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Chou, C.
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overview Dr. Chou's research focuses on the use of unique chemical tools to study the roles of mammalian histone deacetylase (HDAC) in physiological and pathological processes. Using selective HDAC inhibitors and unique chemical activity probes developed in his laboratory, he is investigating the biological roles of specific HDACs through chemical means and their therapeutic potential in cancer.
One or more keywords matched the following items that are connected to Chou, C.
Item TypeName
Academic Article Pimelic diphenylamide 106 is a slow, tight-binding inhibitor of class I histone deacetylases.
Academic Article Chemical probes identify a role for histone deacetylase 3 in Friedreich's ataxia gene silencing.
Academic Article Chromatin structure determines accessibility of a hairpin polyamide-chlorambucil conjugate at histone H4 genes in pancreatic cancer cells.
Academic Article Inhibition of HDAC2 protects the retina from ischemic injury.
Academic Article A two-hit mechanism for pre-mitotic arrest of cancer cell proliferation by a polyamide-alkylator conjugate.
Academic Article Small molecules targeting histone H4 as potential therapeutics for chronic myelogenous leukemia.
Academic Article Design and synthesis of novel hybrid benzamide-peptide histone deacetylase inhibitors.
Academic Article Potent activity against K562 cells by polyamide-seco-CBI conjugates targeting histone H4 genes.
Academic Article Two new pimelic diphenylamide HDAC inhibitors induce sustained frataxin upregulation in cells from Friedreich's ataxia patients and in a mouse model.
Academic Article A novel class of small molecule inhibitors of HDAC6.
Concept Histone Deacetylase 1
Concept Histone Deacetylases
Concept Histone Deacetylase Inhibitors
Concept Histone Deacetylase 2
Concept Histones
Academic Article Acetylation: a lysine modification with neuroprotective effects in ischemic retinal degeneration.
Academic Article Acetylation preserves retinal ganglion cell structure and function in a chronic model of ocular hypertension.
Academic Article Discovery of the first N-hydroxycinnamamide-based histone deacetylase 1/3 dual inhibitors with potent oral antitumor activity.
Academic Article Histone deacetylase inhibitors with enhanced enzymatic inhibition effects and potent in vitro and in vivo antitumor activities.
Academic Article Design and synthesis of a tetrahydroisoquinoline-based hydroxamate derivative (ZYJ-34v), an oral active histone deacetylase inhibitor with potent antitumor activity.
Academic Article Development of N-Hydroxycinnamamide-Based Histone Deacetylase Inhibitors with Indole-Containing Cap Group.
Academic Article Evidence for a non-canonical role of HDAC5 in regulation of the cardiac Ncx1 and Bnp genes.
Academic Article HDACs Regulate miR-133a Expression in Pressure Overload-Induced Cardiac Fibrosis.
Academic Article Design, synthesis, and antitumor evaluation of novel histone deacetylase inhibitors equipped with a phenylsulfonylfuroxan module as a nitric oxide donor.
Academic Article Ischemic preconditioning, retinal neuroprotection and histone deacetylase activities.
Concept Histone Deacetylase 6
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  • Histones