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overview Primary interests: Educational methods for training radiation oncology residents. Genitourinary and gastrointestinal cancers, prostate brachytherapy, pediatric tumors, melan oma and aggressive skin cancers, sarcomas, image-guided and stereotactic radiotherapy /radiosurgery for CNS and extracranial targets, including development of image-guided and tomotherapy approaches for GU and GI cancers. Worked successfully with industry leaders to achieve the first clinical application of QuickLink(TM) device to construct custom built linked seeds in the operating room for prosta te brachytherapy. Train physicians from other institutions on the use of custom built linked seeds with real-time dosimetry for prostate brachytherapy. Delivered first SIR-Spheres(TM) Y-90 treatment for liver metastases in the state of South Carolina. Delivered first Therapsheres(TM)Y-90 treatment for hepatocellular carcinoma in the state of South Carolina. Research Interests: Methods of training physicians/residents in image-based anatomy and radiotherapy planning techniques. Vitamin D and its influence on prostate cancer and colorectal cancer. Detection and implications of circulating tumor cells in prostate cancer. Significance of single nucleotide polymorphisms in radiation sensitivity and toxicity. Clinical research protocol development regarding the treatment of GU tumors, GI tumors, and pediatric malignancies. Integration of new technologies into patient treatment strategies including stereotactic body radiosurgery. Development of image-guided radiotherapy and intensity-modulated radiation therapy (IMRT) regimens including tomotherapy for the treatment of prostate cancer, cholangio-pancreatic tumors, and other malignancies of the genitourinary and gastrointestinal systems. Integration of small molecule therapeutic and nutritional agents with radiotherapy and chemoradiotherapy and their effects on radiosensitivity. DNA-radiation chemistry and molecular effects of hypoxia and other variables of the tumor microenvironment on radiotherapy. Involves detailed Monte Carlo computer simulations of radiation physics and chemistry of clinical photon beams used in radiotherapy.
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