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CD4+CD25- T cells transduced to express MHC class I-restricted epitope-specific TCR synthesize Th1 cytokines and exhibit MHC class I-restricted cytolytic effector function in a human melanoma model.
A coreceptor-independent transgenic human TCR mediates anti-tumor and anti-self immunity in mice.
Inhibition of superoxide generation upon T-cell receptor engagement rescues Mart-1(27-35)-reactive T cells from activation-induced cell death.
Receptors, Antigen, T-Cell
Interferon-gamma (IFN-?)-mediated retinal ganglion cell death in human tyrosinase T cell receptor transgenic mouse.
Promoting thiol expression increases the durability of antitumor T-cell functions.
Immune responses in a mouse model of vitiligo with spontaneous epidermal de- and repigmentation.
Interleukin-12 enhances the function and anti-tumor activity in murine and human CD8(+) T cells.
Lack of p53 Augments Antitumor Functions in Cytolytic T Cells.
Efficacy of Adoptive T-cell Therapy Is Improved by Treatment with the Antioxidant N-Acetyl Cysteine, Which Limits Activation-Induced T-cell Death.
Blocking TCR restimulation induced necroptosis in adoptively transferred T cells improves tumor control.
CAR T Cells in Solid Tumors: Blueprints for Building Effective Therapies.
Thioredoxin-1 improves the immunometabolic phenotype of antitumor T cells.
Receptors Antigen B Cell