Denis Guttridge to Humans
This is a "connection" page, showing publications Denis Guttridge has written about Humans.
Connection Strength
0.683
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Cancer cachexia: involvement of an expanding macroenvironment. Cancer Cell. 2023 03 13; 41(3):581-584.
Score: 0.033
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Emerging signaling mediators in the anorexia-cachexia syndrome of cancer. Trends Cancer. 2022 05; 8(5):397-403.
Score: 0.031
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Modeling Human Cancer-induced Cachexia. Cell Rep. 2019 08 06; 28(6):1612-1622.e4.
Score: 0.026
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Circulating monocyte chemoattractant protein-1 (MCP-1) is associated with cachexia in treatment-na?ve pancreatic cancer patients. J Cachexia Sarcopenia Muscle. 2018 04; 9(2):358-368.
Score: 0.023
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Dysregulated Myogenesis in Rhabdomyosarcoma. Curr Top Dev Biol. 2018; 126:285-297.
Score: 0.023
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Inflammation induced loss of skeletal muscle. Bone. 2015 Nov; 80:131-142.
Score: 0.020
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A TGF-? pathway associated with cancer cachexia. Nat Med. 2015 Nov; 21(11):1248-9.
Score: 0.020
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Impaired regeneration: A role for the muscle microenvironment in cancer cachexia. Semin Cell Dev Biol. 2016 06; 54:82-91.
Score: 0.020
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Inflammation based regulation of cancer cachexia. Biomed Res Int. 2014; 2014:168407.
Score: 0.018
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NF-?B-mediated Pax7 dysregulation in the muscle microenvironment promotes cancer cachexia. J Clin Invest. 2013 Nov; 123(11):4821-35.
Score: 0.017
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Mechanisms of impaired differentiation in rhabdomyosarcoma. FEBS J. 2013 Sep; 280(17):4323-34.
Score: 0.017
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miR-29 acts as a decoy in sarcomas to protect the tumor suppressor A20 mRNA from degradation by HuR. Sci Signal. 2013 Jul 30; 6(286):ra63.
Score: 0.017
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Reining in nuclear factor-kappaB in skeletal muscle disorders. Curr Opin Clin Nutr Metab Care. 2013 May; 16(3):251-7.
Score: 0.017
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Mechanisms for maintaining muscle. Curr Opin Support Palliat Care. 2012 Dec; 6(4):451-6.
Score: 0.016
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Cancer cachexia: mediators, signaling, and metabolic pathways. Cell Metab. 2012 Aug 08; 16(2):153-66.
Score: 0.016
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Making muscles grow by g protein-coupled receptor signaling. Sci Signal. 2011 Nov 29; 4(201):pe45.
Score: 0.015
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NF-?B signaling in skeletal muscle health and disease. Curr Top Dev Biol. 2011; 96:85-119.
Score: 0.014
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TNF inhibits Notch-1 in skeletal muscle cells by Ezh2 and DNA methylation mediated repression: implications in duchenne muscular dystrophy. PLoS One. 2010 Aug 30; 5(8):e12479.
Score: 0.014
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microRNAs: novel components in a muscle gene regulatory network. Cell Cycle. 2009 Jun 15; 8(12):1833-7.
Score: 0.013
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NF-kappaB-YY1-miR-29 regulatory circuitry in skeletal myogenesis and rhabdomyosarcoma. Cancer Cell. 2008 Nov 04; 14(5):369-81.
Score: 0.012
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Skeletal muscle diseases, inflammation, and NF-kappaB signaling: insights and opportunities for therapeutic intervention. Int Rev Immunol. 2008; 27(5):375-87.
Score: 0.012
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NF-kappaB regulation of YY1 inhibits skeletal myogenesis through transcriptional silencing of myofibrillar genes. Mol Cell Biol. 2007 Jun; 27(12):4374-87.
Score: 0.011
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Interplay of IKK/NF-kappaB signaling in macrophages and myofibers promotes muscle degeneration in Duchenne muscular dystrophy. J Clin Invest. 2007 Apr; 117(4):889-901.
Score: 0.011
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Cancer cachexia signaling pathways continue to emerge yet much still points to the proteasome. Clin Cancer Res. 2007 Mar 01; 13(5):1356-61.
Score: 0.011
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Dystrophin glycoprotein complex dysfunction: a regulatory link between muscular dystrophy and cancer cachexia. Cancer Cell. 2005 Nov; 8(5):421-32.
Score: 0.010
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Signaling pathways weigh in on decisions to make or break skeletal muscle. Curr Opin Clin Nutr Metab Care. 2004 Jul; 7(4):443-50.
Score: 0.009
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Tumor necrosis factor-regulated biphasic activation of NF-kappa B is required for cytokine-induced loss of skeletal muscle gene products. J Biol Chem. 2003 Jan 24; 278(4):2294-303.
Score: 0.008
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Editorial: Highlights from the 2020 virtual cancer cachexia conference. Curr Opin Support Palliat Care. 2021 03 01; 15(1):48-49.
Score: 0.007
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NF-kappaB controls cell growth and differentiation through transcriptional regulation of cyclin D1. Mol Cell Biol. 1999 Aug; 19(8):5785-99.
Score: 0.006
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Circulating interleukin-6 is associated with disease progression, but not cachexia in pancreatic cancer. Pancreatology. 2019 Jan; 19(1):80-87.
Score: 0.006
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The TLR7/8/9 Antagonist IMO-8503 Inhibits Cancer-Induced Cachexia. Cancer Res. 2018 12 01; 78(23):6680-6690.
Score: 0.006
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SAMHD1 suppresses innate immune responses to viral infections and inflammatory stimuli by inhibiting the NF-?B and interferon pathways. Proc Natl Acad Sci U S A. 2018 04 17; 115(16):E3798-E3807.
Score: 0.006
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Cancer-associated cachexia. Nat Rev Dis Primers. 2018 01 18; 4:17105.
Score: 0.006
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Perioperative cytokine levels portend early death after pancreatectomy for ductal adenocarcinoma. J Surg Oncol. 2018 May; 117(6):1260-1266.
Score: 0.006
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Evaluation of patritumab with or without erlotinib in combination with standard cytotoxic agents against pediatric sarcoma xenograft models. Pediatr Blood Cancer. 2018 Feb; 65(2).
Score: 0.006
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Predictors of Pancreatic Cancer-Associated Weight Loss and Nutritional Interventions. Pancreas. 2017 10; 46(9):1152-1157.
Score: 0.006
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NF?B signaling in alveolar rhabdomyosarcoma. Dis Model Mech. 2017 09 01; 10(9):1109-1115.
Score: 0.006
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Target specificity, in vivo pharmacokinetics, and efficacy of the putative STAT3 inhibitor LY5 in osteosarcoma, Ewing's sarcoma, and rhabdomyosarcoma. PLoS One. 2017; 12(7):e0181885.
Score: 0.006
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Enhancing the Cell Permeability and Metabolic Stability of Peptidyl Drugs by Reversible Bicyclization. Angew Chem Int Ed Engl. 2017 02 01; 56(6):1525-1529.
Score: 0.005
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Ken Fearon. Cell Metab. 2016 12 13; 24(6):765-766.
Score: 0.005
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Dual Inhibition of MEK and PI3K/Akt Rescues Cancer Cachexia through both Tumor-Extrinsic and -Intrinsic Activities. Mol Cancer Ther. 2017 02; 16(2):344-356.
Score: 0.005
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Characterization of the human protease nexin-1 promoter and its regulation by Sp1 through a G/C-rich activation domain. J Neurochem. 1996 Aug; 67(2):498-507.
Score: 0.005
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Dissection of the Major Hematopoietic Quantitative Trait Locus in Chromosome 6q23.3 Identifies miR-3662 as a Player in Hematopoiesis and Acute Myeloid Leukemia. Cancer Discov. 2016 09; 6(9):1036-51.
Score: 0.005
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The Bromodomain BET Inhibitor JQ1 Suppresses Tumor Angiogenesis in Models of Childhood Sarcoma. Mol Cancer Ther. 2016 05; 15(5):1018-28.
Score: 0.005
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A selective screening platform reveals unique global expression patterns of microRNAs in a cohort of human soft-tissue sarcomas. Lab Invest. 2016 Apr; 96(4):481-91.
Score: 0.005
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Serine/Threonine Kinase MLK4 Determines Mesenchymal Identity in Glioma Stem Cells in an NF-?B-dependent Manner. Cancer Cell. 2016 Feb 08; 29(2):201-13.
Score: 0.005
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Mineralocorticoid receptors are present in skeletal muscle and represent a potential therapeutic target. FASEB J. 2015 Nov; 29(11):4544-54.
Score: 0.005
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Cancer cachexia update in head and neck cancer: Pathophysiology and treatment. Head Neck. 2015 Jul; 37(7):1057-72.
Score: 0.005
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Rhabdomyosarcoma: current challenges and their implications for developing therapies. Cold Spring Harb Perspect Med. 2014 Nov 03; 4(11):a025650.
Score: 0.005
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Cancer cachexia update in head and neck cancer: Definitions and diagnostic features. Head Neck. 2015 Apr; 37(4):594-604.
Score: 0.004
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Microvesicles containing miRNAs promote muscle cell death in cancer cachexia via TLR7. Proc Natl Acad Sci U S A. 2014 Mar 25; 111(12):4525-9.
Score: 0.004
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Expression of cancer-testis antigens MAGEA1, MAGEA3, ACRBP, PRAME, SSX2, and CTAG2 in myxoid and round cell liposarcoma. Mod Pathol. 2014 Sep; 27(9):1238-45.
Score: 0.004
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Protease nexin-1, a thrombin inhibitor, is regulated by interleukin-1 and dexamethasone in normal human fibroblasts. J Biol Chem. 1993 Sep 05; 268(25):18966-74.
Score: 0.004
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Disrupting cytokine signaling in pancreatic cancer: a phase I/II study of etanercept in combination with gemcitabine in patients with advanced disease. Pancreas. 2013 Jul; 42(5):813-8.
Score: 0.004
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Regulation of skeletal muscle oxidative phenotype by classical NF-?B signalling. Biochim Biophys Acta. 2013 Aug; 1832(8):1313-25.
Score: 0.004
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The cancer-testis antigen NY-ESO-1 is highly expressed in myxoid and round cell subset of liposarcomas. Mod Pathol. 2013 Feb; 26(2):282-8.
Score: 0.004
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Report on the Myomatrix Conference April 22-24, 2012, University of Nevada, Reno, Nevada, USA. Neuromuscul Disord. 2013 Feb; 23(2):188-91.
Score: 0.004
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STAT3 activation in skeletal muscle links muscle wasting and the acute phase response in cancer cachexia. PLoS One. 2011; 6(7):e22538.
Score: 0.004
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IL-4R drives dedifferentiation, mitogenesis, and metastasis in rhabdomyosarcoma. Clin Cancer Res. 2011 May 01; 17(9):2757-66.
Score: 0.004
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Mass spectrometric detection of candidate protein biomarkers of cancer cachexia in human urine. Int J Oncol. 2010 Apr; 36(4):973-82.
Score: 0.003
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Zinc modulates the innate immune response in vivo to polymicrobial sepsis through regulation of NF-kappaB. Am J Physiol Lung Cell Mol Physiol. 2010 Jun; 298(6):L744-54.
Score: 0.003
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A novel role for IkappaBzeta in the regulation of IFNgamma production. PLoS One. 2009 Aug 26; 4(8):e6776.
Score: 0.003
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Bortezomib reverses a post-translational mechanism of tumorigenesis for patched1 haploinsufficiency in medulloblastoma. Pediatr Blood Cancer. 2009 Aug; 53(2):136-44.
Score: 0.003
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Epigenetic changes during disease progression in a murine model of human chronic lymphocytic leukemia. Proc Natl Acad Sci U S A. 2009 Aug 11; 106(32):13433-8.
Score: 0.003
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IFN-alpha and bortezomib overcome Bcl-2 and Mcl-1 overexpression in melanoma cells by stimulating the extrinsic pathway of apoptosis. Cancer Res. 2008 Oct 15; 68(20):8351-60.
Score: 0.003
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Cachexia: a new definition. Clin Nutr. 2008 Dec; 27(6):793-9.
Score: 0.003
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Comparison of animal models for head and neck cancer cachexia. Laryngoscope. 2007 Dec; 117(12):2152-8.
Score: 0.003
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Apigenin blocks lipopolysaccharide-induced lethality in vivo and proinflammatory cytokines expression by inactivating NF-kappaB through the suppression of p65 phosphorylation. J Immunol. 2007 Nov 15; 179(10):7121-7.
Score: 0.003
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Epstein-Barr virus-encoded dUTPase enhances proinflammatory cytokine production by macrophages in contact with endothelial cells: evidence for depression-induced atherosclerotic risk. Brain Behav Immun. 2008 Feb; 22(2):215-23.
Score: 0.003
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Transcriptional regulation of parathyroid hormone-related protein promoter P2 by NF-kappaB in adult T-cell leukemia/lymphoma. Leukemia. 2007 Aug; 21(8):1752-62.
Score: 0.003
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Cancer cachexia syndrome in head and neck cancer patients: Part II. Pathophysiology. Head Neck. 2007 May; 29(5):497-507.
Score: 0.003
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Cancer cachexia syndrome in head and neck cancer patients: part I. Diagnosis, impact on quality of life and survival, and treatment. Head Neck. 2007 Apr; 29(4):401-11.
Score: 0.003
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The molecular mechanisms of skeletal muscle wasting: implications for therapy. Surgeon. 2006 Oct; 4(5):273-83.
Score: 0.003
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Assessment of tumor necrosis factor alpha blockade as an intervention to improve tolerability of dose-intensive chemotherapy in cancer patients. J Clin Oncol. 2006 Apr 20; 24(12):1852-9.
Score: 0.003
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ASC directs NF-kappaB activation by regulating receptor interacting protein-2 (RIP2) caspase-1 interactions. J Immunol. 2006 Apr 15; 176(8):4979-86.
Score: 0.003
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NF-kappa B and I kappa B alpha are found in the mitochondria. Evidence for regulation of mitochondrial gene expression by NF-kappa B. J Biol Chem. 2003 Jan 31; 278(5):2963-8.
Score: 0.002
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Wnt signaling promotes oncogenic transformation by inhibiting c-Myc-induced apoptosis. J Cell Biol. 2002 Apr 29; 157(3):429-40.
Score: 0.002
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Suppression of tumor necrosis factor-mediated apoptosis by nuclear factor kappaB-independent bone morphogenetic protein/Smad signaling. J Biol Chem. 2001 Oct 19; 276(42):39259-63.
Score: 0.002
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Inhibition of NF-kappa B activity by thalidomide through suppression of IkappaB kinase activity. J Biol Chem. 2001 Jun 22; 276(25):22382-7.
Score: 0.002
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Wnt-1 signaling inhibits apoptosis by activating beta-catenin/T cell factor-mediated transcription. J Cell Biol. 2001 Jan 08; 152(1):87-96.
Score: 0.002
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Levodopa-carbidopa. Aust Nurses J. 1980 May; 9(10):28-9.
Score: 0.002
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Selective activation of NF-kappa B subunits in human breast cancer: potential roles for NF-kappa B2/p52 and for Bcl-3. Oncogene. 2000 Feb 24; 19(9):1123-31.
Score: 0.002
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NF-kappaB induces expression of the Bcl-2 homologue A1/Bfl-1 to preferentially suppress chemotherapy-induced apoptosis. Mol Cell Biol. 1999 Sep; 19(9):5923-9.
Score: 0.002
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IkappaBalpha gene transfer is cytotoxic to squamous-cell lung cancer cells and sensitizes them to tumor necrosis factor-alpha-mediated cell death. Am J Respir Cell Mol Biol. 1999 Aug; 21(2):238-45.
Score: 0.002