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One or more keywords matched the following properties of Larue, R. Amanda
keywords Stem cell
keywords Hematopoietic stem cell
keywords mesenchymal stem cell
overview Research efforts in my laboratory are focused on the physio-pathological potential of hematopoietic stem cells (HSCs). The adult bone marrow is thought to contain at least two discernible stem cell populations: HSCs, defined by their capability of hematopoietic reconstitution in vivo, and mesenchymal stromal cells (MSC), originally defined by their in vitro potential to differentiate into mesenchymal tissue cells including fibroblasts, fat, cartilage, and bone. Recent studies suggest that organs once thought to be incapable of regenerative ability may indeed be capable of regeneration and repair via stem cells. While the potential of stem cells is clear from studies in which unfractionated or unpurified populations of bone marrow are transplanted, due to technical challenges, controversies have resulted when attempts are made to assign specific potentials to HSCs or MSCs. This has led to the need for stringent, well-defined lineage tracing methods. To this end, my laboratory has developed a transplantation model in which the bone marrow of lethally irradiated recipient mice is reconstituted by a clonal population of cells derived from a single HSC that expresses enhanced green fluorescent protein. This transplantation model is technically complex and experimentally challenging, with only a few laboratories worldwide capable of executing such a transplantation scheme. Our work also employs novel transgenic models to discern HSC-derived cells in tissues. With an eye towards translational potential, we also employ xenograft models to investigate the role(s) of human HSCs. The development of these tools has allowed my laboratory, my mentees, and my collaborators to conduct paradigm-shifting studies of the roles of HSCs in health and disease. Together, these approaches have resulted in discovery of novel roles for HSC and HSC-derived cells in a variety of pathological conditions that directly impact human health, including cancer, cardiovascular disease, pulmonary fibrosis, and orthopedic injury and repair.
One or more keywords matched the following items that are connected to Larue, R. Amanda
Item TypeName
Academic Article Total body irradiation selectively induces murine hematopoietic stem cell senescence.
Academic Article An in vivo analysis of hematopoietic stem cell potential: hematopoietic origin of cardiac valve interstitial cells.
Academic Article Origin of fibroblast colony-forming units.
Academic Article Hematopoietic stem cell origin of human fibroblasts: cell culture studies of female recipients of gender-mismatched stem cell transplantation and patients with chronic myelogenous leukemia.
Academic Article Hematopoietic stem cell origin of mesenchymal cells: opportunity for novel therapeutic approaches.
Academic Article Amelioration of a mouse model of osteogenesis imperfecta with hematopoietic stem cell transplantation: microcomputed tomography studies.
Academic Article Hematopoietic stem cell derived carcinoma-associated fibroblasts: a novel origin.
Academic Article Hematopoietic stem cells are pluripotent and not just "hematopoietic".
Academic Article Hematopoietic origins of fibroblasts: I. In vivo studies of fibroblasts associated with solid tumors.
Academic Article Hematopoietic origins of fibroblasts: II. In vitro studies of fibroblasts, CFU-F, and fibrocytes.
Academic Article Hematopoietic origin of fibroblasts/myofibroblasts: Its pathophysiologic implications.
Academic Article Hematopoietic stem cell origin of adipocytes.
Academic Article MCP1 directs trafficking of hematopoietic stem cell-derived fibroblast precursors in solid tumor.
Academic Article Hematopoietic stem cell origin of connective tissues.
Academic Article Hematopoietic stem cells give rise to osteo-chondrogenic cells.
Concept Neoplastic Stem Cells
Concept Hematopoietic Stem Cell Transplantation
Concept Mesenchymal Stem Cell Transplantation
Concept Tumor Stem Cell Assay
Concept Hematopoietic Stem Cell Mobilization
Concept Stem Cells
Concept Colony-Forming Units Assay
Concept Hematopoietic Stem Cells
Concept Cord Blood Stem Cell Transplantation
Concept Stem Cell Transplantation
Concept Pluripotent Stem Cells
Academic Article MicroRNA-510 promotes cell and tumor growth by targeting peroxiredoxin1 in breast cancer.
Academic Article Differential Reponses of Hematopoietic Stem and Progenitor Cells to mTOR Inhibition.
Academic Article Catalase inhibits ionizing radiation-induced apoptosis in hematopoietic stem and progenitor cells.
Academic Article Hematopoietic stem cell-derived cancer-associated fibroblasts are novel contributors to the pro-tumorigenic microenvironment.
Academic Article Hematopoietic stem cell-derived adipocytes and fibroblasts in the tumor microenvironment.
Academic Article Hematopoietic Origin of Murine Lung Fibroblasts.
Academic Article Plasticity of hematopoietic stem cells.
Academic Article Bone Marrow Stem Cell Contribution to Pulmonary Homeostasis and Disease.
Academic Article Contributions of Mouse and Human Hematopoietic Cells to Remodeling of the Adult Auditory Nerve After Neuron Loss.
Academic Article Hematopoietic Stem Cells as a Novel Source of Dental Tissue Cells.
Academic Article Hematopoietic Stem Cell-derived Adipocytes Promote Tumor Growth and Cancer Cell Migration.
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  • Stem Cells