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One or more keywords matched the following properties of Bastia, Deepak
overview The primary focus of our laboratory is on the investigations of the molecular mechanisms of replication fork arrest, genome stability, checkpoint controls using Saccharomyces cerevisiae and Schizosaccharomyces pombe as model systems. These are topics of intense current interest not only from the perspectives of eukaryotic DNA transactions but also of Cancer Biology. Our laboratory is also interested in the molecular analysis of the human “timeless” protein and TIPIN (timeless-interacting protein). Molecular Mechanisms of Cellular Aging. Recently, using yeast as a model system, we have worked out one (the major) pathway of cellular aging. We have shown that two molecular mechanisms act in a sequence to control replicative life span: (i) autoinhibition of a replication terminator protein called Fob1 and chromosome kissing. Further work is underway to study the molecular mechanisms that lead to aging and senescence. Our laboratory offers outstanding training in nucleic acids biochemistry, enzymology of DNA replication and on protein nucleic acids and protein-protein interactions.
One or more keywords matched the following items that are connected to Bastia, Deepak
Item TypeName
Academic Article Binding of the replication terminator protein Fob1p to the Ter sites of yeast causes polar fork arrest.
Academic Article The Tof1p-Csm3p protein complex counteracts the Rrm3p helicase to control replication termination of Saccharomyces cerevisiae.
Academic Article Mechanistic insights into replication termination as revealed by investigations of the Reb1-Ter3 complex of Schizosaccharomyces pombe.
Academic Article Contrasting roles of checkpoint proteins as recombination modulators at Fob1-Ter complexes with or without fork arrest.
Academic Article Mechanisms of polar arrest of a replication fork.
Academic Article Replication fork arrest and rDNA silencing are two independent and separable functions of the replication terminator protein Fob1 of Saccharomyces cerevisiae.
Academic Article The intra-S phase checkpoint protein Tof1 collaborates with the helicase Rrm3 and the F-box protein Dia2 to maintain genome stability in Saccharomyces cerevisiae.
Concept Silent Information Regulator Proteins, Saccharomyces cerevisiae
Concept Saccharomyces cerevisiae
Concept Saccharomyces cerevisiae Proteins
Academic Article Mechanism and physiological significance of programmed replication termination.
Academic Article Mechanism of regulation of 'chromosome kissing' induced by Fob1 and its physiological significance.
Academic Article Mechanism of Regulation of Intrachromatid Recombination and Long-Range Chromosome Interactions in Saccharomyces cerevisiae.
Academic Article Phosphorylation of CMG helicase and Tof1 is required for programmed fork arrest.
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  • Saccharomyces cerevisiae