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Lopez, Marcelo
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overview Dr. Lopez's research interests are the effect of stress and other environmental factors on alcohol intake and relapse, and the role of learning in the development of addictive behaviors. He is conducting studies to evaluate the effect of stress at different developmental stages on voluntary alcohol intake. Dr. Lopez conducts behavioral pharmacology studies utilizing numerous rodent models of alcohol exposure. This includes studying alcohol dependence and relapse drinking involving a mouse model of chronic intermittent ethanol (CIE) exposure that produces escalation of drinking. This model that has been used to characterize genetic, neurobiological, and behavioral (motivational) factors that influence alcohol self-administration including measures of relapse, tolerance, and behavioral flexibility.
One or more keywords matched the following items that are connected to Lopez, Marcelo
Item TypeName
Academic Article Age- and sex-related differences in alcohol and nicotine effects in C57BL/6J mice.
Academic Article Effects of housing density on weight gain, immune function, behavior, and plasma corticosterone concentrations in BALB/c and C57BL/6 mice.
Academic Article Repeated cycles of chronic intermittent ethanol exposure in mice increases voluntary ethanol drinking and ethanol concentrations in the nucleus accumbens.
Academic Article Intensity and duration of chronic ethanol exposure is critical for subsequent escalation of voluntary ethanol drinking in mice.
Academic Article Chronic social isolation and chronic variable stress during early development induce later elevated ethanol intake in adult C57BL/6J mice.
Academic Article Development of ethanol withdrawal-related sensitization and relapse drinking in mice selected for high- or low-ethanol preference.
Academic Article Repeated cycles of chronic intermittent ethanol exposure leads to the development of tolerance to aversive effects of ethanol in C57BL/6J mice.
Academic Article Increased ethanol drinking after repeated chronic ethanol exposure and withdrawal experience in C57BL/6 mice.
Academic Article Effect of pattern and number of chronic ethanol exposures on subsequent voluntary ethanol intake in C57BL/6J mice.
Academic Article Progress in using mouse inbred strains, consomics, and mutants to identify genes related to stress, anxiety, and alcohol phenotypes.
Academic Article The role of neuroactive steroids in ethanol/stress interactions: proceedings of symposium VII at the Volterra conference on alcohol and stress, May 2008.
Academic Article Similar ethanol drinking in adolescent and adult C57BL/6J mice after chronic ethanol exposure and withdrawal.
Concept Mice, Inbred BALB C
Concept Mice, Inbred C3H
Concept Mice
Concept Mice, Inbred C57BL
Concept Mice, Inbred Strains
Concept Mice, Inbred DBA
Concept Mice, Mutant Strains
Academic Article Operant ethanol self-administration in ethanol dependent mice.
Academic Article Chronic intermittent ethanol exposure and withdrawal alters (3a,5a)-3-hydroxy-pregnan-20-one immunostaining in cortical and limbic brain regions of C57BL/6J mice.
Academic Article Ibudilast reduces alcohol drinking in multiple animal models of alcohol dependence.
Academic Article Repeated episodes of chronic intermittent ethanol promote insensitivity to devaluation of the reinforcing effect of ethanol.
Academic Article KCNN Genes that Encode Small-Conductance Ca2+-Activated K+ Channels Influence Alcohol and Drug Addiction.
Academic Article Differential potassium channel gene regulation in BXD mice reveals novel targets for pharmacogenetic therapies to reduce heavy alcohol drinking.
Academic Article Forced swim stress increases ethanol consumption in C57BL/6J mice with a history of chronic intermittent ethanol exposure.
Academic Article The highly selective orexin/hypocretin 1 receptor antagonist GSK1059865 potently reduces ethanol drinking in ethanol dependent mice.
Academic Article Chronic Intermittent Ethanol Exposure Enhances the Excitability and Synaptic Plasticity of Lateral Orbitofrontal Cortex Neurons and Induces a Tolerance to the Acute Inhibitory Actions of Ethanol.
Academic Article Effect of different stressors on voluntary ethanol intake in ethanol-dependent and nondependent C57BL/6J mice.
Academic Article Time-Course Analysis of Brain Regional Expression Network Responses to Chronic Intermittent Ethanol and Withdrawal: Implications for Mechanisms Underlying Excessive Ethanol Consumption.
Academic Article Stress-Induced Enhancement of Ethanol Intake in C57BL/6J Mice with a History of Chronic Ethanol Exposure: Involvement of Kappa Opioid Receptors.
Academic Article Impact of social isolation and enriched environment during adolescence on voluntary ethanol intake and anxiety in C57BL/6J mice.
Academic Article Withdrawal from chronic intermittent alcohol exposure increases dendritic spine density in the lateral orbitofrontal cortex of mice.
Academic Article Chronic ethanol exposure produces time- and brain region-dependent changes in gene coexpression networks.
Academic Article Alcohol tolerance and nicotine cross-tolerance in adolescent mice.
Academic Article The glucagon-like peptide-1 receptor as a potential treatment target in alcohol use disorder: evidence from human genetic association studies and a mouse model of alcohol dependence.
Academic Article Supersensitive Kappa Opioid Receptors Promotes Ethanol Withdrawal-Related Behaviors and Reduce Dopamine Signaling in the Nucleus Accumbens.
Academic Article Dopamine synthesis in alcohol drinking-prone and -resistant mouse strains.
Academic Article Variable effects of chronic intermittent ethanol exposure on ethanol drinking in a genetically diverse mouse cohort.
Academic Article The allostatic impact of chronic ethanol on gene expression: A genetic analysis of chronic intermittent ethanol treatment in the BXD cohort.
Academic Article Initial genetic dissection of serum neuroactive steroids following chronic intermittent ethanol across BXD mouse strains.
Academic Article Ethanol Dependence Abolishes Monoamine and GIRK (Kir3) Channel Inhibition of Orbitofrontal Cortex Excitability.
Academic Article Genetic divergence in the transcriptional engram of chronic alcohol abuse: A laser-capture RNA-seq study of the mouse mesocorticolimbic system.
Academic Article Prosapip1-Dependent Synaptic Adaptations in the Nucleus Accumbens Drive Alcohol Intake, Seeking, and Reward.
Academic Article Long-term ethanol exposure: Temporal pattern of microRNA expression and associated mRNA gene networks in mouse brain.
Academic Article Effects of monoamines on the intrinsic excitability of lateral orbitofrontal cortex neurons in alcohol-dependent and non-dependent female mice.
Academic Article Increasing Brain-Derived Neurotrophic Factor (BDNF) in medial prefrontal cortex selectively reduces excessive drinking in ethanol dependent mice.
Academic Article Cross-species molecular dissection across alcohol behavioral domains.
Academic Article Sex-dependent differences in ethanol inhibition of mouse lateral orbitofrontal cortex neurons.
Academic Article Dynorphin-kappa opioid receptor activity in the central amygdala modulates binge-like alcohol drinking in mice.
Academic Article Brain Regional and Temporal Changes in BDNF mRNA and microRNA-206 Expression in Mice Exposed to Repeated Cycles of Chronic Intermittent Ethanol and Forced Swim Stress.
Academic Article Early Blood Profile of C57BL/6 Mice Exposed to Chronic Unpredictable Stress.
Academic Article Dynamic c-Fos changes in mouse brain during acute and protracted withdrawal from chronic intermittent ethanol exposure and relapse drinking.
Academic Article Cross-Species Co-analysis of Prefrontal Cortex Chronic Ethanol Transcriptome Responses in Mice and Monkeys.
Academic Article Kappa opioid receptors in the bed nucleus of the stria terminalis regulate binge-like alcohol consumption in male and female mice.
Academic Article The escalation in ethanol consumption following chronic intermittent ethanol exposure is blunted in mice expressing ethanol-resistant GluN1 or GluN2A NMDA receptor subunits.
Academic Article Interaction of chronic intermittent ethanol and repeated stress on structural and functional plasticity in the mouse medial prefrontal cortex.
Academic Article Evaluation of the effect of doxasozin and zonisamide on voluntary ethanol intake in mice that experienced chronic intermittent ethanol exposure and stress.
Academic Article Bioinformatics identification and pharmacological validation of Kcnn3/KCa2 channels as a mediator of negative affective behaviors and excessive alcohol drinking in mice.
Academic Article The histone methyltransferase G9a mediates stress-regulated alcohol drinking.
Academic Article Transcriptome Analysis of Alcohol Drinking in Non-Dependent and Dependent Mice Following Repeated Cycles of Forced Swim Stress Exposure.
Academic Article Brain regional gene expression network analysis identifies unique interactions between chronic ethanol exposure and consumption.
Academic Article Activation of hypothalamic oxytocin neurons reduces binge-like alcohol drinking through signaling at central oxytocin receptors.
Academic Article Dynorphin/Kappa Opioid Receptor Activity Within the Extended Amygdala Contributes to Stress-Enhanced Alcohol Drinking in Mice.
Academic Article Assessing negative affect in mice during abstinence from alcohol drinking: Limitations and future challenges.
Academic Article Alcohol Dependence Modifies Brain Networks Activated During Withdrawal and Reaccess: A c-Fos-Based Analysis in Mice.
Academic Article Alcohol Dependence and the Ventral Hippocampal Influence on Alcohol Drinking in Male Mice.
Academic Article Preclinical and clinical evidence for suppression of alcohol intake by apremilast.
Academic Article Chronic intermittent ethanol exposure differentially alters the excitability of neurons in the orbitofrontal cortex and basolateral amygdala that project to the dorsal striatum.
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