| Item Type | Name |
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Academic Article
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Functional studies of the Mycobacterium tuberculosis iron-dependent regulator.
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Academic Article
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Pimelic diphenylamide 106 is a slow, tight-binding inhibitor of class I histone deacetylases.
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Academic Article
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Chemical probes identify a role for histone deacetylase 3 in Friedreich's ataxia gene silencing.
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Academic Article
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Chromatin structure determines accessibility of a hairpin polyamide-chlorambucil conjugate at histone H4 genes in pancreatic cancer cells.
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Academic Article
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Inhibition of HDAC2 protects the retina from ischemic injury.
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Academic Article
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A two-hit mechanism for pre-mitotic arrest of cancer cell proliferation by a polyamide-alkylator conjugate.
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Academic Article
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Unanticipated differences between alpha- and gamma-diaminobutyric acid-linked hairpin polyamide-alkylator conjugates.
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Academic Article
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Crystal structures, metal activation, and DNA-binding properties of two-domain IdeR from Mycobacterium tuberculosis.
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Academic Article
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Small molecules targeting histone H4 as potential therapeutics for chronic myelogenous leukemia.
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Academic Article
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Growth arrest of BCR-ABL positive cells with a sequence-specific polyamide-chlorambucil conjugate.
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Academic Article
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Design and synthesis of novel hybrid benzamide-peptide histone deacetylase inhibitors.
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Academic Article
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Potent activity against K562 cells by polyamide-seco-CBI conjugates targeting histone H4 genes.
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Academic Article
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Two new pimelic diphenylamide HDAC inhibitors induce sustained frataxin upregulation in cells from Friedreich's ataxia patients and in a mouse model.
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Academic Article
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A novel class of small molecule inhibitors of HDAC6.
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Academic Article
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Vitamin K: a structural basis for the design of novel neuroprotective agents?
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Concept
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Nylons
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Concept
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src Homology Domains
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Concept
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Leukemia, Erythroblastic, Acute
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Concept
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Protein Binding
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Concept
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Neutrophils
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Concept
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Disease Models, Animal
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Concept
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DNA-Binding Proteins
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Concept
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RNA, Small Interfering
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Concept
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Vitamin K
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Concept
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Mycobacterium tuberculosis
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Concept
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Alkylating Agents
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Concept
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Magnetic Resonance Spectroscopy
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Concept
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HeLa Cells
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Concept
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Drug Discovery
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Concept
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Cell Division
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Concept
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Drug Design
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Concept
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Polymers
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Concept
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Cats
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Concept
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Histone Deacetylase 1
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Concept
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Mice, Inbred BALB C
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Concept
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Sodium-Calcium Exchanger
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Concept
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Body Weight
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Concept
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Disulfides
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Concept
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Mice, Obese
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Concept
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Hydrogel, Polyethylene Glycol Dimethacrylate
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Concept
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Antineoplastic Agents, Alkylating
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Concept
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Isoquinolines
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Concept
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Vitamin K 3
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Concept
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Cell Adhesion
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Concept
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Macrophages
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Concept
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Administration, Oral
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Concept
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Animals
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Concept
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Neurodegenerative Diseases
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Concept
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Genes
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Concept
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Chronic Disease
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Concept
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Adenosine Triphosphate
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Concept
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Silver
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Concept
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Mice, Knockout
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Concept
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Hydroxamic Acids
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Concept
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Antineoplastic Agents
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Concept
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Natriuretic Peptide, Brain
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Concept
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Recombinant Proteins
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Concept
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Blotting, Western
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Concept
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Pancreatic Neoplasms
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Concept
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Fusion Proteins, bcr-abl
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Concept
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Neuroprotective Agents
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Concept
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YY1 Transcription Factor
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Concept
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Rats, Inbred BN
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Concept
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Anticonvulsants
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Concept
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Acetyltransferases
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Concept
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Tumor Cells, Cultured
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Concept
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Aminobutyrates
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Concept
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Dose-Response Relationship, Drug
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Concept
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Iron
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Concept
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Caspase 3
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Concept
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Iron-Binding Proteins
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Concept
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Obesity
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Concept
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Chromatin
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Concept
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Mice
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Concept
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Ocular Hypertension
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Concept
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Cell Line, Transformed
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Concept
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DNA Primers
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Concept
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Valproic Acid
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Concept
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Insulin Resistance
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Concept
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Models, Biological
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Concept
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Epilepsy
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Concept
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Drug Evaluation, Preclinical
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Concept
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Transcription, Genetic
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Concept
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Pyrroles
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Concept
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Naphthoquinones
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Concept
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Histone Deacetylases
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Concept
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Dimerization
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Concept
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Repressor Proteins
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Concept
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Tryptophan
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Concept
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Nickel
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Concept
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Mice, Inbred C57BL
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Concept
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Lysine
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Concept
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Cells, Cultured
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Concept
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Huntington Disease
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Concept
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Vitamin K 2
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Concept
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G2 Phase
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Concept
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Nucleic Acid Conformation
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Concept
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Xenograft Model Antitumor Assays
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Concept
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RNA, Messenger
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Concept
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Cell Proliferation
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Concept
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Humans
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Concept
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Heart
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Concept
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Laminin
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Concept
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DNA, Bacterial
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Concept
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Drug Screening Assays, Antitumor
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Concept
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Chlorambucil
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Concept
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Protein Structure, Tertiary
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Concept
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Cardiomegaly
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Concept
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Lymphocytes
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Concept
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Inflammation
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Concept
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Giant Cells
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Concept
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Crystallography, X-Ray
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Concept
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Analysis of Variance
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Concept
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Reverse Transcriptase Polymerase Chain Reaction
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Concept
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Models, Animal
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Concept
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HL-60 Cells
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Concept
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Histone Deacetylase Inhibitors
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Concept
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Bacterial Proteins
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Concept
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Cell Culture Techniques
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Concept
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Electroretinography
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Concept
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Swimming
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Concept
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Protein Structure, Quaternary
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Concept
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K562 Cells
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Concept
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Friedreich Ataxia
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Concept
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Cyclization
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|
Concept
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Pimelic Acids
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Concept
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Acetylation
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Concept
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Binding Sites
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Concept
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Molecular Conformation
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Concept
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Mice, Nude
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Concept
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Mutagenesis
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Concept
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Ischemic Preconditioning
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Concept
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Neoplasm Proteins
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Concept
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Leukemia, Myeloid, Acute
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|
Concept
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Spectrometry, Fluorescence
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Concept
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Leukemia, Myelogenous, Chronic, BCR-ABL Positive
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Concept
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Rats
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Concept
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Reperfusion Injury
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Concept
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In Situ Hybridization
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Concept
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Metals
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Concept
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Ions
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Concept
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Models, Molecular
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Concept
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Benzamides
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Concept
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Enzyme Inhibitors
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|
Concept
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Cell Line
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|
Concept
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Proto-Oncogene Proteins c-fos
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|
Concept
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Dimethylallyltranstransferase
|
|
Concept
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Polymerase Chain Reaction
|
|
Concept
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Sulfides
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|
Concept
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Nitric Oxide Donors
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|
Concept
|
Protein Conformation
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|
Concept
|
Histone Deacetylase 2
|
|
Concept
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U937 Cells
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|
Concept
|
MicroRNAs
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|
Concept
|
Alkylation
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|
Concept
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Promoter Regions, Genetic
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|
Concept
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Gene Silencing
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|
Concept
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Base Sequence
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|
Concept
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Zebrafish
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|
Concept
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Anisotropy
|
|
Concept
|
Immunohistochemistry
|
|
Concept
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Cell Line, Tumor
|
|
Concept
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Molecular Sequence Data
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|
Academic Article
|
Novel Vitamin K analogs suppress seizures in zebrafish and mouse models of epilepsy.
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|
Academic Article
|
Acetylation: a lysine modification with neuroprotective effects in ischemic retinal degeneration.
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|
Academic Article
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Acetylation preserves retinal ganglion cell structure and function in a chronic model of ocular hypertension.
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|
Academic Article
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Discovery of the first N-hydroxycinnamamide-based histone deacetylase 1/3 dual inhibitors with potent oral antitumor activity.
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Academic Article
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Short laminin peptide for improved neural stem cell growth.
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Academic Article
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Discovery of a Pair of Diastereomers as Potent HDACs Inhibitors: Determination of Absolute Configuration, Biological Activity Comparison and Computational Study.
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|
Academic Article
|
Histone deacetylase inhibitors with enhanced enzymatic inhibition effects and potent in vitro and in vivo antitumor activities.
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Academic Article
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Design and synthesis of a tetrahydroisoquinoline-based hydroxamate derivative (ZYJ-34v), an oral active histone deacetylase inhibitor with potent antitumor activity.
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|
Academic Article
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Development of N-Hydroxycinnamamide-Based Histone Deacetylase Inhibitors with Indole-Containing Cap Group.
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Academic Article
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Structure-activity relationship study of vitamin k derivatives yields highly potent neuroprotective agents.
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|
Academic Article
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Evidence for a non-canonical role of HDAC5 in regulation of the cardiac Ncx1 and Bnp genes.
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Academic Article
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HDACs Regulate miR-133a Expression in Pressure Overload-Induced Cardiac Fibrosis.
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Academic Article
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Design, synthesis, and antitumor evaluation of novel histone deacetylase inhibitors equipped with a phenylsulfonylfuroxan module as a nitric oxide donor.
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Academic Article
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Silver-catalyzed direct thiolation of quinones by activation of aryl disulfides to synthesize quinonyl aryl thioethers.
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Academic Article
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Mechanism of Action of 2-Aminobenzamide HDAC Inhibitors in Reversing Gene Silencing in Friedreich's Ataxia.
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Academic Article
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Ischemic preconditioning, retinal neuroprotection and histone deacetylase activities.
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|
Academic Article
|
Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance.
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|
Concept
|
Chemistry Techniques, Synthetic
|
|
Concept
|
Real-Time Polymerase Chain Reaction
|
|
Concept
|
MCF-7 Cells
|
|
Concept
|
Molecular Docking Simulation
|
|
Concept
|
Neuroprotection
|
|
Concept
|
Imatinib Mesylate
|
|
Concept
|
Histone Deacetylase 6
|
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Concept
|
Homeobox Protein Nkx-2.5
|
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Concept
|
HEK293 Cells
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