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Atkinson, Carl

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Property	Value
fax	843-792-2464
keywords	chronic lung disease
overview	Heart transplantation is an accept treatment modality for patients with end-stage heart disease. These patients have reached the end of conventional pharmacological therapy or surgical interventions and the only therapeutic option left is heart transplantation. Current first year survival rates post transplantation varies between 80-95%, and patients surviving beyond the first can expect an average half-life of 11 years. While these results are acceptable patients eventually succumb to chronic rejection which manifests as an obliterative vascular lesion which restricts the hearts blood supply and eventually leads to heart failure. The precise mechanisms that contribute to the development of chronic rejection are unknown, but recent data implicates the early ischemic damage these hearts receive due to the transplant process and brain death. Results from kidney transplantation have shown that the quality of the donor organ is important for post transplant survival. Organs donated from living donors perform better than those harvested from cadaveric donors. It is believed that the processes stimulated during brain death in these cadaveric donors, activates the donor heart rendering it more susceptible to ischemic damage, upon implantation, and ultimately acute and chronic rejection. The mechanisms responsible for these inflammatory changes to the donor organ are poorly characterized. Our research focuses on the elucidation of these mechanisms and the application of novel therapies that can be applied to the donor prior to transplantation to limit donor organ damage. During brain death all of the organs in the body are exposed to ischemia and chaotic changes in blood supply and pressure. Our studies have implicated the complement system in the activation of the donor heart. The complement system is composed of a series of serum proteins that work in a concerted fashion to induce cell death, promote inflammation and pro-inflammatory cytokines. We have been working with complement inhibitory proteins with the aim to reduce complement mediated brain death induced inflammation and ultimately to reduce the incidence and severity of both acute and chronic rejection.

One or more keywords matched the following items that are connected to Atkinson, Carl

Item Type	Name
Academic Article	Histopathology of cardiac xenograft rejection in the pig-to-baboon model.
Academic Article	Heat shock protein, inducible nitric oxide synthase and apoptotic markers in the acute phase of human cardiac transplantation.
Academic Article	Microvascular changes in small airways predispose to obliterative bronchiolitis after lung transplantation.
Academic Article	Investigation of second genetic hits at the BMPR2 locus as a modulator of disease progression in familial pulmonary arterial hypertension.
Academic Article	Endothelial activation in the transplanted human heart from organ retrieval to 3 months after transplantation: an observational study.
Academic Article	Complement plays an important role in spinal cord injury and represents a therapeutic target for improving recovery following trauma.
Academic Article	Is obliterative bronchiolitis in lung transplantation associated with microvascular damage to small airways?
Academic Article	A novel targeted inhibitor of the alternative pathway of complement and its therapeutic application in ischemia/reperfusion injury.
Academic Article	Posttransplant lymphoproliferative disorder associated with primate gamma-herpesvirus in cynomolgus monkeys used in pig-to-primate renal xenotransplantation and primate renal allotransplantation.
Academic Article	A complement-dependent balance between hepatic ischemia/reperfusion injury and liver regeneration in mice.
Academic Article	Complement-dependent inflammation and injury in a murine model of brain dead donor hearts.
Academic Article	Alterations in gene expression of complement components in chronic rhinosinusitis.
Academic Article	The alternative and terminal pathways of complement mediate post-traumatic spinal cord inflammation and injury.
Academic Article	Primary pulmonary hypertension is associated with reduced pulmonary vascular expression of type II bone morphogenetic protein receptor.
Academic Article	Complement inhibition alleviates paraquat-induced acute lung injury.
Academic Article	CD4+ T cells and complement independently mediate graft ischemia in the rejection of mouse orthotopic tracheal transplants.
Academic Article	A targeted complement-dependent strategy to improve the outcome of mAb therapy, and characterization in a murine model of metastatic cancer.
Academic Article	The energy metabolism in the right and left ventricles of human donor hearts across transplantation.
Academic Article	Alternative complement pathway deficiency ameliorates chronic smoke-induced functional and morphological ocular injury.
Academic Article	Neointimal smooth muscle cells in human cardiac allograft coronary artery vasculopathy are of donor origin.
Academic Article	Use of 18FDG-pet to discriminate between infection and rejection in lung transplant recipients.
Academic Article	Polymers of Z alpha1-antitrypsin co-localize with neutrophils in emphysematous alveoli and are chemotactic in vivo.
Academic Article	Dysfunctional Smad signaling contributes to abnormal smooth muscle cell proliferation in familial pulmonary arterial hypertension.
Academic Article	Angiogenesis occurs within the intimal proliferation that characterizes transplant coronary artery vasculopathy.
Academic Article	Targeted complement inhibition by C3d recognition ameliorates tissue injury without apparent increase in susceptibility to infection.
Academic Article	Complement-dependent P-selectin expression and injury following ischemic stroke.
Academic Article	A complement C3 inhibitor specifically targeted to sites of complement activation effectively ameliorates collagen-induced arthritis in DBA/1J mice.
Academic Article	Low-dose targeted complement inhibition protects against renal disease and other manifestations of autoimmune disease in MRL/lpr mice.
Academic Article	Modulation of protective T cell immunity by complement inhibitor expression on tumor cells.
Academic Article	Toll-like receptor 4 is a key mediator of murine steatotic liver warm ischemia/reperfusion injury.
Academic Article	A role for complement in the enhanced susceptibility of steatotic livers to ischemia and reperfusion injury.
Academic Article	Cigarette smoke extract stimulates interleukin-8 production in human airway epithelium and is attenuated by superoxide dismutase in vitro.
Academic Article	Ketamine-xylazine-acepromazine compared with isoflurane for anesthesia during liver transplantation in rodents.
Academic Article	Deposition of C4d and C3d in cardiac transplants: a factor in the development of coronary artery vasculopathy.
Academic Article	Murine Kupffer cells are protective in total hepatic ischemia/reperfusion injury with bowel congestion through IL-10.
Academic Article	Murine complement deficiency ameliorates acute cigarette smoke-induced nasal damage.
Academic Article	Targeted complement inhibitors protect against posttransplant cardiac ischemia and reperfusion injury and reveal an important role for the alternative pathway of complement activation.
Academic Article	Toll-like receptor 4 knockout mice are protected from endothelial overactivation in the absence of Kupffer cells after total hepatic ischemia/reperfusion.
Academic Article	Human sinonasal epithelial cells direct dendritic function and T-cell T helper 1/T helper 2 skewing following Aspergillus exposure.
Academic Article	Increased presence of dendritic cells and dendritic cell chemokines in the sinus mucosa of chronic rhinosinusitis with nasal polyps and allergic fungal rhinosinusitis.
Academic Article	Complement-dependent injury and protection in a murine model of acute dextran sulfate sodium-induced colitis.
Academic Article	A new treatment for neurogenic inflammation caused by EV71 with CR2-targeted complement inhibitor.
Academic Article	Donor brain death exacerbates complement-dependent ischemia/reperfusion injury in transplanted hearts.
Concept	Cytokines
Concept	Tissue Distribution
Concept	Diagnosis, Differential
Concept	Muscle, Smooth, Vascular
Concept	Oligodeoxyribonucleotides, Antisense
Concept	Heterocyclic Compounds, 4 or More Rings
Concept	Chromosomes, Human, Y
Concept	Immunotherapy
Concept	Epithelial Cells
Concept	Enzyme-Linked Immunosorbent Assay
Concept	Protein Binding
Concept	Neutrophils
Concept	Disease Models, Animal
Concept	Intestinal Mucosa
Concept	Myocardial Ischemia
Concept	RNA
Concept	Anesthesia
Concept	Retinal Pigment Epithelium
Concept	Kidney Glomerulus
Concept	Apoptosis
Concept	Interleukin-10
Concept	Necrosis
Concept	Folic Acid
Concept	Prognosis
Concept	Annexin A4
Concept	Elastin
Concept	Kidney Transplantation
Concept	DNA-Binding Proteins
Concept	Mixed Function Oxygenases
Concept	Microscopy, Electron
Concept	Lung Neoplasms
Concept	Intestinal Diseases
Concept	RNA, Small Interfering
Concept	Dextran Sulfate
Concept	Transcription Factor CHOP
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Concept	Complement C5a
Concept	Emphysema
Concept	Heat-Shock Proteins
Concept	Interferon-gamma
Concept	Nicotine
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Concept	Lupus Nephritis
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Concept	Hematopoietic Stem Cell Transplantation
Concept	Vitamin D Deficiency
Concept	Pulmonary Disease, Chronic Obstructive
Concept	Incidence
Concept	Gammaherpesvirinae
Concept	25-Hydroxyvitamin D3 1-alpha-Hydroxylase
Concept	Neoplasm Metastasis
Concept	Airway Obstruction
Concept	Heterozygote
Concept	Macaca fascicularis
Concept	Complement Membrane Attack Complex
Concept	Liver Regeneration
Concept	p38 Mitogen-Activated Protein Kinases
Concept	Fibrinolytic Agents
Concept	Isoflurane
Concept	Communicable Diseases
Concept	Gene Expression
Concept	Polymers
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Concept	Pyrazoles
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Concept	Autophagy
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Concept	CD8-Positive T-Lymphocytes
Concept	Antigen-Antibody Complex
Concept	Kidney Diseases
Concept	Complement C2
Concept	Sensitivity and Specificity
Concept	Hypoxia
Concept	Self Tolerance
Concept	Vascular Cell Adhesion Molecule-1
Concept	Urinary Bladder Neoplasms
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Concept	Cell Adhesion Molecules
Concept	Aorta, Thoracic
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Concept	Myocardial Reperfusion
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Concept	HSP70 Heat-Shock Proteins
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Concept	Random Allocation
Concept	Mice, Knockout
Concept	Clodronic Acid
Concept	Immunosuppressive Agents
Concept	Wound Healing
Concept	Cohort Studies
Concept	Complement Pathway, Classical
Concept	Antibodies
Concept	Peptide Fragments
Concept	Endothelial Cells
Concept	Receptor, Endothelin A
Concept	Lung Injury
Concept	Coronary Artery Disease
Concept	Leukemia
Concept	Hypertension, Pulmonary
Concept	Myocytes, Cardiac
Concept	Stroke
Concept	Fungi
Concept	Acute Disease
Concept	Biological Products
Concept	Coronary Vessels
Concept	Recombinant Proteins
Concept	Pulmonary Artery
Concept	Hematinics
Concept	STAT3 Transcription Factor
Concept	CD55 Antigens
Concept	Single-Chain Antibodies
Concept	Complement Pathway, Mannose-Binding Lectin
Concept	Chemotaxis
Concept	Adolescent
Concept	CHO Cells
Concept	Blotting, Western
Concept	Lymphoma
Concept	Bronchi
Concept	bcl-2-Associated X Protein
Concept	Toll-Like Receptor 4
Concept	T-Lymphocytes, Regulatory
Concept	Complement C3a
Concept	Complement Factor H
Concept	Cold Ischemia
Concept	B7-1 Antigen
Concept	Membrane Cofactor Protein
Concept	Antigens, Differentiation, Myelomonocytic
Concept	Acepromazine
Concept	Lipopolysaccharides
Concept	Neutrophil Infiltration
Concept	Transplantation Tolerance
Concept	Ventricular Remodeling
Concept	Thrombin
Concept	Acute Lung Injury
Concept	Regeneration
Concept	Myocardial Infarction
Concept	Neovascularization, Pathologic
Concept	Polysaccharides
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Concept	Dietary Supplements
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Concept	Smad Proteins
Concept	Up-Regulation
Concept	Leukocyte Count
Concept	Energy Metabolism
Concept	Transplantation, Heterologous
Concept	Homozygote
Concept	Enterovirus A, Human
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Concept	Interleukin-5
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Concept	Cell Differentiation
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Concept	Inflammation Mediators
Concept	Receptors, Complement 3d
Concept	Clinical Trials as Topic
Concept	Complement Inactivator Proteins
Concept	Aspergillus fumigatus
Concept	Oropharyngeal Neoplasms
Concept	Models, Biological
Concept	Leukocyte Common Antigens
Concept	Cardiovascular Diseases
Concept	Kinetics
Concept	Lipids
Concept	Bone Morphogenetic Protein Receptors, Type II
Concept	Germ-Line Mutation
Concept	Lung Diseases
Concept	Mitogen-Activated Protein Kinase 3
Concept	Microscopy, Confocal
Concept	Leukocytes
Concept	Dimerization
Concept	Colitis
Concept	Tumor Necrosis Factor-alpha
Concept	Antibody-Dependent Cell Cytotoxicity
Concept	Nystagmus, Optokinetic
Concept	Gene Expression Regulation, Developmental
Concept	Graft vs Host Disease
Concept	Transplants
Concept	Mice, Inbred ICR
Concept	Hepatectomy
Concept	Melanoma
Concept	Immunity, Innate
Concept	Anesthetics, Inhalation
Concept	Antibodies, Bispecific
Concept	B7-2 Antigen
Concept	Tissue Engineering
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Concept	Organ Specificity
Concept	Complement C6
Concept	Complement System Proteins
Concept	Adult
Concept	Mice, Inbred C57BL
Concept	Bone Morphogenetic Proteins
Concept	Retrospective Studies
Concept	Anti-Inflammatory Agents
Concept	Leukocyte Elastase
Concept	Gene Expression Regulation
Concept	Tunica Intima
Concept	Receptors, Complement
Concept	Melanoma, Experimental
Concept	Mitochondria, Liver
Concept	Male
Concept	Bronchoalveolar Lavage Fluid
Concept	Tobacco
Concept	Cells, Cultured
Concept	Immunoglobulin M
Concept	Alanine Transaminase
Concept	Cell Hypoxia
Concept	Loss of Heterozygosity
Concept	Mice, Transgenic
Concept	Recovery of Function
Concept	T-Lymphocytes
Concept	Nitric Oxide Synthase
Concept	Locomotion
Concept	Phosphates
Concept	Animals, Genetically Modified
Concept	Oxygen
Concept	Tumor Virus Infections
Concept	Visual Acuity
Concept	Antigens, CD
Concept	Epitopes
Concept	Transplantation, Homologous
Concept	Injections, Intraperitoneal
Concept	Signal Transduction
Concept	Monocytes
Concept	P-Selectin
Concept	Female
Concept	DNA Mutational Analysis
Concept	Complement C3d
Concept	Anastomosis, Surgical
Concept	Free Radical Scavengers
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Concept	Immunoglobulin G
Concept	RNA, Messenger
Concept	Warm Ischemia
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Concept	Oxidative Stress
Concept	Heart
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Concept	Neural Tube Defects
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Concept	Receptors, Complement 3b
Concept	Myocytes, Smooth Muscle
Concept	Smoking
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Concept	Longitudinal Studies
Concept	Cell Death
Concept	Pneumonia
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Concept	Inflammation
Concept	CD11b Antigen
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Concept	Ketamine
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Concept	Receptor, Anaphylatoxin C5a
Concept	Aorta, Abdominal
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Concept	Microglia
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Concept	Electroretinography
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Concept	Papillomaviridae
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Concept	Nasal Mucosa
Concept	Graft Rejection
Concept	Papio
Concept	Case-Control Studies
Concept	Ischemic Preconditioning
Concept	Microcirculation
Concept	Mucin-1
Concept	Models, Cardiovascular
Concept	Platelet Endothelial Cell Adhesion Molecule-1
Concept	Gene Expression Regulation, Neoplastic
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Concept	Middle Aged
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Concept	Gene Knockout Techniques
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Concept	Follow-Up Studies
Concept	Glutamyl Aminopeptidase
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Concept	Immunohistochemistry
Concept	Lung Diseases, Interstitial
Concept	Immune Tolerance
Concept	Respiratory Mucosa
Concept	Mice, Mutant Strains
Concept	Cell Line, Tumor
Concept	Pulmonary Emphysema
Concept	Molecular Sequence Data
Concept	Immunologic Memory
Concept	Scotland
Concept	Myelitis
Academic Article	Cigarette smoke exposure is associated with vitamin D3 deficiencies in patients with chronic rhinosinusitis.
Academic Article	Smoke exposure causes endoplasmic reticulum stress and lipid accumulation in retinal pigment epithelium through oxidative stress and complement activation.
Academic Article	Dissecting the complement pathway in hepatic injury and regeneration with a novel protective strategy.
Academic Article	Immunosuppressive nano-therapeutic micelles downregulate endothelial cell inflammation and immunogenicity.
Academic Article	New therapeutic and diagnostic opportunities for injured tissue-specific targeting of complement inhibitors and imaging modalities.
Academic Article	A Targeted Inhibitor of the Alternative Complement Pathway Accelerates Recovery From Smoke-Induced Ocular Injury.
Academic Article	Modulation of post-stroke degenerative and regenerative processes and subacute protection by site-targeted inhibition of the alternative pathway of complement.
Academic Article	Relationship between Targeting Efficacy of Liposomes and the Dosage of Targeting Antibody Using Surface Plasmon Resonance.
Academic Article	Folic acid in pregnancy and mortality from cancer and cardiovascular disease: further follow-up of the Aberdeen folic acid supplementation trial.
Academic Article	Targeting pathogenic postischemic self-recognition by natural IgM to protect against posttransplantation cardiac reperfusion injury.
Academic Article	Deficiency of the Angiotensinase Aminopeptidase A Increases Susceptibility to Glomerular Injury.
Academic Article	Serum Proteins Associated with Emphysema Progression in Severe Alpha-1 Antitrypsin Deficiency.
Academic Article	Natural IgM antibodies that bind neoepitopes exposed as a result of spinal cord injury , drive secondary injury by activating complement.
Academic Article	Impact of tobacco smoke on upper airway dendritic cell accumulation and regulation by sinonasal epithelial cells.
Academic Article	Dietary vitamin D3 deficiency exacerbates sinonasal inflammation and alters local 25(OH)D3 metabolism.
Academic Article	The role of regulatory T cells in the regulation of upper airway inflammation.
Academic Article	Donor pretreatment with nebulized complement C3a receptor antagonist mitigates brain-death induced immunological injury post-lung transplant.
Academic Article	C3a receptor antagonism as a novel therapeutic target for chronic rhinosinusitis.
Academic Article	HDAC inhibition helps post-MI healing by modulating macrophage polarization.
Academic Article	Organ preservation with targeted rapamycin nanoparticles: a pre-treatment strategy preventing chronic rejection in vivo.
Academic Article	Smoking-induced control of miR-133a-3p alters the expression of EGFR and HuR in HPV-infected oropharyngeal cancer.
Academic Article	Complement C3a and C5a receptors promote GVHD by suppressing mitophagy in recipient dendritic cells.
Academic Article	Emphysema-associated Autoreactive Antibodies Exacerbate Post-Lung Transplant Ischemia-Reperfusion Injury.
Academic Article	Contribution of Epithelial Cell Dysfunction to the Pathogenesis of Chronic Rhinosinusitis with Nasal Polyps.
Academic Article	Targeting the Complement Alternative Pathway Permits Graft Versus Leukemia Activity while Preventing Graft Versus Host Disease.
Academic Article	MicroRNA-206 antagomiR?enriched extracellular vesicles attenuate lung ischemia?reperfusion injury through CXCL1 regulation in alveolar epithelial cells.
Academic Article	A novel injury site-natural antibody targeted complement inhibitor protects against lung transplant injury.
Academic Article	Surgical Innovation: Heart Transplantation After Cardiac Death.
Academic Article	Adoptive Transfer of Regulatory Immune Cells in Organ Transplantation.
Academic Article	T-cell Immunometabolism: Therapeutic Implications in Organ Transplantation.
Academic Article	Ex vivo blockade of PI3K gamma or delta signaling enhances the antitumor potency of adoptively transferred CD8+ T cells.
Academic Article	Immunization Against Oxidized Elastin Exacerbates Structural and Functional Damage in Mouse Model of Smoke-Induced Ocular Injury.
Concept	Long Term Adverse Effects
Concept	Molecular Targeted Therapy
Concept	Endoplasmic Reticulum Stress
Concept	Th17 Cells
Concept	Class I Phosphatidylinositol 3-Kinases
Concept	Class Ib Phosphatidylinositol 3-Kinase
Concept	Inflammasomes
Concept	Real-Time Polymerase Chain Reaction
Concept	Antagomirs
Concept	Primary Cell Culture
Concept	Tobacco Products
Concept	Mitochondrial Dynamics
Concept	Vascularized Composite Allotransplantation
Concept	Allografts
Concept	Composite Tissue Allografts
Concept	Isografts
Concept	Cell- and Tissue-Based Therapy
Concept	Rhinitis, Allergic
Concept	ErbB Receptors
Concept	ELAV-Like Protein 1
Academic Article	In Situ Pre-Treatment of Vascularized Composite Allografts With a Targeted Complement Inhibitor Protects Against Brain Death and Ischemia Reperfusion Induced Injuries.
Academic Article	Modulating donor mitochondrial fusion/fission delivers immunoprotective effects in cardiac transplantation.
Academic Article	Increasing the efficacy and safety of a human complement inhibitor for treating post-transplant cardiac ischemia reperfusion injury by targeting to a graft-specific neoepitope.
Academic Article	Set Up for Failure: Pre-Existing Autoantibodies in Lung Transplant.
Academic Article	Pro-inflammatory IgG1 N-glycan signature correlates with primary graft dysfunction onset in COPD patients.
Academic Article	Characterization of Novel P-Selectin Targeted Complement Inhibitors in Murine Models of Hindlimb Injury and Transplantation.
Academic Article	Nanotherapeutics in transplantation: How do we get to clinical implementation?
Academic Article	Role of C3a as a Novel Regulator of 25(OH)D3 to 1a,25-Dihydroxyvitamin D3 Metabolism in Upper Airway Epithelial Cells.
Academic Article	Resolution of post-lung transplant ischemia-reperfusion injury is modulated via Resolvin D1-FPR2 and Maresin 1-LGR6 signaling.
Academic Article	Complement inhibition alleviates donor brain death-induced liver injury and posttransplant cascade injury by regulating phosphoinositide 3-kinase signaling.
Academic Article	The Highly Sensitized Recipient: Pretransplant and Posttransplant Considerations.
Academic Article	Crosstalk between pro-survival sphingolipid metabolism and complement signaling induces inflammasome-mediated tumor metastasis.

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