Connection

Adviye Ergul to Male

This is a "connection" page, showing publications Adviye Ergul has written about Male.
Connection Strength

1.677
  1. Deferoxamine prevents poststroke memory impairment in female diabetic rats: potential links to hemorrhagic transformation and ferroptosis. Am J Physiol Heart Circ Physiol. 2023 02 01; 324(2):H212-H225.
    View in: PubMed
    Score: 0.045
  2. Cerebral microvascular matrix metalloproteinase-3 (MMP3) contributes to vascular injury after stroke in female diabetic rats. Neurochem Int. 2023 01; 162:105462.
    View in: PubMed
    Score: 0.045
  3. Vascular contributions to cognitive impairment/dementia in diabetes: role of endothelial cells and pericytes. Am J Physiol Cell Physiol. 2022 10 01; 323(4):C1177-C1189.
    View in: PubMed
    Score: 0.044
  4. Diabetic rats are more susceptible to cognitive decline in a model of microemboli-mediated vascular contributions to cognitive impairment and dementia. Brain Res. 2020 12 15; 1749:147132.
    View in: PubMed
    Score: 0.039
  5. Deferoxamine Treatment Prevents Post-Stroke Vasoregression and Neurovascular Unit Remodeling Leading to Improved Functional Outcomes in Type 2 Male Diabetic Rats: Role of Endothelial Ferroptosis. Transl Stroke Res. 2021 08; 12(4):615-630.
    View in: PubMed
    Score: 0.039
  6. Diabetes-related sex differences in the brain endothelin system following ischemia in vivo and in human brain endothelial cells in vitro. Can J Physiol Pharmacol. 2020 Sep; 98(9):587-595.
    View in: PubMed
    Score: 0.038
  7. Microglia knockdown reduces inflammation and preserves cognition in diabetic animals after experimental stroke. J Neuroinflammation. 2020 Apr 28; 17(1):137.
    View in: PubMed
    Score: 0.038
  8. Delayed Administration of Angiotensin II Type 2 Receptor (AT2R) Agonist Compound 21 Prevents the Development of Post-stroke Cognitive Impairment in Diabetes Through the Modulation of Microglia Polarization. Transl Stroke Res. 2020 08; 11(4):762-775.
    View in: PubMed
    Score: 0.037
  9. Diabetic Stroke Promotes a Sexually Dimorphic Expansion of T Cells. Neuromolecular Med. 2019 12; 21(4):445-453.
    View in: PubMed
    Score: 0.035
  10. NLRP3 inflammasome inhibition with MCC950 improves diabetes-mediated cognitive impairment and vasoneuronal remodeling after ischemia. Pharmacol Res. 2019 04; 142:237-250.
    View in: PubMed
    Score: 0.035
  11. Post-stroke neovascularization and functional outcomes differ in diabetes depending on severity of injury and sex: Potential link to hemorrhagic transformation. Exp Neurol. 2019 01; 311:106-114.
    View in: PubMed
    Score: 0.034
  12. Poststroke cognitive impairment and hippocampal neurovascular remodeling: the impact of diabetes and sex. Am J Physiol Heart Circ Physiol. 2018 11 01; 315(5):H1402-H1413.
    View in: PubMed
    Score: 0.033
  13. Inhibition of Toll-Like Receptor-4 (TLR-4) Improves Neurobehavioral Outcomes After Acute Ischemic Stroke in Diabetic Rats: Possible Role of Vascular Endothelial TLR-4. Mol Neurobiol. 2019 Mar; 56(3):1607-1617.
    View in: PubMed
    Score: 0.033
  14. Peroxynitrite-Induced Tyrosine Nitration Contributes to Matrix Metalloprotease-3 Activation: Relevance to Hyperglycemic Ischemic Brain Injury and Tissue Plasminogen Activator. Neurochem Res. 2018 Feb; 43(2):259-266.
    View in: PubMed
    Score: 0.032
  15. TLR2 knockout protects against diabetes-mediated changes in cerebral perfusion and cognitive deficits. Am J Physiol Regul Integr Comp Physiol. 2017 06 01; 312(6):R927-R937.
    View in: PubMed
    Score: 0.030
  16. Linagliptin treatment improves cerebrovascular function and remodeling and restores reduced cerebral perfusion in Type 2 diabetes. Am J Physiol Regul Integr Comp Physiol. 2016 09 01; 311(3):R466-77.
    View in: PubMed
    Score: 0.029
  17. Diabetes-mediated middle cerebral artery remodeling is restored by linagliptin: Interaction with the vascular smooth muscle cell endothelin system. Life Sci. 2016 Aug 15; 159:76-82.
    View in: PubMed
    Score: 0.028
  18. Linagliptin reduces effects of ET-1 and TLR2-mediated cerebrovascular hyperreactivity in diabetes. Life Sci. 2016 Aug 15; 159:90-96.
    View in: PubMed
    Score: 0.028
  19. Matrix Metalloprotease 3 Exacerbates Hemorrhagic Transformation and Worsens Functional Outcomes in Hyperglycemic Stroke. Stroke. 2016 Mar; 47(3):843-51.
    View in: PubMed
    Score: 0.028
  20. Linagliptin attenuates diabetes-induced cerebral pathological neovascularization in a blood glucose-independent manner: Potential role of ET-1. Life Sci. 2016 Aug 15; 159:83-89.
    View in: PubMed
    Score: 0.028
  21. Comparative Analysis of Different Methods of Ischemia/Reperfusion in Hyperglycemic Stroke Outcomes: Interaction with tPA. Transl Stroke Res. 2015 Jun; 6(3):171-80.
    View in: PubMed
    Score: 0.026
  22. SOD1 overexpression prevents acute hyperglycemia-induced cerebral myogenic dysfunction: relevance to contralateral hemisphere and stroke outcomes. Am J Physiol Heart Circ Physiol. 2015 Mar 01; 308(5):H456-66.
    View in: PubMed
    Score: 0.026
  23. Cerebrovasculoprotective effects of azilsartan medoxomil in diabetes. Transl Res. 2014 Nov; 164(5):424-32.
    View in: PubMed
    Score: 0.025
  24. Reply to "Letter to the editor: 'Targeting cerebrovascular myogenic dysfunction in stroke'". Am J Physiol Heart Circ Physiol. 2014 May 15; 306(10):H1483.
    View in: PubMed
    Score: 0.025
  25. Hyperglycemia, acute ischemic stroke, and thrombolytic therapy. Transl Stroke Res. 2014 Aug; 5(4):442-453.
    View in: PubMed
    Score: 0.025
  26. Comparative analysis of the neurovascular injury and functional outcomes in experimental stroke models in diabetic Goto-Kakizaki rats. Brain Res. 2013 Dec 06; 1541:106-14.
    View in: PubMed
    Score: 0.024
  27. Protein nitration impairs the myogenic tone of rat middle cerebral arteries in both ischemic and nonischemic hemispheres after ischemic stroke. Am J Physiol Heart Circ Physiol. 2013 Dec; 305(12):H1726-35.
    View in: PubMed
    Score: 0.024
  28. Early effects of high-fat diet on neurovascular function and focal ischemic brain injury. Am J Physiol Regul Integr Comp Physiol. 2013 Jun 01; 304(11):R1001-8.
    View in: PubMed
    Score: 0.023
  29. Targets of vascular protection in acute ischemic stroke differ in type 2 diabetes. Am J Physiol Heart Circ Physiol. 2013 Mar 15; 304(6):H806-15.
    View in: PubMed
    Score: 0.023
  30. Cerebrovascular complications of diabetes: focus on stroke. Endocr Metab Immune Disord Drug Targets. 2012 Jun; 12(2):148-58.
    View in: PubMed
    Score: 0.022
  31. Cerebral myogenic reactivity and blood flow in type 2 diabetic rats: role of peroxynitrite in hypoxia-mediated loss of myogenic tone. J Pharmacol Exp Ther. 2012 Aug; 342(2):407-15.
    View in: PubMed
    Score: 0.022
  32. Enhanced cerebral but not peripheral angiogenesis in the Goto-Kakizaki model of type 2 diabetes involves VEGF and peroxynitrite signaling. Diabetes. 2012 Jun; 61(6):1533-42.
    View in: PubMed
    Score: 0.021
  33. The effect of endothelin receptor A antagonism on basilar artery endothelium-dependent relaxation after ischemic stroke. Life Sci. 2012 Oct 15; 91(13-14):676-80.
    View in: PubMed
    Score: 0.021
  34. Comparison of selective versus dual endothelin receptor antagonism on cerebrovascular dysfunction in diabetes. Neurol Res. 2011 Mar; 33(2):185-91.
    View in: PubMed
    Score: 0.020
  35. Endothelial endothelin B receptor-mediated prevention of cerebrovascular remodeling is attenuated in diabetes because of up-regulation of smooth muscle endothelin receptors. J Pharmacol Exp Ther. 2011 Apr; 337(1):9-15.
    View in: PubMed
    Score: 0.020
  36. Endothelin-1-mediated cerebrovascular remodeling is not associated with increased ischemic brain injury in diabetes. Can J Physiol Pharmacol. 2010 Aug; 88(8):788-95.
    View in: PubMed
    Score: 0.019
  37. Vascular protection in diabetic stroke: role of matrix metalloprotease-dependent vascular remodeling. J Cereb Blood Flow Metab. 2010 Dec; 30(12):1928-38.
    View in: PubMed
    Score: 0.019
  38. Dual endothelin receptor antagonism prevents remodeling of resistance arteries in diabetes. Can J Physiol Pharmacol. 2010 Jun; 88(6):616-21.
    View in: PubMed
    Score: 0.019
  39. Adaptive cerebral neovascularization in a model of type 2 diabetes: relevance to focal cerebral ischemia. Diabetes. 2010 Jan; 59(1):228-35.
    View in: PubMed
    Score: 0.018
  40. Glycemic control prevents microvascular remodeling and increased tone in type 2 diabetes: link to endothelin-1. Am J Physiol Regul Integr Comp Physiol. 2009 Apr; 296(4):R952-9.
    View in: PubMed
    Score: 0.017
  41. Differential effects of diet-induced dyslipidemia and hyperglycemia on mesenteric resistance artery structure and function in type 2 diabetes. J Pharmacol Exp Ther. 2009 Jan; 328(1):123-30.
    View in: PubMed
    Score: 0.017
  42. Impaired insulin-mediated vasorelaxation in a nonobese model of type 2 diabetes: role of endothelin-1. Can J Physiol Pharmacol. 2008 Jun; 86(6):358-64.
    View in: PubMed
    Score: 0.016
  43. Effect of chronic and selective endothelin receptor antagonism on microvascular function in type 2 diabetes. Am J Physiol Heart Circ Physiol. 2008 Jun; 294(6):H2743-9.
    View in: PubMed
    Score: 0.016
  44. Effect of chronic endothelin receptor antagonism on cerebrovascular function in type 2 diabetes. Am J Physiol Regul Integr Comp Physiol. 2008 Apr; 294(4):R1213-9.
    View in: PubMed
    Score: 0.016
  45. Increased hemorrhagic transformation and altered infarct size and localization after experimental stroke in a rat model type 2 diabetes. BMC Neurol. 2007 Oct 15; 7:33.
    View in: PubMed
    Score: 0.016
  46. Evidence for vasculoprotective effects of ETB receptors in resistance artery remodeling in diabetes. Diabetes. 2007 Nov; 56(11):2753-8.
    View in: PubMed
    Score: 0.016
  47. Differential effects of ET(A) and ET(B) receptor antagonism on oxidative stress in type 2 diabetes. Vascul Pharmacol. 2007 Aug-Sep; 47(2-3):125-30.
    View in: PubMed
    Score: 0.015
  48. Elevated endothelin-1 levels are associated with decreased arterial elasticity in hypertensive patients. J Clin Hypertens (Greenwich). 2006 Aug; 8(8):549-54.
    View in: PubMed
    Score: 0.015
  49. Microvascular versus macrovascular dysfunction in type 2 diabetes: differences in contractile responses to endothelin-1. Exp Biol Med (Maywood). 2006 Jun; 231(6):1016-21.
    View in: PubMed
    Score: 0.014
  50. Type-2 diabetes-induced changes in vascular extracellular matrix gene expression: relation to vessel size. Cardiovasc Diabetol. 2006 Feb 17; 5:3.
    View in: PubMed
    Score: 0.014
  51. Endothelin antagonism prevents early EGFR transactivation but not increased matrix metalloproteinase activity in diabetes. Am J Physiol Regul Integr Comp Physiol. 2006 Feb; 290(2):R435-41.
    View in: PubMed
    Score: 0.014
  52. Vascular dysfunction of venous bypass conduits is mediated by reactive oxygen species in diabetes: role of endothelin-1. J Pharmacol Exp Ther. 2005 Apr; 313(1):70-7.
    View in: PubMed
    Score: 0.013
  53. Downregulation of vascular matrix metalloproteinase inducer and activator proteins in hypertensive patients. Am J Hypertens. 2004 Sep; 17(9):775-82.
    View in: PubMed
    Score: 0.013
  54. Native matrix metalloproteinase characteristics may influence early stenosis of venous versus arterial coronary artery bypass grafting conduits. Chest. 2004 May; 125(5):1853-8.
    View in: PubMed
    Score: 0.012
  55. Stress upregulates arterial matrix metalloproteinase expression and activity via endothelin A receptor activation. Am J Physiol Heart Circ Physiol. 2003 Nov; 285(5):H2225-32.
    View in: PubMed
    Score: 0.012
  56. Saphenous vein endothelin system expression and activity in African American patients. Arterioscler Thromb Vasc Biol. 2002 Jul 01; 22(7):1122-7.
    View in: PubMed
    Score: 0.011
  57. Selective downregulation of endothelin-B receptors in diabetic African-American patients. Ethn Dis. 2002; 12(1):S1-46-50.
    View in: PubMed
    Score: 0.011
  58. Vascular endothelin converting enzyme-1 expression and activity is upregulated in clinical diabetes. Ethn Dis. 2002; 12(4):S3-5-9.
    View in: PubMed
    Score: 0.011
  59. Stimulation of angiotensin II receptor 2 preserves cognitive function and is associated with an enhanced cerebral vascular density after stroke. Vascul Pharmacol. 2021 12; 141:106904.
    View in: PubMed
    Score: 0.010
  60. Stroke promotes the development of brain atrophy and delayed cell death in hypertensive rats. Sci Rep. 2020 11 19; 10(1):20233.
    View in: PubMed
    Score: 0.010
  61. Neurovascular protection in voltage-gated proton channel Hv1 knock-out rats after ischemic stroke: interaction with Na+ /H+ exchanger-1 antagonism. Physiol Rep. 2019 08; 7(13):e14142.
    View in: PubMed
    Score: 0.009
  62. Angiotensin II type 2 receptor stimulation with compound 21 improves neurological function after stroke in female rats: a pilot study. Am J Physiol Heart Circ Physiol. 2019 05 01; 316(5):H1192-H1201.
    View in: PubMed
    Score: 0.009
  63. Inhibition of Ephrin-B2 in brain pericytes decreases cerebral pathological neovascularization in diabetic rats. PLoS One. 2019; 14(1):e0210523.
    View in: PubMed
    Score: 0.009
  64. Endothelial stromelysin1 regulation by the forkhead box-O transcription factors is crucial in the exudative phase of acute lung injury. Pharmacol Res. 2019 03; 141:249-263.
    View in: PubMed
    Score: 0.009
  65. Angiotensin receptor (AT2R) agonist C21 prevents cognitive decline after permanent stroke in aged animals-A randomized double- blind pre-clinical study. Behav Brain Res. 2019 02 01; 359:560-569.
    View in: PubMed
    Score: 0.008
  66. RAS modulation prevents progressive cognitive impairment after experimental stroke: a randomized, blinded preclinical trial. J Neuroinflammation. 2018 Aug 13; 15(1):229.
    View in: PubMed
    Score: 0.008
  67. Dose-response, therapeutic time-window and tPA-combinatorial efficacy of compound 21: A randomized, blinded preclinical trial in a rat model of thromboembolic stroke. J Cereb Blood Flow Metab. 2019 08; 39(8):1635-1647.
    View in: PubMed
    Score: 0.008
  68. Role of angiotensin system modulation on progression of cognitive impairment and brain MRI changes in aged hypertensive animals - A randomized double- blind pre-clinical study. Behav Brain Res. 2018 07 02; 346:29-40.
    View in: PubMed
    Score: 0.008
  69. Minocycline in Acute Cerebral Hemorrhage: An Early Phase Randomized Trial. Stroke. 2017 10; 48(10):2885-2887.
    View in: PubMed
    Score: 0.008
  70. Mechanisms of acute neurovascular protection with AT1 blockade after stroke: Effect of prestroke hypertension. PLoS One. 2017; 12(6):e0178867.
    View in: PubMed
    Score: 0.008
  71. Role of interleukin-10 in the neuroprotective effect of the Angiotensin Type 2 Receptor agonist, compound 21, after ischemia/reperfusion injury. Eur J Pharmacol. 2017 Mar 15; 799:128-134.
    View in: PubMed
    Score: 0.008
  72. High-fat diet increases O-GlcNAc levels in cerebral arteries: a link to vascular dysfunction associated with hyperlipidaemia/obesity? Clin Sci (Lond). 2016 06 01; 130(11):871-80.
    View in: PubMed
    Score: 0.007
  73. Brain-Derived Neurotrophic Factor Knockdown Blocks the Angiogenic and Protective Effects of Angiotensin Modulation After Experimental Stroke. Mol Neurobiol. 2017 01; 54(1):661-670.
    View in: PubMed
    Score: 0.007
  74. The Akt inhibitor, triciribine, ameliorates chronic hypoxia-induced vascular pruning and TGF?-induced pulmonary fibrosis. Br J Pharmacol. 2015 Aug; 172(16):4173-88.
    View in: PubMed
    Score: 0.007
  75. Remote ischemic postconditioning: harnessing endogenous protection in a murine model of vascular cognitive impairment. Transl Stroke Res. 2015 Feb; 6(1):69-77.
    View in: PubMed
    Score: 0.006
  76. Low-dose candesartan enhances molecular mediators of neuroplasticity and subsequent functional recovery after ischemic stroke in rats. Mol Neurobiol. 2015; 51(3):1542-53.
    View in: PubMed
    Score: 0.006
  77. Combined therapy with COX-2 inhibitor and 20-HETE inhibitor reduces colon tumor growth and the adverse effects of ischemic stroke associated with COX-2 inhibition. Am J Physiol Regul Integr Comp Physiol. 2014 Sep 15; 307(6):R693-703.
    View in: PubMed
    Score: 0.006
  78. Candesartan induces a prolonged proangiogenic effect and augments endothelium-mediated neuroprotection after oxygen and glucose deprivation: role of vascular endothelial growth factors A and B. J Pharmacol Exp Ther. 2014 Jun; 349(3):444-57.
    View in: PubMed
    Score: 0.006
  79. Thioredoxin-interacting protein is required for endothelial NLRP3 inflammasome activation and cell death in a rat model of high-fat diet. Diabetologia. 2014 Feb; 57(2):413-23.
    View in: PubMed
    Score: 0.006
  80. Candesartan reduces the hemorrhage associated with delayed tissue plasminogen activator treatment in rat embolic stroke. Neurochem Res. 2013 Dec; 38(12):2668-77.
    View in: PubMed
    Score: 0.006
  81. Nox2-derived superoxide contributes to cerebral vascular dysfunction in diet-induced obesity. Stroke. 2013 Nov; 44(11):3195-201.
    View in: PubMed
    Score: 0.006
  82. Reduced endothelium-dependent relaxation to anandamide in mesenteric arteries from young obese Zucker rats. PLoS One. 2013; 8(5):e63449.
    View in: PubMed
    Score: 0.006
  83. Response to letter regarding article, "Remote ischemic perconditioning is effective alone and in combination with intravenous tissue-type". Stroke. 2013 Apr; 44(4):e37.
    View in: PubMed
    Score: 0.006
  84. Peroxynitrite mediates testosterone-induced vasodilation of microvascular resistance vessels. J Pharmacol Exp Ther. 2013 Apr; 345(1):7-14.
    View in: PubMed
    Score: 0.006
  85. Oxidative stress and cardiovascular risk in overweight children in an exercise intervention program. Child Obes. 2013 Feb; 9(1):15-21.
    View in: PubMed
    Score: 0.006
  86. AT1 receptor antagonism is proangiogenic in the brain: BDNF a novel mediator. J Pharmacol Exp Ther. 2013 Feb; 344(2):348-59.
    View in: PubMed
    Score: 0.006
  87. Remote ischemic perconditioning is effective alone and in combination with intravenous tissue-type plasminogen activator in murine model of embolic stroke. Stroke. 2012 Oct; 43(10):2794-9.
    View in: PubMed
    Score: 0.006
  88. Vascular protection by angiotensin receptor antagonism involves differential VEGF expression in both hemispheres after experimental stroke. PLoS One. 2011; 6(9):e24551.
    View in: PubMed
    Score: 0.005
  89. Matrix metalloproteinase-9 in an exploratory trial of intravenous minocycline for acute ischemic stroke. Stroke. 2011 Sep; 42(9):2633-5.
    View in: PubMed
    Score: 0.005
  90. Effects of spironolactone on cerebral vessel structure in rats with sustained hypertension. Am J Hypertens. 2011 Jun; 24(6):708-15.
    View in: PubMed
    Score: 0.005
  91. Erectile dysfunction in young non-obese type II diabetic Goto-Kakizaki rats is associated with decreased eNOS phosphorylation at Ser1177. J Sex Med. 2010 Nov; 7(11):3620-34.
    View in: PubMed
    Score: 0.005
  92. Minocycline to improve neurologic outcome in stroke (MINOS): a dose-finding study. Stroke. 2010 Oct; 41(10):2283-7.
    View in: PubMed
    Score: 0.005
  93. O-GlcNAcylation contributes to augmented vascular reactivity induced by endothelin 1. Hypertension. 2010 Jan; 55(1):180-8.
    View in: PubMed
    Score: 0.005
  94. Minocycline and tissue-type plasminogen activator for stroke: assessment of interaction potential. Stroke. 2009 Sep; 40(9):3028-33.
    View in: PubMed
    Score: 0.004
  95. Early atorvastatin reduces hemorrhage after acute cerebral ischemia in diabetic rats. J Pharmacol Exp Ther. 2009 Aug; 330(2):532-40.
    View in: PubMed
    Score: 0.004
  96. Diet-induced obesity causes cerebral vessel remodeling and increases the damage caused by ischemic stroke. Microvasc Res. 2009 Jun; 78(1):100-6.
    View in: PubMed
    Score: 0.004
  97. Candesartan augments ischemia-induced proangiogenic state and results in sustained improvement after stroke. Stroke. 2009 May; 40(5):1870-6.
    View in: PubMed
    Score: 0.004
  98. Interleukin-10 attenuates vascular responses to endothelin-1 via effects on ERK1/2-dependent pathway. Am J Physiol Heart Circ Physiol. 2009 Feb; 296(2):H489-96.
    View in: PubMed
    Score: 0.004
  99. Activation of the ET-1/ETA pathway contributes to erectile dysfunction associated with mineralocorticoid hypertension. J Sex Med. 2008 Dec; 5(12):2793-807.
    View in: PubMed
    Score: 0.004
  100. DOCA-salt treatment enhances responses to endothelin-1 in murine corpus cavernosum. Can J Physiol Pharmacol. 2008 Jun; 86(6):320-8.
    View in: PubMed
    Score: 0.004
  101. Blood pressure lowering after experimental cerebral ischemia provides neurovascular protection. J Hypertens. 2007 Apr; 25(4):855-9.
    View in: PubMed
    Score: 0.004
  102. Delayed minocycline inhibits ischemia-activated matrix metalloproteinases 2 and 9 after experimental stroke. BMC Neurosci. 2006 Jul 17; 7:56.
    View in: PubMed
    Score: 0.004
  103. Hypertension after experimental cerebral ischemia: candesartan provides neurovascular protection. J Hypertens. 2006 Mar; 24(3):535-9.
    View in: PubMed
    Score: 0.004
  104. Effect of neutrophil depletion on gelatinase expression, edema formation and hemorrhagic transformation after focal ischemic stroke. BMC Neurosci. 2005 Aug 03; 6:49.
    View in: PubMed
    Score: 0.003
  105. Sepiapterin decreases vasorelaxation in nitric oxide synthase inhibition-induced hypertension. J Cardiovasc Pharmacol. 2004 Jan; 43(1):93-8.
    View in: PubMed
    Score: 0.003
  106. Neuroprotection by tempol in a model of iron-induced oxidative stress in acute ischemic stroke. Am J Physiol Regul Integr Comp Physiol. 2004 Feb; 286(2):R283-8.
    View in: PubMed
    Score: 0.003
Connection Strength

The connection strength for concepts is the sum of the scores for each matching publication.

Publication scores are based on many factors, including how long ago they were written and whether the person is a first or senior author.