Search Result Details

This page shows the details of why an item matched the keywords from your search.
One or more keywords matched the following properties of Kalivas, Peter
PropertyValue
overview The Kalivas lab studies neuroplasticity underlying the development of addiction to drugs of abuse, as well as the learning and memory deficits associated with impoverished rearing environments. Research is at the level of protein biochemistry, neural circuitry and behavioral modeling. The current focus for both addiction and isolation rearing is in adaptations in excitatory neurotransmission. In collaboration with electrophysiologists in the department (Drs Lavin, Seamans, Woodward) we are elucidating the fundamental role of extracellular glutamate homeostatis in regulating neurotransmission and neuroplasticity. This has led to preclinical and clinical evaluations of specific proteins as targets in treating addiction, including metabotropic glutamate receptors and the cystine-glutamate exchanger. Brain circuitry underlying addiction: Long-term cellular changes in the glutamate neurons projecting from the prefrontal cortex to the basal ganglia are critical mediators of addictive behaviors. This includes changes in glutamate homeostasis and G-protein signaling, and involves proteins such as Homer, xCT, AGS3 and mGluRs.
One or more keywords matched the following items that are connected to Kalivas, Peter
Item TypeName
Academic Article A circuitry model of the expression of behavioral sensitization to amphetamine-like psychostimulants.
Academic Article MDMA elicits behavioral and neurochemical sensitization in rats.
Academic Article Neuroadaptations involved in amphetamine and cocaine addiction.
Academic Article A role for sensitization in craving and relapse in cocaine addiction.
Academic Article Regional distribution and cellular localization of gamma-aminobutyric acid subtype 1 receptor mRNA in the rat brain.
Academic Article Apomorphine decreases extracellular GABA in the ventral pallidum of rats with 6-OHDA lesions in the nucleus accumbens.
Academic Article Correlation between behavioral sensitization to cocaine and G protein ADP-ribosylation in the ventral tegmental area.
Academic Article Cellular mechanisms of behavioral sensitization to drugs of abuse.
Academic Article Context-specific enhancement of glutamate transmission by cocaine.
Academic Article Dopamine transmission in the initiation and expression of drug- and stress-induced sensitization of motor activity.
Academic Article The involvement of the mediodorsal nucleus of the thalamus and the midbrain extrapyramidal area in locomotion elicited from the ventral pallidum.
Academic Article Effect of microinjections of apamin into the A10 dopamine region of rats: a behavioral and neurochemical analysis.
Academic Article Repeated cocaine administration attenuates group I metabotropic glutamate receptor-mediated glutamate release and behavioral activation: a potential role for Homer.
Academic Article Repeated cocaine administration into the rat ventral tegmental area produces behavioral sensitization to a systemic cocaine challenge.
Academic Article Expression of glutamate receptor subunit/subtype messenger RNAS for NMDAR1, GLuR1, GLuR2 and mGLuR5 by accumbal projection neurons.
Academic Article The monoamine neurons of the rat brain preferentially express a splice variant of alpha1B subunit of the N-type calcium channel.
Academic Article Effects of cocaine and footshock stress on extracellular dopamine levels in the ventral striatum.
Academic Article Brain circuitry and the reinstatement of cocaine-seeking behavior.
Academic Article Dissociable roles for the dorsal and median raph? in the facilitatory effect of 5-HT1A receptor stimulation upon cocaine-induced locomotion and sensitization.
Academic Article Recent understanding in the mechanisms of addiction.
Academic Article NAC-1 is a brain POZ/BTB protein that can prevent cocaine-induced sensitization in the rat.
Academic Article Activation of orbital and medial prefrontal cortex by methylphenidate in cocaine-addicted subjects but not in controls: relevance to addiction.
Academic Article Behavioral and neurochemical phenotyping of Homer1 mutant mice: possible relevance to schizophrenia.
Academic Article The neural basis of addiction: a pathology of motivation and choice.
Academic Article Nrf2 gene deletion fails to alter psychostimulant-induced behavior or neurotoxicity.
Academic Article Effects of d-amphetamine injected into the nucleus accumbens on ethanol reinforced behavior.
Academic Article Neurobiology of cocaine addiction: implications for new pharmacotherapy.
Academic Article Changes in gamma-aminobutyric acid, mu-opioid and neurotensin receptors in the accumbens-pallidal projection after discrete quinolinic acid lesions in the nucleus accumbens.
Academic Article Neurotensin in the ventral pallidum increases extracellular gamma-aminobutyric acid and differentially affects cue- and cocaine-primed reinstatement.
Academic Article Neuroplasticity in the mesolimbic dopamine system and cocaine addiction.
Academic Article Automated quantification of dendritic spine density and spine head diameter in medium spiny neurons of the nucleus accumbens.
Academic Article Glutamate and reinstatement.
Academic Article Effects of 5-hydroxytryptophan on extracellular serotonin in the spinal cord of rats with experimental allergic encephalomyelitis.
Academic Article A single intra-PFC infusion of BDNF prevents cocaine-induced alterations in extracellular glutamate within the nucleus accumbens.
Academic Article Extended methamphetamine self-administration in rats results in a selective reduction of dopamine transporter levels in the prefrontal cortex and dorsal striatum not accompanied by marked monoaminergic depletion.
Academic Article Amphetamine lowers extracellular GABA concentration in the ventral pallidum.
Academic Article Matrix-assisted laser desorption/ionization tissue profiling of secretoneurin in the nucleus accumbens shell from cocaine-sensitized rats.
Academic Article Group II metabotropic glutamate receptors (mGlu2/3) in drug addiction.
Academic Article Sexual refractoriness and locomotion effects on brain monoamines in the male rat.
Academic Article High sensitivity HPLC assay for GABA in brain dialysis studies.
Academic Article Autoradiographic localization of mu-opioid and neurotensin receptors within the mesolimbic dopamine system.
Academic Article Regulation of the mesocorticolimbic dopamine system by glutamic acid receptor subtypes.
Academic Article Role of perisynaptic parameters in neurotransmitter homeostasis--computational study of a general synapse.
Academic Article Predisposition to addiction: pharmacokinetics, pharmacodynamics, and brain circuitry.
Academic Article A comparison of 5-hydroxytryptophan effects on rat lumbar spinal cord serotonin release and monosynaptic response amplitude.
Academic Article The acute histopathology of MPTP in the mouse CNS.
Academic Article Behavioral and neurochemical effects of acute and daily cocaine administration in rats.
Academic Article The effect of cholinergic stimulation in the nucleus accumbens on locomotor behavior.
Academic Article Effects of daily cocaine and morphine treatment on somatodendritic and terminal field dopamine release.
Academic Article Enkephalin release into the ventral tegmental area in response to stress: modulation of mesocorticolimbic dopamine.
Academic Article Behavioral and neurochemical effect of daily injection with neurotensin into the ventral tegmental area.
Academic Article Thyrotropin-releasing hormone: neurogenesis of actions in the pentobarbital narcotized rat.
Academic Article Interactions of neurotensin with brain dopamine systems.
Academic Article Behavioral effects of hypothalamic hypophysiotropic hormones, neurotensin, substance P and other neuropeptides.
Academic Article Influence of cholecystokinin on central monoaminergic pathways.
Academic Article Neurotensin neurons in the ventral tegmental area project to the medial nucleus accumbens.
Academic Article Neuroanatomical dissociation of thyrotropin-releasing hormone induced shaking behavior and thermogenic mechanisms.
Academic Article Effect of septohippocampal lesions on thyrotropin-releasing hormone antagonism of pentobarbital narcosis.
Academic Article Neuroanatomical sites of action of neurotensin.
Academic Article Antinociception after microinjection of neurotensin into the central amygdaloid nucleus of the rat.
Academic Article Neuroanatomy and neurochemical mechanisms of time-dependent sensitization.
Academic Article Selective activation of dopamine transmission in the shell of the nucleus accumbens by stress.
Academic Article Microinjection of the D2 agonist quinpirole into the A10 dopamine region blocks amphetamine-, but not cocaine-stimulated motor activity.
Academic Article The relationship between MRNA levels and the locomotor response to novelty.
Academic Article Chronic haloperidol does not alter G protein alpha-subunit levels in rats.
Academic Article High and low behavioral response to novelty is associated with differences in neurotensin and substance P content.
Academic Article Possible role for G-proteins in behavioral sensitization to cocaine.
Academic Article Dopamine regulation of extracellular glutamate in the nucleus accumbens.
Academic Article NAC-1, a rat brain mRNA, is increased in the nucleus accumbens three weeks after chronic cocaine self-administration.
Academic Article Sensitization to psychostimulants and stress after injection of pertussis toxin into the A10 dopamine region.
Academic Article Contribution of dihydro-beta-erythroidine sensitive nicotinic acetylcholine receptors in the ventral tegmental area to cocaine-induced behavioral sensitization in rats.
Academic Article Dopaminergic involvement in locomotion elicited from the ventral pallidum/substantia innominata.
Academic Article Homer proteins: implications for neuropsychiatric disorders.
Academic Article Specificity in the projection patterns of accumbal core and shell in the rat.
Academic Article Animal models and brain circuits in drug addiction.
Academic Article Modulation of A10 dopamine neurons by gamma-aminobutyric acid agonists.
Academic Article Requirement for the POZ/BTB protein NAC1 in acute but not chronic psychomotor stimulant response.
Academic Article Brain norepinephrine rediscovered in addiction research.
Academic Article Anti-ceramidase LCL385 acutely reduces BCL-2 expression in the hippocampus but is not associated with an increase of learned helplessness in rats.
Academic Article Neuronal pentraxins modulate cocaine-induced neuroadaptations.
Academic Article The role of cystine-glutamate exchange in nicotine dependence in rats and humans.
Academic Article Extinction circuits for fear and addiction overlap in prefrontal cortex.
Academic Article Substance K and substance P in the ventral tegmental area.
Academic Article Harnessing neuroplasticity for clinical applications.
Academic Article Brain region-specific gene expression changes after chronic intermittent ethanol exposure and early withdrawal in C57BL/6J mice.
Academic Article Use of vivo-morpholinos for control of protein expression in the adult rat brain.
Academic Article Bipolar disorder and substance misuse: pathological and therapeutic implications of their comorbidity and cross-sensitisation.
Academic Article A catecholaminergic projection from the ventral tegmental area to the diagonal band of Broca: modulation by neurotensin.
Academic Article Microinjection of neurotensin into the ventral tegmental area produces hypothermia: evaluation of dopaminergic mediation.
Academic Article Sensitization occurs to the locomotor effects of morphine and the specific mu opioid receptor agonist, DAGO, administered repeatedly to the ventral tegmental area but not to the nucleus accumbens.
Academic Article Enkephalin modulation of A10 dopamine neurons: a role in dopamine sensitization.
Academic Article Behavioral cross-sensitization between cocaine and enkephalin in the A10 dopamine region.
Academic Article Mesolimbic dopamine lesions produce an augmented behavioral response to enkephalin.
Academic Article Neurotensin in the ventromedial mesencephalon of the rat: anatomical and functional considerations.
Academic Article Possible involvement of serotonergic neurotransmission in neurotensin but not morphine analgesia.
Academic Article Neurotensin microinjection into the nucleus accumbens antagonizes dopamine-induced increase in locomotion and rearing.
Academic Article Bombesin-induced locomotor hyperactivity: evaluation of the involvement of the mesolimbic dopamine system.
Academic Article Neuroanatomical site specific modulation of spontaneous motor activity by neurotensin.
Academic Article Increase in spontaneous motor activity following infusion of neurotensin into the ventral tegmental area.
Academic Article Effect of inhibiting enkephalin catabolism in the VTA on motor activity and extracellular dopamine.
Academic Article Response to intracerebral administration of cerebrospinal fluid in the pentobarbital pretreated rat.
Academic Article Dopamine depletion produces augmented behavioral responses to a mu-, but not a delta-opioid receptor agonist in the nucleus accumbens: lack of a role for receptor upregulation.
Academic Article Cocaine alters glutamic acid decarboxylase differentially in the nucleus accumbens core and shell.
Academic Article Interactions between dopamine and excitatory amino acids in behavioral sensitization to psychostimulants.
Academic Article Behavioral and neurochemical sensitization following cocaine self-administration.
Academic Article A topographically organized gamma-aminobutyric acid projection from the ventral pallidum to the nucleus accumbens in the rat.
Academic Article Neurotransmitter regulation of dopamine neurons in the ventral tegmental area.
Academic Article Patterns of glucose use after bicuculline-induced convulsions in relationship to gamma-aminobutyric acid and mu-opioid receptors in the ventral pallidum--functional markers for the ventral pallidum.
Academic Article Robustness of G protein changes in cocaine sensitization shown with immunoblotting.
Academic Article Thyrotropin-releasing hormone: central site of action in antagonism of pentobarbital narcosis.
Academic Article Substance P in the ventral pallidum: projection from the ventral striatum, and electrophysiological and behavioral consequences of pallidal substance P.
Academic Article The mediodorsal nucleus of the thalamus in rats--I. forebrain gabaergic innervation.
Concept Hypoxia-Ischemia, Brain
Concept Brain
Concept Brain Diseases
Concept Brain Chemistry
Concept Brain Mapping
Concept Brain Stem
Concept Brain-Derived Neurotrophic Factor
Academic Article Getting to the core of addiction: hatching the addiction egg.
Academic Article The rostral subcommissural ventral pallidum is a mix of ventral pallidal neurons and neurons from adjacent areas: an electrophysiological study.
Academic Article The story of glutamate in drug addiction and of N-acetylcysteine as a potential pharmacotherapy.
Academic Article Synaptic plasticity mediating cocaine relapse requires matrix metalloproteinases.
Academic Article Astrocytic dysfunction and addiction: consequences of impaired glutamate homeostasis.
Academic Article Abstinence From Drug Dependence After Bilateral Globus Pallidus Hypoxic-Ischemic Injury.
Academic Article The tetrapartite synapse: Extracellular matrix remodeling contributes to corticoaccumbens plasticity underlying drug addiction.
Academic Article Optogenetic inhibition of cortical afferents in the nucleus accumbens simultaneously prevents cue-induced transient synaptic potentiation and cocaine-seeking behavior.
Academic Article Behaviorally relevant measures of glutamate transmission? Commentary on Di Chiara et al., 'Estimation of in-vivo neurotransmitter release by brain microdialysis: the issue of validity'
Academic Article Metaplasticity at the addicted tetrapartite synapse: A common denominator of drug induced adaptations and potential treatment target for addiction.
Academic Article Corticostriatal plasticity, neuronal ensembles, and regulation of drug-seeking behavior.
Academic Article Accumbens brain-derived neurotrophic factor (BDNF) transmission inhibits cocaine seeking.
Academic Article Circuit selectivity in drug versus natural reward seeking behaviors.
Academic Article Non-Opioid Treatments for Opioid Use Disorder: Rationales and Data to Date.
Academic Article Extrasynaptic therapeutic targets in substance use and stress disorders.
Academic Article N-acetylcysteine improves impulse control and attenuates relapse-like alcohol intake in long-term drinking rats.
Search Criteria
  • Brain