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Hannun, Yusuf
One or more keywords matched the following items that are connected to Hannun, Yusuf
Item TypeName
Academic Article Modulation of transforming growth factor-beta (TGF-beta) signaling by endogenous sphingolipid mediators.
Academic Article The sphingosine kinase 1/sphingosine-1-phosphate pathway mediates COX-2 induction and PGE2 production in response to TNF-alpha.
Academic Article Sphingosine kinase 1 (SPHK1) is induced by transforming growth factor-beta and mediates TIMP-1 up-regulation.
Academic Article Tumor necrosis factor induces the loss of sphingosine kinase-1 by a cathepsin B-dependent mechanism.
Academic Article Roles for C16-ceramide and sphingosine 1-phosphate in regulating hepatocyte apoptosis in response to tumor necrosis factor-alpha.
Academic Article Regulation of the sphingosine-recycling pathway for ceramide generation by oxidative stress, and its role in controlling c-Myc/Max function.
Academic Article Dihydrosphingosine 1-phosphate stimulates MMP1 gene expression via activation of ERK1/2-Ets1 pathway in human fibroblasts.
Academic Article Acid ceramidase but not acid sphingomyelinase is required for tumor necrosis factor-{alpha}-induced PGE2 production.
Academic Article A role for sphingosine kinase 1 in dextran sulfate sodium-induced colitis.
Academic Article Antiapoptotic roles of ceramide-synthase-6-generated C16-ceramide via selective regulation of the ATF6/CHOP arm of ER-stress-response pathways.
Academic Article Regulated secretion of acid sphingomyelinase: implications for selectivity of ceramide formation.
Academic Article Inhibition of tumor necrosis factor-induced cell death in MCF7 by a novel inhibitor of neutral sphingomyelinase.
Academic Article Isofagomine in vivo effects in a neuronopathic Gaucher disease mouse.
Academic Article Sphingosine inhibits monocyte tissue factor-initiated coagulation by altering factor VII binding.
Academic Article Ceramide activates the stress-activated protein kinases.
Academic Article A mitochondrial pool of sphingomyelin is involved in TNFalpha-induced Bax translocation to mitochondria.
Academic Article Resistance to TRAIL is associated with defects in ceramide signaling that can be overcome by exogenous C6-ceramide without requiring down-regulation of cellular FLICE inhibitory protein.
Academic Article Stress-induced sphingolipid signaling: role of type-2 neutral sphingomyelinase in murine cell apoptosis and proliferation.
Academic Article Sphingosine inhibition of agonist-dependent secretion and activation of human platelets implies that protein kinase C is a necessary and common event of the signal transduction pathways.
Academic Article Sphingosylphosphocholine reduces the calcium ion requirement for activating tissue transglutaminase.
Concept Transforming Growth Factor beta
Concept Receptors, Platelet-Derived Growth Factor
Concept Transcription Factor CHOP
Concept Factor XIII
Concept Transcription Factor DP1
Concept Myeloid Differentiation Factor 88
Concept Receptor, Platelet-Derived Growth Factor beta
Concept Factor VII
Concept Receptors, Nerve Growth Factor
Concept Tumor Necrosis Factor-alpha
Concept Activating Transcription Factor 6
Concept Interferon Regulatory Factor-3
Concept Receptor, Nerve Growth Factor
Concept Epidermal Growth Factor
Concept Receptors, Tumor Necrosis Factor
Concept Platelet Activating Factor
Academic Article Sustained activation of protein kinase C induces delayed phosphorylation and regulates the fate of epidermal growth factor receptor.
Academic Article Novel sphingosine kinase-1 inhibitor, LCL351, reduces immune responses in murine DSS-induced colitis.
Academic Article Identification of sphingomyelin turnover as an effector mechanism for the action of tumor necrosis factor alpha and gamma-interferon. Specific role in cell differentiation.
Academic Article Regulation of the epidermal growth factor receptor phosphorylation state by sphingosine in A431 human epidermoid carcinoma cells.
Academic Article Activation of a retinoblastoma-protein-dependent pathway by sphingosine.
Academic Article Neurotrophins induce sphingomyelin hydrolysis. Modulation by co-expression of p75NTR with Trk receptors.
Academic Article Activation of the sphingomyelin cycle through the low-affinity neurotrophin receptor.
Academic Article Identification of a distinct pool of sphingomyelin involved in the sphingomyelin cycle.
Academic Article Identification of arachidonic acid as a mediator of sphingomyelin hydrolysis in response to tumor necrosis factor alpha.
Academic Article Tumor necrosis factor-alpha (TNF-alpha) signal transduction through ceramide. Dissociation of growth inhibitory effects of TNF-alpha from activation of nuclear factor-kappa B.
Academic Article Programmed cell death induced by ceramide.
Academic Article Role of ceramide in stimulation of the transcription of cytosolic phospholipase A2 and cyclooxygenase 2.
Academic Article prICE: a downstream target for ceramide-induced apoptosis and for the inhibitory action of Bcl-2.
Academic Article Cytokine response modifier A (CrmA) inhibits ceramide formation in response to tumor necrosis factor (TNF)-alpha: CrmA and Bcl-2 target distinct components in the apoptotic pathway.
Academic Article Selective involvement of ceramide in cytokine-induced apoptosis. Ceramide inhibits phorbol ester activation of nuclear factor kappaB.
Academic Article Phospholipase A2 is necessary for tumor necrosis factor alpha-induced ceramide generation in L929 cells.
Academic Article Mechanisms of ceramide-mediated apoptosis.
Academic Article Glutathione regulation of neutral sphingomyelinase in tumor necrosis factor-alpha-induced cell death.
Academic Article Platelet-activating factor receptor activation. An initiator step in HIV-1 neuropathogenesis.
Academic Article Roles of AKT and sphingosine kinase in the antiapoptotic effects of bile duct ligation in mouse liver.
Academic Article Role for neutral sphingomyelinase-2 in tumor necrosis factor alpha-stimulated expression of vascular cell adhesion molecule-1 (VCAM) and intercellular adhesion molecule-1 (ICAM) in lung epithelial cells: p38 MAPK is an upstream regulator of nSMase2.
Academic Article Role for furin in tumor necrosis factor alpha-induced activation of the matrix metalloproteinase/sphingolipid mitogenic pathway.
Academic Article Regulation of neutral sphingomyelinase-2 (nSMase2) by tumor necrosis factor-alpha involves protein kinase C-delta in lung epithelial cells.
Academic Article Acid beta-glucosidase 1 counteracts p38delta-dependent induction of interleukin-6: possible role for ceramide as an anti-inflammatory lipid.
Academic Article The Polycomb group protein EED couples TNF receptor 1 to neutral sphingomyelinase.
Academic Article Neutral sphingomyelinase 2 (nSMase2) is the primary neutral sphingomyelinase isoform activated by tumour necrosis factor-a in MCF-7 cells.
Academic Article Epidermal growth factor-induced cellular invasion requires sphingosine-1-phosphate/sphingosine-1-phosphate 2 receptor-mediated ezrin activation.
Academic Article A signaling cascade mediated by ceramide, src and PDGFR? coordinates the activation of the redox-sensitive neutral sphingomyelinase-2 and sphingosine kinase-1.
Academic Article Sphingosine kinase 1 regulates tumor necrosis factor-mediated RANTES induction through p38 mitogen-activated protein kinase but independently of nuclear factor ?B activation.
Academic Article Intracellular sphingosine kinase 2-derived sphingosine-1-phosphate mediates epidermal growth factor-induced ezrin-radixin-moesin phosphorylation and cancer cell invasion.
Academic Article Tumor Necrosis Factor-a (TNFa)-induced Ceramide Generation via Ceramide Synthases Regulates Loss of Focal Adhesion Kinase (FAK) and Programmed Cell Death.
Academic Article The Synergy between Palmitate and TNF-a for CCL2 Production Is Dependent on the TRIF/IRF3 Pathway: Implications for Metabolic Inflammation.
Academic Article Identification of an acid sphingomyelinase ceramide kinase pathway in the regulation of the chemokine CCL5.
Academic Article Function of the cloned putative neutral sphingomyelinase as lyso-platelet activating factor-phospholipase C.
Academic Article Proteolytic cleavage of phospholipase C-gamma1 during apoptosis in Molt-4 cells.
Academic Article Functional dichotomy of protein kinase C (PKC) in tumor necrosis factor-alpha (TNF-alpha ) signal transduction in L929 cells. Translocation and inactivation of PKC by TNF-alpha.
Academic Article Ceramide in apoptosis: an overview and current perspectives.
Academic Article Biochemical properties of mammalian neutral sphingomyelinase 2 and its role in sphingolipid metabolism.
Academic Article Neutral sphingomyelinase 2 regulates inflammatory responses in monocytes/macrophages induced by TNF-a.
Academic Article Ceramide kinase regulates TNF-a-induced immune responses in human monocytic cells.
Academic Article A Milk-Fat Based Diet Increases Metastasis in the MMTV-PyMT Mouse Model of Breast Cancer.
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