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Kalivas, Peter
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overview The Kalivas lab studies neuroplasticity underlying the development of addiction to drugs of abuse, as well as the learning and memory deficits associated with impoverished rearing environments. Research is at the level of protein biochemistry, neural circuitry and behavioral modeling. The current focus for both addiction and isolation rearing is in adaptations in excitatory neurotransmission. In collaboration with electrophysiologists in the department (Drs Lavin, Seamans, Woodward) we are elucidating the fundamental role of extracellular glutamate homeostatis in regulating neurotransmission and neuroplasticity. This has led to preclinical and clinical evaluations of specific proteins as targets in treating addiction, including metabotropic glutamate receptors and the cystine-glutamate exchanger. Brain circuitry underlying addiction: Long-term cellular changes in the glutamate neurons projecting from the prefrontal cortex to the basal ganglia are critical mediators of addictive behaviors. This includes changes in glutamate homeostasis and G-protein signaling, and involves proteins such as Homer, xCT, AGS3 and mGluRs.
One or more keywords matched the following items that are connected to Kalivas, Peter
Item TypeName
Academic Article The NMDA antagonist, dizocilpine, enhances cocaine reinforcement without influencing mesoaccumbens dopamine transmission.
Academic Article MDMA elicits behavioral and neurochemical sensitization in rats.
Academic Article Neuroadaptations involved in amphetamine and cocaine addiction.
Academic Article Ibotenic acid lesions of the dorsal prefrontal cortex disrupt the expression of behavioral sensitization to cocaine.
Academic Article A role for sensitization in craving and relapse in cocaine addiction.
Academic Article Calcium-mediated second messengers modulate the expression of behavioral sensitization to cocaine.
Academic Article Neural systems for behavioral activation and reward.
Academic Article Correlation between behavioral sensitization to cocaine and G protein ADP-ribosylation in the ventral tegmental area.
Academic Article Glutamate transmission in the nucleus accumbens mediates relapse in cocaine addiction.
Academic Article The involvement of the mediodorsal nucleus of the thalamus and the midbrain extrapyramidal area in locomotion elicited from the ventral pallidum.
Academic Article Drug addiction: to the cortex.and beyond!
Academic Article Effect of acute and daily neurotensin and enkephalin treatments on extracellular dopamine in the nucleus accumbens.
Academic Article Interrupted expression of NAC-1 augments the behavioral responses to cocaine.
Academic Article Involvement of the pallidal-thalamocortical circuit in adaptive behavior.
Academic Article A role for nucleus accumbens glutamate transmission in the relapse to cocaine-seeking behavior.
Academic Article Effects of cocaine and footshock stress on extracellular dopamine levels in the ventral striatum.
Academic Article Brain circuitry and the reinstatement of cocaine-seeking behavior.
Academic Article Prefrontal glutamate release into the core of the nucleus accumbens mediates cocaine-induced reinstatement of drug-seeking behavior.
Academic Article AGS3: a G-Protein regulator of addiction-associated behaviors.
Academic Article Nucleus accumbens Homer proteins regulate behavioral sensitization to cocaine.
Academic Article Activator of G protein signaling 3: a gatekeeper of cocaine sensitization and drug seeking.
Academic Article Homer2 gene deletion in mice produces a phenotype similar to chronic cocaine treated rats.
Academic Article Regulation of locomotor activity by metabotropic glutamate receptors in the nucleus accumbens and ventral tegmental area.
Academic Article Activation of orbital and medial prefrontal cortex by methylphenidate in cocaine-addicted subjects but not in controls: relevance to addiction.
Academic Article Cocaine-induced reinstatement requires endogenous stimulation of mu-opioid receptors in the ventral pallidum.
Academic Article Behavioral and neurochemical phenotyping of Homer1 mutant mice: possible relevance to schizophrenia.
Academic Article The neural basis of addiction: a pathology of motivation and choice.
Academic Article Homer isoforms differentially regulate cocaine-induced neuroplasticity.
Academic Article Alterations in dopaminergic and glutamatergic transmission in the induction and expression of behavioral sensitization: a critical review of preclinical studies.
Academic Article Nrf2 gene deletion fails to alter psychostimulant-induced behavior or neurotoxicity.
Academic Article Development of an alcohol deprivation and escalation effect in C57BL/6J mice.
Academic Article Effects of d-amphetamine injected into the nucleus accumbens on ethanol reinforced behavior.
Academic Article Extended access to cocaine self-administration enhances drug-primed reinstatement but not behavioral sensitization.
Academic Article Is cocaine desire reduced by N-acetylcysteine?
Academic Article Neuroplasticity in the mesolimbic dopamine system and cocaine addiction.
Academic Article Locomotor behavior.
Academic Article Infralimbic prefrontal cortex is responsible for inhibiting cocaine seeking in extinguished rats.
Academic Article Addiction as a pathology in prefrontal cortical regulation of corticostriatal habit circuitry.
Academic Article Glutamate and reinstatement.
Academic Article The circuitry mediating cocaine-induced reinstatement of drug-seeking behavior.
Academic Article Neuroscience: Lack of inhibition leads to abuse.
Academic Article Role of the prefrontal cortex and nucleus accumbens in reinstating methamphetamine seeking.
Academic Article Interactions between neuropeptides and dopamine neurons in the ventromedial mesencephalon.
Academic Article The infralimbic cortex regulates the consolidation of extinction after cocaine self-administration.
Academic Article Sexual refractoriness and locomotion effects on brain monoamines in the male rat.
Academic Article Chronic N-acetylcysteine during abstinence or extinction after cocaine self-administration produces enduring reductions in drug seeking.
Academic Article AKAP signaling in reinstated cocaine seeking revealed by iTRAQ proteomic analysis.
Academic Article Regulation of the mesocorticolimbic dopamine system by glutamic acid receptor subtypes.
Academic Article Integrins modulate relapse to cocaine-seeking.
Academic Article Optogenetic inhibition of cocaine seeking in rats.
Academic Article Optogenetic evidence that pallidal projections, not nigral projections, from the nucleus accumbens core are necessary for reinstating cocaine seeking.
Academic Article Sensitization to repeated enkephalin administration into the ventral tegmental area of the rat. I. Behavioral characterization.
Academic Article Endogenous enkephalin modulation of dopamine neurons in ventral tegmental area.
Academic Article The effect of cholinergic stimulation in the nucleus accumbens on locomotor behavior.
Academic Article Dopamine microinjection into the nucleus accumbens: correlation between metabolism and behavior.
Academic Article Behavioral and neurochemical effect of daily injection with neurotensin into the ventral tegmental area.
Academic Article Thyrotropin-releasing hormone: neurogenesis of actions in the pentobarbital narcotized rat.
Academic Article Interactions of neurotensin with brain dopamine systems.
Academic Article Behavioral effects of hypothalamic hypophysiotropic hormones, neurotensin, substance P and other neuropeptides.
Academic Article Behavioral and neurochemical effects of neurotensin microinjection into the ventral tegmental area of the rat.
Academic Article Neuroanatomical dissociation of thyrotropin-releasing hormone induced shaking behavior and thermogenic mechanisms.
Academic Article Homer1 proteins and AMPA receptors modulate cocaine-induced behavioural plasticity.
Academic Article Histamine-induced arousal in the conscious and pentobarbital-pretreated rat.
Academic Article The relationship between MRNA levels and the locomotor response to novelty.
Academic Article Time course of tyrosine hydroxylase expression after behavioral sensitization to cocaine.
Academic Article Behavioral and neurochemical studies of opioid effects in the pedunculopontine nucleus and mediodorsal thalamus.
Academic Article Time course of extracellular dopamine and behavioral sensitization to cocaine. II. Dopamine perikarya.
Academic Article Time course of extracellular dopamine and behavioral sensitization to cocaine. I. Dopamine axon terminals.
Academic Article High and low behavioral response to novelty is associated with differences in neurotensin and substance P content.
Academic Article Repeated intra-ventral tegmental area administration of SKF-38393 induces behavioral and neurochemical sensitization to a subsequent cocaine challenge.
Academic Article Repeated cocaine modifies the mechanism by which amphetamine releases dopamine.
Academic Article Choose to study choice in addiction.
Academic Article Limbic and motor circuitry underlying footshock-induced reinstatement of cocaine-seeking behavior.
Academic Article Novel ideas about novelty. Commentary on Badiani and Robinson drug-induced neurobehavioral plasticity: the role of environmental context.
Academic Article Sensitization to psychostimulants and stress after injection of pertussis toxin into the A10 dopamine region.
Academic Article Unmanageable motivation in addiction: a pathology in prefrontal-accumbens glutamate transmission.
Academic Article Cystine/glutamate exchange regulates metabotropic glutamate receptor presynaptic inhibition of excitatory transmission and vulnerability to cocaine seeking.
Academic Article Contribution of dihydro-beta-erythroidine sensitive nicotinic acetylcholine receptors in the ventral tegmental area to cocaine-induced behavioral sensitization in rats.
Academic Article Distinct roles for different Homer1 isoforms in behaviors and associated prefrontal cortex function.
Academic Article Cocaine increases actin cycling: effects in the reinstatement model of drug seeking.
Academic Article The group II metabotropic glutamate receptor agonist, LY379268, inhibits both cocaine- and food-seeking behavior in rats.
Academic Article Long-term neuroadaptations produced by withdrawal from repeated cocaine treatment: role of dopaminergic receptors in modulating cortical excitability.
Academic Article Role of acetylcholine transmission in nucleus accumbens and ventral tegmental area in heroin-seeking induced by conditioned cues.
Academic Article Animal models and brain circuits in drug addiction.
Academic Article N-acetylcysteine reduces extinction responding and induces enduring reductions in cue- and heroin-induced drug-seeking.
Academic Article Requirement for the POZ/BTB protein NAC1 in acute but not chronic psychomotor stimulant response.
Academic Article Opposing roles for the ventral prefrontal cortex and the basolateral amygdala on the spontaneous recovery of cocaine-seeking in rats.
Academic Article Glutamate release in the nucleus accumbens core is necessary for heroin seeking.
Academic Article Neuropharmacology of addiction--setting the scene.
Academic Article Effects of training and withdrawal periods on heroin seeking induced by conditioned cue in an animal of model of relapse.
Academic Article N-Acetylcysteine reverses cocaine-induced metaplasticity.
Academic Article Extinction training after cocaine self-administration induces glutamatergic plasticity to inhibit cocaine seeking.
Academic Article Using glutamate homeostasis as a target for treating addictive disorders.
Academic Article Drug wanting: behavioral sensitization and relapse to drug-seeking behavior.
Academic Article New medications for drug addiction hiding in glutamatergic neuroplasticity.
Academic Article The effect of N-acetylcysteine in the nucleus accumbens on neurotransmission and relapse to cocaine.
Academic Article Neural circuit competition in cocaine-seeking: roles of the infralimbic cortex and nucleus accumbens shell.
Academic Article Role of mGluR5 neurotransmission in reinstated cocaine-seeking.
Academic Article Bipolar disorder and substance misuse: pathological and therapeutic implications of their comorbidity and cross-sensitisation.
Academic Article Enkephalin modulation of A10 dopamine neurons: a role in dopamine sensitization.
Academic Article Behavioral cross-sensitization between cocaine and enkephalin in the A10 dopamine region.
Academic Article Sensitization to repeated enkephalin administration into the ventral tegmental area of the rat. II. Involvement of the mesolimbic dopamine system.
Academic Article Substance P modulation of dopamine in the nucleus accumbens.
Academic Article Amphetamine produces sensitized increases in locomotion and extracellular dopamine preferentially in the nucleus accumbens shell of rats administered repeated cocaine.
Academic Article Dopamine depletion produces augmented behavioral responses to a mu-, but not a delta-opioid receptor agonist in the nucleus accumbens: lack of a role for receptor upregulation.
Academic Article The role of mesoaccumbens--pallidal circuitry in novelty-induced behavioral activation.
Academic Article Behavioral and neurochemical sensitization following cocaine self-administration.
Academic Article Individual differences in behavior following amphetamine, GBR-12909, or apomorphine but not SKF-38393 or quinpirole.
Academic Article Neural substrate of sensitization to psychostimulants.
Academic Article Robustness of G protein changes in cocaine sensitization shown with immunoblotting.
Academic Article Dopamine depletion augments endogenous opioid-induced locomotion in the nucleus accumbens using both mu 1 and delta opioid receptors.
Academic Article Sensitization to stress and psychostimulants. Involvement of dopamine transmission versus the HPA axis.
Academic Article Substance P in the ventral pallidum: projection from the ventral striatum, and electrophysiological and behavioral consequences of pallidal substance P.
Academic Article Repeated cocaine augments excitatory amino acid transmission in the nucleus accumbens only in rats having developed behavioral sensitization.
Academic Article The mediodorsal nucleus of the thalamus in rats--II. Behavioral and neurochemical effects of GABA agonists.
Concept Motor Activity
Concept Alcohol Drinking
Concept Computer Simulation
Concept Statistics as Topic
Concept Habits
Concept Smoking Cessation
Concept Exploratory Behavior
Concept Behavior, Animal
Concept Social Isolation
Concept Smoking
Concept Psychomotor Performance
Concept Stereotyped Behavior
Concept Feeding Behavior
Concept Consummatory Behavior
Concept Behavior, Addictive
Concept Image Processing, Computer-Assisted
Concept Choice Behavior
Concept Temperance
Concept Sexual Behavior, Animal
Concept Behavior
Concept Adaptation, Psychological
Academic Article Modafinil attenuates reinstatement of cocaine seeking: role for cystine-glutamate exchange and metabotropic glutamate receptors.
Academic Article Chronic administration of the methylxanthine propentofylline impairs reinstatement to cocaine by a GLT-1-dependent mechanism.
Academic Article Prelimbic cortex and ventral tegmental area modulate synaptic plasticity differentially in nucleus accumbens during cocaine-reinstated drug seeking.
Academic Article Synaptic glutamate spillover due to impaired glutamate uptake mediates heroin relapse.
Academic Article "Mourning" a lost opportunity.
Academic Article a2d-1 signaling in nucleus accumbens is necessary for cocaine-induced relapse.
Academic Article Astrocytic dysfunction and addiction: consequences of impaired glutamate homeostasis.
Academic Article Rapid, transient potentiation of dendritic spines in context-induced relapse to cocaine seeking.
Academic Article The Nucleus Accumbens: Mechanisms of Addiction across Drug Classes Reflect the Importance of Glutamate Homeostasis.
Academic Article The good and bad news about glutamate in drug addiction.
Academic Article Addiction-like Synaptic Impairments in Diet-Induced Obesity.
Academic Article Gq-DREADD Selectively Initiates Glial Glutamate Release and Inhibits Cue-induced Cocaine Seeking.
Academic Article Optogenetic inhibition of cortical afferents in the nucleus accumbens simultaneously prevents cue-induced transient synaptic potentiation and cocaine-seeking behavior.
Academic Article Glutamate transporter GLT-1 mediates N-acetylcysteine inhibition of cocaine reinstatement.
Academic Article Cocaine Use Reverses Striatal Plasticity Produced During Cocaine Seeking.
Academic Article The Direct and Indirect Pathways of the Nucleus Accumbens are not What You Think.
Academic Article Chemogenetic Activation of an Extinction Neural Circuit Reduces Cue-Induced Reinstatement of Cocaine Seeking.
Academic Article Loss of Plasticity in the D2-Accumbens Pallidal Pathway Promotes Cocaine Seeking.
Academic Article Accumbens Mechanisms for Cued Sucrose Seeking.
Academic Article HDAC5 and Its Target Gene, Npas4, Function in the Nucleus Accumbens to Regulate Cocaine-Conditioned Behaviors.
Academic Article Restoration of Kv7 Channel-Mediated Inhibition Reduces Cued-Reinstatement of Cocaine Seeking.
Academic Article Accumbens nNOS Interneurons Regulate Cocaine Relapse.
Academic Article Corticostriatal plasticity, neuronal ensembles, and regulation of drug-seeking behavior.
Academic Article A Model of ?9-Tetrahydrocannabinol Self-administration and Reinstatement That Alters Synaptic Plasticity in Nucleus Accumbens.
Academic Article Accumbens brain-derived neurotrophic factor (BDNF) transmission inhibits cocaine seeking.
Academic Article Drug Refraining and Seeking Potentiate Synapses on Distinct Populations of Accumbens Medium Spiny Neurons.
Academic Article Ventral Pallidum Is the Primary Target for Accumbens D1 Projections Driving Cocaine Seeking.
Academic Article Transient synaptic potentiation in nucleus accumbens shell during refraining from cocaine seeking.
Academic Article Extracellular Matrix Signaling Through ?3 Integrin Mediates Cocaine Cue-Induced Transient Synaptic Plasticity and Relapse.
Academic Article N-Acetylcysteine treatment during acute stress prevents stress-induced augmentation of addictive drug use and relapse.
Academic Article Post-translational S-glutathionylation of cofilin increases actin cycling during cocaine seeking.
Academic Article Dynamic CRMP2 Regulation of CaV2.2 in the Prefrontal Cortex Contributes to the Reinstatement of Cocaine Seeking.
Academic Article Heroin Cue-Evoked Astrocytic Structural Plasticity at Nucleus Accumbens Synapses Inhibits Heroin Seeking.
Academic Article The loss of NMDAR-dependent LTD following cannabinoid self-administration is restored by positive allosteric modulation of CB1 receptors.
Academic Article N-acetylcysteine mitigates acute opioid withdrawal behaviors and CNS oxidative stress in neonatal rats.
Academic Article Relapse-Associated Transient Synaptic Potentiation Requires Integrin-Mediated Activation of Focal Adhesion Kinase and Cofilin in D1-Expressing Neurons.
Academic Article Heroin Seeking and Extinction From Seeking Activate Matrix Metalloproteinases at Synapses on Distinct Subpopulations of Accumbens Cells.
Academic Article Astrocytes as cellular mediators of cue reactivity in addiction.
Academic Article Cocaine and sucrose rewards recruit different seeking ensembles in the nucleus accumbens core.
Academic Article Circuit selectivity in drug versus natural reward seeking behaviors.
Academic Article Non-Opioid Treatments for Opioid Use Disorder: Rationales and Data to Date.
Concept Drug-Seeking Behavior
Academic Article Behavioral and accumbens synaptic plasticity induced by cues associated with restraint stress.
Academic Article Drug versus non-drug behaviors: A dual-reward model of sex differences and neurobiological mechanisms in rats.
Academic Article Novelty-induced locomotor behavior predicts heroin addiction vulnerability in male, but not female, rats.
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