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Hildebrandt, John
One or more keywords matched the following items that are connected to Hildebrandt, John
Item TypeName
Academic Article Receptor docking sites for G-protein betagamma subunits. Implications for signal regulation.
Academic Article Heterogeneous processing of a G protein gamma subunit at a site critical for protein and membrane interactions.
Academic Article A major G protein alpha O isoform in bovine brain is deamidated at Asn346 and Asn347, residues involved in receptor coupling.
Academic Article A mutation in the putative Mg(2+)-binding site of Gs alpha prevents its activation by receptors.
Academic Article Identification of a region in G protein gamma subunits conserved across species but hypervariable among subunit isoforms.
Academic Article Characterization of deamidated G protein subunits.
Academic Article Structural characterization of intact G protein gamma subunits by mass spectrometry.
Academic Article Characterization of the major bovine brain Go alpha isoforms. Mapping the structural differences between the alpha subunit isoforms identifies a variable region of the protein involved in receptor interactions.
Academic Article The N54 mutant of Galphas has a conditional dominant negative phenotype which suppresses hormone-stimulated but not basal cAMP levels.
Academic Article The relationship of G(o)alpha subunit deamidation to the tissue distribution, nucleotide binding properties, and betagamma dimer interactions of G(o)alpha subunit isoforms.
Academic Article Gamma 2 subunit of G protein heterotrimer is an N-end rule ubiquitylation substrate.
Academic Article Effect of ras-gene transformation on the inhibition of NIH3T3 cell growth by pertussis toxin.
Academic Article Identification of Gbetagamma binding sites in the third intracellular loop of the M(3)-muscarinic receptor and their role in receptor regulation.
Academic Article Genomic analysis of G protein gamma subunits in human and mouse - the relationship between conserved gene structure and G protein betagamma dimer formation.
Academic Article G Protein betagamma dimer formation: Gbeta and Ggamma differentially determine efficiency of in vitro dimer formation.
Academic Article Proteomic analysis of bovine brain G protein gamma subunit processing heterogeneity.
Academic Article Bring your own G protein.
Academic Article Role of the chaperonin CCT/TRiC complex in G protein betagamma-dimer assembly.
Academic Article Distinct guanine nucleotide binding and release properties of the three Gi proteins.
Academic Article Differential regulation of G protein subunit expression in mouse oocytes, eggs, and early embryos.
Academic Article Analysis of signal transfer from receptor to Go/Gi in different membrane environments and receptor-independent activators of brain G protein.
Academic Article Separation and analysis of G protein gamma subunits.
Academic Article Synthesis and assembly of G protein ?? dimers: comparison of in vitro and in vivo studies.
Academic Article Two forms of the bovine brain Go that stimulate the inositol trisphosphate-mediated Cl- currents in Xenopus oocytes. Distinct guanine nucleotide binding properties.
Academic Article ADP-ribosylation of membrane components by pertussis and cholera toxin.
Academic Article Pertussis toxin alters the growth characteristics of Swiss 3T3 cells.
Academic Article Purification of Ns and Ni, the coupling proteins of hormone-sensitive adenylyl cyclases without intervention of activating regulatory ligands.
Academic Article Characterization by two-dimensional peptide mapping of the gamma subunits of Ns and Ni, the regulatory proteins of adenylyl cyclase, and of transducin, the guanine nucleotide-binding protein of rod outer segments of the eye.
Academic Article Updated protocols and comments on the purification without use of activating ligands of the coupling proteins Ns and Ni of the hormone sensitive adenylyl cyclase.
Academic Article Mechanisms in the vectorial receptor-adenylate cyclase signal transduction.
Academic Article Stimulation and inhibition of adenylyl cyclases mediated by distinct regulatory proteins.
Academic Article Pertussis toxin substrate, the putative Ni component of adenylyl cyclases, is an alpha beta heterodimer regulated by guanine nucleotide and magnesium.
Academic Article Effects of guanine nucleotides and Mg on human erythrocyte Ni and Ns, the regulatory components of adenylyl cyclase.
Academic Article Inhibitory regulation of adenylyl cyclase in the absence of stimulatory regulation. Requirements and kinetics of guanine nucleotide-induced inhibition of the cyc- S49 adenylyl cyclase.
Academic Article Guanine nucleotide inhibition of cyc- S49 mouse lymphoma cell membrane adenylyl cyclase.
Academic Article Gi is involved in ethanol inhibition of L-type calcium channels in undifferentiated but not differentiated PC-12 cells.
Academic Article Factors determining specificity of signal transduction by G-protein-coupled receptors. Regulation of signal transfer from receptor to G-protein.
Academic Article Bovine brain GO isoforms have distinct gamma subunit compositions.
Academic Article Alterations in macrophage G proteins are associated with endotoxin tolerance.
Academic Article Characterization of a G-protein activator in the neuroblastoma-glioma cell hybrid NG108-15.
Academic Article Role of subunit diversity in signaling by heterotrimeric G proteins.
Academic Article A dominant negative Galphas mutant that prevents thyroid-stimulating hormone receptor activation of cAMP production and inositol 1,4,5-trisphosphate turnover: competition by different G proteins for activation by a common receptor.
Academic Article Complex haplotype structure of the human GNAS gene identifies a recombination hotspot centred on a single nucleotide polymorphism widely used in association studies.
Academic Article Hormone inhibition of adenylyl cyclase. Differences in the mechanisms for inhibition by hormones and G protein beta gamma.
Academic Article Sequence dependence and differential expression of Ggamma5 subunit isoforms of the heterotrimeric G proteins variably processed after prenylation in mammalian cells.
Academic Article Aquaporin 0-calmodulin interaction and the effect of aquaporin 0 phosphorylation.
Academic Article G protein subunit interactions. Studies with biotinylated G protein subunits.
Academic Article Identification of a gamma subunit associated with the adenylyl cyclase regulatory proteins Ns and Ni.
Academic Article Interaction of the stimulatory and inhibitory regulatory proteins of the adenylyl cyclase system with the catalytic component of cyc-S49 cell membranes.
Academic Article Glucagon-induced heterologous desensitization of the MDCK cell adenylyl cyclase. Increases in the apparent levels of the inhibitory regulator (Ni).
Academic Article Divalent cation regulation of adenylyl cyclase. An allosteric site on the catalytic component.
Academic Article Determination of the complete covalent structure of the gamma 2 subunit of bovine brain G proteins by mass spectrometry.
Academic Article Synthesis and use of biotinylated beta gamma complexes prepared from bovine brain G proteins.
Academic Article The effect of pertussis toxin on the growth of vascular smooth muscle cells stimulated by serum or platelet-derived growth factor.
Academic Article Analysis of G protein gamma subunit heterogeneity using mass spectrometry.
Academic Article Gbeta subunit interacts with a peptide encoding region 956-982 of adenylyl cyclase 2. Cross-linking of the peptide to free Gbetagamma but not the heterotrimer.
Academic Article A surface on the G protein beta-subunit involved in interactions with adenylyl cyclases.
Concept Receptors, Neurotransmitter
Concept Alprostadil
Concept Muscle, Smooth, Vascular
Concept Guanine Nucleotides
Concept Protein Binding
Concept Molecular Weight
Concept Calcium Channel Blockers
Concept Temperature
Concept Transducin
Concept Protein Prenylation
Concept Receptors, Adrenergic, alpha-1
Concept Mass Spectrometry
Concept Protein Processing, Post-Translational
Concept Adrenergic alpha-Agonists
Concept GTP-Binding Protein alpha Subunits, Gi-Go
Concept Brain
Concept Receptor, Muscarinic M2
Concept Mutant Chimeric Proteins
Concept Rats, Inbred Strains
Concept Cell Division
Concept Heterotrimeric GTP-Binding Proteins
Concept COS Cells
Concept Mutagenesis, Site-Directed
Concept HSP40 Heat-Shock Proteins
Concept Isoproterenol
Concept PC12 Cells
Concept Polymorphism, Single Nucleotide
Concept DNA, Complementary
Concept Sensitivity and Specificity
Concept Prostaglandins E
Concept Aorta, Thoracic
Concept Receptors, Cell Surface
Concept Calcium Channels
Concept Genes, Dominant
Concept GTP-Binding Proteins
Concept Genomics
Concept Oncogene Protein p21(ras)
Concept Transcription Initiation Site
Concept Dogs
Concept Receptor, Muscarinic M3
Concept Phylogeny
Concept Ubiquitin
Concept Erythrocytes
Concept Animals
Concept Binding, Competitive
Concept Blotting, Northern
Concept Adenylate Cyclase Toxin
Concept Poly(ADP-ribose) Polymerases
Concept Ligands
Concept GTP-Binding Protein gamma Subunits
Concept Guanylyl Imidodiphosphate
Concept DNA
Concept Platelet-Derived Growth Factor
Concept Nucleoside Diphosphate Sugars
Concept Succinimides
Concept Adenosine Triphosphate
Concept Protein Biosynthesis
Concept Amino Acid Sequence
Concept Antibodies
Concept Ovum
Concept Neoplasms, Experimental
Concept beta-Adrenergic Receptor Kinases
Concept Adenylyl Cyclases
Concept Nucleotidyltransferases
Concept Propranolol
Concept Cyclic AMP-Dependent Protein Kinases
Concept Blotting, Western
Concept Lymphoma
Concept Iodine Radioisotopes
Concept 3T3 Cells
Concept Lipopolysaccharides
Concept Guanosine Triphosphate
Concept Inositol Phosphates
Concept Endotoxins
Concept Indicators and Reagents
Concept Glioma
Concept Dose-Response Relationship, Drug
Concept GTP-Binding Protein alpha Subunits, Gs
Concept Xenopus
Concept Chromatography, Gel
Concept Spectrometry, Mass, Electrospray Ionization
Concept Mice
Concept Cell Differentiation
Concept Cell Line, Transformed
Concept Alanine
Concept Calmodulin
Concept Models, Biological
Concept Kinetics
Concept Transcription, Genetic
Concept Brain Chemistry
Concept Receptors, Purinergic P1
Concept Receptors, Muscarinic
Concept Molecular Structure
Concept Antihypertensive Agents
Concept Edetic Acid
Concept Phospholipase C beta
Concept Chromatography, High Pressure Liquid
Concept Conserved Sequence
Concept Aspartic Acid
Concept Exons
Concept Cerebral Cortex
Concept Genes, ras
Concept Thyrotropin
Concept Lysine
Concept Enzyme Activation
Concept Adenosine Diphosphate Ribose
Concept Isomerism
Concept Magnesium Chloride
Concept Esterification
Concept Manganese
Concept Epitopes
Concept Neuroblastoma
Concept Receptors, Thromboxane A2, Prostaglandin H2
Concept Guanosine 5'-O-(3-Thiotriphosphate)
Concept Signal Transduction
Concept Rod Cell Outer Segment
Concept Protein Structure, Secondary
Concept Hormones
Concept Humans
Concept Cattle
Concept Chaperonin Containing TCP-1
Concept Receptor, Adenosine A2A
Concept Chromatography, Ion Exchange
Concept Centrifugation, Density Gradient
Concept Membrane Glycoproteins
Concept Somatostatin
Concept Turkeys
Concept Biological Transport
Concept Rabbits
Concept Reticulocytes
Concept Protein Structure, Tertiary
Concept Electrophoresis, Polyacrylamide Gel
Concept Colforsin
Concept Valine
Concept GTP-Binding Protein beta Subunits
Concept Macrophages, Peritoneal
Concept Cholera Toxin
Concept Bufo marinus
Concept Receptors, Thyrotropin
Concept Expressed Sequence Tags
Concept Protein Multimerization
Concept GTP Phosphohydrolases
Concept Cell Cycle
Concept Chymotrypsin
Concept Magnesium
Concept Virulence Factors, Bordetella
Concept Quinoxalines
Concept Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
Concept Reverse Transcriptase Polymerase Chain Reaction
Concept Memory
Concept Nerve Growth Factors
Concept Spodoptera
Concept Cross-Linking Reagents
Concept Blood Physiological Phenomena
Concept Protein Structure, Quaternary
Concept Sodium Fluoride
Concept Fluorides
Concept Binding Sites
Concept Erythrocyte Membrane
Concept Cell Transformation, Neoplastic
Concept Chromogranins
Concept NAD
Concept Chloride Channels
Concept Spectrometry, Fluorescence
Concept Guinea Pigs
Concept Oogenesis
Concept Glucagon
Concept Rats
Concept Sequence Homology, Amino Acid
Concept Chelating Agents
Concept Peptide Mapping
Concept Biotin
Concept Proline
Concept Oocytes
Concept Substrate Specificity
Concept RNA 3' Polyadenylation Signals
Concept Models, Molecular
Concept Alternative Splicing
Concept Proteomics
Concept Chaperonins
Concept Aquaporins
Concept Diterpenes
Concept Chromatography
Concept Chromatography, Affinity
Concept Protein Conformation
Concept Serine
Concept Bordetella pertussis
Concept Promoter Regions, Genetic
Concept Inositol 1,4,5-Trisphosphate
Concept Metalloendopeptidases
Concept Cyclic AMP
Concept Base Sequence
Concept Asparagine
Concept Immunosorbent Techniques
Concept Receptors, Adrenergic, alpha-2
Concept Molecular Sequence Data
Concept Pertussis Toxin
Concept Immunoblotting
Concept Guanosine Diphosphate
Concept Phosphorylation
Academic Article The N54-as Mutant Has Decreased Affinity for ?? and Suggests a Mechanism for Coupling Heterotrimeric G Protein Nucleotide Exchange with Subunit Dissociation.
Concept In Vitro Techniques
Concept Adenylyl Cyclase Inhibitors
Concept Brimonidine Tartrate
Concept HEK293 Cells
Search Criteria
  • Inositol
  • 1
  • 4
  • 5
  • Trisphosphate
  • Receptors