Denis Guttridge to Animals
This is a "connection" page, showing publications Denis Guttridge has written about Animals.
Connection Strength
1.611
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Emerging signaling mediators in the anorexia-cachexia syndrome of cancer. Trends Cancer. 2022 05; 8(5):397-403.
Score: 0.060
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Modeling Human Cancer-induced Cachexia. Cell Rep. 2019 08 06; 28(6):1612-1622.e4.
Score: 0.050
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NF-?B inhibition rescues cardiac function by remodeling calcium genes in a Duchenne muscular dystrophy model. Nat Commun. 2018 08 24; 9(1):3431.
Score: 0.047
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NF-?B regulates GDF-15 to suppress macrophage surveillance during early tumor development. J Clin Invest. 2017 Oct 02; 127(10):3796-3809.
Score: 0.044
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MyoD Regulates Skeletal Muscle Oxidative Metabolism Cooperatively with Alternative NF-?B. Cell Rep. 2016 10 04; 17(2):514-526.
Score: 0.041
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An NF-?B--EphrinA5-Dependent Communication between NG2(+) Interstitial Cells and Myoblasts Promotes Muscle Growth in Neonates. Dev Cell. 2016 Jan 25; 36(2):215-24.
Score: 0.039
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Analysis of Aerobic Respiration in Intact Skeletal Muscle Tissue by Microplate-Based Respirometry. Methods Mol Biol. 2016; 1460:337-43.
Score: 0.039
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Inflammation induced loss of skeletal muscle. Bone. 2015 Nov; 80:131-142.
Score: 0.039
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A TGF-? pathway associated with cancer cachexia. Nat Med. 2015 Nov; 21(11):1248-9.
Score: 0.039
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Impaired regeneration: A role for the muscle microenvironment in cancer cachexia. Semin Cell Dev Biol. 2016 06; 54:82-91.
Score: 0.038
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NF-?B functions in tumor initiation by suppressing the surveillance of both innate and adaptive immune cells. Cell Rep. 2014 Oct 09; 9(1):90-103.
Score: 0.036
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Inflammation based regulation of cancer cachexia. Biomed Res Int. 2014; 2014:168407.
Score: 0.035
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NF-?B-mediated Pax7 dysregulation in the muscle microenvironment promotes cancer cachexia. J Clin Invest. 2013 Nov; 123(11):4821-35.
Score: 0.034
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Mechanisms of impaired differentiation in rhabdomyosarcoma. FEBS J. 2013 Sep; 280(17):4323-34.
Score: 0.033
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miR-29 acts as a decoy in sarcomas to protect the tumor suppressor A20 mRNA from degradation by HuR. Sci Signal. 2013 Jul 30; 6(286):ra63.
Score: 0.033
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Reining in nuclear factor-kappaB in skeletal muscle disorders. Curr Opin Clin Nutr Metab Care. 2013 May; 16(3):251-7.
Score: 0.032
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IKKa and alternative NF-?B regulate PGC-1? to promote oxidative muscle metabolism. J Cell Biol. 2012 Feb 20; 196(4):497-511.
Score: 0.030
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Detection of NF-?B activity in skeletal muscle cells by electrophoretic mobility shift analysis. Methods Mol Biol. 2012; 798:505-16.
Score: 0.030
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Making muscles grow by g protein-coupled receptor signaling. Sci Signal. 2011 Nov 29; 4(201):pe45.
Score: 0.029
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NF-?B signaling in skeletal muscle health and disease. Curr Top Dev Biol. 2011; 96:85-119.
Score: 0.028
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TNF inhibits Notch-1 in skeletal muscle cells by Ezh2 and DNA methylation mediated repression: implications in duchenne muscular dystrophy. PLoS One. 2010 Aug 30; 5(8):e12479.
Score: 0.027
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NF-kappaB signaling: a tale of two pathways in skeletal myogenesis. Physiol Rev. 2010 Apr; 90(2):495-511.
Score: 0.026
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NF-kappaB functions in stromal fibroblasts to regulate early postnatal muscle development. J Biol Chem. 2010 Feb 19; 285(8):5479-87.
Score: 0.026
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RelA/p65 functions to maintain cellular senescence by regulating genomic stability and DNA repair. EMBO Rep. 2009 Nov; 10(11):1272-8.
Score: 0.025
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microRNAs: novel components in a muscle gene regulatory network. Cell Cycle. 2009 Jun 15; 8(12):1833-7.
Score: 0.025
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The RelA/p65 subunit of NF-kappaB specifically regulates cyclin D1 protein stability: implications for cell cycle withdrawal and skeletal myogenesis. J Cell Biochem. 2009 Jan 01; 106(1):42-51.
Score: 0.024
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NF-kappaB-YY1-miR-29 regulatory circuitry in skeletal myogenesis and rhabdomyosarcoma. Cancer Cell. 2008 Nov 04; 14(5):369-81.
Score: 0.024
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IKK/NF-kappaB regulates skeletal myogenesis via a signaling switch to inhibit differentiation and promote mitochondrial biogenesis. J Cell Biol. 2008 Feb 25; 180(4):787-802.
Score: 0.023
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Skeletal muscle diseases, inflammation, and NF-kappaB signaling: insights and opportunities for therapeutic intervention. Int Rev Immunol. 2008; 27(5):375-87.
Score: 0.022
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NF-kappaB regulation of YY1 inhibits skeletal myogenesis through transcriptional silencing of myofibrillar genes. Mol Cell Biol. 2007 Jun; 27(12):4374-87.
Score: 0.021
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Interplay of IKK/NF-kappaB signaling in macrophages and myofibers promotes muscle degeneration in Duchenne muscular dystrophy. J Clin Invest. 2007 Apr; 117(4):889-901.
Score: 0.021
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Cancer cachexia signaling pathways continue to emerge yet much still points to the proteasome. Clin Cancer Res. 2007 Mar 01; 13(5):1356-61.
Score: 0.021
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Dystrophin glycoprotein complex dysfunction: a regulatory link between muscular dystrophy and cancer cachexia. Cancer Cell. 2005 Nov; 8(5):421-32.
Score: 0.019
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RelA/p65 regulation of IkappaBbeta. Mol Cell Biol. 2005 Jun; 25(12):4956-68.
Score: 0.019
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Cancer cachexia is regulated by selective targeting of skeletal muscle gene products. J Clin Invest. 2004 Aug; 114(3):370-8.
Score: 0.018
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Signaling pathways weigh in on decisions to make or break skeletal muscle. Curr Opin Clin Nutr Metab Care. 2004 Jul; 7(4):443-50.
Score: 0.018
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Tumor necrosis factor-regulated biphasic activation of NF-kappa B is required for cytokine-induced loss of skeletal muscle gene products. J Biol Chem. 2003 Jan 24; 278(4):2294-303.
Score: 0.016
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STAT3 in tumor fibroblasts promotes an immunosuppressive microenvironment in pancreatic cancer. Life Sci Alliance. 2022 11; 5(11).
Score: 0.015
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Extracellular vesicles derived from tumour cells as a trigger of energy crisis in the skeletal muscle. J Cachexia Sarcopenia Muscle. 2022 02; 13(1):481-494.
Score: 0.015
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NF-kappaB-induced loss of MyoD messenger RNA: possible role in muscle decay and cachexia. Science. 2000 Sep 29; 289(5488):2363-6.
Score: 0.014
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The RNA demethylase FTO is required for maintenance of bone mass and functions to protect osteoblasts from genotoxic damage. Proc Natl Acad Sci U S A. 2019 09 03; 116(36):17980-17989.
Score: 0.013
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NF-kappaB controls cell growth and differentiation through transcriptional regulation of cyclin D1. Mol Cell Biol. 1999 Aug; 19(8):5785-99.
Score: 0.012
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Requirement for NF-?B in maintenance of molecular and behavioral circadian rhythms in mice. Genes Dev. 2018 11 01; 32(21-22):1367-1379.
Score: 0.012
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The TLR7/8/9 Antagonist IMO-8503 Inhibits Cancer-Induced Cachexia. Cancer Res. 2018 12 01; 78(23):6680-6690.
Score: 0.012
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SAMHD1 suppresses innate immune responses to viral infections and inflammatory stimuli by inhibiting the NF-?B and interferon pathways. Proc Natl Acad Sci U S A. 2018 04 17; 115(16):E3798-E3807.
Score: 0.011
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Evaluation of patritumab with or without erlotinib in combination with standard cytotoxic agents against pediatric sarcoma xenograft models. Pediatr Blood Cancer. 2018 Feb; 65(2).
Score: 0.011
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Thrombin causes a marked delay in skeletal myogenesis that correlates with the delayed expression of myogenin and p21CIP1/WAF1. J Biol Chem. 1997 Sep 26; 272(39):24117-20.
Score: 0.011
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NF?B signaling in alveolar rhabdomyosarcoma. Dis Model Mech. 2017 09 01; 10(9):1109-1115.
Score: 0.011
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Target specificity, in vivo pharmacokinetics, and efficacy of the putative STAT3 inhibitor LY5 in osteosarcoma, Ewing's sarcoma, and rhabdomyosarcoma. PLoS One. 2017; 12(7):e0181885.
Score: 0.011
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Dual Inhibition of MEK and PI3K/Akt Rescues Cancer Cachexia through both Tumor-Extrinsic and -Intrinsic Activities. Mol Cancer Ther. 2017 02; 16(2):344-356.
Score: 0.010
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Characterization of the human protease nexin-1 promoter and its regulation by Sp1 through a G/C-rich activation domain. J Neurochem. 1996 Aug; 67(2):498-507.
Score: 0.010
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?Np63 mediates cellular survival and metastasis in canine osteosarcoma. Oncotarget. 2016 Jul 26; 7(30):48533-48546.
Score: 0.010
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Dissection of the Major Hematopoietic Quantitative Trait Locus in Chromosome 6q23.3 Identifies miR-3662 as a Player in Hematopoiesis and Acute Myeloid Leukemia. Cancer Discov. 2016 09; 6(9):1036-51.
Score: 0.010
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Mechano-signalling pathways in an experimental intensive critical illness myopathy model. J Physiol. 2016 08 01; 594(15):4371-88.
Score: 0.010
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Dietary Apigenin Exerts Immune-Regulatory Activity in Vivo by Reducing NF-?B Activity, Halting Leukocyte Infiltration and Restoring Normal Metabolic Function. Int J Mol Sci. 2016 Mar 01; 17(3):323.
Score: 0.010
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The Bromodomain BET Inhibitor JQ1 Suppresses Tumor Angiogenesis in Models of Childhood Sarcoma. Mol Cancer Ther. 2016 05; 15(5):1018-28.
Score: 0.010
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Serine/Threonine Kinase MLK4 Determines Mesenchymal Identity in Glioma Stem Cells in an NF-?B-dependent Manner. Cancer Cell. 2016 Feb 08; 29(2):201-13.
Score: 0.010
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Preclinical Investigation of the Novel Histone Deacetylase Inhibitor AR-42 in the Treatment of Cancer-Induced Cachexia. J Natl Cancer Inst. 2015 Dec; 107(12):djv274.
Score: 0.010
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Mineralocorticoid receptors are present in skeletal muscle and represent a potential therapeutic target. FASEB J. 2015 Nov; 29(11):4544-54.
Score: 0.009
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Metabolomic profiling reveals severe skeletal muscle group-specific perturbations of metabolism in aged FBN rats. Biogerontology. 2014 Jun; 15(3):217-32.
Score: 0.009
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Microvesicles containing miRNAs promote muscle cell death in cancer cachexia via TLR7. Proc Natl Acad Sci U S A. 2014 Mar 25; 111(12):4525-9.
Score: 0.009
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Microglia induce motor neuron death via the classical NF-?B pathway in amyotrophic lateral sclerosis. Neuron. 2014 Mar 05; 81(5):1009-1023.
Score: 0.009
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Regulation of skeletal muscle oxidative phenotype by classical NF-?B signalling. Biochim Biophys Acta. 2013 Aug; 1832(8):1313-25.
Score: 0.008
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NF-?B inhibition delays DNA damage-induced senescence and aging in mice. J Clin Invest. 2012 Jul; 122(7):2601-12.
Score: 0.008
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IKKa-mediated signaling circuitry regulates early B lymphopoiesis during hematopoiesis. Blood. 2012 Jun 07; 119(23):5467-77.
Score: 0.008
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Loss of miR-29 in myoblasts contributes to dystrophic muscle pathogenesis. Mol Ther. 2012 Jun; 20(6):1222-33.
Score: 0.008
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M-CSF induces monocyte survival by activating NF-?B p65 phosphorylation at Ser276 via protein kinase C. PLoS One. 2011; 6(12):e28081.
Score: 0.007
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NF-?B negatively impacts the myogenic potential of muscle-derived stem cells. Mol Ther. 2012 Mar; 20(3):661-8.
Score: 0.007
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STAT3 activation in skeletal muscle links muscle wasting and the acute phase response in cancer cachexia. PLoS One. 2011; 6(7):e22538.
Score: 0.007
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Myeloid-derived suppressor cell inhibition of the IFN response in tumor-bearing mice. Cancer Res. 2011 Aug 01; 71(15):5101-10.
Score: 0.007
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Oral resveratrol therapy inhibits cancer-induced skeletal muscle and cardiac atrophy in vivo. Nutr Cancer. 2011; 63(5):749-62.
Score: 0.007
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Systemic delivery of NEMO binding domain/IKK? inhibitory peptide to young mdx mice improves dystrophic skeletal muscle histopathology. Neurobiol Dis. 2011 Sep; 43(3):598-608.
Score: 0.007
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Improvement of cardiac contractile function by peptide-based inhibition of NF-?B in the utrophin/dystrophin-deficient murine model of muscular dystrophy. J Transl Med. 2011 May 17; 9:68.
Score: 0.007
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IL-4R drives dedifferentiation, mitogenesis, and metastasis in rhabdomyosarcoma. Clin Cancer Res. 2011 May 01; 17(9):2757-66.
Score: 0.007
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Peptide-based inhibition of NF-?B rescues diaphragm muscle contractile dysfunction in a murine model of Duchenne muscular dystrophy. Mol Med. 2011 May-Jun; 17(5-6):508-15.
Score: 0.007
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DUX4, a candidate gene for facioscapulohumeral muscular dystrophy, causes p53-dependent myopathy in vivo. Ann Neurol. 2011 Mar; 69(3):540-52.
Score: 0.007
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Inhibition of the IKK/NF-?B pathway by AAV gene transfer improves muscle regeneration in older mdx mice. Gene Ther. 2010 Dec; 17(12):1476-83.
Score: 0.007
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Zinc modulates the innate immune response in vivo to polymicrobial sepsis through regulation of NF-kappaB. Am J Physiol Lung Cell Mol Physiol. 2010 Jun; 298(6):L744-54.
Score: 0.007
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Bortezomib reverses a post-translational mechanism of tumorigenesis for patched1 haploinsufficiency in medulloblastoma. Pediatr Blood Cancer. 2009 Aug; 53(2):136-44.
Score: 0.006
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Epigenetic changes during disease progression in a murine model of human chronic lymphocytic leukemia. Proc Natl Acad Sci U S A. 2009 Aug 11; 106(32):13433-8.
Score: 0.006
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IFN-alpha and bortezomib overcome Bcl-2 and Mcl-1 overexpression in melanoma cells by stimulating the extrinsic pathway of apoptosis. Cancer Res. 2008 Oct 15; 68(20):8351-60.
Score: 0.006
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Immunocompetent murine model of cancer cachexia for head and neck squamous cell carcinoma. Head Neck. 2008 Mar; 30(3):320-6.
Score: 0.006
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Prevention of upper aerodigestive tract cancer in zinc-deficient rodents: inefficacy of genetic or pharmacological disruption of COX-2. Int J Cancer. 2008 Mar 01; 122(5):978-89.
Score: 0.006
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Comparison of animal models for head and neck cancer cachexia. Laryngoscope. 2007 Dec; 117(12):2152-8.
Score: 0.006
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The effect of altered Toll-like receptor 4 signaling on cancer cachexia. Arch Otolaryngol Head Neck Surg. 2007 Dec; 133(12):1263-9.
Score: 0.006
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Apigenin blocks lipopolysaccharide-induced lethality in vivo and proinflammatory cytokines expression by inactivating NF-kappaB through the suppression of p65 phosphorylation. J Immunol. 2007 Nov 15; 179(10):7121-7.
Score: 0.006
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Biomechanical signals suppress TAK1 activation to inhibit NF-kappaB transcriptional activation in fibrochondrocytes. J Immunol. 2007 Nov 01; 179(9):6246-54.
Score: 0.006
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Transcriptional regulation of parathyroid hormone-related protein promoter P2 by NF-kappaB in adult T-cell leukemia/lymphoma. Leukemia. 2007 Aug; 21(8):1752-62.
Score: 0.005
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Cancer cachexia syndrome in head and neck cancer patients: Part II. Pathophysiology. Head Neck. 2007 May; 29(5):497-507.
Score: 0.005
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The molecular mechanisms of skeletal muscle wasting: implications for therapy. Surgeon. 2006 Oct; 4(5):273-83.
Score: 0.005
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ASC directs NF-kappaB activation by regulating receptor interacting protein-2 (RIP2) caspase-1 interactions. J Immunol. 2006 Apr 15; 176(8):4979-86.
Score: 0.005
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Role for activating transcription factor 3 in stress-induced beta-cell apoptosis. Mol Cell Biol. 2004 Jul; 24(13):5721-32.
Score: 0.004
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NF-kappa B and I kappa B alpha are found in the mitochondria. Evidence for regulation of mitochondrial gene expression by NF-kappa B. J Biol Chem. 2003 Jan 31; 278(5):2963-8.
Score: 0.004
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Wnt signaling promotes oncogenic transformation by inhibiting c-Myc-induced apoptosis. J Cell Biol. 2002 Apr 29; 157(3):429-40.
Score: 0.004
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Suppression of tumor necrosis factor-mediated apoptosis by nuclear factor kappaB-independent bone morphogenetic protein/Smad signaling. J Biol Chem. 2001 Oct 19; 276(42):39259-63.
Score: 0.004
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Wnt-1 signaling inhibits apoptosis by activating beta-catenin/T cell factor-mediated transcription. J Cell Biol. 2001 Jan 08; 152(1):87-96.
Score: 0.003
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Akt suppresses apoptosis by stimulating the transactivation potential of the RelA/p65 subunit of NF-kappaB. Mol Cell Biol. 2000 Mar; 20(5):1626-38.
Score: 0.003