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Griffin, William
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keywords drinking
overview Dr. Griffin uses mouse models to study the neurobiological adaptations in the brain that underlie addiction. In particular, areas of active investigation include examining the glutamatergic and dopaminergic signaling systems in brain regions like the nucleus accumbens and dorsolateral striatum which are known to be involved in the regulation of alcohol drinking and other drug taking behaviors. Methods: stereotaxic surgery in mice jugular catheter implantation in mice microinjection procedures microdialysis procedures HPLC techniques with electrochemical and fluorescent detection gas chromatography with flame ionization detection Behavioral Methods: models of free-choice ethanol drinking operant self-administration procedures with ethanol and stimulants conditioned place preference with ethanol and stimulants drug discrimination procedures with ethanol and stimulants conditioned taste aversion procedures measures of ataxia
One or more keywords matched the following items that are connected to Griffin, William
Item TypeName
Academic Article Repeated cycles of chronic intermittent ethanol exposure in mice increases voluntary ethanol drinking and ethanol concentrations in the nucleus accumbens.
Academic Article Intensity and duration of chronic ethanol exposure is critical for subsequent escalation of voluntary ethanol drinking in mice.
Academic Article The interactive effects of methylphenidate and ethanol on ethanol consumption and locomotor activity in mice.
Academic Article Repeated cycles of chronic intermittent ethanol exposure leads to the development of tolerance to aversive effects of ethanol in C57BL/6J mice.
Academic Article Voluntary ethanol drinking in mice and ethanol concentrations in the nucleus accumbens.
Academic Article Commentary on Marczinski and colleagues: mixing an energy drink with an alcoholic beverage increases motivation for more alcohol in college students.
Concept Alcohol Drinking
Concept Drinking Behavior
Academic Article Increased extracellular glutamate in the nucleus accumbens promotes excessive ethanol drinking in ethanol dependent mice.
Academic Article Alcohol dependence and free-choice drinking in mice.
Academic Article Kv7 channels in the nucleus accumbens are altered by chronic drinking and are targets for reducing alcohol consumption.
Academic Article Oxytocin Reduces Ethanol Self-Administration in Mice.
Academic Article Prosapip1-Dependent Synaptic Adaptations in the Nucleus Accumbens Drive Alcohol Intake, Seeking, and Reward.
Academic Article Increasing Brain-Derived Neurotrophic Factor (BDNF) in medial prefrontal cortex selectively reduces excessive drinking in ethanol dependent mice.
Academic Article Dynorphin-kappa opioid receptor activity in the central amygdala modulates binge-like alcohol drinking in mice.
Academic Article Brain Regional and Temporal Changes in BDNF mRNA and microRNA-206 Expression in Mice Exposed to Repeated Cycles of Chronic Intermittent Ethanol and Forced Swim Stress.
Academic Article Dynamic c-Fos changes in mouse brain during acute and protracted withdrawal from chronic intermittent ethanol exposure and relapse drinking.
Academic Article Kappa opioid receptors in the bed nucleus of the stria terminalis regulate binge-like alcohol consumption in male and female mice.
Academic Article Effects of ceftriaxone on ethanol drinking and GLT-1 expression in ethanol dependence and relapse drinking.
Academic Article Effect of caffeine on alcohol drinking in mice.
Concept Binge Drinking
Academic Article Activation of hypothalamic oxytocin neurons reduces binge-like alcohol drinking through signaling at central oxytocin receptors.
Academic Article Dynorphin/Kappa Opioid Receptor Activity Within the Extended Amygdala Contributes to Stress-Enhanced Alcohol Drinking in Mice.
Academic Article Alcohol Dependence and the Ventral Hippocampal Influence on Alcohol Drinking in Male Mice.
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  • Drinking