Search Result Details

This page shows the details of why an item matched the keywords from your search.
One or more keywords matched the following properties of Lee, Kyu-ho
overview The Lee laboratory focus on early heart development, particularly as it pertains to mechanisms causing congenital heart disease in humans. We currently study the genetic pathways leading to and emanating from the early cardiac transcription factor, Nkx2-5, which has long been associated with congenital anomalies. Alteration of Nkx2-5 expression levels has a profound effect on development of the Second Heart Field (SHF), a distinct set of heart precursors which gives rise to both outflow tract (OFT) and right ventricle at the aortic pole of the embryonic heart. Disruption of Nkx2-5 expression in mouse models results in a spectrum of defects from severe hypoplasia of OFT and right ventricle to milder OFT rotation or alignment defects such as double outlet right ventricle (DORV). Missense mutations of Nkx2-5 in human kindreds are similarly associated with OFT defects like DORV and Tetralogy of Fallot. This represents a significant clinical association: of the congenital heart anomalies that occur in nearly one percent of all human live births, nearly one-third involve the OFT and associated aorta and pulmonary artery. Our efforts are directed towards two main pathways to discovery: Identification of the direct downstream gene targets of the Nkx2-5 transcription factor in cells of the second heart field. Delineation of the transcriptional regulation of Nkx2-5 in second heart field. The Lee laboratory has also begun a pilot effort to understand the linkage between ectopic expression of Nkx2-5 in human placenta, and pre-eclampsia, or hypertension and proteinuria in pregnancy. Pre-eclampsia (PE) occurs in 2-7% of all pregnancies, and is a leading cause of maternal morbidity and premature birth. We have recently found unusually high levels of Nkx2.5 expression in placental trophoblast cells in a subset of women with early onset and severe pre-eclampsis (EOSPE) associated with high levels of an emerging marker of pre-eclampsia, the anti-angiogenic factor sFlt-1. We hypothesize that this linkage is due to the activation of expression of an Nkx2-5 target gene, khdrbs1/Sam68, which may influence production of sFlt-1 transcripts through regulation of alternative mRNA splicing of the parent VEGFR1 RNA. Interestingly, the statistical linkage between Nkx2-5 and sFlt-1 levels show racial differences, which may lead to novel insights into both distinct causes of PE between individuals, and the factors related to differential disease incidence and severity between racial groups. Lee lab PE research efforts are directed toward human and animal model efforts: Expanded human tissue expression profiling to further explore racial and etiologic associations between elevated Nkx2-5 and target gene expression and disease. Use of mouse models testing the effect of abnormal Nkx2-5 expression in the placenta on development and maternal morbidity during pregnancy.
Person ID 2528
One or more keywords matched the following items that are connected to Lee, Kyu-ho
Item TypeName
Academic Article Jarid2 is among a set of genes differentially regulated by Nkx2.5 during outflow tract morphogenesis.
Academic Article Evolutionary conservation of Nkx2.5 autoregulation in the second heart field.
Concept Protein-Tyrosine Kinases
Concept Disease Models, Animal
Concept DNA-Binding Proteins
Concept Transforming Growth Factor beta
Concept Receptors, Platelet-Derived Growth Factor
Concept Cell Lineage
Concept Costs and Cost Analysis
Concept Endocardium
Concept Gene Expression
Concept Oligonucleotide Probes
Concept DNA, Complementary
Concept Sensitivity and Specificity
Concept Receptors, Cell Surface
Concept Animals
Concept GATA6 Transcription Factor
Concept Genes
Concept Platelet-Derived Growth Factor
Concept Noonan Syndrome
Concept Trans-Activators
Concept Amino Acid Sequence
Concept Heart Valves
Concept Mice, Knockout
Concept Myocytes, Cardiac
Concept Enhancer Elements, Genetic
Concept YY1 Transcription Factor
Concept Heart Failure
Concept Olfactory Mucosa
Concept Biopsy
Concept Myocardium
Concept GATA4 Transcription Factor
Concept Protein Tyrosine Phosphatase, Non-Receptor Type 11
Concept Smad Proteins
Concept Mice
Concept Mesoderm
Concept DNA Primers
Concept Calmodulin
Concept Intercellular Signaling Peptides and Proteins
Concept Repressor Proteins
Concept Xenopus Proteins
Concept Mice, Inbred C57BL
Concept Bone Morphogenetic Proteins
Concept Endoderm
Concept Cells, Cultured
Concept Mice, Transgenic
Concept Zebrafish Proteins
Concept Decision Support Techniques
Concept Chickens
Concept Erythroid-Specific DNA-Binding Factors
Concept Drosophila
Concept RNA, Messenger
Concept Survival Rate
Concept Humans
Concept Heart
Concept Lentigo
Concept Homeodomain Proteins
Concept Smad1 Protein
Concept Mucus
Concept Cardiomegaly
Concept Epithelium
Concept Odorants
Concept Reverse Transcriptase Polymerase Chain Reaction
Concept Clinical Competence
Concept Models, Genetic
Concept South Carolina
Concept Binding Sites
Concept Case-Control Studies
Concept Mutagenesis
Concept Drosophila Proteins
Concept Endothelin-1
Concept Retinol-Binding Proteins
Concept Rats
Concept Sequence Homology, Amino Acid
Concept African Americans
Concept Sequence Homology, Nucleic Acid
Concept In Situ Hybridization
Concept GATA5 Transcription Factor
Concept Rana pipiens
Concept Breast Neoplasms
Concept Pre-Eclampsia
Concept Oligonucleotide Array Sequence Analysis
Concept Heart Ventricles
Concept Lymphatic Metastasis
Concept Polymerase Chain Reaction
Concept Protein Conformation
Concept Mutation, Missense
Concept MicroRNAs
Concept Bone Morphogenetic Protein 2
Concept Promoter Regions, Genetic
Concept Bone Morphogenetic Protein 4
Concept Myogenic Regulatory Factors
Concept Base Sequence
Concept Alleles
Concept Zebrafish
Concept Genes, Homeobox
Concept Endothelium
Concept Nerve Tissue Proteins
Concept Pharynx
Concept Cell Line, Tumor
Concept Molecular Sequence Data
Academic Article Placental Nkx2-5 and target gene expression in early-onset and severe preeclampsia.
Academic Article MicroRNA-1 negatively regulates expression of the hypertrophy-associated calmodulin and Mef2a genes.
Academic Article Development of heart valves requires Gata4 expression in endothelial-derived cells.
Academic Article SMAD-mediated modulation of YY1 activity regulates the BMP response and cardiac-specific expression of a GATA4/5/6-dependent chick Nkx2.5 enhancer.
Academic Article sucker encodes a zebrafish Endothelin-1 required for ventral pharyngeal arch development.
Academic Article Cloning and genetic mapping of zebrafish BMP-2.
Academic Article The molecular nature of zebrafish swirl: BMP2 function is essential during early dorsoventral patterning.
Academic Article A new tinman-related gene, nkx2.7, anticipates the expression of nkx2.5 and nkx2.3 in zebrafish heart and pharyngeal endoderm.
Academic Article Isolation and characterization of the alpha platelet-derived growth factor receptor from rat olfactory epithelium.
Academic Article Isolation of an olfactory cDNA: similarity to retinol-binding protein suggests a role in olfaction.
Academic Article Developmental SHP2 dysfunction underlies cardiac hypertrophy in Noonan syndrome with multiple lentigines.
Concept Polycomb Repressive Complex 2
Concept MEF2 Transcription Factors
Concept ErbB Receptors
Concept Homeobox Protein Nkx-2.5
Concept HEK293 Cells
Search Criteria
  • Homeobox
  • Protein
  • Nkx
  • 2
  • 5