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One or more keywords matched the following properties of Haemmerich, Dieter
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keywords temperature sensitive liposomes
keywords thermosensitive liposomes
overview The research interests of our lab include image-guided therapies, image-guided drug delivery, biomedical instrumentation, measurement of thermal and dielectric tissue properties, and computational modeling of biological heat transfer and drug delivery problems. Specifically, we have been working on: 1) Image-guided drug delivery by thermosensitive liposomes (TSL): TSL are nanoparticle drug delivery systems that release the encapsulated drug when exposed to hyperthermia (>40 ÂșC). After systemic administration of TSL (e.g. infusion), hyperthermia is locally applied to the targeted tissue region resulting in localized drug delivery. We have been working on: (1) use of in vivo fluorescence imaging for real-time monitoring of drug delivery; (2) in vitro devices for characterization of TSL release kinetics; (3) Computational models of TSL drug delivery to identify relevant parameters of TSL, tumor, and hyperthermia with the goal of optimizing delivery. 2) Tumor ablation (radiofrequency ablation; microwave ablation; focused ultrasound) Tumor ablation employs heat or cold to locally destroy cancerous tissue, and is used clinically for treatment of liver, lung, and other cancers. Various methods of tissue heating such as radiofrequency heating or microwaves have been employed. We have been developing novel and improved ablation devices by combining computer simulation, ex vivo tissue studies, and in vivo studies in large animals. 3) Cardiac catheter ablation (radiofrequency ablation; cryo ablation): Ablation is used as therapy for cardiac arrhythmia, where a small tissue region in the heart responsible for arrhythmia is destroyed by heat or cold. We have been investigating the biophysics of cardiac catheter ablation via computer simulations, ex vivo tissue models, and in vivo studies, with the goal of developing more effective devices as well as characterizing tissue effects of heat and cold.
One or more keywords matched the following items that are connected to Haemmerich, Dieter
Item TypeName
Academic Article Mathematical spatio-temporal model of drug delivery from low temperature sensitive liposomes during radiofrequency tumour ablation.
Academic Article Comparison of conventional chemotherapy, stealth liposomes and temperature-sensitive liposomes in a mathematical model.
Academic Article Mild hyperthermia triggered doxorubicin release from optimized stealth thermosensitive liposomes improves intratumoral drug delivery and efficacy.
Academic Article Targeted drug delivery by high intensity focused ultrasound mediated hyperthermia combined with temperature-sensitive liposomes: computational modelling and preliminary in vivovalidation.
Academic Article Improved intratumoral nanoparticle extravasation and penetration by mild hyperthermia.
Concept Liposomes
Academic Article Increased Duration of Heating Boosts Local Drug Deposition during Radiofrequency Ablation in Combination with Thermally Sensitive Liposomes (ThermoDox) in a Porcine Model.
Academic Article Drug release kinetics of temperature sensitive liposomes measured at high-temporal resolution with a millifluidic device.
Academic Article Temperature sensitive liposomes combined with thermal ablation: Effects of duration and timing of heating in mathematical models and in vivo.
Academic Article A Unified Mathematical Model for Nano-Liposomal Drug Delivery to Solid Tumors.
Academic Article Localized delivery of therapeutic doxorubicin dose across the canine blood-brain barrier with hyperthermia and temperature sensitive liposomes.
Academic Article Thermosensitive Liposomes for Image-Guided Drug Delivery.
Academic Article Non-invasive image-guided targeted drug delivery.
Academic Article In vitro Measurement of Release Kinetics of Temperature Sensitive Liposomes with a Fluorescence Imaging System.
Academic Article Real-time fluorescence imaging for visualization and drug uptake prediction during drug delivery by thermosensitive liposomes.
Academic Article Computer Modeling of Drug Delivery with Thermosensitive Liposomes in a Realistic Three-Dimensional Geometry.
Academic Article Drug transport kinetics of intravascular triggered drug delivery systems.
Academic Article Untargeted Large Volume Hyperthermia Reduces Tumor Drug Uptake From Thermosensitive Liposomes.
Academic Article Selecting ideal drugs for encapsulation in thermosensitive liposomes and other triggered nanoparticles.
Academic Article Review of the Delivery Kinetics of Thermosensitive Liposomes.
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  • Liposomes