH2-terminal kinase. Hum Mol Genet. 2007 Aug 01; 16(15):1862-71.
    View in: PubMed
    Score: 0.036
  16. Analysis of the role of ubiquitin-interacting motifs in ubiquitin binding and ubiquitylation. J Biol Chem. 2004 Aug 06; 279(32):33528-37.
    View in: PubMed
    Score: 0.029
  17. N-type Ca2+ channels as scaffold proteins in the assembly of signaling molecules for GABAB receptor effects. J Biol Chem. 2004 Jun 04; 279(23):24649-58.
    View in: PubMed
    Score: 0.029
  18. Intersectin activates Ras but stimulates transcription through an independent pathway involving JNK. J Biol Chem. 2003 Nov 21; 278(47):47038-45.
    View in: PubMed
    Score: 0.028
  19. Neuroblastoma differentiation in?vivo excludes cranial tumors. Dev Cell. 2021 10 11; 56(19):2752-2764.e6.
    View in: PubMed
    Score: 0.025
  20. The Nf2 tumor suppressor, merlin, functions in Rac-dependent signaling. Dev Cell. 2001 Jul; 1(1):63-72.
    View in: PubMed
    Score: 0.024
  21. The P-type ATPase transporter ATP7A promotes angiogenesis by limiting autophagic degradation of VEGFR2. Nat Commun. 2021 05 25; 12(1):3091.
    View in: PubMed
    Score: 0.024
  22. Caveolin-1 stabilizes ATP7A, a copper transporter for extracellular SOD, in vascular tissue to maintain endothelial function. Am J Physiol Cell Physiol. 2020 11 01; 319(5):C933-C944.
    View in: PubMed
    Score: 0.023
  23. Involvement of NH(2)-terminal sequences in the negative regulation of Vav signaling and transforming activity. J Biol Chem. 1999 Oct 22; 274(43):30410-8.
    View in: PubMed
    Score: 0.021
  24. The src homology 2 and phosphotyrosine binding domains of the ShcC adaptor protein function as inhibitors of mitogenic signaling by the epidermal growth factor receptor. J Biol Chem. 1998 Aug 07; 273(32):20431-7.
    View in: PubMed
    Score: 0.020
  25. Akt2 (Protein Kinase B Beta) Stabilizes ATP7A, a Copper Transporter for Extracellular Superoxide Dismutase, in Vascular Smooth Muscle: Novel Mechanism to Limit Endothelial Dysfunction in Type 2 Diabetes Mellitus. Arterioscler Thromb Vasc Biol. 2018 03; 38(3):529-541.
    View in: PubMed
    Score: 0.019
  26. Protein Kinase A (PKA) Phosphorylation of Shp2 Protein Inhibits Its Phosphatase Activity and Modulates Ligand Specificity. J Biol Chem. 2015 May 08; 290(19):12058-67.
    View in: PubMed
    Score: 0.016
  27. UCR1C is a novel activator of phosphodiesterase 4 (PDE4) long isoforms and attenuates cardiomyocyte hypertrophy. Cell Signal. 2015 May; 27(5):908-22.
    View in: PubMed
    Score: 0.015
  28. Rac and Rho mediate opposing hormonal regulation of the ether-a-go-go-related potassium channel. Curr Biol. 2002 Jan 08; 12(1):27-33.
    View in: PubMed
    Score: 0.006
  29. The mammalian ShcB and ShcC phosphotyrosine docking proteins function in the maturation of sensory and sympathetic neurons. Neuron. 2000 Dec; 28(3):819-33.
    View in: PubMed
    Score: 0.006
  30. Intersectin can regulate the Ras/MAP kinase pathway independent of its role in endocytosis. J Biol Chem. 2000 Sep 22; 275(38):29894-9.
    View in: PubMed
    Score: 0.006
  31. Differential regulation of SHC proteins by nerve growth factor in sensory neurons and PC12 cells. Eur J Neurosci. 1998 Jun; 10(6):1995-2008.
    View in: PubMed
    Score: 0.005
Connection Strength

The connection strength for concepts is the sum of the scores for each matching publication.

Publication scores are based on many factors, including how long ago they were written and whether the person is a first or senior author.