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overview
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Dr. Griffin uses mouse models to study the neurobiological adaptations in the brain that underlie addiction. In particular, areas of active investigation include examining the glutamatergic and dopaminergic signaling systems in brain regions like the nucleus accumbens and dorsolateral striatum which are known to be involved in the regulation of alcohol drinking and other drug taking behaviors.
Methods:
stereotaxic surgery in mice
jugular catheter implantation in mice
microinjection procedures
microdialysis procedures
HPLC techniques with electrochemical and fluorescent detection
gas chromatography with flame ionization detection
Behavioral Methods:
models of free-choice ethanol drinking
operant self-administration procedures with ethanol and stimulants
conditioned place preference with ethanol and stimulants
drug discrimination procedures with ethanol and stimulants
conditioned taste aversion procedures
measures of ataxia
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Griffin, William