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Exploiting a natural conformational switch to engineer an interleukin-2 'superkine'.
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Exploiting a natural conformational switch to engineer an interleukin-2 'superkine'.
Exploiting a natural conformational switch to engineer an interleukin-2 'superkine'. Nature. 2012 Mar 25; 484(7395):529-33.
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PubMed
subject areas
Animals
Binding Sites
Cell Line
Cell Proliferation
Crystallography, X-Ray
Directed Molecular Evolution
Humans
Immunotherapy
Interleukin-2
Interleukin-2 Receptor alpha Subunit
Interleukin-2 Receptor beta Subunit
Killer Cells, Natural
Mice
Mice, Inbred C57BL
Models, Molecular
Molecular Dynamics Simulation
Mutant Proteins
Mutation
Neoplasm Transplantation
Neoplasms
Phosphorylation
Protein Conformation
Protein Engineering
STAT5 Transcription Factor
Surface Plasmon Resonance
T-Lymphocytes
authors with profiles
Carsten Krieg