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Anton, Raymond
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overview Dr. Anton is a Distinguished University Professor and senior investigator with over 25 years of research experience. He is considered an international expert in biologic markers of alcohol use as well as in new treatments for alcohol use disorders (AUD's), as evidenced by conducting over 15 clinical trials. He participated in PROJECT Match as well as being the chair of the COMBINE Study and first author of its publication in JAMA. His team also developed one of he first fMRI alcohol cue tasks showing activation in salient brain reward systems that could be blocked by medications. As a current holder of a Senior Scientist Career and Mentoring Award (K05) he has used that support to integrate genetics and neuroimaging into his clinical trial work. His group has begun to bring together the brain-imaging paradigm with genetics and pharmacogenetics, providing the best technology available to investigate alcohol effects on the human brain as they relate to alcoholism vulnerability and treatment.
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Item TypeName
Academic Article Childhood hyperactivity, gender, and Cloninger's personality dimensions in alcoholics.
Academic Article Further validation of the Obsessive-Compulsive Drinking Scale (OCDS). Relationship to alcoholism severity.
Academic Article Carbohydrate-deficient transferrin and alcohol use in medical examiner cases.
Academic Article Female alcoholic outpatients and female college students: a correlational study of self-reported alcohol consumption and carbohydrate-deficient transferrin levels.
Academic Article The relationship of cognitive functioning to amount of recent and lifetime alcohol consumption in outpatient alcoholics.
Academic Article Alcohol craving--a renaissance.
Academic Article Factor structure and predictive validity of the Obsessive Compulsive Drinking Scale.
Academic Article Recurrent detoxification may elevate alcohol craving as measured by the Obsessive Compulsive Drinking scale.
Academic Article A double-blind, placebo-controlled outpatient trial of pergolide for cocaine dependence.
Academic Article The role of craving in alcohol use, dependence, and treatment.
Academic Article Activation of prefrontal cortex and anterior thalamus in alcoholic subjects on exposure to alcohol-specific cues.
Academic Article Carbohydrate deficient transferrin in abstaining patients with end-stage liver disease.
Academic Article Naltrexone for alcohol dependence: comments on Morris et al. (2001).
Academic Article The effect of drinking intensity and frequency on serum carbohydrate-deficient transferrin and gamma-glutamyl transferase levels in outpatient alcoholics.
Academic Article Neurobehavioural basis for the pharmacotherapy of alcoholism: current and future directions.
Academic Article Contribution of carbohydrate deficient transferrin to gamma glutamyl transpeptidase in evaluating progress of patients in treatment for alcoholism.
Academic Article Multiple previous alcohol detoxifications are associated with decreased medial temporal and paralimbic function in the postwithdrawal period.
Academic Article Naltrexone and cognitive behavioral therapy for the treatment of outpatient alcoholics: results of a placebo-controlled trial.
Academic Article Alleles of a functional serotonin transporter promoter polymorphism are associated with major depression in alcoholics.
Academic Article Increased severity of alcohol withdrawal in in-patient alcoholics with a co-existing anxiety diagnosis.
Academic Article Differential brain activity in alcoholics and social drinkers to alcohol cues: relationship to craving.
Academic Article Current pharmacotherapies of alcoholism: a U.S. perspective.
Academic Article Challenges to medications development in treating alcohol dependence: an international perspective.
Academic Article Following alcohol consumption, nontreatment-seeking alcoholics report greater stimulation but similar sedation compared with social drinkers.
Academic Article Does comorbid anxiety or depression affect clinical outcomes in patients with post-traumatic stress disorder and alcohol use disorders?
Academic Article Drinking in alcoholics following an alcohol challenge research protocol.
Academic Article What is craving? Models and implications for treatment.
Academic Article Excessive alcohol consumption and hypertension: clinical implications of current research.
Academic Article Revealing alcohol abuse: to ask or to test?
Academic Article COMBINE genetics study: the pharmacogenetics of alcoholism treatment response: genes and mechanisms.
Academic Article Naltrexone treatment of adolescent alcoholics: an open-label pilot study.
Academic Article Alcohol biomarker screening in medical and surgical settings.
Academic Article Combined pharmacotherapies and behavioral interventions for alcohol dependence: the COMBINE study: a randomized controlled trial.
Academic Article Perspectives on the pathophysiology of fetal alcohol syndrome.
Academic Article A multicentre, randomized, double-blind, placebo-controlled trial of naltrexone in the treatment of alcohol dependence or abuse.
Academic Article Multiple previous detoxifications are associated with less responsive treatment and heavier drinking during an index outpatient detoxification.
Academic Article Treatment of patients with substance use disorders, second edition. American Psychiatric Association.
Academic Article Variation in GABRA2 predicts drinking behavior in project MATCH subjects.
Academic Article Alcohol consumption, %CDT, GGT and blood pressure change during alcohol treatment.
Academic Article Combined pharmacotherapies and behavioral interventions for alcohol dependence (The COMBINE Study): examination of posttreatment drinking outcomes.
Academic Article A randomized, multicenter, double-blind, placebo-controlled study of the efficacy and safety of aripiprazole for the treatment of alcohol dependence.
Academic Article Genetic basis for predicting response to naltrexone in the treatment of alcohol dependence.
Academic Article Naltrexone for the management of alcohol dependence.
Academic Article OPRM1 Asn40Asp predicts response to naltrexone treatment: a haplotype-based approach.
Academic Article Pro-opiomelanocortin gene variation related to alcohol or drug dependence: evidence and replications across family- and population-based studies.
Academic Article Efficacy of a combination of flumazenil and gabapentin in the treatment of alcohol dependence: relationship to alcohol withdrawal symptoms.
Academic Article Aripiprazole: a drug with a novel mechanism of action and possible efficacy for alcohol dependence.
Academic Article The effect of aripiprazole on cue-induced brain activation and drinking parameters in alcoholics.
Academic Article Liver disease and HPLC quantification of disialotransferrin for heavy alcohol use: a case series.
Academic Article Substance abuse is a disease of the human brain: focus on alcohol.
Academic Article Lithium treatment of depressed and nondepressed alcoholics.
Academic Article Stability of fMRI striatal response to alcohol cues: a hierarchical linear modeling approach.
Academic Article The differential effects of medication on mood, sleep disturbance, and work ability in outpatient alcohol detoxification.
Academic Article Gabapentin combined with naltrexone for the treatment of alcohol dependence.
Academic Article The role of the Asn40Asp polymorphism of the mu opioid receptor gene (OPRM1) on alcoholism etiology and treatment: a critical review.
Academic Article The Alcohol Clinical Trials Initiative (ACTIVE): purpose and goals for assessing important and salient issues for medications development in alcohol use disorders.
Academic Article Functional neuroimaging studies of alcohol cue reactivity: a quantitative meta-analysis and systematic review.
Academic Article Array-based profiling of DNA methylation changes associated with alcohol dependence.
Academic Article Interacting effects of naltrexone and OPRM1 and DAT1 variation on the neural response to alcohol cues.
Academic Article Biomarkers as aids to identification of relapse in alcoholic patients.
Academic Article A clinical laboratory paradigm for evaluating medication effects on alcohol consumption: naltrexone and nalmefene.
Academic Article Commentary on Subbaraman et al. (2013) [corrected]: cravings as a mediator and moderator of drinking outcomes in the COMBINE Study.
Academic Article Stereotypic wall climbing in mice during ethanol withdrawal: a new measure of physical dependence.
Academic Article Alcohol, pregnancy, and prostaglandins.
Academic Article Sertraline and cognitive behavioral therapy for depressed alcoholics: results of a placebo-controlled trial.
Academic Article Issues in the definition and measurement of drinking outcomes in alcoholism treatment research.
Academic Article Assessment issues and strategies in alcoholism treatment matching research.
Academic Article A placebo-controlled trial of buspirone in anxious inpatient alcoholics.
Academic Article Carbohydrate-deficient transferrin and false-positive results for alcohol abuse in primary biliary cirrhosis: differential diagnosis by detection of mitochondrial autoantibodies.
Academic Article Carbohydrate-deficient transferrin as a measure of immoderate drinking: remaining issues.
Academic Article Two methods for measuring carbohydrate-deficient transferrin in inpatient alcoholics and healthy controls compared.
Academic Article The obsessive compulsive drinking scale: A new method of assessing outcome in alcoholism treatment studies.
Academic Article Neurobehavioural basis for the pharmacotherapy of alcoholism: current and future directions.
Academic Article Alcohol-related seizures and the kindling effect of repeated detoxifications: the influence of cocaine.
Academic Article Carbohydrate-deficient transferrin as an indicator of drinking status during a treatment outcome study.
Academic Article Pharmacotherapy of alcoholism--10 years of progress.
Academic Article Naltrexone effects on alcohol consumption in a clinical laboratory paradigm: temporal effects of drinking.
Academic Article Self-report and biomarker alcohol screening by primary care physicians: the need to translate research into guidelines and practice.
Academic Article A multi-site dose ranging study of nalmefene in the treatment of alcohol dependence.
Academic Article Biochemical alcohol screening in primary health care.
Academic Article Recent advances in the pharmacotherapy of alcoholism.
Academic Article A review of genetic, biological, pharmacological, and clinical factors that affect carbohydrate-deficient transferrin levels.
Academic Article Effects of naltrexone and nalmefene on subjective response to alcohol among non-treatment-seeking alcoholics and social drinkers.
Academic Article Effectiveness of naltrexone in a community treatment program.
Academic Article Treatment of alcohol withdrawal.
Academic Article Sertraline in the treatment of co-occurring alcohol dependence and posttraumatic stress disorder.
Academic Article Naltrexone combined with either cognitive behavioral or motivational enhancement therapy for alcohol dependence.
Academic Article Design and analysis of trials of combination therapies.
Academic Article Measurement and choice of drinking outcome variables in the COMBINE Study.
Academic Article Cold pressor task reactivity: predictors of alcohol use among alcohol-dependent individuals with and without comorbid posttraumatic stress disorder.
Academic Article The impact of alcohol dependence and posttraumatic stress disorder on cold pressor task response.
Academic Article Thyrotropin and prolactin response to thyrotropin-releasing hormone in depressed and nondepressed alcoholic men.
Academic Article Factors affecting %CDT status at entry into a multisite clinical treatment trial: experience from the COMBINE Study.
Academic Article A double-blind evaluation of gabapentin on alcohol effects and drinking in a clinical laboratory paradigm.
Academic Article What role does measuring medication compliance play in evaluating the efficacy of naltrexone?
Academic Article Markers in the 5'-region of GABRG1 associate to alcohol dependence and are in linkage disequilibrium with markers in the adjacent GABRA2 gene.
Academic Article Topiramate for treating alcohol dependence: a randomized controlled trial.
Academic Article An evaluation of mu-opioid receptor (OPRM1) as a predictor of naltrexone response in the treatment of alcohol dependence: results from the Combined Pharmacotherapies and Behavioral Interventions for Alcohol Dependence (COMBINE) study.
Academic Article Naltrexone and cognitive behavioral therapy for the treatment of alcohol dependence: do sex differences exist?
Academic Article Effect of naltrexone and ondansetron on alcohol cue-induced activation of the ventral striatum in alcohol-dependent people.
Academic Article Improvement of physical health and quality of life of alcohol-dependent individuals with topiramate treatment: US multisite randomized controlled trial.
Academic Article Aripiprazole effects on alcohol consumption and subjective reports in a clinical laboratory paradigm--possible influence of self-control.
Academic Article Blood pressure reduction during treatment for alcohol dependence: results from the Combining Medications and Behavioral Interventions for Alcoholism (COMBINE) study.
Academic Article COMT genotype influences the effect of alcohol on blood pressure: results from the COMBINE study.
Academic Article Alcohol treatment effects on secondary nondrinking outcomes and quality of life: the COMBINE study.
Academic Article Population admixture modulates risk for alcohol dependence.
Academic Article Association of markers in the 3' region of the GluR5 kainate receptor subunit gene to alcohol dependence.
Academic Article A useful test for monitoring alcohol use.
Academic Article Variation in the gene encoding the serotonin transporter is associated with a measure of sociopathy in alcoholics.
Academic Article Editorial commentary: alcohol biomarker papers.
Academic Article Interaction of FKBP5 with childhood adversity on risk for post-traumatic stress disorder.
Academic Article The COMBINE Study-: An Overview of the Largest Pharmacotherapy Study to Date for Treating Alcohol Dependence.
Academic Article Neurocognitive performance, alcohol withdrawal, and effects of a combination of flumazenil and gabapentin in alcohol dependence.
Academic Article GABRG1 and GABRA2 variation associated with alcohol dependence in African Americans.
Academic Article Naltrexone modification of drinking effects in a subacute treatment and bar-lab paradigm: influence of OPRM1 and dopamine transporter (SLC6A3) genes.
Academic Article Variation in regulator of G-protein signaling 17 gene (RGS17) is associated with multiple substance dependence diagnoses.
Academic Article Hypermethylation of OPRM1 promoter region in European Americans with alcohol dependence.
Academic Article Effects of a GABA-ergic medication combination and initial alcohol withdrawal severity on cue-elicited brain activation among treatment-seeking alcoholics.
Academic Article Modeling longitudinal drinking data in clinical trials: an application to the COMBINE study.
Academic Article Alcohol detoxification and withdrawal seizures: clinical support for a kindling hypothesis.
Academic Article Effect of prenatal alcohol exposure on consumption of alcohol and alcohol-induced sleep time in mice.
Academic Article Multisite clinical trials in alcoholism treatment research: organizational, methodological and management issues.
Academic Article Carbohydrate-deficient transferrin levels in a female population.
Academic Article The Obsessive Compulsive Drinking Scale: a self-rated instrument for the quantification of thoughts about alcohol and drinking behavior.
Academic Article Implications of recent neuropsychopharmacologic research for understanding the etiology and development of alcoholism.
Academic Article A correlational study of carbohydrate-deficient transferrin values and alcohol consumption among Hispanic college students.
Academic Article Carbohydrate-deficient transferrin and gamma-glutamyltransferase as markers of heavy alcohol consumption: gender differences.
Academic Article Neurobehavioral aspects of the pharmacotherapy of alcohol dependence.
Academic Article Cerebrospinal fluid concentrations of corticotropin-releasing hormone (CRH) and diazepam-binding inhibitor (DBI) during alcohol withdrawal and abstinence.
Academic Article New methodologies for pharmacological treatment trials for alcohol dependence.
Academic Article The use of carbohydrate deficient transferrin as an indicator of alcohol consumption during treatment and follow-up.
Academic Article Ritanserin in the treatment of alcohol dependence--a multi-center clinical trial. Ritanserin Study Group.
Academic Article Proposed recommendations for research on biochemical markers for problematic drinking.
Academic Article A double-blind comparison of abecarnil and diazepam in the treatment of uncomplicated alcohol withdrawal.
Concept Alcohol-Induced Disorders, Nervous System
Concept Alcoholism
Concept Alcohol-Related Disorders
Academic Article Results of a double-blind, placebo-controlled pharmacotherapy trial in alcoholism conducted in Germany and comparison with the US COMBINE study.
Academic Article Genome-wide association study of alcohol dependence:significant findings in African- and European-Americans including novel risk loci.
Academic Article A phase 2, placebo-controlled study of the opioid receptor antagonist LY2196044 for the treatment of alcohol dependence.
Academic Article Interactive effects of OPRM1 and DAT1 genetic variation on subjective responses to alcohol.
Academic Article Risks of alcohol use disorders related to drinking patterns in the U.S. general population.
Academic Article Cumulative proportion of responders analysis (CPRA) as a tool to assess treatment outcome in alcohol clinical trials.
Academic Article Varenicline effects on drinking, craving and neural reward processing among non-treatment-seeking alcohol-dependent individuals.
Academic Article Pharmacologic treatment of alcoholism.
Academic Article Methods to analyze treatment effects in the presence of missing data for a continuous heavy drinking outcome measure when participants drop out from treatment in alcohol clinical trials.
Academic Article Alcohol-Induced Stimulation Mediates the Effect of a GABRA2 SNP on Alcohol Self-Administrated among Alcohol-Dependent Individuals.
Academic Article The Reasons for Heavy Drinking Questionnaire: Factor Structure and Validity in Alcohol-Dependent Adults Involved in Clinical Trials.
Academic Article Associations Between Recent Heavy Drinking and Dorsal Anterior Cingulate N-Acetylaspartate and Glutamate Concentrations in Non-Treatment-Seeking Individuals with Alcohol Dependence.
Academic Article Association between a brief alcohol craving measure and drinking in the following week.
Academic Article Proof-of-Concept Study to Assess the Nociceptin Receptor Antagonist LY2940094 as a New Treatment for Alcohol Dependence.
Academic Article Relationship of Abnormal Chromatographic Pattern for Carbohydrate-Deficient Transferrin with Severe Liver Disease.
Academic Article Predictors of Naltrexone Response in a Randomized Trial: Reward-Related Brain Activation, OPRM1 Genotype, and Smoking Status.
Academic Article Aripiprazole Suppression of Drinking in a Clinical Laboratory Paradigm: Influence of Impulsivity and Self-Control.
Academic Article Clinical Validation of Reduced Alcohol Consumption After Treatment for Alcohol Dependence Using the World Health Organization Risk Drinking Levels.
Academic Article Unique prefrontal GABA and glutamate disturbances in co-occurring bipolar disorder and alcohol dependence.
Academic Article Dopaminergic Genetic Variation Influences Aripiprazole Effects on Alcohol Self-Administration and the Neural Response to Alcohol Cues in a Randomized Trial.
Academic Article Nicotine-Use/Smoking Is Associated with the Efficacy of Naltrexone in the Treatment of Alcohol Dependence.
Academic Article Reply: Carbohydrate Deficient Transferrin in Patients with Cirrhosis: A Tale of Bridges.
Academic Article Change in non-abstinent WHO drinking risk levels and alcohol dependence: a 3 year follow-up study in the US general population.
Academic Article Transdiagnostic Effects of Ventromedial Prefrontal Cortex Transcranial Magnetic Stimulation on Cue Reactivity.
Academic Article Reduction in Nonabstinent WHO Drinking Risk Levels and Change in Risk for Liver Disease and Positive AUDIT-C Scores: Prospective 3-Year Follow-Up Results in the U.S. General Population.
Academic Article The dopamine transporter VNTR polymorphism moderates the relationship between acute response to alcohol and future alcohol use disorder symptoms.
Academic Article Drinking Risk Level Reductions Associated with Improvements in Physical Health and Quality of Life Among Individuals with Alcohol Use Disorder.
Academic Article Brain Glutamate, GABA, and Glutamine Levels and Associations with Recent Drinking in Treatment-Na?ve Individuals with Alcohol Use Disorder Versus Light Drinkers.
Academic Article Reduction in non-abstinent WHO drinking risk levels and depression/anxiety disorders: 3-year follow-up results in the US general population.
Academic Article Evaluation of Drinking Risk Levels as Outcomes in Alcohol Pharmacotherapy Trials: A Secondary Analysis of 3 Randomized Clinical Trials.
Academic Article Maintenance of World Health Organization Risk Drinking Level Reductions and Posttreatment Functioning Following a Large Alcohol Use Disorder Clinical Trial.
Academic Article Evidence for a unique association between fronto-cortical glycine levels and recent heavy drinking in treatment na?ve individuals with alcohol use disorder.
Academic Article Intraindividual changes in brain GABA, glutamate, and glutamine during monitored abstinence from alcohol in treatment-naive individuals with alcohol use disorder.
Academic Article Medications for Treating Alcoholism.
Academic Article Disulfiram Treatment of Alcoholism.
Academic Article Systematic review and meta-analysis of the moderating effect of rs1799971 in OPRM1, the mu-opioid receptor gene, on response to naltrexone treatment of alcohol use disorder.
Academic Article World Health Organization risk drinking level reductions are associated with improved functioning and are sustained among patients with mild, moderate and severe alcohol dependence in clinical trials in the United States and United Kingdom.
Academic Article Stability of Drinking Reductions and Long-term Functioning Among Patients with Alcohol Use Disorder.
Academic Article The World Health Organization Risk Drinking Levels Measure of Alcohol Consumption: Prevalence and Health Correlates in Nationally Representative Surveys of U.S. Adults, 2001-2002 and 2012-2013.
Academic Article Piloting of the Just Say Know prevention program: a psychoeducational approach to translating the neuroscience of addiction to youth.
Academic Article The Utility of Carbohydrate-Deficient Transferrin in Identifying Chronic Alcohol Users in the Injured Patient: Expanding the Toolkit.
Academic Article Efficacy of Gabapentin for the Treatment of Alcohol Use Disorder in Patients With Alcohol Withdrawal Symptoms: A Randomized Clinical Trial.
Academic Article Reduction in World Health Organization Risk Drinking Levels and Cardiovascular Disease.
Academic Article Opioid and Dopamine Genes Interact to Predict Naltrexone Response in a Randomized Alcohol Use Disorder Clinical Trial.
Concept Fetal Alcohol Spectrum Disorders
Academic Article Effects of Gabapentin on Dorsal Anterior Cingulate Cortex GABA and Glutamate Levels and Their Associations With Abstinence in Alcohol Use Disorder: A Randomized Clinical Trial.
Academic Article Epigenetic moderators of naltrexone efficacy in reducing heavy drinking in Alcohol Use Disorder: a randomized trial.
Academic Article Genetic contributions to alcohol use disorder treatment outcomes: a genome-wide pharmacogenomics study.
Academic Article The Relationship Between Reductions in WHO Risk Drinking Levels During Treatment and Subsequent Healthcare Costs for the ACTIVE Workgroup.
Academic Article Effects of pharmacological and genetic regulation of COMT activity in alcohol use disorder: a randomized, placebo-controlled trial of tolcapone.
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  • Alcoholism