| Item Type | Name |
|
Academic Article
|
Synthesis of key precursors of radiolabeled sphingolipids.
|
|
Academic Article
|
Modulation of transforming growth factor-beta (TGF-beta) signaling by endogenous sphingolipid mediators.
|
|
Academic Article
|
Sphingolipids in vascular biology.
|
|
Academic Article
|
The structural requirements for ceramide activation of serine-threonine protein phosphatases.
|
|
Academic Article
|
Quantitative measurement of different ceramide species from crude cellular extracts by normal-phase high-performance liquid chromatography coupled to atmospheric pressure ionization mass spectrometry.
|
|
Academic Article
|
Down-regulation of sphingosine kinase-1 by DNA damage: dependence on proteases and p53.
|
|
Academic Article
|
Sphingosine kinase 1 (SPHK1) is induced by transforming growth factor-beta and mediates TIMP-1 up-regulation.
|
|
Academic Article
|
Inhibition of growth and telomerase activity by novel cationic ceramide analogs with high solubility in human head and neck squamous cell carcinoma cells.
|
|
Academic Article
|
Regulation of the sphingosine-recycling pathway for ceramide generation by oxidative stress, and its role in controlling c-Myc/Max function.
|
|
Academic Article
|
Combined therapeutic use of AdGFPFasL and small molecule inhibitors of ceramide metabolism in prostate and head and neck cancers: a status report.
|
|
Academic Article
|
New insights on the use of desipramine as an inhibitor for acid ceramidase.
|
|
Academic Article
|
Molecular cloning and characterization of OsCDase, a ceramidase enzyme from rice.
|
|
Academic Article
|
A role for sphingosine kinase 1 in dextran sulfate sodium-induced colitis.
|
|
Academic Article
|
Molecular mechanisms of ceramide-mediated telomerase inhibition in the A549 human lung adenocarcinoma cell line.
|
|
Academic Article
|
Determination of ceramides and diglycerides by the diglyceride kinase assay.
|
|
Academic Article
|
Acid ceramidase upregulation in prostate cancer: role in tumor development and implications for therapy.
|
|
Academic Article
|
Selective knockdown of ceramide synthases reveals complex interregulation of sphingolipid metabolism.
|
|
Academic Article
|
Mitochondrially targeted ceramides preferentially promote autophagy, retard cell growth, and induce apoptosis.
|
|
Academic Article
|
Purification and characterization of a second type of neutral ceramidase from rat brain: a second more hydrophobic form of rat brain ceramidase.
|
|
Academic Article
|
Acid ceramidase-mediated production of sphingosine 1-phosphate promotes prostate cancer invasion through upregulation of cathepsin B.
|
|
Academic Article
|
Role for ceramide in cell cycle arrest.
|
|
Academic Article
|
EpCAM is overexpressed in breast cancer and is a potential target for breast cancer gene therapy.
|
|
Academic Article
|
A mitochondrial pool of sphingomyelin is involved in TNFalpha-induced Bax translocation to mitochondria.
|
|
Academic Article
|
Altered adipose and plasma sphingolipid metabolism in obesity: a potential mechanism for cardiovascular and metabolic risk.
|
|
Academic Article
|
Synthesis and bioevaluation of omega-N-amino analogs of B13.
|
|
Academic Article
|
AMPK inhibitor Compound C stimulates ceramide production and promotes Bax redistribution and apoptosis in MCF7 breast carcinoma cells.
|
|
Academic Article
|
Blood sphingolipidomics in healthy humans: impact of sample collection methodology.
|
|
Academic Article
|
Role for Sit4p-dependent mitochondrial dysfunction in mediating the shortened chronological lifespan and oxidative stress sensitivity of Isc1p-deficient cells.
|
|
Academic Article
|
Cellular morphogenesis under stress is influenced by the sphingolipid pathway gene ISC1 and DNA integrity checkpoint genes in Saccharomyces cerevisiae.
|
|
Concept
|
Antineoplastic Combined Chemotherapy Protocols
|
|
Concept
|
Vesicular Transport Proteins
|
|
Concept
|
Cytokines
|
|
Concept
|
Tandem Mass Spectrometry
|
|
Concept
|
Adenovirus E1A Proteins
|
|
Concept
|
Muscle, Smooth, Vascular
|
|
Concept
|
Oligodeoxyribonucleotides, Antisense
|
|
Concept
|
Insulin
|
|
Concept
|
Matrix Metalloproteinase 14
|
|
Concept
|
Macrophages, Alveolar
|
|
Concept
|
Enzyme-Linked Immunosorbent Assay
|
|
Concept
|
Neutrophils
|
|
Concept
|
T-Lymphocytes, Cytotoxic
|
|
Concept
|
Disease Models, Animal
|
|
Concept
|
Intestinal Mucosa
|
|
Concept
|
DNA Methylation
|
|
Concept
|
Retinal Pigment Epithelium
|
|
Concept
|
Goblet Cells
|
|
Concept
|
Interleukin-10
|
|
Concept
|
Temperature
|
|
Concept
|
Anti-Bacterial Agents
|
|
Concept
|
Receptor, trkC
|
|
Concept
|
Pseudomonas
|
|
Concept
|
Brain Neoplasms
|
|
Concept
|
Bacillus cereus
|
|
Concept
|
Transforming Growth Factor beta
|
|
Concept
|
Microscopy, Electron
|
|
Concept
|
Acetic Acid
|
|
Concept
|
Terminology as Topic
|
|
Concept
|
Aldehyde-Lyases
|
|
Concept
|
Receptors, Platelet-Derived Growth Factor
|
|
Concept
|
Lung Neoplasms
|
|
Concept
|
RNA, Small Interfering
|
|
Concept
|
ras GTPase-Activating Proteins
|
|
Concept
|
Histone Chaperones
|
|
Concept
|
Defensins
|
|
Concept
|
Bone Development
|
|
Concept
|
Lysophospholipids
|
|
Concept
|
Caspase 1
|
|
Concept
|
Mycobacterium tuberculosis
|
|
Concept
|
2,4-Dinitrophenol
|
|
Concept
|
Kaplan-Meier Estimate
|
|
Concept
|
Heat-Shock Proteins
|
|
Concept
|
Caspase 2
|
|
Concept
|
Interferon-gamma
|
|
Concept
|
Caspase 9
|
|
Concept
|
Genes, Plant
|
|
Concept
|
Phorbol 12,13-Dibutyrate
|
|
Concept
|
Animals, Newborn
|
|
Concept
|
Ultraviolet Rays
|
|
Concept
|
Alkylating Agents
|
|
Concept
|
Mitochondria
|
|
Concept
|
Zellweger Syndrome
|
|
Concept
|
Phosphorus Radioisotopes
|
|
Concept
|
Flow Cytometry
|
|
Concept
|
Prostatic Neoplasms
|
|
Concept
|
Magnetic Resonance Spectroscopy
|
|
Concept
|
Antigens, Polyomavirus Transforming
|
|
Concept
|
Neoplasm Metastasis
|
|
Concept
|
Ergosterol
|
|
Concept
|
Mitogen-Activated Protein Kinases
|
|
Concept
|
Arabidopsis
|
|
Concept
|
Recurrence
|
|
Concept
|
Sphingolipids
|
|
Concept
|
Prolactin
|
|
Concept
|
Rats, Inbred Strains
|
|
Concept
|
1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine
|
|
Concept
|
Ion Channels
|
|
Concept
|
Mutagens
|
|
Concept
|
Cell Division
|
|
Concept
|
Leukemia, B-Cell
|
|
Concept
|
p38 Mitogen-Activated Protein Kinases
|
|
Concept
|
Phosphatidylinositols
|
|
Concept
|
Drug Design
|
|
Concept
|
Actins
|
|
Concept
|
Cytotoxins
|
|
Concept
|
Matrix Metalloproteinase 1
|
|
Concept
|
COS Cells
|
|
Concept
|
Intercellular Adhesion Molecule-1
|
|
Concept
|
Membrane Potentials
|
|
Concept
|
Oligonucleotide Probes
|
|
Concept
|
Mutagenesis, Site-Directed
|
|
Concept
|
Nitric Oxide
|
|
Concept
|
Leukemia, Lymphoid
|
|
Concept
|
Epoprostenol
|
|
Concept
|
Ileum
|
|
Concept
|
Dietary Fats
|
|
Concept
|
Phosphatidylglycerols
|
|
Concept
|
Carmustine
|
|
Concept
|
p300-CBP Transcription Factors
|
|
Concept
|
Fluorescent Dyes
|
|
Concept
|
Mitochondrial Membranes
|
|
Concept
|
Lipoproteins, LDL
|
|
Concept
|
Arthritis, Experimental
|
|
Concept
|
Mice, Inbred BALB C
|
|
Concept
|
Microarray Analysis
|
|
Concept
|
Phosphatidylinositol 4,5-Diphosphate
|
|
Concept
|
Pyrazoles
|
|
Concept
|
DNA, Complementary
|
|
Concept
|
Fluorescent Antibody Technique
|
|
Concept
|
Microscopy, Electron, Transmission
|
|
Concept
|
Receptor, Cannabinoid, CB1
|
|
Concept
|
Eicosanoids
|
|
Concept
|
Disease Progression
|
|
Concept
|
CD8-Positive T-Lymphocytes
|
|
Concept
|
Desmogleins
|
|
Concept
|
Long-Term Potentiation
|
|
Concept
|
Mice, Obese
|
|
Concept
|
Electric Conductivity
|
|
Concept
|
Polyethylene Glycols
|
|
Concept
|
HSP27 Heat-Shock Proteins
|
|
Concept
|
Cadherins
|
|
Concept
|
Ceramides
|
|
Concept
|
Antifungal Agents
|
|
Concept
|
Hedgehog Proteins
|
|
Concept
|
Monoamine Oxidase Inhibitors
|
|
Concept
|
Sensitivity and Specificity
|
|
Concept
|
Vascular Cell Adhesion Molecule-1
|
|
Concept
|
Urinary Bladder Neoplasms
|
|
Concept
|
Endothelium, Vascular
|
|
Concept
|
Telomerase
|
|
Concept
|
Dictyostelium
|
|
Concept
|
Cell Adhesion Molecules
|
|
Concept
|
Receptors, Cell Surface
|
|
Concept
|
Norbornanes
|
|
Concept
|
Isoquinolines
|
|
Concept
|
CD59 Antigens
|
|
Concept
|
Brefeldin A
|
|
Concept
|
Proto-Oncogenes
|
|
Concept
|
Leukemia, Myeloid
|
|
Concept
|
Registries
|
|
Concept
|
Dependovirus
|
|
Concept
|
Sodium-Potassium-Exchanging ATPase
|
|
Concept
|
Ceruloplasmin
|
|
Concept
|
Treatment Outcome
|
|
Concept
|
Receptors, Interleukin-2
|
|
Concept
|
Calcitriol
|
|
Concept
|
Pargyline
|
|
Concept
|
Macrophages
|
|
Concept
|
National Institutes of Health (U.S.)
|
|
Concept
|
Serotonin
|
|
Concept
|
Tretinoin
|
|
Concept
|
Rats, Inbred Lew
|
|
Concept
|
HIV-1
|
|
Concept
|
Membrane Potential, Mitochondrial
|
|
Concept
|
Receptor, Cannabinoid, CB2
|
|
Concept
|
Serpins
|
|
Concept
|
Fibronectins
|
|
Concept
|
Lysosomes
|
|
Concept
|
Hemolysis
|
|
Concept
|
Potassium
|
|
Concept
|
Macrolides
|
|
Concept
|
Arginine
|
|
Concept
|
Protein Kinase Inhibitors
|
|
Concept
|
Research Design
|
|
Concept
|
Amino Acid Substitution
|
|
Concept
|
Hair Follicle
|
|
Concept
|
Protein Phosphatase 2
|
|
Concept
|
Lymphoma, Mantle-Cell
|
|
Concept
|
Cyclic Nucleotide Phosphodiesterases, Type 5
|
|
Concept
|
Animals
|
|
Concept
|
Thioredoxin Reductase 1
|
|
Concept
|
Binding, Competitive
|
|
Concept
|
Genetic Complementation Test
|
|
Concept
|
Antigens, Neoplasm
|
|
Concept
|
Isopropyl Thiogalactoside
|
|
Concept
|
Feasibility Studies
|
|
Concept
|
GTP-Binding Protein alpha Subunits, Gq-G11
|
|
Concept
|
Mammals
|
|
Concept
|
Myeloid Differentiation Factor 88
|
|
Concept
|
Neurodegenerative Diseases
|
|
Concept
|
1-Methyl-3-isobutylxanthine
|
|
Concept
|
Receptor, Platelet-Derived Growth Factor beta
|
|
Concept
|
Psychosine
|
|
Concept
|
Demography
|
|
Concept
|
Statistics as Topic
|
|
Concept
|
Ovarian Neoplasms
|
|
Concept
|
Amino Acid Sequence
|
|
Concept
|
Disease-Free Survival
|
|
Concept
|
Resting Phase, Cell Cycle
|
|
Concept
|
Membrane Lipids
|
|
Concept
|
Receptors, G-Protein-Coupled
|
|
Concept
|
Random Allocation
|
|
Concept
|
Mice, Knockout
|
|
Concept
|
Baculoviridae
|
|
Concept
|
Immunosuppressive Agents
|
|
Concept
|
Heme Oxygenase-1
|
|
Concept
|
Mink
|
|
Concept
|
Anticarcinogenic Agents
|
|
Concept
|
Hydroxamic Acids
|
|
Concept
|
Cohort Studies
|
|
Concept
|
Nuclear Envelope
|
|
Concept
|
Plasminogen Activator Inhibitor 1
|
|
Concept
|
Antibodies
|
|
Concept
|
Integrin alphaVbeta3
|
|
Concept
|
Growth Hormone
|
|
Concept
|
Antineoplastic Agents
|
|
Concept
|
Animal Feed
|
|
Concept
|
Leukemia
|
|
Concept
|
Neoplasms, Experimental
|
|
Concept
|
Aspirin
|
|
Concept
|
Electric Impedance
|
|
Concept
|
Mice, Inbred C3H
|
|
Concept
|
Lipid Peroxidation
|
|
Concept
|
Calcium
|
|
Concept
|
Laboratories
|
|
Concept
|
RNA, Fungal
|
|
Concept
|
Receptors, Neuropeptide
|
|
Concept
|
Cell-Derived Microparticles
|
|
Concept
|
Inositol
|
|
Concept
|
Prostaglandin Endoperoxides, Synthetic
|
|
Concept
|
Intracellular Membranes
|
|
Concept
|
Mitogens
|
|
Concept
|
Precipitin Tests
|
|
Concept
|
Hydrogen Peroxide
|
|
Concept
|
12-Hydroxy-5,8,10,14-eicosatetraenoic Acid
|
|
Concept
|
Troponin
|
|
Concept
|
Antimycin A
|
|
Concept
|
Colorectal Neoplasms
|
|
Concept
|
Blotting, Western
|
|
Concept
|
Exosomes
|
|
Concept
|
Microscopy, Atomic Force
|
|
Concept
|
Toll-Like Receptor 4
|
|
Concept
|
Cerebellar Ataxia
|
|
Concept
|
Ascorbic Acid
|
|
Concept
|
Crohn Disease
|
|
Concept
|
Leukemia-Lymphoma, Adult T-Cell
|
|
Concept
|
Lipopolysaccharides
|
|
Concept
|
Chemokine CXCL2
|
|
Concept
|
Guanosine Triphosphate
|
|
Concept
|
Interleukin-1 Receptor-Associated Kinases
|
|
Concept
|
Hydroxyeicosatetraenoic Acids
|
|
Concept
|
Receptors, Pattern Recognition
|
|
Concept
|
Neurotrophin 3
|
|
Concept
|
Neovascularization, Pathologic
|
|
Concept
|
Longevity
|
|
Concept
|
Shiga Toxin
|
|
Concept
|
Poly A
|
|
Concept
|
Carcinoma, Transitional Cell
|
|
Concept
|
Glioma
|
|
Concept
|
Biopsy
|
|
Concept
|
Myocardium
|
|
Concept
|
Antineoplastic Agents, Phytogenic
|
|
Concept
|
Oryza
|
|
Concept
|
Dose-Response Relationship, Drug
|
|
Concept
|
Receptors, Nerve Growth Factor
|
|
Concept
|
Mitogen-Activated Protein Kinase 13
|
|
Concept
|
Dietary Supplements
|
|
Concept
|
Iron
|
|
Concept
|
Electron Transport Complex IV
|
|
Concept
|
Cathepsin B
|
|
Concept
|
Cystic Fibrosis Transmembrane Conductance Regulator
|
|
Concept
|
Growth Inhibitors
|
|
Concept
|
Head and Neck Neoplasms
|
|
Concept
|
Lymphocytes, Tumor-Infiltrating
|
|
Concept
|
Cysteine Endopeptidases
|
|
Concept
|
Durapatite
|
|
Concept
|
Caspase 3
|
|
Concept
|
Leukocyte Count
|
|
Concept
|
Obesity
|
|
Concept
|
Masoprocol
|
|
Concept
|
Carcinogens
|
|
Concept
|
Spectrometry, Mass, Electrospray Ionization
|
|
Concept
|
Genes, jun
|
|
Concept
|
Genes, bcl-2
|
|
Concept
|
Mice
|
|
Concept
|
Clinical Trials as Topic
|
|
Concept
|
DNA Primers
|
|
Concept
|
CASP8 and FADD-Like Apoptosis Regulating Protein
|
|
Concept
|
Insulin Resistance
|
|
Concept
|
Immunoenzyme Techniques
|
|
Concept
|
Models, Biological
|
|
Concept
|
Statistics, Nonparametric
|
|
Concept
|
Nucleosomes
|
|
Concept
|
Charcot-Marie-Tooth Disease
|
|
Concept
|
Hep G2 Cells
|
|
Concept
|
Milk
|
|
Concept
|
Oxidants
|
|
Concept
|
Sympathetic Nervous System
|
|
Concept
|
Adenocarcinoma
|
|
Concept
|
Cyclooxygenase 2 Inhibitors
|
|
Concept
|
Phosphotyrosine
|
|
Concept
|
Research Personnel
|
|
Concept
|
Microscopy, Confocal
|
|
Concept
|
Precursor B-Cell Lymphoblastic Leukemia-Lymphoma
|
|
Concept
|
Adiponectin
|
|
Concept
|
Histone Deacetylases
|
|
Concept
|
Tumor Necrosis Factor-alpha
|
|
Concept
|
Genes, Fungal
|
|
Concept
|
Dinoprostone
|
|
Concept
|
Melanoma
|
|
Concept
|
Conserved Sequence
|
|
Concept
|
Hydroxyapatites
|
|
Concept
|
Matrix Metalloproteinase 9
|
|
Concept
|
Patch-Clamp Techniques
|
|
Concept
|
Enzyme Activators
|
|
Concept
|
Neoplasm Recurrence, Local
|
|
Concept
|
rab GTP-Binding Proteins
|
|
Concept
|
Phosphatidylinositol Phosphates
|
|
Concept
|
Matrix Metalloproteinase 2
|
|
Concept
|
Saposins
|
|
Concept
|
Peer Review, Research
|
|
Concept
|
Genes, ras
|
|
Concept
|
Cosmetics
|
|
Concept
|
Phosphatidic Acids
|
|
Concept
|
Mice, Inbred C57BL
|
|
Concept
|
Lysine
|
|
Concept
|
Receptors, Vitronectin
|
|
Concept
|
Retrospective Studies
|
|
Concept
|
Cytoprotection
|
|
Concept
|
Proto-Oncogene Proteins c-akt
|
|
Concept
|
Toll-Like Receptor 2
|
|
Concept
|
Phospholipase C gamma
|
|
Concept
|
Melanoma, Experimental
|
|
Concept
|
Platelet Count
|
|
Concept
|
Transferrin
|
|
Concept
|
Mitochondria, Liver
|
|
Concept
|
Neoplasms, Squamous Cell
|
|
Concept
|
Sequence Deletion
|
|
Concept
|
Focal Adhesion Kinase 1
|
|
Concept
|
Consensus Sequence
|
|
Concept
|
Phorbol Esters
|
|
Concept
|
Caspase 7
|
|
Concept
|
Liver Neoplasms
|
|
Concept
|
Mice, Transgenic
|
|
Concept
|
Cell Separation
|
|
Concept
|
15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid
|
|
Concept
|
Isomerism
|
|
Concept
|
T-Lymphocytes
|
|
Concept
|
Mitochondria, Heart
|
|
Concept
|
Chromatography, Thin Layer
|
|
Concept
|
Microsomes, Liver
|
|
Concept
|
Butylated Hydroxytoluene
|
|
Concept
|
Phosphatidylcholines
|
|
Concept
|
Oxygen
|
|
Concept
|
Fas-Associated Death Domain Protein
|
|
Concept
|
Tetradecanoylphorbol Acetate
|
|
Concept
|
Manganese
|
|
Concept
|
Antigens, CD
|
|
Concept
|
Cathepsin D
|
|
Concept
|
Authorship
|
|
Concept
|
Receptor, Insulin
|
|
Concept
|
Neoplasm Invasiveness
|
|
Concept
|
Eye Neoplasms
|
|
Concept
|
Neuroblastoma
|
|
Concept
|
Integrin alpha6beta1
|
|
Concept
|
Methyl Methanesulfonate
|
|
Concept
|
Isotope Labeling
|
|
Concept
|
Monocytes
|
|
Concept
|
Benzylidene Compounds
|
|
Concept
|
Disease
|
|
Concept
|
Interleukin-2
|
|
Concept
|
Free Radical Scavengers
|
|
Concept
|
G2 Phase
|
|
Concept
|
Intestine, Small
|
|
Concept
|
Xenograft Model Antitumor Assays
|
|
Concept
|
Nucleic Acid Synthesis Inhibitors
|
|
Concept
|
Severity of Illness Index
|
|
Concept
|
RNA, Messenger
|
|
Concept
|
Protein Structure, Secondary
|
|
Concept
|
Caspase 8
|
|
Concept
|
Survival Rate
|
|
Concept
|
MAP Kinase Signaling System
|
|
Concept
|
Humans
|
|
Concept
|
Multiprotein Complexes
|
|
Concept
|
Transglutaminases
|
|
Concept
|
Doxorubicin
|
|
Concept
|
Precursor Cell Lymphoblastic Leukemia-Lymphoma
|
|
Concept
|
Mesylates
|
|
Concept
|
Jurkat Cells
|
|
Concept
|
Hot Temperature
|
|
Concept
|
Cattle
|
|
Concept
|
Antidepressive Agents, Tricyclic
|
|
Concept
|
L-Serine Dehydratase
|
|
Concept
|
Prostate
|
|
Concept
|
Melanins
|
|
Concept
|
Cell Movement
|
|
Concept
|
Ornithine Decarboxylase
|
|
Concept
|
Thymidylate Synthase
|
|
Concept
|
beta Catenin
|
|
Concept
|
Antigen Presentation
|
|
Concept
|
Leukemia, T-Cell
|
|
Concept
|
Pilot Projects
|
|
Concept
|
Receptor, Angiotensin, Type 1
|
|
Concept
|
Membrane Glycoproteins
|
|
Concept
|
Sphingosine N-Acyltransferase
|
|
Concept
|
Suppressor of Cytokine Signaling Proteins
|
|
Concept
|
Drug Screening Assays, Antitumor
|
|
Concept
|
Linoleic Acids
|
|
Concept
|
Rabbits
|
|
Concept
|
Raphanus
|
|
Concept
|
Sphingolipidoses
|
|
Concept
|
Integrin beta1
|
|
Concept
|
Glucosylceramides
|
|
Concept
|
Liver Cirrhosis
|
|
Concept
|
Dactinomycin
|
|
Concept
|
Protein Structure, Tertiary
|
|
Concept
|
Molecular Probes
|
|
Concept
|
Adaptor Proteins, Signal Transducing
|
|
Concept
|
Interleukin-1
|
|
Concept
|
Phospholipids
|
|
Concept
|
Interferon Regulatory Factor-3
|
|
Concept
|
Cardiolipins
|
|
Concept
|
Inhibitory Concentration 50
|
|
Concept
|
Silver Staining
|
|
Concept
|
Cysteine Proteinase Inhibitors
|
|
Concept
|
Microscopy, Fluorescence
|
|
Concept
|
Oncogene Protein v-akt
|
|
Concept
|
Macrophages, Peritoneal
|
|
Concept
|
Carcinoma, Non-Small-Cell Lung
|
|
Concept
|
Caspases
|
|
Concept
|
Opossums
|
|
Concept
|
Mammary Neoplasms, Experimental
|
|
Concept
|
Inflammation
|
|
Concept
|
Retinoblastoma-Binding Protein 1
|
|
Concept
|
Diacylglycerol O-Acyltransferase
|
|
Concept
|
Etoposide
|
|
Concept
|
Mammary Tumor Virus, Mouse
|
|
Concept
|
Zinc
|
|
Concept
|
Leukemia, Monocytic, Acute
|
|
Concept
|
Ionophores
|
|
Concept
|
Catalytic Domain
|
|
Concept
|
Mitochondria, Muscle
|
|
Concept
|
Myocardial Reperfusion Injury
|
|
Concept
|
Dinitrophenols
|
|
Concept
|
Proto-Oncogene Proteins c-raf
|
|
Concept
|
Antigens, Surface
|
|
Concept
|
Neuronal Ceroid-Lipofuscinoses
|
|
Concept
|
Intestines
|
|
Concept
|
Chemokine CCL5
|
|
Concept
|
Receptor Protein-Tyrosine Kinases
|
|
Concept
|
Magnesium
|
|
Concept
|
Liver Transplantation
|
|
Concept
|
Cluster Analysis
|
|
Concept
|
Multienzyme Complexes
|
|
Concept
|
Detergents
|
|
Concept
|
Isoindoles
|
|
Concept
|
Angiotensin II
|
|
Concept
|
Green Fluorescent Proteins
|
|
Concept
|
ras Proteins
|
|
Concept
|
Analysis of Variance
|
|
Concept
|
Smad3 Protein
|
|
Concept
|
Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
|
|
Concept
|
Reverse Transcriptase Polymerase Chain Reaction
|
|
Concept
|
Enzyme Stability
|
|
Concept
|
Feeding Behavior
|
|
Concept
|
Models, Animal
|
|
Concept
|
Serine C-Palmitoyltransferase
|
|
Concept
|
Protease Inhibitors
|
|
Concept
|
Reaction Time
|
|
Concept
|
Leukemia, Promyelocytic, Acute
|
|
Concept
|
HL-60 Cells
|
|
Concept
|
Palmitoyl Coenzyme A
|
|
Concept
|
Interleukin-1beta
|
|
Concept
|
Imino Pyranoses
|
|
Concept
|
Troponin T
|
|
Concept
|
Nerve Growth Factors
|
|
Concept
|
Platelet Aggregation Inhibitors
|
|
Concept
|
Phosphatidylserines
|
|
Concept
|
Models, Genetic
|
|
Concept
|
Naphthalenes
|
|
Concept
|
Touch
|
|
Concept
|
Metabolomics
|
|
Concept
|
Retinoblastoma
|
|
Concept
|
Spodoptera
|
|
Concept
|
Lysosomal-Associated Membrane Protein 2
|
|
Concept
|
Antioxidants
|
|
Concept
|
Capsid Proteins
|
|
Concept
|
Lipoxygenase Inhibitors
|
|
Concept
|
Group II Phospholipases A2
|
|
Concept
|
Carcinoma
|
|
Concept
|
Glycosphingolipids
|
|
Concept
|
G1 Phase
|
|
Concept
|
Niemann-Pick Diseases
|
|
Concept
|
Autoantigens
|
|
Concept
|
Glycerophospholipids
|
|
Concept
|
Luciferases
|
|
Concept
|
Alzheimer Disease
|
|
Concept
|
Leukocytes, Mononuclear
|
|
Concept
|
Oligonucleotides, Antisense
|
|
Concept
|
Pseudomonas aeruginosa
|
|
Concept
|
Platelet Membrane Glycoproteins
|
|
Concept
|
Calcification, Physiologic
|
|
Concept
|
Phagocytosis
|
|
Concept
|
Myelin Basic Protein
|
|
Concept
|
Electrophoretic Mobility Shift Assay
|
|
Concept
|
Carcinoma, Hepatocellular
|
|
Concept
|
Receptor, ErbB-2
|
|
Concept
|
Acetylation
|
|
Concept
|
Electron Spin Resonance Spectroscopy
|
|
Concept
|
Th1 Cells
|
|
Concept
|
Binding Sites
|
|
Concept
|
Cyclophosphamide
|
|
Concept
|
Rats, Inbred F344
|
|
Concept
|
Molecular Conformation
|
|
Concept
|
Lymphohistiocytosis, Hemophagocytic
|
|
Concept
|
Receptors, Lysosphingolipid
|
|
Concept
|
Interleukin-8
|
|
Concept
|
Cell Transformation, Neoplastic
|
|
Concept
|
Carcinoma, Renal Cell
|
|
Concept
|
Lymph Nodes
|
|
Concept
|
Microbial Viability
|
|
Concept
|
Carcinoma, Squamous Cell
|
|
Concept
|
Depsipeptides
|
|
Concept
|
Mice, Nude
|
|
Concept
|
Mice, SCID
|
|
Concept
|
Case-Control Studies
|
|
Concept
|
Chemokines, CXC
|
|
Concept
|
Mutagenesis
|
|
Concept
|
Receptor, Nerve Growth Factor
|
|
Concept
|
Caenorhabditis elegans Proteins
|
|
Concept
|
Microbial Sensitivity Tests
|
|
Concept
|
Chemokine CCL2
|
|
Concept
|
Epidermal Growth Factor
|
|
Concept
|
Mice, Inbred Strains
|
|
Concept
|
Genes, myc
|
|
Concept
|
Sphingomyelins
|
|
Concept
|
Leukemia, Myeloid, Acute
|
|
Concept
|
Spectrometry, Fluorescence
|
|
Concept
|
Glucose Intolerance
|
|
Concept
|
Atmospheric Pressure
|
|
Concept
|
Microfilament Proteins
|
|
Concept
|
Histocompatibility Antigens Class II
|
|
Concept
|
Extracellular Signal-Regulated MAP Kinases
|
|
Concept
|
Reproducibility of Results
|
|
Concept
|
Fas Ligand Protein
|
|
Concept
|
Gamma Rays
|
|
Concept
|
Leukocytosis
|
|
Concept
|
CD4-Positive T-Lymphocytes
|
|
Concept
|
JNK Mitogen-Activated Protein Kinases
|
|
Concept
|
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
|
|
Concept
|
Platelet Membrane Glycoprotein IIb
|
|
Concept
|
HLA-DR4 Antigen
|
|
Concept
|
Kidney Neoplasms
|
|
Concept
|
Leptin
|
|
Concept
|
Rats
|
|
Concept
|
Gaucher Disease
|
|
Concept
|
Niemann-Pick Disease, Type C
|
|
Concept
|
Radiation-Sensitizing Agents
|
|
Concept
|
Chelating Agents
|
|
Concept
|
Proto-Oncogene Proteins p21(ras)
|
|
Concept
|
Reperfusion Injury
|
|
Concept
|
Interleukin-6
|
|
Concept
|
Sulfoglycosphingolipids
|
|
Concept
|
Ferritins
|
|
Concept
|
Spleen
|
|
Concept
|
Metals
|
|
Concept
|
Models, Molecular
|
|
Concept
|
Protein Sorting Signals
|
|
Concept
|
Integrins
|
|
Concept
|
Microsomes
|
|
Concept
|
Potassium Channels
|
|
Concept
|
Fibrosis
|
|
Concept
|
Enzyme Inhibitors
|
|
Concept
|
Clathrin
|
|
Concept
|
Tamoxifen
|
|
Concept
|
Receptor, trkA
|
|
Concept
|
Cytological Techniques
|
|
Concept
|
Farber Lipogranulomatosis
|
|
Concept
|
Breast Neoplasms
|
|
Concept
|
Allosteric Site
|
|
Concept
|
Oligonucleotide Array Sequence Analysis
|
|
Concept
|
B-Lymphocytes
|
|
Concept
|
Deferoxamine
|
|
Concept
|
Point Mutation
|
|
Concept
|
Lymphatic Metastasis
|
|
Concept
|
Rats, Sprague-Dawley
|
|
Concept
|
Polymerase Chain Reaction
|
|
Concept
|
Swine
|
|
Concept
|
Adaptor Proteins, Vesicular Transport
|
|
Concept
|
Hippocampus
|
|
Concept
|
Proteasome Endopeptidase Complex
|
|
Concept
|
United States
|
|
Concept
|
Chemokine CXCL1
|
|
Concept
|
Bayes Theorem
|
|
Concept
|
Protein Conformation
|
|
Concept
|
Sulfonamides
|
|
Concept
|
Fumonisins
|
|
Concept
|
Colon
|
|
Concept
|
Gene Deletion
|
|
Concept
|
Cholesterol
|
|
Concept
|
Mice, Inbred DBA
|
|
Concept
|
Risk Assessment
|
|
Concept
|
In Situ Hybridization, Fluorescence
|
|
Concept
|
Receptors, Tumor Necrosis Factor
|
|
Concept
|
U937 Cells
|
|
Concept
|
Metabolic Syndrome
|
|
Concept
|
CDC28 Protein Kinase, S cerevisiae
|
|
Concept
|
PubMed
|
|
Concept
|
Mutation, Missense
|
|
Concept
|
Risk
|
|
Concept
|
Hepatic Stellate Cells
|
|
Concept
|
MicroRNAs
|
|
Concept
|
Thromboembolism
|
|
Concept
|
Receptors, Antigen, B-Cell
|
|
Concept
|
Risk Factors
|
|
Concept
|
Phenylalanine
|
|
Concept
|
Daunorubicin
|
|
Concept
|
Chemokines
|
|
Concept
|
Octoxynol
|
|
Concept
|
Promoter Regions, Genetic
|
|
Concept
|
Inositol 1,4,5-Trisphosphate
|
|
Concept
|
Copper
|
|
Concept
|
Phosphatidylinositol 3-Kinases
|
|
Concept
|
Deoxycytidine
|
|
Concept
|
Nitrobenzenes
|
|
Concept
|
Fluorescent Antibody Technique, Indirect
|
|
Concept
|
Coenzyme A Ligases
|
|
Concept
|
Base Sequence
|
|
Concept
|
Amino Acid Motifs
|
|
Concept
|
RNA Probes
|
|
Concept
|
Platelet Activating Factor
|
|
Concept
|
Hyperplasia
|
|
Concept
|
Tissue Array Analysis
|
|
Concept
|
Killer Cells, Natural
|
|
Concept
|
Muscle, Skeletal
|
|
Concept
|
Gene Knockdown Techniques
|
|
Concept
|
Oleic Acid
|
|
Concept
|
Phospholipid Transfer Proteins
|
|
Concept
|
Immunohistochemistry
|
|
Concept
|
Glioblastoma
|
|
Concept
|
Cholangiocarcinoma
|
|
Concept
|
Pharynx
|
|
Concept
|
Acyltransferases
|
|
Concept
|
Colonic Neoplasms
|
|
Concept
|
Respiratory Mucosa
|
|
Concept
|
Mice, Mutant Strains
|
|
Concept
|
Actin Cytoskeleton
|
|
Concept
|
Antibiotics, Antineoplastic
|
|
Concept
|
Hemorrhage
|
|
Concept
|
Prostaglandins
|
|
Concept
|
Peroxisomes
|
|
Concept
|
Immunoblotting
|
|
Concept
|
TNF-Related Apoptosis-Inducing Ligand
|
|
Concept
|
fas Receptor
|
|
Concept
|
Trypan Blue
|
|
Concept
|
Cell Count
|
|
Concept
|
Troponin I
|
|
Academic Article
|
Essential roles of neutral ceramidase and sphingosine in mitochondrial dysfunction due to traumatic brain injury.
|
|
Academic Article
|
ATRA transcriptionally induces nSMase2 through CBP/p300-mediated histone acetylation.
|
|
Academic Article
|
Identification of ISC1 (YER019w) as inositol phosphosphingolipid phospholipase C in Saccharomyces cerevisiae.
|
|
Academic Article
|
Preparation of radiolabeled ceramides and phosphosphingolipids.
|
|
Academic Article
|
Purification and characterization of a membrane-bound nonlysosomal ceramidase from rat brain.
|
|
Academic Article
|
Novel sphingosine kinase-1 inhibitor, LCL351, reduces immune responses in murine DSS-induced colitis.
|
|
Academic Article
|
Inhibiting glucosylceramide synthase exacerbates cisplatin-induced acute kidney injury.
|
|
Academic Article
|
Identification and characterization of protein phosphatase 2C activation by ceramide.
|
|
Academic Article
|
Ceramide stimulates a cytosolic protein phosphatase.
|
|
Academic Article
|
15-Hydroxyeicosatetraenoic acid-mediated potentiation of thrombin-induced platelet functions occurs via enhanced production of phosphoinositide-derived second messengers--sn-1,2-diacylglycerol and inositol-1,4,5-trisphosphate.
|
|
Academic Article
|
Retinoblastoma protein dephosphorylation induced by D-erythro-sphingosine.
|
|
Academic Article
|
Cloning and characterization of the major promoter of the human protein kinase C beta gene. Regulation by phorbol esters.
|
|
Academic Article
|
Sphingosine activation of protein kinases in Jurkat T cells. In vitro phosphorylation of endogenous protein substrates and specificity of action.
|
|
Academic Article
|
Use of sphingosine as inhibitor of protein kinase C.
|
|
Academic Article
|
Arachidonic and cis-unsaturated fatty acids induce selective platelet substrate phosphorylation through activation of cytosolic protein kinase C.
|
|
Academic Article
|
Diacylglycerol overcomes aspirin inhibition of platelets: evidence for a necessary role for diacylglycerol accumulation in platelet activation.
|
|
Academic Article
|
Functions of sphingolipids and sphingolipid breakdown products in cellular regulation.
|
|
Academic Article
|
Protein kinase C regulation by sphingosine/lysosphingolipids.
|
|
Academic Article
|
Regulation of the epidermal growth factor receptor phosphorylation state by sphingosine in A431 human epidermoid carcinoma cells.
|
|
Academic Article
|
Aminoacridines, potent inhibitors of protein kinase C.
|
|
Academic Article
|
Mechanism of regulation of protein kinase C by lipid second messengers.
|
|
Academic Article
|
12(S)-HETE enhancement of prostate tumor cell invasion: selective role of PKC alpha.
|
|
Academic Article
|
12(S)-hydroxyeicosatetraenoic acid and 13(S)-hydroxyoctadecadienoic acid regulation of protein kinase C-alpha in melanoma cells: role of receptor-mediated hydrolysis of inositol phospholipids.
|
|
Academic Article
|
Ceramide induces interleukin 6 gene expression in human fibroblasts.
|
|
Academic Article
|
Activation of a retinoblastoma-protein-dependent pathway by sphingosine.
|
|
Academic Article
|
Ceramide: a stress signal and mediator of growth suppression and apoptosis.
|
|
Academic Article
|
Protein kinase C: cellular target of the second messenger arachidonic acid?
|
|
Academic Article
|
Retinoblastoma gene product as a downstream target for a ceramide-dependent pathway of growth arrest.
|
|
Academic Article
|
Regulation of protein kinase C (PKC) expression by iron: effect of different iron compounds on PKC-beta and PKC-alpha gene expression and role of the 5'-flanking region of the PKC-beta gene in the response to ferric transferrin.
|
|
Academic Article
|
Activation of the sphingomyelin cycle through the low-affinity neurotrophin receptor.
|
|
Academic Article
|
Identification of arachidonic acid as a mediator of sphingomyelin hydrolysis in response to tumor necrosis factor alpha.
|
|
Academic Article
|
Modulation of cytosolic protein phosphorylation by sphingosylphosphorylcholine.
|
|
Academic Article
|
Identification, partial purification, and characterization of a novel phospholipid-dependent and fatty acid-activated protein kinase from human platelets.
|
|
Academic Article
|
Immunolocalization of PKC zeta in rat photoreceptor inner segments.
|
|
Academic Article
|
Tumor necrosis factor-alpha (TNF-alpha) signal transduction through ceramide. Dissociation of growth inhibitory effects of TNF-alpha from activation of nuclear factor-kappa B.
|
|
Academic Article
|
Selective regulation of protein kinase C isoenzymes by oleic acid in human platelets.
|
|
Academic Article
|
Programmed cell death induced by ceramide.
|
|
Academic Article
|
Bcl-2 interrupts the ceramide-mediated pathway of cell death.
|
|
Academic Article
|
(1S,2R)-D-erythro-2-(N-myristoylamino)-1-phenyl-1-propanol as an inhibitor of ceramidase.
|
|
Academic Article
|
Functions of ceramide in coordinating cellular responses to stress.
|
|
Academic Article
|
Ceramide: a novel lipid mediator of apoptosis.
|
|
Academic Article
|
Involvement of yeast sphingolipids in the heat stress response of Saccharomyces cerevisiae.
|
|
Academic Article
|
Purification and characterization of a membrane bound neutral pH optimum magnesium-dependent and phosphatidylserine-stimulated sphingomyelinase from rat brain.
|
|
Academic Article
|
cPKC-dependent sequestration of membrane-recycling components in a subset of recycling endosomes.
|
|
Academic Article
|
The sphingolipid pathway regulates Pkc1 through the formation of diacylglycerol in Cryptococcus neoformans.
|
|
Academic Article
|
The extended family of neutral sphingomyelinases.
|
|
Academic Article
|
Sphingosine kinase-1 is cleaved by cathepsin B in vitro: identification of the initial cleavage sites for the protease.
|
|
Academic Article
|
Analysis of membrane topology of neutral sphingomyelinase 2.
|
|
Academic Article
|
Mechanism of inhibition of sequestration of protein kinase C alpha/betaII by ceramide. Roles of ceramide-activated protein phosphatases and phosphorylation/dephosphorylation of protein kinase C alpha/betaII on threonine 638/641.
|
|
Academic Article
|
A guide to biochemical systems modeling of sphingolipids for the biochemist.
|
|
Academic Article
|
Principles of bioactive lipid signalling: lessons from sphingolipids.
|
|
Academic Article
|
Remodeling of cellular cytoskeleton by the acid sphingomyelinase/ceramide pathway.
|
|
Academic Article
|
Bioactive sphingolipids: metabolism and function.
|
|
Academic Article
|
Sphingomyelin metabolism at the plasma membrane: implications for bioactive sphingolipids.
|
|
Academic Article
|
The neutral sphingomyelinase family: identifying biochemical connections.
|
|
Academic Article
|
Delayed phosphorylation of classical protein kinase C (PKC) substrates requires PKC internalization and formation of the pericentrion in a phospholipase D (PLD)-dependent manner.
|
|
Academic Article
|
Protein phosphatase 1a mediates ceramide-induced ERM protein dephosphorylation: a novel mechanism independent of phosphatidylinositol 4, 5-biphosphate (PIP2) and myosin/ERM phosphatase.
|
|
Academic Article
|
Sphingolipid metabolism and neutral sphingomyelinases.
|
|
Academic Article
|
A signaling cascade mediated by ceramide, src and PDGFR? coordinates the activation of the redox-sensitive neutral sphingomyelinase-2 and sphingosine kinase-1.
|
|
Academic Article
|
Sustained PKC?II activity confers oncogenic properties in a phospholipase D- and mTOR-dependent manner.
|
|
Academic Article
|
Sphingolipid signalling mediates mitochondrial dysfunctions and reduced chronological lifespan in the yeast model of Niemann-Pick type C1.
|
|
Academic Article
|
Roles and regulation of neutral sphingomyelinase-2 in cellular and pathological processes.
|
|
Academic Article
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Activity of neutral and alkaline ceramidases on fluorogenic N-acylated coumarin-containing aminodiols.
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Academic Article
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Substantial contribution of extrinsic risk factors to cancer development.
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Academic Article
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Loss of neutral ceramidase protects cells from nutrient- and energy -deprivation-induced cell death.
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Academic Article
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Alkaline ceramidase 2 and its bioactive product sphingosine are novel regulators of the DNA damage response.
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Academic Article
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Murine Model for Colitis-Associated Cancer of the Colon.
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Academic Article
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Wu et al. reply.
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Academic Article
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Contributions of the Intrinsic Mutation Process to Cancer Mutation and Risk Burdens.
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Academic Article
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Quantification of 3-ketodihydrosphingosine using HPLC-ESI-MS/MS to study SPT activity in yeast Saccharomyces cerevisiae.
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Academic Article
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Sphingosine 1-phosphate activation of ERM contributes to vascular calcification.
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Academic Article
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An intrinsic lipid-binding interface controls sphingosine kinase 1 function.
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Academic Article
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Acetic acid induces Sch9p-dependent translocation of Isc1p from the endoplasmic reticulum into mitochondria.
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Academic Article
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Probing de novo sphingolipid metabolism in mammalian cells utilizing mass spectrometry.
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Academic Article
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Identification of an acid sphingomyelinase ceramide kinase pathway in the regulation of the chemokine CCL5.
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Academic Article
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Tsc3 regulates SPT amino acid choice in Saccharomyces cerevisiae by promoting alanine in the sphingolipid pathway.
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Academic Article
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Functions of neutral ceramidase in the Golgi apparatus.
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Academic Article
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Approaches for probing and evaluating mammalian sphingolipid metabolism.
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Academic Article
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A novel assay for apoptotic body formation and membrane release during apoptosis.
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Academic Article
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Function of the cloned putative neutral sphingomyelinase as lyso-platelet activating factor-phospholipase C.
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Academic Article
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Rapid replenishment of sphingomyelin in the plasma membrane upon degradation by sphingomyelinase in NIH3T3 cells overexpressing the phosphatidylinositol transfer protein beta.
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Academic Article
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The Ceramide-centric universe of lipid-mediated cell regulation: stress encounters of the lipid kind.
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Academic Article
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Sphingosine-1-phosphate receptor 3 potentiates inflammatory programs in normal and leukemia stem cells to promote differentiation.
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Academic Article
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Targeting acid ceramidase inhibits YAP/TAZ signaling to reduce fibrosis in mice.
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Academic Article
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Neutral Sphingomyelinase 2 Heightens Anti-Melanoma Immune Responses and Anti-PD-1 Therapy Efficacy.
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Concept
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Olive Oil
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Concept
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Mechanistic Target of Rapamycin Complex 1
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Concept
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Myristoylated Alanine-Rich C Kinase Substrate
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Concept
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Acute Kidney Injury
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Concept
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Phosphatidylinositol 3-Kinase
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Concept
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Myofibroblasts
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Concept
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Real-Time Polymerase Chain Reaction
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Concept
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Programmed Cell Death 1 Receptor
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Concept
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Caspase Inhibitors
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Concept
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Matrix Metalloproteinase Inhibitors
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Concept
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Molecular Docking Simulation
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Concept
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Polycomb Repressive Complex 2
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Concept
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Mitochondrial Dynamics
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Concept
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Cannabinoid Receptor Agonists
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Concept
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Cannabinoid Receptor Antagonists
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Concept
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Carcinogenesis
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Concept
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Gene Ontology
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Concept
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ErbB Receptors
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Concept
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Datasets as Topic
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Concept
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Cell Self Renewal
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Concept
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Mutation Accumulation
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Concept
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Celecoxib
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Concept
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Suppressor of Cytokine Signaling 3 Protein
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Concept
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Uncoupling Protein 3
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Concept
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Glycogen Synthase Kinase 3 beta
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Concept
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Epithelial Cell Adhesion Molecule
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Concept
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NF-KappaB Inhibitor alpha
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Concept
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Smoothened Receptor
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Concept
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Protein Domains
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Concept
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Mice, 129 Strain
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Academic Article
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Asah2 Represses the p53-Hmox1 Axis to Protect Myeloid-Derived Suppressor Cells from Ferroptosis.
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Academic Article
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Build a registry of results that students can replicate.
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