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Item TypeName
Academic Article Synthesis of key precursors of radiolabeled sphingolipids.
Academic Article Modulation of transforming growth factor-beta (TGF-beta) signaling by endogenous sphingolipid mediators.
Academic Article Sphingolipids in vascular biology.
Academic Article The structural requirements for ceramide activation of serine-threonine protein phosphatases.
Academic Article Quantitative measurement of different ceramide species from crude cellular extracts by normal-phase high-performance liquid chromatography coupled to atmospheric pressure ionization mass spectrometry.
Academic Article Down-regulation of sphingosine kinase-1 by DNA damage: dependence on proteases and p53.
Academic Article Sphingosine kinase 1 (SPHK1) is induced by transforming growth factor-beta and mediates TIMP-1 up-regulation.
Academic Article Inhibition of growth and telomerase activity by novel cationic ceramide analogs with high solubility in human head and neck squamous cell carcinoma cells.
Academic Article Regulation of the sphingosine-recycling pathway for ceramide generation by oxidative stress, and its role in controlling c-Myc/Max function.
Academic Article Combined therapeutic use of AdGFPFasL and small molecule inhibitors of ceramide metabolism in prostate and head and neck cancers: a status report.
Academic Article New insights on the use of desipramine as an inhibitor for acid ceramidase.
Academic Article Molecular cloning and characterization of OsCDase, a ceramidase enzyme from rice.
Academic Article A role for sphingosine kinase 1 in dextran sulfate sodium-induced colitis.
Academic Article Molecular mechanisms of ceramide-mediated telomerase inhibition in the A549 human lung adenocarcinoma cell line.
Academic Article Determination of ceramides and diglycerides by the diglyceride kinase assay.
Academic Article Acid ceramidase upregulation in prostate cancer: role in tumor development and implications for therapy.
Academic Article Selective knockdown of ceramide synthases reveals complex interregulation of sphingolipid metabolism.
Academic Article Mitochondrially targeted ceramides preferentially promote autophagy, retard cell growth, and induce apoptosis.
Academic Article Purification and characterization of a second type of neutral ceramidase from rat brain: a second more hydrophobic form of rat brain ceramidase.
Academic Article Acid ceramidase-mediated production of sphingosine 1-phosphate promotes prostate cancer invasion through upregulation of cathepsin B.
Academic Article Role for ceramide in cell cycle arrest.
Academic Article EpCAM is overexpressed in breast cancer and is a potential target for breast cancer gene therapy.
Academic Article A mitochondrial pool of sphingomyelin is involved in TNFalpha-induced Bax translocation to mitochondria.
Academic Article Altered adipose and plasma sphingolipid metabolism in obesity: a potential mechanism for cardiovascular and metabolic risk.
Academic Article Synthesis and bioevaluation of omega-N-amino analogs of B13.
Academic Article AMPK inhibitor Compound C stimulates ceramide production and promotes Bax redistribution and apoptosis in MCF7 breast carcinoma cells.
Academic Article Blood sphingolipidomics in healthy humans: impact of sample collection methodology.
Academic Article Role for Sit4p-dependent mitochondrial dysfunction in mediating the shortened chronological lifespan and oxidative stress sensitivity of Isc1p-deficient cells.
Academic Article Cellular morphogenesis under stress is influenced by the sphingolipid pathway gene ISC1 and DNA integrity checkpoint genes in Saccharomyces cerevisiae.
Concept Antineoplastic Combined Chemotherapy Protocols
Concept Vesicular Transport Proteins
Concept Cytokines
Concept Tandem Mass Spectrometry
Concept Adenovirus E1A Proteins
Concept Muscle, Smooth, Vascular
Concept Oligodeoxyribonucleotides, Antisense
Concept Insulin
Concept Matrix Metalloproteinase 14
Concept Macrophages, Alveolar
Concept Enzyme-Linked Immunosorbent Assay
Concept Neutrophils
Concept T-Lymphocytes, Cytotoxic
Concept Disease Models, Animal
Concept Intestinal Mucosa
Concept DNA Methylation
Concept Retinal Pigment Epithelium
Concept Goblet Cells
Concept Interleukin-10
Concept Temperature
Concept Anti-Bacterial Agents
Concept Receptor, trkC
Concept Pseudomonas
Concept Brain Neoplasms
Concept Bacillus cereus
Concept Transforming Growth Factor beta
Concept Microscopy, Electron
Concept Acetic Acid
Concept Terminology as Topic
Concept Aldehyde-Lyases
Concept Receptors, Platelet-Derived Growth Factor
Concept Lung Neoplasms
Concept RNA, Small Interfering
Concept ras GTPase-Activating Proteins
Concept Histone Chaperones
Concept Defensins
Concept Bone Development
Concept Lysophospholipids
Concept Caspase 1
Concept Mycobacterium tuberculosis
Concept 2,4-Dinitrophenol
Concept Kaplan-Meier Estimate
Concept Heat-Shock Proteins
Concept Caspase 2
Concept Interferon-gamma
Concept Caspase 9
Concept Genes, Plant
Concept Phorbol 12,13-Dibutyrate
Concept Animals, Newborn
Concept Ultraviolet Rays
Concept Alkylating Agents
Concept Mitochondria
Concept Zellweger Syndrome
Concept Phosphorus Radioisotopes
Concept Flow Cytometry
Concept Prostatic Neoplasms
Concept Magnetic Resonance Spectroscopy
Concept Antigens, Polyomavirus Transforming
Concept Neoplasm Metastasis
Concept Ergosterol
Concept Mitogen-Activated Protein Kinases
Concept Arabidopsis
Concept Recurrence
Concept Sphingolipids
Concept Prolactin
Concept Rats, Inbred Strains
Concept 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine
Concept Ion Channels
Concept Mutagens
Concept Cell Division
Concept Leukemia, B-Cell
Concept p38 Mitogen-Activated Protein Kinases
Concept Phosphatidylinositols
Concept Drug Design
Concept Actins
Concept Cytotoxins
Concept Matrix Metalloproteinase 1
Concept COS Cells
Concept Intercellular Adhesion Molecule-1
Concept Membrane Potentials
Concept Oligonucleotide Probes
Concept Mutagenesis, Site-Directed
Concept Nitric Oxide
Concept Leukemia, Lymphoid
Concept Epoprostenol
Concept Ileum
Concept Dietary Fats
Concept Phosphatidylglycerols
Concept Carmustine
Concept p300-CBP Transcription Factors
Concept Fluorescent Dyes
Concept Mitochondrial Membranes
Concept Lipoproteins, LDL
Concept Arthritis, Experimental
Concept Mice, Inbred BALB C
Concept Microarray Analysis
Concept Phosphatidylinositol 4,5-Diphosphate
Concept Pyrazoles
Concept DNA, Complementary
Concept Fluorescent Antibody Technique
Concept Microscopy, Electron, Transmission
Concept Receptor, Cannabinoid, CB1
Concept Eicosanoids
Concept Disease Progression
Concept CD8-Positive T-Lymphocytes
Concept Desmogleins
Concept Long-Term Potentiation
Concept Mice, Obese
Concept Electric Conductivity
Concept Polyethylene Glycols
Concept HSP27 Heat-Shock Proteins
Concept Cadherins
Concept Ceramides
Concept Antifungal Agents
Concept Hedgehog Proteins
Concept Monoamine Oxidase Inhibitors
Concept Sensitivity and Specificity
Concept Vascular Cell Adhesion Molecule-1
Concept Urinary Bladder Neoplasms
Concept Endothelium, Vascular
Concept Telomerase
Concept Dictyostelium
Concept Cell Adhesion Molecules
Concept Receptors, Cell Surface
Concept Norbornanes
Concept Isoquinolines
Concept CD59 Antigens
Concept Brefeldin A
Concept Proto-Oncogenes
Concept Leukemia, Myeloid
Concept Registries
Concept Dependovirus
Concept Sodium-Potassium-Exchanging ATPase
Concept Ceruloplasmin
Concept Treatment Outcome
Concept Receptors, Interleukin-2
Concept Calcitriol
Concept Pargyline
Concept Macrophages
Concept National Institutes of Health (U.S.)
Concept Serotonin
Concept Tretinoin
Concept Rats, Inbred Lew
Concept HIV-1
Concept Membrane Potential, Mitochondrial
Concept Receptor, Cannabinoid, CB2
Concept Serpins
Concept Fibronectins
Concept Lysosomes
Concept Hemolysis
Concept Potassium
Concept Macrolides
Concept Arginine
Concept Protein Kinase Inhibitors
Concept Research Design
Concept Amino Acid Substitution
Concept Hair Follicle
Concept Protein Phosphatase 2
Concept Lymphoma, Mantle-Cell
Concept Cyclic Nucleotide Phosphodiesterases, Type 5
Concept Animals
Concept Thioredoxin Reductase 1
Concept Binding, Competitive
Concept Genetic Complementation Test
Concept Antigens, Neoplasm
Concept Isopropyl Thiogalactoside
Concept Feasibility Studies
Concept GTP-Binding Protein alpha Subunits, Gq-G11
Concept Mammals
Concept Myeloid Differentiation Factor 88
Concept Neurodegenerative Diseases
Concept 1-Methyl-3-isobutylxanthine
Concept Receptor, Platelet-Derived Growth Factor beta
Concept Psychosine
Concept Demography
Concept Statistics as Topic
Concept Ovarian Neoplasms
Concept Amino Acid Sequence
Concept Disease-Free Survival
Concept Resting Phase, Cell Cycle
Concept Membrane Lipids
Concept Receptors, G-Protein-Coupled
Concept Random Allocation
Concept Mice, Knockout
Concept Baculoviridae
Concept Immunosuppressive Agents
Concept Heme Oxygenase-1
Concept Mink
Concept Anticarcinogenic Agents
Concept Hydroxamic Acids
Concept Cohort Studies
Concept Nuclear Envelope
Concept Plasminogen Activator Inhibitor 1
Concept Antibodies
Concept Integrin alphaVbeta3
Concept Growth Hormone
Concept Antineoplastic Agents
Concept Animal Feed
Concept Leukemia
Concept Neoplasms, Experimental
Concept Aspirin
Concept Electric Impedance
Concept Mice, Inbred C3H
Concept Lipid Peroxidation
Concept Calcium
Concept Laboratories
Concept RNA, Fungal
Concept Receptors, Neuropeptide
Concept Cell-Derived Microparticles
Concept Inositol
Concept Prostaglandin Endoperoxides, Synthetic
Concept Intracellular Membranes
Concept Mitogens
Concept Precipitin Tests
Concept Hydrogen Peroxide
Concept 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid
Concept Troponin
Concept Antimycin A
Concept Colorectal Neoplasms
Concept Blotting, Western
Concept Exosomes
Concept Microscopy, Atomic Force
Concept Toll-Like Receptor 4
Concept Cerebellar Ataxia
Concept Ascorbic Acid
Concept Crohn Disease
Concept Leukemia-Lymphoma, Adult T-Cell
Concept Lipopolysaccharides
Concept Chemokine CXCL2
Concept Guanosine Triphosphate
Concept Interleukin-1 Receptor-Associated Kinases
Concept Hydroxyeicosatetraenoic Acids
Concept Receptors, Pattern Recognition
Concept Neurotrophin 3
Concept Neovascularization, Pathologic
Concept Longevity
Concept Shiga Toxin
Concept Poly A
Concept Carcinoma, Transitional Cell
Concept Glioma
Concept Biopsy
Concept Myocardium
Concept Antineoplastic Agents, Phytogenic
Concept Oryza
Concept Dose-Response Relationship, Drug
Concept Receptors, Nerve Growth Factor
Concept Mitogen-Activated Protein Kinase 13
Concept Dietary Supplements
Concept Iron
Concept Electron Transport Complex IV
Concept Cathepsin B
Concept Cystic Fibrosis Transmembrane Conductance Regulator
Concept Growth Inhibitors
Concept Head and Neck Neoplasms
Concept Lymphocytes, Tumor-Infiltrating
Concept Cysteine Endopeptidases
Concept Durapatite
Concept Caspase 3
Concept Leukocyte Count
Concept Obesity
Concept Masoprocol
Concept Carcinogens
Concept Spectrometry, Mass, Electrospray Ionization
Concept Genes, jun
Concept Genes, bcl-2
Concept Mice
Concept Clinical Trials as Topic
Concept DNA Primers
Concept CASP8 and FADD-Like Apoptosis Regulating Protein
Concept Insulin Resistance
Concept Immunoenzyme Techniques
Concept Models, Biological
Concept Statistics, Nonparametric
Concept Nucleosomes
Concept Charcot-Marie-Tooth Disease
Concept Hep G2 Cells
Concept Milk
Concept Oxidants
Concept Sympathetic Nervous System
Concept Adenocarcinoma
Concept Cyclooxygenase 2 Inhibitors
Concept Phosphotyrosine
Concept Research Personnel
Concept Microscopy, Confocal
Concept Precursor B-Cell Lymphoblastic Leukemia-Lymphoma
Concept Adiponectin
Concept Histone Deacetylases
Concept Tumor Necrosis Factor-alpha
Concept Genes, Fungal
Concept Dinoprostone
Concept Melanoma
Concept Conserved Sequence
Concept Hydroxyapatites
Concept Matrix Metalloproteinase 9
Concept Patch-Clamp Techniques
Concept Enzyme Activators
Concept Neoplasm Recurrence, Local
Concept rab GTP-Binding Proteins
Concept Phosphatidylinositol Phosphates
Concept Matrix Metalloproteinase 2
Concept Saposins
Concept Peer Review, Research
Concept Genes, ras
Concept Cosmetics
Concept Phosphatidic Acids
Concept Mice, Inbred C57BL
Concept Lysine
Concept Receptors, Vitronectin
Concept Retrospective Studies
Concept Cytoprotection
Concept Proto-Oncogene Proteins c-akt
Concept Toll-Like Receptor 2
Concept Phospholipase C gamma
Concept Melanoma, Experimental
Concept Platelet Count
Concept Transferrin
Concept Mitochondria, Liver
Concept Neoplasms, Squamous Cell
Concept Sequence Deletion
Concept Focal Adhesion Kinase 1
Concept Consensus Sequence
Concept Phorbol Esters
Concept Caspase 7
Concept Liver Neoplasms
Concept Mice, Transgenic
Concept Cell Separation
Concept 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid
Concept Isomerism
Concept T-Lymphocytes
Concept Mitochondria, Heart
Concept Chromatography, Thin Layer
Concept Microsomes, Liver
Concept Butylated Hydroxytoluene
Concept Phosphatidylcholines
Concept Oxygen
Concept Fas-Associated Death Domain Protein
Concept Tetradecanoylphorbol Acetate
Concept Manganese
Concept Antigens, CD
Concept Cathepsin D
Concept Authorship
Concept Receptor, Insulin
Concept Neoplasm Invasiveness
Concept Eye Neoplasms
Concept Neuroblastoma
Concept Integrin alpha6beta1
Concept Methyl Methanesulfonate
Concept Isotope Labeling
Concept Monocytes
Concept Benzylidene Compounds
Concept Disease
Concept Interleukin-2
Concept Free Radical Scavengers
Concept G2 Phase
Concept Intestine, Small
Concept Xenograft Model Antitumor Assays
Concept Nucleic Acid Synthesis Inhibitors
Concept Severity of Illness Index
Concept RNA, Messenger
Concept Protein Structure, Secondary
Concept Caspase 8
Concept Survival Rate
Concept MAP Kinase Signaling System
Concept Humans
Concept Multiprotein Complexes
Concept Transglutaminases
Concept Doxorubicin
Concept Precursor Cell Lymphoblastic Leukemia-Lymphoma
Concept Mesylates
Concept Jurkat Cells
Concept Hot Temperature
Concept Cattle
Concept Antidepressive Agents, Tricyclic
Concept L-Serine Dehydratase
Concept Prostate
Concept Melanins
Concept Cell Movement
Concept Ornithine Decarboxylase
Concept Thymidylate Synthase
Concept beta Catenin
Concept Antigen Presentation
Concept Leukemia, T-Cell
Concept Pilot Projects
Concept Receptor, Angiotensin, Type 1
Concept Membrane Glycoproteins
Concept Sphingosine N-Acyltransferase
Concept Suppressor of Cytokine Signaling Proteins
Concept Drug Screening Assays, Antitumor
Concept Linoleic Acids
Concept Rabbits
Concept Raphanus
Concept Sphingolipidoses
Concept Integrin beta1
Concept Glucosylceramides
Concept Liver Cirrhosis
Concept Dactinomycin
Concept Protein Structure, Tertiary
Concept Molecular Probes
Concept Adaptor Proteins, Signal Transducing
Concept Interleukin-1
Concept Phospholipids
Concept Interferon Regulatory Factor-3
Concept Cardiolipins
Concept Inhibitory Concentration 50
Concept Silver Staining
Concept Cysteine Proteinase Inhibitors
Concept Microscopy, Fluorescence
Concept Oncogene Protein v-akt
Concept Macrophages, Peritoneal
Concept Carcinoma, Non-Small-Cell Lung
Concept Caspases
Concept Opossums
Concept Mammary Neoplasms, Experimental
Concept Inflammation
Concept Retinoblastoma-Binding Protein 1
Concept Diacylglycerol O-Acyltransferase
Concept Etoposide
Concept Mammary Tumor Virus, Mouse
Concept Zinc
Concept Leukemia, Monocytic, Acute
Concept Ionophores
Concept Catalytic Domain
Concept Mitochondria, Muscle
Concept Myocardial Reperfusion Injury
Concept Dinitrophenols
Concept Proto-Oncogene Proteins c-raf
Concept Antigens, Surface
Concept Neuronal Ceroid-Lipofuscinoses
Concept Intestines
Concept Chemokine CCL5
Concept Receptor Protein-Tyrosine Kinases
Concept Magnesium
Concept Liver Transplantation
Concept Cluster Analysis
Concept Multienzyme Complexes
Concept Detergents
Concept Isoindoles
Concept Angiotensin II
Concept Green Fluorescent Proteins
Concept ras Proteins
Concept Analysis of Variance
Concept Smad3 Protein
Concept Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
Concept Reverse Transcriptase Polymerase Chain Reaction
Concept Enzyme Stability
Concept Feeding Behavior
Concept Models, Animal
Concept Serine C-Palmitoyltransferase
Concept Protease Inhibitors
Concept Reaction Time
Concept Leukemia, Promyelocytic, Acute
Concept HL-60 Cells
Concept Palmitoyl Coenzyme A
Concept Interleukin-1beta
Concept Imino Pyranoses
Concept Troponin T
Concept Nerve Growth Factors
Concept Platelet Aggregation Inhibitors
Concept Phosphatidylserines
Concept Models, Genetic
Concept Naphthalenes
Concept Touch
Concept Metabolomics
Concept Retinoblastoma
Concept Spodoptera
Concept Lysosomal-Associated Membrane Protein 2
Concept Antioxidants
Concept Capsid Proteins
Concept Lipoxygenase Inhibitors
Concept Group II Phospholipases A2
Concept Carcinoma
Concept Glycosphingolipids
Concept G1 Phase
Concept Niemann-Pick Diseases
Concept Autoantigens
Concept Glycerophospholipids
Concept Luciferases
Concept Alzheimer Disease
Concept Leukocytes, Mononuclear
Concept Oligonucleotides, Antisense
Concept Pseudomonas aeruginosa
Concept Platelet Membrane Glycoproteins
Concept Calcification, Physiologic
Concept Phagocytosis
Concept Myelin Basic Protein
Concept Electrophoretic Mobility Shift Assay
Concept Carcinoma, Hepatocellular
Concept Receptor, ErbB-2
Concept Acetylation
Concept Electron Spin Resonance Spectroscopy
Concept Th1 Cells
Concept Binding Sites
Concept Cyclophosphamide
Concept Rats, Inbred F344
Concept Molecular Conformation
Concept Lymphohistiocytosis, Hemophagocytic
Concept Receptors, Lysosphingolipid
Concept Interleukin-8
Concept Cell Transformation, Neoplastic
Concept Carcinoma, Renal Cell
Concept Lymph Nodes
Concept Microbial Viability
Concept Carcinoma, Squamous Cell
Concept Depsipeptides
Concept Mice, Nude
Concept Mice, SCID
Concept Case-Control Studies
Concept Chemokines, CXC
Concept Mutagenesis
Concept Receptor, Nerve Growth Factor
Concept Caenorhabditis elegans Proteins
Concept Microbial Sensitivity Tests
Concept Chemokine CCL2
Concept Epidermal Growth Factor
Concept Mice, Inbred Strains
Concept Genes, myc
Concept Sphingomyelins
Concept Leukemia, Myeloid, Acute
Concept Spectrometry, Fluorescence
Concept Glucose Intolerance
Concept Atmospheric Pressure
Concept Microfilament Proteins
Concept Histocompatibility Antigens Class II
Concept Extracellular Signal-Regulated MAP Kinases
Concept Reproducibility of Results
Concept Fas Ligand Protein
Concept Gamma Rays
Concept Leukocytosis
Concept CD4-Positive T-Lymphocytes
Concept JNK Mitogen-Activated Protein Kinases
Concept Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Concept Platelet Membrane Glycoprotein IIb
Concept HLA-DR4 Antigen
Concept Kidney Neoplasms
Concept Leptin
Concept Rats
Concept Gaucher Disease
Concept Niemann-Pick Disease, Type C
Concept Radiation-Sensitizing Agents
Concept Chelating Agents
Concept Proto-Oncogene Proteins p21(ras)
Concept Reperfusion Injury
Concept Interleukin-6
Concept Sulfoglycosphingolipids
Concept Ferritins
Concept Spleen
Concept Metals
Concept Models, Molecular
Concept Protein Sorting Signals
Concept Integrins
Concept Microsomes
Concept Potassium Channels
Concept Fibrosis
Concept Enzyme Inhibitors
Concept Clathrin
Concept Tamoxifen
Concept Receptor, trkA
Concept Cytological Techniques
Concept Farber Lipogranulomatosis
Concept Breast Neoplasms
Concept Allosteric Site
Concept Oligonucleotide Array Sequence Analysis
Concept B-Lymphocytes
Concept Deferoxamine
Concept Point Mutation
Concept Lymphatic Metastasis
Concept Rats, Sprague-Dawley
Concept Polymerase Chain Reaction
Concept Swine
Concept Adaptor Proteins, Vesicular Transport
Concept Hippocampus
Concept Proteasome Endopeptidase Complex
Concept United States
Concept Chemokine CXCL1
Concept Bayes Theorem
Concept Protein Conformation
Concept Sulfonamides
Concept Fumonisins
Concept Colon
Concept Gene Deletion
Concept Cholesterol
Concept Mice, Inbred DBA
Concept Risk Assessment
Concept In Situ Hybridization, Fluorescence
Concept Receptors, Tumor Necrosis Factor
Concept U937 Cells
Concept Metabolic Syndrome
Concept CDC28 Protein Kinase, S cerevisiae
Concept PubMed
Concept Mutation, Missense
Concept Risk
Concept Hepatic Stellate Cells
Concept MicroRNAs
Concept Thromboembolism
Concept Receptors, Antigen, B-Cell
Concept Risk Factors
Concept Phenylalanine
Concept Daunorubicin
Concept Chemokines
Concept Octoxynol
Concept Promoter Regions, Genetic
Concept Inositol 1,4,5-Trisphosphate
Concept Copper
Concept Phosphatidylinositol 3-Kinases
Concept Deoxycytidine
Concept Nitrobenzenes
Concept Fluorescent Antibody Technique, Indirect
Concept Coenzyme A Ligases
Concept Base Sequence
Concept Amino Acid Motifs
Concept RNA Probes
Concept Platelet Activating Factor
Concept Hyperplasia
Concept Tissue Array Analysis
Concept Killer Cells, Natural
Concept Muscle, Skeletal
Concept Gene Knockdown Techniques
Concept Oleic Acid
Concept Phospholipid Transfer Proteins
Concept Immunohistochemistry
Concept Glioblastoma
Concept Cholangiocarcinoma
Concept Pharynx
Concept Acyltransferases
Concept Colonic Neoplasms
Concept Respiratory Mucosa
Concept Mice, Mutant Strains
Concept Actin Cytoskeleton
Concept Antibiotics, Antineoplastic
Concept Hemorrhage
Concept Prostaglandins
Concept Peroxisomes
Concept Immunoblotting
Concept TNF-Related Apoptosis-Inducing Ligand
Concept fas Receptor
Concept Trypan Blue
Concept Cell Count
Concept Troponin I
Academic Article Essential roles of neutral ceramidase and sphingosine in mitochondrial dysfunction due to traumatic brain injury.
Academic Article ATRA transcriptionally induces nSMase2 through CBP/p300-mediated histone acetylation.
Academic Article Identification of ISC1 (YER019w) as inositol phosphosphingolipid phospholipase C in Saccharomyces cerevisiae.
Academic Article Preparation of radiolabeled ceramides and phosphosphingolipids.
Academic Article Purification and characterization of a membrane-bound nonlysosomal ceramidase from rat brain.
Academic Article Novel sphingosine kinase-1 inhibitor, LCL351, reduces immune responses in murine DSS-induced colitis.
Academic Article Inhibiting glucosylceramide synthase exacerbates cisplatin-induced acute kidney injury.
Academic Article Identification and characterization of protein phosphatase 2C activation by ceramide.
Academic Article Ceramide stimulates a cytosolic protein phosphatase.
Academic Article 15-Hydroxyeicosatetraenoic acid-mediated potentiation of thrombin-induced platelet functions occurs via enhanced production of phosphoinositide-derived second messengers--sn-1,2-diacylglycerol and inositol-1,4,5-trisphosphate.
Academic Article Retinoblastoma protein dephosphorylation induced by D-erythro-sphingosine.
Academic Article Cloning and characterization of the major promoter of the human protein kinase C beta gene. Regulation by phorbol esters.
Academic Article Sphingosine activation of protein kinases in Jurkat T cells. In vitro phosphorylation of endogenous protein substrates and specificity of action.
Academic Article Use of sphingosine as inhibitor of protein kinase C.
Academic Article Arachidonic and cis-unsaturated fatty acids induce selective platelet substrate phosphorylation through activation of cytosolic protein kinase C.
Academic Article Diacylglycerol overcomes aspirin inhibition of platelets: evidence for a necessary role for diacylglycerol accumulation in platelet activation.
Academic Article Functions of sphingolipids and sphingolipid breakdown products in cellular regulation.
Academic Article Protein kinase C regulation by sphingosine/lysosphingolipids.
Academic Article Regulation of the epidermal growth factor receptor phosphorylation state by sphingosine in A431 human epidermoid carcinoma cells.
Academic Article Aminoacridines, potent inhibitors of protein kinase C.
Academic Article Mechanism of regulation of protein kinase C by lipid second messengers.
Academic Article 12(S)-HETE enhancement of prostate tumor cell invasion: selective role of PKC alpha.
Academic Article 12(S)-hydroxyeicosatetraenoic acid and 13(S)-hydroxyoctadecadienoic acid regulation of protein kinase C-alpha in melanoma cells: role of receptor-mediated hydrolysis of inositol phospholipids.
Academic Article Ceramide induces interleukin 6 gene expression in human fibroblasts.
Academic Article Activation of a retinoblastoma-protein-dependent pathway by sphingosine.
Academic Article Ceramide: a stress signal and mediator of growth suppression and apoptosis.
Academic Article Protein kinase C: cellular target of the second messenger arachidonic acid?
Academic Article Retinoblastoma gene product as a downstream target for a ceramide-dependent pathway of growth arrest.
Academic Article Regulation of protein kinase C (PKC) expression by iron: effect of different iron compounds on PKC-beta and PKC-alpha gene expression and role of the 5'-flanking region of the PKC-beta gene in the response to ferric transferrin.
Academic Article Activation of the sphingomyelin cycle through the low-affinity neurotrophin receptor.
Academic Article Identification of arachidonic acid as a mediator of sphingomyelin hydrolysis in response to tumor necrosis factor alpha.
Academic Article Modulation of cytosolic protein phosphorylation by sphingosylphosphorylcholine.
Academic Article Identification, partial purification, and characterization of a novel phospholipid-dependent and fatty acid-activated protein kinase from human platelets.
Academic Article Immunolocalization of PKC zeta in rat photoreceptor inner segments.
Academic Article Tumor necrosis factor-alpha (TNF-alpha) signal transduction through ceramide. Dissociation of growth inhibitory effects of TNF-alpha from activation of nuclear factor-kappa B.
Academic Article Selective regulation of protein kinase C isoenzymes by oleic acid in human platelets.
Academic Article Programmed cell death induced by ceramide.
Academic Article Bcl-2 interrupts the ceramide-mediated pathway of cell death.
Academic Article (1S,2R)-D-erythro-2-(N-myristoylamino)-1-phenyl-1-propanol as an inhibitor of ceramidase.
Academic Article Functions of ceramide in coordinating cellular responses to stress.
Academic Article Ceramide: a novel lipid mediator of apoptosis.
Academic Article Involvement of yeast sphingolipids in the heat stress response of Saccharomyces cerevisiae.
Academic Article Purification and characterization of a membrane bound neutral pH optimum magnesium-dependent and phosphatidylserine-stimulated sphingomyelinase from rat brain.
Academic Article cPKC-dependent sequestration of membrane-recycling components in a subset of recycling endosomes.
Academic Article The sphingolipid pathway regulates Pkc1 through the formation of diacylglycerol in Cryptococcus neoformans.
Academic Article The extended family of neutral sphingomyelinases.
Academic Article Sphingosine kinase-1 is cleaved by cathepsin B in vitro: identification of the initial cleavage sites for the protease.
Academic Article Analysis of membrane topology of neutral sphingomyelinase 2.
Academic Article Mechanism of inhibition of sequestration of protein kinase C alpha/betaII by ceramide. Roles of ceramide-activated protein phosphatases and phosphorylation/dephosphorylation of protein kinase C alpha/betaII on threonine 638/641.
Academic Article A guide to biochemical systems modeling of sphingolipids for the biochemist.
Academic Article Principles of bioactive lipid signalling: lessons from sphingolipids.
Academic Article Remodeling of cellular cytoskeleton by the acid sphingomyelinase/ceramide pathway.
Academic Article Bioactive sphingolipids: metabolism and function.
Academic Article Sphingomyelin metabolism at the plasma membrane: implications for bioactive sphingolipids.
Academic Article The neutral sphingomyelinase family: identifying biochemical connections.
Academic Article Delayed phosphorylation of classical protein kinase C (PKC) substrates requires PKC internalization and formation of the pericentrion in a phospholipase D (PLD)-dependent manner.
Academic Article Protein phosphatase 1a mediates ceramide-induced ERM protein dephosphorylation: a novel mechanism independent of phosphatidylinositol 4, 5-biphosphate (PIP2) and myosin/ERM phosphatase.
Academic Article Sphingolipid metabolism and neutral sphingomyelinases.
Academic Article A signaling cascade mediated by ceramide, src and PDGFR? coordinates the activation of the redox-sensitive neutral sphingomyelinase-2 and sphingosine kinase-1.
Academic Article Sustained PKC?II activity confers oncogenic properties in a phospholipase D- and mTOR-dependent manner.
Academic Article Sphingolipid signalling mediates mitochondrial dysfunctions and reduced chronological lifespan in the yeast model of Niemann-Pick type C1.
Academic Article Roles and regulation of neutral sphingomyelinase-2 in cellular and pathological processes.
Academic Article Activity of neutral and alkaline ceramidases on fluorogenic N-acylated coumarin-containing aminodiols.
Academic Article Substantial contribution of extrinsic risk factors to cancer development.
Academic Article Loss of neutral ceramidase protects cells from nutrient- and energy -deprivation-induced cell death.
Academic Article Alkaline ceramidase 2 and its bioactive product sphingosine are novel regulators of the DNA damage response.
Academic Article Murine Model for Colitis-Associated Cancer of the Colon.
Academic Article Wu et al. reply.
Academic Article Contributions of the Intrinsic Mutation Process to Cancer Mutation and Risk Burdens.
Academic Article Quantification of 3-ketodihydrosphingosine using HPLC-ESI-MS/MS to study SPT activity in yeast Saccharomyces cerevisiae.
Academic Article Sphingosine 1-phosphate activation of ERM contributes to vascular calcification.
Academic Article An intrinsic lipid-binding interface controls sphingosine kinase 1 function.
Academic Article Acetic acid induces Sch9p-dependent translocation of Isc1p from the endoplasmic reticulum into mitochondria.
Academic Article Probing de novo sphingolipid metabolism in mammalian cells utilizing mass spectrometry.
Academic Article Identification of an acid sphingomyelinase ceramide kinase pathway in the regulation of the chemokine CCL5.
Academic Article Tsc3 regulates SPT amino acid choice in Saccharomyces cerevisiae by promoting alanine in the sphingolipid pathway.
Academic Article Functions of neutral ceramidase in the Golgi apparatus.
Academic Article Approaches for probing and evaluating mammalian sphingolipid metabolism.
Academic Article A novel assay for apoptotic body formation and membrane release during apoptosis.
Academic Article Function of the cloned putative neutral sphingomyelinase as lyso-platelet activating factor-phospholipase C.
Academic Article Rapid replenishment of sphingomyelin in the plasma membrane upon degradation by sphingomyelinase in NIH3T3 cells overexpressing the phosphatidylinositol transfer protein beta.
Academic Article The Ceramide-centric universe of lipid-mediated cell regulation: stress encounters of the lipid kind.
Academic Article Sphingosine-1-phosphate receptor 3 potentiates inflammatory programs in normal and leukemia stem cells to promote differentiation.
Academic Article Targeting acid ceramidase inhibits YAP/TAZ signaling to reduce fibrosis in mice.
Academic Article Neutral Sphingomyelinase 2 Heightens Anti-Melanoma Immune Responses and Anti-PD-1 Therapy Efficacy.
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Academic Article Asah2 Represses the p53-Hmox1 Axis to Protect Myeloid-Derived Suppressor Cells from Ferroptosis.
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