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One or more keywords matched the following properties of Kalivas, Peter
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overview The Kalivas lab studies neuroplasticity underlying the development of addiction to drugs of abuse, as well as the learning and memory deficits associated with impoverished rearing environments. Research is at the level of protein biochemistry, neural circuitry and behavioral modeling. The current focus for both addiction and isolation rearing is in adaptations in excitatory neurotransmission. In collaboration with electrophysiologists in the department (Drs Lavin, Seamans, Woodward) we are elucidating the fundamental role of extracellular glutamate homeostatis in regulating neurotransmission and neuroplasticity. This has led to preclinical and clinical evaluations of specific proteins as targets in treating addiction, including metabotropic glutamate receptors and the cystine-glutamate exchanger. Brain circuitry underlying addiction: Long-term cellular changes in the glutamate neurons projecting from the prefrontal cortex to the basal ganglia are critical mediators of addictive behaviors. This includes changes in glutamate homeostasis and G-protein signaling, and involves proteins such as Homer, xCT, AGS3 and mGluRs.
One or more keywords matched the following items that are connected to Kalivas, Peter
Item TypeName
Academic Article Neuroadaptations in cystine-glutamate exchange underlie cocaine relapse.
Academic Article Cystine/glutamate antiporter regulation of vesicular glutamate release.
Academic Article Regulation of extracellular glutamate in the prefrontal cortex: focus on the cystine glutamate exchanger and group I metabotropic glutamate receptors.
Academic Article Computational model of extracellular glutamate in the nucleus accumbens incorporates neuroadaptations by chronic cocaine.
Academic Article Bidirectional modulation of cystine/glutamate exchanger activity in cultured cortical astrocytes.
Academic Article Cystine/glutamate exchange regulates metabotropic glutamate receptor presynaptic inhibition of excitatory transmission and vulnerability to cocaine seeking.
Academic Article Cystine/glutamate exchange modulates glutathione supply for neuroprotection from oxidative stress and cell proliferation.
Academic Article The role of cystine-glutamate exchange in nicotine dependence in rats and humans.
Academic Article Ceftriaxone restores glutamate homeostasis and prevents relapse to cocaine seeking.
Academic Article The effect of N-acetylcysteine in the nucleus accumbens on neurotransmission and relapse to cocaine.
Academic Article The cystine/glutamate antiporter system x(c)(-) in health and disease: from molecular mechanisms to novel therapeutic opportunities.
Concept Cystine
Academic Article Modafinil attenuates reinstatement of cocaine seeking: role for cystine-glutamate exchange and metabotropic glutamate receptors.
Academic Article N-acetylcysteine improves impulse control and attenuates relapse-like alcohol intake in long-term drinking rats.
Search Criteria
  • Cystine