John O'Bryan to Mutation
This is a "connection" page, showing publications John O'Bryan has written about Mutation.
Connection Strength
1.644
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Identification of the nucleotide-free state as a therapeutic vulnerability for inhibition of selected oncogenic RAS mutants. Cell Rep. 2022 02 08; 38(6):110322.
Score: 0.533
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Inhibition of RAS: proven and potential vulnerabilities. Biochem Soc Trans. 2020 10 30; 48(5):1831-1841.
Score: 0.488
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Targeting the "undruggable" RAS with biologics. Adv Cancer Res. 2022; 153:237-266.
Score: 0.129
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Selective and noncovalent targeting of RAS mutants for inhibition and degradation. Nat Commun. 2021 05 11; 12(1):2656.
Score: 0.127
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Biology, pathology, and therapeutic targeting of RAS. Adv Cancer Res. 2020; 148:69-146.
Score: 0.119
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Therapeutic targeting of RAS: New hope for drugging the "undruggable". Biochim Biophys Acta Mol Cell Res. 2020 02; 1867(2):118570.
Score: 0.114
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Intersectin enhances huntingtin aggregation and neurodegeneration through activation of c-Jun-NH2-terminal kinase. Hum Mol Genet. 2007 Aug 01; 16(15):1862-71.
Score: 0.048
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Inhibition of RAS-driven signaling and tumorigenesis with a pan-RAS monobody targeting the Switch I/II pocket. Proc Natl Acad Sci U S A. 2022 10 25; 119(43):e2204481119.
Score: 0.035
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Binding specificity and mutational analysis of the phosphotyrosine binding domain of the brain-specific adaptor protein ShcC. J Biol Chem. 1996 May 17; 271(20):11787-91.
Score: 0.022
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Protein Kinase A (PKA) Phosphorylation of Shp2 Protein Inhibits Its Phosphatase Activity and Modulates Ligand Specificity. J Biol Chem. 2015 May 08; 290(19):12058-67.
Score: 0.021
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Rac and Rho mediate opposing hormonal regulation of the ether-a-go-go-related potassium channel. Curr Biol. 2002 Jan 08; 12(1):27-33.
Score: 0.008