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One or more keywords matched the following properties of George, Mark
overview As an undergraduate student in philosophy at Davidson College in Davidson, NC, Dr. George first began studying the relationship between mind and brain, or brain/behavior relationships. He has continued this interest throughout his career with a focus on using brain imaging and brain stimulation to understand depression and devise new treatments. He received his medical degree from the Medical University of South Carolina in Charleston in 1985, where he continued with dual residencies in both neurology and psychiatry. He is board certified in both areas. Following his residency training he worked for one year (1990-91) as a Visiting Research Fellow in the Raymond Way Neuropsychiatry Research Group at the Institute of Neurology, Queen Square, London, England. During his fellowship he wrote one of the first textbooks in the new area of brain activation and imaging. He then moved to Washington, DC, working with Dr. Robert Post in the Biological Psychiatry Branch of the Intramural National Institute of Mental Health (NIMH). During his 4 years at NIMH he was one of the first to use functional imaging (particularly oxygen PET) and discovered that specific brain regions change activity during normal emotions. He then started using imaging to understand brain changes that occur in depression and mania, a quest that he and many others are still pursuing. This imaging work directly led to his pioneering use of a non-invasive brain stimulation method, transcranial magnetic stimulation (TMS), as a probe of neuronal circuits regulating mood, and to clinical trials using TMS as an antidepressant. In 1993 while at the NIMH, he discovered that daily prefrontal rTMS over several weeks could treat depression and ever since he has worked to grow the science of TMS, both in terms of how it works in the brain, and in critically evaluating its therapeutic applications, especially in the area of treating depression. This was FDA approved in October, 2008. He has completed the pivotal study in this area with NIH funding and is now investigating its effectiveness in the VA population through a VA cooperative study. In 1995 he moved back to Charleston and built the functional neuroimaging division and brain stimulation laboratories. This imaging group has grown into the MUSC Center for Advanced Imaging Research, which is now part of the SC Brain Imaging Center of Excellence. He continues to use imaging (particularly functional MRI) and non-invasive stimulation (TMS, or VNS), either separately or more recently in combination, to understand the brain regions involved in regulating emotion in health and disease. In June 1998 at MUSC, he also pioneered another new treatment for resistant depression, vagus nerve stimulation (VNS). This was FDA approved in 2006. He and his group have used MRI imaging to understand VNS brain effects. He is a world expert in brain stimulation, and depression, and is the editor-in-chief of a new journal he launched with Elsevier in 2008 called, Brain Stimulation: Basic, Translation and Clinical Research in Neuromodulation. He has been continuously funded by NIH and other funding agencies since his fellowships. He has received both a NARSAD Young Investigator and Independent Investigator Award to pursue TMS research in depression. He has received numerous international awards including the NARSAD Klerman Award (2000), NARSAD Falcone Award (2008) and the Lifetime Achievement Award (2007) given by the World Federation of Societies of Biological Psychiatry (WFSBP). In 2009 US News and World Report named him one of 14 ‘medical pioneers who are not holding back’. He is on several editorial review boards and NIH study sections, has published over 400 scientific articles or book chapters, and has written or edited 6 books.
One or more keywords matched the following items that are connected to George, Mark
Item TypeName
Academic Article Vagus nerve stimulation (VNS): utility in neuropsychiatric disorders.
Academic Article A review of functional neuroimaging studies of vagus nerve stimulation (VNS).
Academic Article Acute vagus nerve stimulation using different pulse widths produces varying brain effects.
Academic Article Vagus nerve stimulation affects pain perception in depressed adults.
Academic Article Vagus nerve stimulation for treatment-resistant depression: a randomized, controlled acute phase trial.
Academic Article Effects of 12 months of vagus nerve stimulation in treatment-resistant depression: a naturalistic study.
Academic Article A one-year comparison of vagus nerve stimulation with treatment as usual for treatment-resistant depression.
Academic Article Two-year outcome of vagus nerve stimulation (VNS) for treatment of major depressive episodes.
Academic Article Acute and long-term VNS effects on pain perception in a case of treatment-resistant depression.
Academic Article Vagus nerve stimulation acutely alters food craving in adults with depression.
Academic Article Brain stimulation for the treatment of psychiatric disorders.
Academic Article Interregional cerebral metabolic associativity during a continuous performance task (Part I): healthy adults.
Academic Article Changes in cerebral activations during movement execution and imagery after parietal cortex TMS interleaved with 3T MRI.
Academic Article Noninvasive techniques for probing neurocircuitry and treating illness: vagus nerve stimulation (VNS), transcranial magnetic stimulation (TMS) and transcranial direct current stimulation (tDCS).
Academic Article Neural network dysfunction in bipolar depression: clues from the efficacy of lamotrigine.
Academic Article WFSBP Guidelines on Brain Stimulation Treatments in Psychiatry.
Academic Article A pilot study of vagus nerve stimulation (VNS) for treatment-resistant anxiety disorders.
Academic Article From the Editor-in-Chief's desk. Brain Stimulation enters a new decade with Volume 3.
Academic Article A potential role for thalamocingulate circuitry in human maternal behavior.
Academic Article Cortical and subcortical brain effects of transcranial magnetic stimulation (TMS)-induced movement: an interleaved TMS/functional magnetic resonance imaging study.
Academic Article Cerebral blood flow changes during vagus nerve stimulation for depression.
Academic Article VNS therapy in treatment-resistant depression: clinical evidence and putative neurobiological mechanisms.
Academic Article Vagus nerve stimulation (VNS) for depression: what do we know now and what should be done next?
Academic Article Vagus nerve stimulation for the treatment of depression and other neuropsychiatric disorders.
Academic Article Serial vagus nerve stimulation functional MRI in treatment-resistant depression.
Academic Article Durability of antidepressant response to vagus nerve stimulation (VNS).
Academic Article Vagus nerve stimulation and emotional responses to food among depressed patients.
Academic Article Controversy: Repetitive transcranial magnetic stimulation or transcranial direct current stimulation shows efficacy in treating psychiatric diseases (depression, mania, schizophrenia, obsessive-complusive disorder, panic, posttraumatic stress disorder).
Concept Vagus Nerve Stimulation
Concept Vagus Nerve
Concept Nerve Net
Concept Transcutaneous Electric Nerve Stimulation
Academic Article Treating the depressions with superficial brain stimulation methods.
Academic Article Executive control circuitry differentiates degree of success in weight loss following gastric-bypass surgery.
Academic Article Consensus Paper: Probing Homeostatic Plasticity of Human Cortex With Non-invasive Transcranial Brain Stimulation.
Academic Article Repetitive transcranial magnetic stimulation (rTMS) of the dorsolateral prefrontal cortex reduces resting-state insula activity and modulates functional connectivity of the orbitofrontal cortex in cigarette smokers.
Academic Article Neurophysiologic effects of transcutaneous auricular vagus nerve stimulation (taVNS) via electrical stimulation of the tragus: A concurrent taVNS/fMRI study and review.
Academic Article Short trains of transcutaneous auricular vagus nerve stimulation (taVNS) have parameter-specific effects on heart rate.
Academic Article Tragus or cymba conchae? Investigating the anatomical foundation of transcutaneous auricular vagus nerve stimulation (taVNS).
Academic Article Transcutaneous auricular vagus nerve stimulation (taVNS) for improving oromotor function in newborns.
Academic Article Laboratory Administration of Transcutaneous Auricular Vagus Nerve Stimulation (taVNS): Technique, Targeting, and Considerations.
Academic Article Transcutaneous Auricular Vagus Nerve Stimulation-Paired Rehabilitation for Oromotor Feeding Problems in Newborns: An Open-Label Pilot Study.
Academic Article Design and validation of a closed-loop, motor-activated auricular vagus nerve stimulation (MAAVNS) system for neurorehabilitation.
Academic Article Decreased interhemispheric connectivity and increased cortical excitability in unmedicated schizophrenia: A prefrontal interleaved TMS fMRI study.
Academic Article Shaping plasticity with non-invasive brain stimulation in the treatment of psychiatric disorders: Present and future.
Academic Article Neurophysiologic Effects of Transcutaneous Auricular Vagus Nerve Stimulation (taVNS) via Electrical Stimulation of the Tragus: A Concurrent taVNS/fMRI Study and Review.
Academic Article A pilot randomized controlled trial of supervised, at-home, self-administered transcutaneous auricular vagus nerve stimulation (taVNS) to manage long COVID symptoms.
Academic Article A pilot randomized controlled trial of supervised, at-home, self-administered transcutaneous auricular vagus nerve stimulation (taVNS) to manage long COVID symptoms.
Academic Article Transcutaneous auricular vagus nerve stimulation (taVNS) given for poor feeding in at-risk infants also improves their motor abilities.
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  • Vagus Nerve