John O'Bryan to Humans
This is a "connection" page, showing publications John O'Bryan has written about Humans.
Connection Strength
0.628
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Identification of the nucleotide-free state as a therapeutic vulnerability for inhibition of selected oncogenic RAS mutants. Cell Rep. 2022 02 08; 38(6):110322.
Score: 0.030
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Targeting the "undruggable" RAS with biologics. Adv Cancer Res. 2022; 153:237-266.
Score: 0.029
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Targeting the KRAS a4-a5 allosteric interface inhibits pancreatic cancer tumorigenesis. Small GTPases. 2022 Jan; 13(1):114-127.
Score: 0.029
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Probing RAS Function with Monobodies. Methods Mol Biol. 2021; 2262:281-302.
Score: 0.028
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Inhibition of RAS: proven and potential vulnerabilities. Biochem Soc Trans. 2020 10 30; 48(5):1831-1841.
Score: 0.028
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Biology, pathology, and therapeutic targeting of RAS. Adv Cancer Res. 2020; 148:69-146.
Score: 0.027
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Therapeutic targeting of RAS: New hope for drugging the "undruggable". Biochim Biophys Acta Mol Cell Res. 2020 02; 1867(2):118570.
Score: 0.026
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Pharmacological targeting of RAS: Recent success with direct inhibitors. Pharmacol Res. 2019 01; 139:503-511.
Score: 0.024
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Targeting the a4-a5 interface of RAS results in multiple levels of inhibition. Small GTPases. 2019 09; 10(5):378-387.
Score: 0.023
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Direct inhibition of RAS: Quest for the Holy Grail? Semin Cancer Biol. 2019 02; 54:138-148.
Score: 0.023
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Inhibition of RAS function through targeting an allosteric regulatory site. Nat Chem Biol. 2017 Jan; 13(1):62-68.
Score: 0.021
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Intersectin scaffold proteins and their role in cell signaling and endocytosis. Biochim Biophys Acta Mol Cell Res. 2017 Jan; 1864(1):23-30.
Score: 0.021
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Phosphatidylinositol 3-kinase, class 2 beta (PI3KC2?) isoform contributes to neuroblastoma tumorigenesis. Cancer Lett. 2015 Apr 10; 359(2):262-8.
Score: 0.019
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Receptor tyrosine kinase ubiquitylation involves the dynamic regulation of Cbl-Spry2 by intersectin 1 and the Shp2 tyrosine phosphatase. Mol Cell Biol. 2014 Jan; 34(2):271-9.
Score: 0.017
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Emerging roles for intersectin (ITSN) in regulating signaling and disease pathways. Int J Mol Sci. 2013 Apr 10; 14(4):7829-52.
Score: 0.016
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A new dimension to Ras function: a novel role for nucleotide-free Ras in Class II phosphatidylinositol 3-kinase beta (PI3KC2?) regulation. PLoS One. 2012; 7(9):e45360.
Score: 0.016
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Intersectin (ITSN) family of scaffolds function as molecular hubs in protein interaction networks. PLoS One. 2012; 7(4):e36023.
Score: 0.015
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Intersectin 1 is required for neuroblastoma tumorigenesis. Oncogene. 2012 Nov 15; 31(46):4828-34.
Score: 0.015
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Intersectin 1 enhances Cbl ubiquitylation of epidermal growth factor receptor through regulation of Sprouty2-Cbl interaction. Mol Cell Biol. 2012 Feb; 32(4):817-25.
Score: 0.015
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Intersectin 1 contributes to phenotypes in vivo: implications for Down's syndrome. Neuroreport. 2011 Oct 26; 22(15):767-72.
Score: 0.015
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Intersecting pathways in cell biology. Sci Signal. 2010 Dec 14; 3(152):re10.
Score: 0.014
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Regulation of neuron survival through an intersectin-phosphoinositide 3'-kinase C2beta-AKT pathway. Mol Cell Biol. 2007 Nov; 27(22):7906-17.
Score: 0.011
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Intersectin enhances huntingtin aggregation and neurodegeneration through activation of c-Jun-NH2-terminal kinase. Hum Mol Genet. 2007 Aug 01; 16(15):1862-71.
Score: 0.011
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Ubiquitin-interacting motifs inhibit aggregation of polyQ-expanded huntingtin. J Biol Chem. 2007 Mar 30; 282(13):10096-10103.
Score: 0.011
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Intersectin regulates epidermal growth factor receptor endocytosis, ubiquitylation, and signaling. Mol Pharmacol. 2006 Nov; 70(5):1643-53.
Score: 0.010
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The U-box ligase carboxyl-terminus of Hsc 70-interacting protein ubiquitylates Epsin. Biochem Biophys Res Commun. 2005 Mar 11; 328(2):550-9.
Score: 0.009
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Analysis of the role of ubiquitin-interacting motifs in ubiquitin binding and ubiquitylation. J Biol Chem. 2004 Aug 06; 279(32):33528-37.
Score: 0.009
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Intersectin activates Ras but stimulates transcription through an independent pathway involving JNK. J Biol Chem. 2003 Nov 21; 278(47):47038-45.
Score: 0.008
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Inhibition of RAS-driven signaling and tumorigenesis with a pan-RAS monobody targeting the Switch I/II pocket. Proc Natl Acad Sci U S A. 2022 10 25; 119(43):e2204481119.
Score: 0.008
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Ceramide synthase 6 impacts T-cell allogeneic response and graft-versus-host disease through regulating N-RAS/ERK pathway. Leukemia. 2022 07; 36(7):1907-1915.
Score: 0.008
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Neuroblastoma differentiation in?vivo excludes cranial tumors. Dev Cell. 2021 10 11; 56(19):2752-2764.e6.
Score: 0.007
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Mitogenesis and endocytosis: What's at the INTERSECTIoN? Oncogene. 2001 Oct 01; 20(44):6300-8.
Score: 0.007
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The P-type ATPase transporter ATP7A promotes angiogenesis by limiting autophagic degradation of VEGFR2. Nat Commun. 2021 05 25; 12(1):3091.
Score: 0.007
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Selective and noncovalent targeting of RAS mutants for inhibition and degradation. Nat Commun. 2021 05 11; 12(1):2656.
Score: 0.007
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Intersectin, an adaptor protein involved in clathrin-mediated endocytosis, activates mitogenic signaling pathways. J Biol Chem. 2000 Sep 01; 275(35):27414-20.
Score: 0.007
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The src homology 2 and phosphotyrosine binding domains of the ShcC adaptor protein function as inhibitors of mitogenic signaling by the epidermal growth factor receptor. J Biol Chem. 1998 Aug 07; 273(32):20431-7.
Score: 0.006
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Akt2 (Protein Kinase B Beta) Stabilizes ATP7A, a Copper Transporter for Extracellular Superoxide Dismutase, in Vascular Smooth Muscle: Novel Mechanism to Limit Endothelial Dysfunction in Type 2 Diabetes Mellitus. Arterioscler Thromb Vasc Biol. 2018 03; 38(3):529-541.
Score: 0.006
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Silencing Intersectin 1 Slows Orthotopic Neuroblastoma Growth in Mice. J Pediatr Hematol Oncol. 2017 11; 39(8):e413-e418.
Score: 0.006
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Binding specificity and mutational analysis of the phosphotyrosine binding domain of the brain-specific adaptor protein ShcC. J Biol Chem. 1996 May 17; 271(20):11787-91.
Score: 0.005
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A mammalian adaptor protein with conserved Src homology 2 and phosphotyrosine-binding domains is related to Shc and is specifically expressed in the brain. Proc Natl Acad Sci U S A. 1996 Apr 02; 93(7):2729-34.
Score: 0.005
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Protein Kinase A (PKA) Phosphorylation of Shp2 Protein Inhibits Its Phosphatase Activity and Modulates Ligand Specificity. J Biol Chem. 2015 May 08; 290(19):12058-67.
Score: 0.005
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UCR1C is a novel activator of phosphodiesterase 4 (PDE4) long isoforms and attenuates cardiomyocyte hypertrophy. Cell Signal. 2015 May; 27(5):908-22.
Score: 0.005
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The transforming receptor tyrosine kinase, Axl, is post-translationally regulated by proteolytic cleavage. J Biol Chem. 1995 Jan 13; 270(2):551-7.
Score: 0.005
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Down syndrome: genes, model systems, and progress towards pharmacotherapies and clinical trials for cognitive deficits. Cytogenet Genome Res. 2013; 141(4):260-71.
Score: 0.004
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axl, a transforming gene isolated from primary human myeloid leukemia cells, encodes a novel receptor tyrosine kinase. Mol Cell Biol. 1991 Oct; 11(10):5016-31.
Score: 0.004
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The ubiquitin-interacting motif protein, S5a, is ubiquitinated by all types of ubiquitin ligases by a mechanism different from typical substrate recognition. J Biol Chem. 2009 May 08; 284(19):12622-32.
Score: 0.003
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The Ews/Fli-1 fusion gene switches the differentiation program of neuroblastomas to Ewing sarcoma/peripheral primitive neuroectodermal tumors. Cancer Res. 2004 Feb 15; 64(4):1266-77.
Score: 0.002
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Involvement of NH(2)-terminal sequences in the negative regulation of Vav signaling and transforming activity. J Biol Chem. 1999 Oct 22; 274(43):30410-8.
Score: 0.002
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Expression of axl, a transforming receptor tyrosine kinase, in normal and malignant hematopoiesis. Blood. 1994 Sep 15; 84(6):1931-41.
Score: 0.001
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Overexpression of matrix Gla protein mRNA in malignant human breast cells: isolation by differential cDNA hybridization. Oncogene. 1990 Sep; 5(9):1391-5.
Score: 0.001