Search Result Details

This page shows the details of why an item matched the keywords from your search.
One or more keywords matched the following properties of Davies, Christopher
PropertyValue
overview Our group uses the technique of X-ray crystallography, as well as other biochemical approaches, to decipher the structure and function of enzymes involved in peptidoglycan synthesis in bacteria. Primarily, we study penicillin-binding proteins (PBPs), the well-known molecular targets for ß-lactam antibiotics. Mutations in these proteins are a major contributor to antibiotic resistance in bacteria and our current focus is to understand how such mutations impact the structure and kinetics of PBPs, with the goal of developing new antimicrobials that circumvent such mechanisms. Following our development of a fluorescence-polarization assay, we also conduct high-throughput screening against large chemical libraries to identify new inhibitors of PBPs for drug development. Finally, as X-ray crystallographers, we collaborate with a number of groups, both within MUSC and beyond, on various structural biology projects.
One or more keywords matched the following items that are connected to Davies, Christopher
Item TypeName
Academic Article Structural basis for phosphomannose isomerase activity in phosphoglucose isomerase from Pyrobaculum aerophilum: a subtle difference between distantly related enzymes.
Academic Article Structure of the N-terminal domain of human CEACAM1: binding target of the opacity proteins during invasion of Neisseria meningitidis and N. gonorrhoeae.
Academic Article Crystal structure of pi initiator protein-iteron complex of plasmid R6K: implications for initiation of plasmid DNA replication.
Academic Article Crystal structures of penicillin-binding protein 2 from penicillin-susceptible and -resistant strains of Neisseria gonorrhoeae reveal an unexpectedly subtle mechanism for antibiotic resistance.
Academic Article Direct binding of glyceraldehyde 3-phosphate dehydrogenase to telomeric DNA protects telomeres against chemotherapy-induced rapid degradation.
Academic Article Helicase-contrahelicase interaction and the mechanism of termination of DNA replication.
Academic Article Crystal structure of Escherichia coli penicillin-binding protein 5 bound to a tripeptide boronic acid inhibitor: a role for Ser-110 in deacylation.
Academic Article A large displacement of the SXN motif of Cys115-modified penicillin-binding protein 5 from Escherichia coli.
Academic Article Crystal structures of the lytic transglycosylase MltA from N.gonorrhoeae and E.coli: insights into interdomain movements and substrate binding.
Academic Article Human tissue transglutaminase is inhibited by pharmacologic and chemical acetylation.
Academic Article Unusual conformation of the SxN motif in the crystal structure of penicillin-binding protein A from Mycobacterium tuberculosis.
Academic Article Crystal structures of covalent complexes of ?-lactam antibiotics with Escherichia coli penicillin-binding protein 5: toward an understanding of antibiotic specificity.
Academic Article The role of the ?5-a11 loop in the active-site dynamics of acylated penicillin-binding protein A from Mycobacterium tuberculosis.
Academic Article High-throughput screening for novel inhibitors of Neisseria gonorrhoeae penicillin-binding protein 2.
Concept Protein Binding
Concept DNA-Binding Proteins
Concept GTP-Binding Proteins
Concept Carrier Proteins
Concept Penicillin-Binding Proteins
Concept RNA-Binding Proteins
Academic Article Structural effect of the Asp345a insertion in penicillin-binding protein 2 from penicillin-resistant strains of Neisseria gonorrhoeae.
Academic Article Crystal structure of a deacylation-defective mutant of penicillin-binding protein 5 at 2.3-A resolution.
Academic Article The crystal structure of ribosomal protein S4 reveals a two-domain molecule with an extensive RNA-binding surface: one domain shows structural homology to the ETS DNA-binding motif.
Academic Article Conformational variability of the N-terminal helix in the structure of ribosomal protein S15.
Academic Article The activation domain of the MotA transcription factor from bacteriophage T4.
Academic Article Structural evidence for specific S8-RNA and S8-protein interactions within the 30S ribosomal subunit: ribosomal protein S8 from Bacillus stearothermophilus at 1.9 A resolution.
Academic Article The crystal structure of ribosomal protein L14 reveals an important organizational component of the translational apparatus.
Academic Article Structures of prokaryotic ribosomal proteins: implications for RNA binding and evolution.
Academic Article Crystal structure of prokaryotic ribosomal protein L9: a bi-lobed RNA-binding protein.
Academic Article A site for CD4 binding in the beta 1 domain of the MHC class II protein HLA-DR1.
Academic Article Penicillin-Binding Protein 3 Is Essential for Growth of Pseudomonas aeruginosa.
Academic Article Alanine 501 Mutations in Penicillin-Binding Protein 2 from Neisseria gonorrhoeae: Structure, Mechanism, and Effects on Cephalosporin Resistance and Biological Fitness.
Academic Article The Structure of the Biofilm-controlling Response Regulator BfmR from Acinetobacter baumannii Reveals Details of Its DNA-binding Mechanism.
Academic Article Recognition of the ?-lactam carboxylate triggers acylation of Neisseria gonorrhoeae penicillin-binding protein 2.
Academic Article Mutations in penicillin-binding protein 2 from cephalosporin-resistant Neisseria gonorrhoeae hinder ceftriaxone acylation by restricting protein dynamics.
Search Criteria
  • Carrier Proteins