Igor Roninson to Animals
This is a "connection" page, showing publications Igor Roninson has written about Animals.
Connection Strength
0.637
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Systemic Toxicity Reported for CDK8/19 Inhibitors CCT251921 and MSC2530818 Is Not Due to Target Inhibition. Cells. 2019 11 09; 8(11).
Score: 0.051
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CDK8 Selectively Promotes the Growth of Colon Cancer Metastases in the Liver by Regulating Gene Expression of TIMP3 and Matrix Metalloproteinases. Cancer Res. 2018 12 01; 78(23):6594-6606.
Score: 0.047
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Cyclin-dependent kinase 8 mediates chemotherapy-induced tumor-promoting paracrine activities. Proc Natl Acad Sci U S A. 2012 Aug 21; 109(34):13799-804.
Score: 0.031
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A subunit of coatomer protein complex offers a novel tumor-specific target through a surprising mechanism. Autophagy. 2011 Dec; 7(12):1551-2.
Score: 0.029
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Hallmarks of senescence in carcinogenesis and cancer therapy. Oncogene. 2004 Apr 12; 23(16):2919-33.
Score: 0.017
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Tumor cell senescence in cancer treatment. Cancer Res. 2003 Jun 01; 63(11):2705-15.
Score: 0.016
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Genetic suppressor elements in the characterization and identification of tumor suppressor genes. Methods Mol Biol. 2003; 222:413-36.
Score: 0.016
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Inhibition of CDK8/19 Mediator kinase potentiates HER2-targeting drugs and bypasses resistance to these agents in?vitro and in?vivo. Proc Natl Acad Sci U S A. 2022 08 09; 119(32):e2201073119.
Score: 0.015
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Oncogenic functions of tumour suppressor p21(Waf1/Cip1/Sdi1): association with cell senescence and tumour-promoting activities of stromal fibroblasts. Cancer Lett. 2002 May 08; 179(1):1-14.
Score: 0.015
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A Selective and Orally Bioavailable Quinoline-6-Carbonitrile-Based Inhibitor of CDK8/19 Mediator Kinase with Tumor-Enriched Pharmacokinetics. J Med Chem. 2022 02 24; 65(4):3420-3433.
Score: 0.015
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Molecular determinants of terminal growth arrest induced in tumor cells by a chemotherapeutic agent. Proc Natl Acad Sci U S A. 2002 Jan 08; 99(1):389-94.
Score: 0.015
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If not apoptosis, then what? Treatment-induced senescence and mitotic catastrophe in tumor cells. Drug Resist Updat. 2001 Oct; 4(5):303-13.
Score: 0.015
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Analysis of MDR1 P-glycoprotein conformational changes in permeabilized cells using differential immunoreactivity. Biochemistry. 2001 Apr 10; 40(14):4312-22.
Score: 0.014
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P-glycoprotein-mediated colchicine resistance in different cell lines correlates with the effects of colchicine on P-glycoprotein conformation. Biochemistry. 2001 Apr 10; 40(14):4323-31.
Score: 0.014
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Coordinate changes in drug resistance and drug-induced conformational transitions in altered-function mutants of the multidrug transporter P-glycoprotein. Biochemistry. 2001 Apr 10; 40(14):4332-9.
Score: 0.014
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Effects of the multidrug transporter P-glycoprotein on cellular responses to ionizing radiation. Cancer Res. 2000 May 15; 60(10):2576-8.
Score: 0.013
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Genome Editing As an Approach to the Study of in Vivo Transcription Reprogramming. Dokl Biochem Biophys. 2020 Jan; 490(1):43-46.
Score: 0.013
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Characterizing CDK8/19 Inhibitors through a NF?B-Dependent Cell-Based Assay. Cells. 2019 10 06; 8(10).
Score: 0.013
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A senescence-like phenotype distinguishes tumor cells that undergo terminal proliferation arrest after exposure to anticancer agents. Cancer Res. 1999 Aug 01; 59(15):3761-7.
Score: 0.013
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Structural insight into substrate and inhibitor discrimination by human P-glycoprotein. Science. 2019 02 15; 363(6428):753-756.
Score: 0.012
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Mediator kinase CDK8/CDK19 drives YAP1-dependent BMP4-induced EMT in cancer. Oncogene. 2018 08; 37(35):4792-4808.
Score: 0.012
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Internal ribosomal entry site-containing retroviral vectors with green fluorescent protein and drug resistance markers. Hum Gene Ther. 1998 May 20; 9(8):1233-6.
Score: 0.012
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Structure of a zosuquidar and UIC2-bound human-mouse chimeric ABCB1. Proc Natl Acad Sci U S A. 2018 02 27; 115(9):E1973-E1982.
Score: 0.011
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Isolation of altered-function mutants and genetic suppressor elements of multidrug transporter P-glycoprotein by expression selection from retroviral libraries. Methods Enzymol. 1998; 292:225-48.
Score: 0.011
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Applications of green fluorescent protein as a marker of retroviral vectors. Somat Cell Mol Genet. 1997 Sep; 23(5):325-40.
Score: 0.011
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Inhibition of CDK8 mediator kinase suppresses estrogen dependent transcription and the growth of estrogen receptor positive breast cancer. Oncotarget. 2017 Feb 21; 8(8):12558-12575.
Score: 0.011
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Isolation of genetic suppressor elements (GSEs) from random fragment cDNA libraries in retroviral vectors. Methods Mol Biol. 1997; 69:221-40.
Score: 0.010
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Inducible retroviral vectors regulated by lac repressor in mammalian cells. Gene. 1996 Dec 12; 183(1-2):137-42.
Score: 0.010
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Effects of infection rate and selection pressure on gene expression from an internal promoter of a double gene retroviral vector. Somat Cell Mol Genet. 1996 Jul; 22(4):291-309.
Score: 0.010
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Involvement of MDR1 P-glycoprotein in multifactorial resistance to methotrexate. Int J Cancer. 1996 Mar 01; 65(5):613-9.
Score: 0.010
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P-glycoprotein confers methotrexate resistance in 3T6 cells with deficient carrier-mediated methotrexate uptake. Proc Natl Acad Sci U S A. 1996 Feb 06; 93(3):1238-42.
Score: 0.010
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Genetic suppressor elements: new tools for molecular oncology--thirteenth Cornelius P. Rhoads Memorial Award Lecture. Cancer Res. 1995 Sep 15; 55(18):4023-8.
Score: 0.010
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Cloning mammalian genes by expression selection of genetic suppressor elements: association of kinesin with drug resistance and cell immortalization. Proc Natl Acad Sci U S A. 1994 Apr 26; 91(9):3744-8.
Score: 0.009
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Efficient inhibition of P-glycoprotein-mediated multidrug resistance with a monoclonal antibody. Proc Natl Acad Sci U S A. 1992 Jul 01; 89(13):5824-8.
Score: 0.008
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From amplification to function: the case of the MDR1 gene. Mutat Res. 1992 May; 276(3):151-61.
Score: 0.008
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Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy. 2012 Apr; 8(4):445-544.
Score: 0.008
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The role of the MDR1 (P-glycoprotein) gene in multidrug resistance in vitro and in vivo. Biochem Pharmacol. 1992 Jan 09; 43(1):95-102.
Score: 0.007
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Effects of conditional depletion of topoisomerase II on cell cycle progression in mammalian cells. Cell Cycle. 2011 Oct 15; 10(20):3505-14.
Score: 0.007
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Multidrug resistance after retroviral transfer of the human MDR1 gene correlates with P-glycoprotein density in the plasma membrane and is not affected by cytotoxic selection. Proc Natl Acad Sci U S A. 1991 Aug 15; 88(16):7386-90.
Score: 0.007
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Structure and expression of the human MDR (P-glycoprotein) gene family. Mol Cell Biol. 1989 Sep; 9(9):3808-20.
Score: 0.006
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Effect of target secondary structure on RNAi efficiency. RNA. 2007 Oct; 13(10):1631-40.
Score: 0.005
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Use of in-gel DNA renaturation for detection and cloning of amplified genes. Methods Enzymol. 1987; 151:332-71.
Score: 0.005
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Detection of amplified sequences in mammalian DNA by in-gel renaturation and SINE hybridization. Somat Cell Mol Genet. 1986 Nov; 12(6):611-23.
Score: 0.005
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Amplification of specific DNA sequences correlates with multi-drug resistance in Chinese hamster cells. Nature. 1984 Jun 14-20; 309(5969):626-8.
Score: 0.004
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Expression and partial DNA sequence of the chicken beta H-globin gene. J Biol Chem. 1983 Jan 25; 258(2):802-9.
Score: 0.004
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Gene evolution in the chicken beta-globin cluster. Cell. 1982 Mar; 28(3):515-21.
Score: 0.004
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Growth retardation and increased apoptosis in mice with homozygous disruption of the Akt1 gene. Genes Dev. 2001 Sep 01; 15(17):2203-8.
Score: 0.004
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cDNA sequence of a new chicken embryonic rho-globin. Proc Natl Acad Sci U S A. 1981 Aug; 78(8):4782-5.
Score: 0.004
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Alteration of skin protein kinase C alpha protein and mRNA levels during induced mouse hair growth. J Dermatol. 1999 Apr; 26(4):203-9.
Score: 0.003
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Altered expression of ubiquitous kinesin heavy chain results in resistance to etoposide and hypersensitivity to colchicine: mapping of the domain associated with drug response. Cancer Res. 1998 Aug 01; 58(15):3423-8.
Score: 0.003
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Identification of p53 genetic suppressor elements which confer resistance to cisplatin. Oncogene. 1997 Jan 16; 14(2):185-93.
Score: 0.003
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Altered drug-stimulated ATPase activity in mutants of the human multidrug resistance protein. J Biol Chem. 1996 Jan 26; 271(4):1877-83.
Score: 0.002
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Resistance to taxol chemotherapy produced in mouse marrow cells by safety-modified retroviruses containing a human MDR-1 transcription unit. Gene Ther. 1995 Jun; 2(4):279-84.
Score: 0.002
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Human (MDR1) and mouse (mdr1, mdr3) P-glycoproteins can be distinguished by their respective drug resistance profiles and sensitivity to modulators. Biochemistry. 1995 Jan 10; 34(1):32-9.
Score: 0.002
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Binding properties of monoclonal antibodies recognizing external epitopes of the human MDR1 P-glycoprotein. Int J Cancer. 1993 Sep 30; 55(3):478-84.
Score: 0.002
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Correlation between amount of virus with altered nucleotide sequence and the monkey test for acceptability of oral poliovirus vaccine. Proc Natl Acad Sci U S A. 1991 Jan 01; 88(1):199-203.
Score: 0.002
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Multidrug resistance of DNA-mediated transformants is linked to transfer of the human mdr1 gene. Mol Cell Biol. 1986 Nov; 6(11):4039-45.
Score: 0.001
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Localization of multidrug resistance-associated DNA sequences to human chromosome 7. Somat Cell Mol Genet. 1986 Jul; 12(4):415-20.
Score: 0.001
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Human multidrug-resistant cell lines: increased mdr1 expression can precede gene amplification. Science. 1986 May 02; 232(4750):643-5.
Score: 0.001
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Isolation and characterization of DNA sequences amplified in multidrug-resistant hamster cells. Proc Natl Acad Sci U S A. 1986 Jan; 83(2):337-41.
Score: 0.001
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Acquisition and loss of amplified genes: dramatic effects of hormones, tumor promoters and cytotoxic drugs. Princess Takamatsu Symp. 1983; 14:235-54.
Score: 0.001
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Control of hemoglobin expression in chick embryonic development. Prog Clin Biol Res. 1982; 102 pt A:35-46.
Score: 0.001