Connection

Igor Roninson to Animals

This is a "connection" page, showing publications Igor Roninson has written about Animals.
Connection Strength

0.637
  1. Systemic Toxicity Reported for CDK8/19 Inhibitors CCT251921 and MSC2530818 Is Not Due to Target Inhibition. Cells. 2019 11 09; 8(11).
    View in: PubMed
    Score: 0.051
  2. CDK8 Selectively Promotes the Growth of Colon Cancer Metastases in the Liver by Regulating Gene Expression of TIMP3 and Matrix Metalloproteinases. Cancer Res. 2018 12 01; 78(23):6594-6606.
    View in: PubMed
    Score: 0.047
  3. Cyclin-dependent kinase 8 mediates chemotherapy-induced tumor-promoting paracrine activities. Proc Natl Acad Sci U S A. 2012 Aug 21; 109(34):13799-804.
    View in: PubMed
    Score: 0.031
  4. A subunit of coatomer protein complex offers a novel tumor-specific target through a surprising mechanism. Autophagy. 2011 Dec; 7(12):1551-2.
    View in: PubMed
    Score: 0.029
  5. Hallmarks of senescence in carcinogenesis and cancer therapy. Oncogene. 2004 Apr 12; 23(16):2919-33.
    View in: PubMed
    Score: 0.017
  6. Tumor cell senescence in cancer treatment. Cancer Res. 2003 Jun 01; 63(11):2705-15.
    View in: PubMed
    Score: 0.016
  7. Genetic suppressor elements in the characterization and identification of tumor suppressor genes. Methods Mol Biol. 2003; 222:413-36.
    View in: PubMed
    Score: 0.016
  8. Inhibition of CDK8/19 Mediator kinase potentiates HER2-targeting drugs and bypasses resistance to these agents in?vitro and in?vivo. Proc Natl Acad Sci U S A. 2022 08 09; 119(32):e2201073119.
    View in: PubMed
    Score: 0.015
  9. Oncogenic functions of tumour suppressor p21(Waf1/Cip1/Sdi1): association with cell senescence and tumour-promoting activities of stromal fibroblasts. Cancer Lett. 2002 May 08; 179(1):1-14.
    View in: PubMed
    Score: 0.015
  10. A Selective and Orally Bioavailable Quinoline-6-Carbonitrile-Based Inhibitor of CDK8/19 Mediator Kinase with Tumor-Enriched Pharmacokinetics. J Med Chem. 2022 02 24; 65(4):3420-3433.
    View in: PubMed
    Score: 0.015
  11. Molecular determinants of terminal growth arrest induced in tumor cells by a chemotherapeutic agent. Proc Natl Acad Sci U S A. 2002 Jan 08; 99(1):389-94.
    View in: PubMed
    Score: 0.015
  12. If not apoptosis, then what? Treatment-induced senescence and mitotic catastrophe in tumor cells. Drug Resist Updat. 2001 Oct; 4(5):303-13.
    View in: PubMed
    Score: 0.015
  13. Analysis of MDR1 P-glycoprotein conformational changes in permeabilized cells using differential immunoreactivity. Biochemistry. 2001 Apr 10; 40(14):4312-22.
    View in: PubMed
    Score: 0.014
  14. P-glycoprotein-mediated colchicine resistance in different cell lines correlates with the effects of colchicine on P-glycoprotein conformation. Biochemistry. 2001 Apr 10; 40(14):4323-31.
    View in: PubMed
    Score: 0.014
  15. Coordinate changes in drug resistance and drug-induced conformational transitions in altered-function mutants of the multidrug transporter P-glycoprotein. Biochemistry. 2001 Apr 10; 40(14):4332-9.
    View in: PubMed
    Score: 0.014
  16. Effects of the multidrug transporter P-glycoprotein on cellular responses to ionizing radiation. Cancer Res. 2000 May 15; 60(10):2576-8.
    View in: PubMed
    Score: 0.013
  17. Genome Editing As an Approach to the Study of in Vivo Transcription Reprogramming. Dokl Biochem Biophys. 2020 Jan; 490(1):43-46.
    View in: PubMed
    Score: 0.013
  18. Characterizing CDK8/19 Inhibitors through a NF?B-Dependent Cell-Based Assay. Cells. 2019 10 06; 8(10).
    View in: PubMed
    Score: 0.013
  19. A senescence-like phenotype distinguishes tumor cells that undergo terminal proliferation arrest after exposure to anticancer agents. Cancer Res. 1999 Aug 01; 59(15):3761-7.
    View in: PubMed
    Score: 0.013
  20. Structural insight into substrate and inhibitor discrimination by human P-glycoprotein. Science. 2019 02 15; 363(6428):753-756.
    View in: PubMed
    Score: 0.012
  21. Mediator kinase CDK8/CDK19 drives YAP1-dependent BMP4-induced EMT in cancer. Oncogene. 2018 08; 37(35):4792-4808.
    View in: PubMed
    Score: 0.012
  22. Internal ribosomal entry site-containing retroviral vectors with green fluorescent protein and drug resistance markers. Hum Gene Ther. 1998 May 20; 9(8):1233-6.
    View in: PubMed
    Score: 0.012
  23. Structure of a zosuquidar and UIC2-bound human-mouse chimeric ABCB1. Proc Natl Acad Sci U S A. 2018 02 27; 115(9):E1973-E1982.
    View in: PubMed
    Score: 0.011
  24. Isolation of altered-function mutants and genetic suppressor elements of multidrug transporter P-glycoprotein by expression selection from retroviral libraries. Methods Enzymol. 1998; 292:225-48.
    View in: PubMed
    Score: 0.011
  25. Applications of green fluorescent protein as a marker of retroviral vectors. Somat Cell Mol Genet. 1997 Sep; 23(5):325-40.
    View in: PubMed
    Score: 0.011
  26. Inhibition of CDK8 mediator kinase suppresses estrogen dependent transcription and the growth of estrogen receptor positive breast cancer. Oncotarget. 2017 Feb 21; 8(8):12558-12575.
    View in: PubMed
    Score: 0.011
  27. Isolation of genetic suppressor elements (GSEs) from random fragment cDNA libraries in retroviral vectors. Methods Mol Biol. 1997; 69:221-40.
    View in: PubMed
    Score: 0.010
  28. Inducible retroviral vectors regulated by lac repressor in mammalian cells. Gene. 1996 Dec 12; 183(1-2):137-42.
    View in: PubMed
    Score: 0.010
  29. Effects of infection rate and selection pressure on gene expression from an internal promoter of a double gene retroviral vector. Somat Cell Mol Genet. 1996 Jul; 22(4):291-309.
    View in: PubMed
    Score: 0.010
  30. Involvement of MDR1 P-glycoprotein in multifactorial resistance to methotrexate. Int J Cancer. 1996 Mar 01; 65(5):613-9.
    View in: PubMed
    Score: 0.010
  31. P-glycoprotein confers methotrexate resistance in 3T6 cells with deficient carrier-mediated methotrexate uptake. Proc Natl Acad Sci U S A. 1996 Feb 06; 93(3):1238-42.
    View in: PubMed
    Score: 0.010
  32. Genetic suppressor elements: new tools for molecular oncology--thirteenth Cornelius P. Rhoads Memorial Award Lecture. Cancer Res. 1995 Sep 15; 55(18):4023-8.
    View in: PubMed
    Score: 0.010
  33. Cloning mammalian genes by expression selection of genetic suppressor elements: association of kinesin with drug resistance and cell immortalization. Proc Natl Acad Sci U S A. 1994 Apr 26; 91(9):3744-8.
    View in: PubMed
    Score: 0.009
  34. Efficient inhibition of P-glycoprotein-mediated multidrug resistance with a monoclonal antibody. Proc Natl Acad Sci U S A. 1992 Jul 01; 89(13):5824-8.
    View in: PubMed
    Score: 0.008
  35. From amplification to function: the case of the MDR1 gene. Mutat Res. 1992 May; 276(3):151-61.
    View in: PubMed
    Score: 0.008
  36. Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy. 2012 Apr; 8(4):445-544.
    View in: PubMed
    Score: 0.008
  37. The role of the MDR1 (P-glycoprotein) gene in multidrug resistance in vitro and in vivo. Biochem Pharmacol. 1992 Jan 09; 43(1):95-102.
    View in: PubMed
    Score: 0.007
  38. Effects of conditional depletion of topoisomerase II on cell cycle progression in mammalian cells. Cell Cycle. 2011 Oct 15; 10(20):3505-14.
    View in: PubMed
    Score: 0.007
  39. Multidrug resistance after retroviral transfer of the human MDR1 gene correlates with P-glycoprotein density in the plasma membrane and is not affected by cytotoxic selection. Proc Natl Acad Sci U S A. 1991 Aug 15; 88(16):7386-90.
    View in: PubMed
    Score: 0.007
  40. Structure and expression of the human MDR (P-glycoprotein) gene family. Mol Cell Biol. 1989 Sep; 9(9):3808-20.
    View in: PubMed
    Score: 0.006
  41. Effect of target secondary structure on RNAi efficiency. RNA. 2007 Oct; 13(10):1631-40.
    View in: PubMed
    Score: 0.005
  42. Use of in-gel DNA renaturation for detection and cloning of amplified genes. Methods Enzymol. 1987; 151:332-71.
    View in: PubMed
    Score: 0.005
  43. Detection of amplified sequences in mammalian DNA by in-gel renaturation and SINE hybridization. Somat Cell Mol Genet. 1986 Nov; 12(6):611-23.
    View in: PubMed
    Score: 0.005
  44. Amplification of specific DNA sequences correlates with multi-drug resistance in Chinese hamster cells. Nature. 1984 Jun 14-20; 309(5969):626-8.
    View in: PubMed
    Score: 0.004
  45. Expression and partial DNA sequence of the chicken beta H-globin gene. J Biol Chem. 1983 Jan 25; 258(2):802-9.
    View in: PubMed
    Score: 0.004
  46. Gene evolution in the chicken beta-globin cluster. Cell. 1982 Mar; 28(3):515-21.
    View in: PubMed
    Score: 0.004
  47. Growth retardation and increased apoptosis in mice with homozygous disruption of the Akt1 gene. Genes Dev. 2001 Sep 01; 15(17):2203-8.
    View in: PubMed
    Score: 0.004
  48. cDNA sequence of a new chicken embryonic rho-globin. Proc Natl Acad Sci U S A. 1981 Aug; 78(8):4782-5.
    View in: PubMed
    Score: 0.004
  49. Alteration of skin protein kinase C alpha protein and mRNA levels during induced mouse hair growth. J Dermatol. 1999 Apr; 26(4):203-9.
    View in: PubMed
    Score: 0.003
  50. Altered expression of ubiquitous kinesin heavy chain results in resistance to etoposide and hypersensitivity to colchicine: mapping of the domain associated with drug response. Cancer Res. 1998 Aug 01; 58(15):3423-8.
    View in: PubMed
    Score: 0.003
  51. Identification of p53 genetic suppressor elements which confer resistance to cisplatin. Oncogene. 1997 Jan 16; 14(2):185-93.
    View in: PubMed
    Score: 0.003
  52. Altered drug-stimulated ATPase activity in mutants of the human multidrug resistance protein. J Biol Chem. 1996 Jan 26; 271(4):1877-83.
    View in: PubMed
    Score: 0.002
  53. Resistance to taxol chemotherapy produced in mouse marrow cells by safety-modified retroviruses containing a human MDR-1 transcription unit. Gene Ther. 1995 Jun; 2(4):279-84.
    View in: PubMed
    Score: 0.002
  54. Human (MDR1) and mouse (mdr1, mdr3) P-glycoproteins can be distinguished by their respective drug resistance profiles and sensitivity to modulators. Biochemistry. 1995 Jan 10; 34(1):32-9.
    View in: PubMed
    Score: 0.002
  55. Binding properties of monoclonal antibodies recognizing external epitopes of the human MDR1 P-glycoprotein. Int J Cancer. 1993 Sep 30; 55(3):478-84.
    View in: PubMed
    Score: 0.002
  56. Correlation between amount of virus with altered nucleotide sequence and the monkey test for acceptability of oral poliovirus vaccine. Proc Natl Acad Sci U S A. 1991 Jan 01; 88(1):199-203.
    View in: PubMed
    Score: 0.002
  57. Multidrug resistance of DNA-mediated transformants is linked to transfer of the human mdr1 gene. Mol Cell Biol. 1986 Nov; 6(11):4039-45.
    View in: PubMed
    Score: 0.001
  58. Localization of multidrug resistance-associated DNA sequences to human chromosome 7. Somat Cell Mol Genet. 1986 Jul; 12(4):415-20.
    View in: PubMed
    Score: 0.001
  59. Human multidrug-resistant cell lines: increased mdr1 expression can precede gene amplification. Science. 1986 May 02; 232(4750):643-5.
    View in: PubMed
    Score: 0.001
  60. Isolation and characterization of DNA sequences amplified in multidrug-resistant hamster cells. Proc Natl Acad Sci U S A. 1986 Jan; 83(2):337-41.
    View in: PubMed
    Score: 0.001
  61. Acquisition and loss of amplified genes: dramatic effects of hormones, tumor promoters and cytotoxic drugs. Princess Takamatsu Symp. 1983; 14:235-54.
    View in: PubMed
    Score: 0.001
  62. Control of hemoglobin expression in chick embryonic development. Prog Clin Biol Res. 1982; 102 pt A:35-46.
    View in: PubMed
    Score: 0.001
Connection Strength

The connection strength for concepts is the sum of the scores for each matching publication.

Publication scores are based on many factors, including how long ago they were written and whether the person is a first or senior author.