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overview My laboratory is focused on the analysis of signaling and gene regulatory pathways, which play a role in cardiac failure. Recently, others and we have demonstrated that protein acetylation, regulated by histone acetyltransferases (HATs) and histone deacetylases (HDACs), plays a significant role in modulating gene expression in cardiac pathologies. Importantly, treatment with HDAC inhibitors preserves ventricular remodeling and cardiac function in models of cardiac hypertrophy, myocardial infarction (MI) and heart failure. We have demonstrated that the acetylation state of specific transcription factors affects their interaction with co-activators and co-repressors. Therefore, HDACs can facilitate gene activation via the direct deacetylation of transcription factors allowing for recruitment of co-activators to the promoter. We utilize both isolated adult cardiac myocytes as well as animal models of hypertrophy, MI and heart failure to determine the signals that regulate HDACs and HATs and how the resulting changes in protein acetylation modulate cardiomyocyte and ventricular function. Our goal is to translate our basic and pre-clinical discoveries into important new therapies for patients with heart disease.
Person ID 2650
phone 843-876-5045
One or more keywords matched the following items that are connected to Menick, Donald
Item TypeName
Academic Article Microtubule stabilization in pressure overload cardiac hypertrophy.
Academic Article Sequence of the feline cardiac sarcoplasmic reticulum Ca(2+)-ATPase.
Academic Article The role of GATA, CArG, E-box, and a novel element in the regulation of cardiac expression of the Na+-Ca2+ exchanger gene.
Academic Article Overexpression of class I, II or IVb beta-tubulin isotypes in CHO cells is insufficient to confer resistance to paclitaxel.
Academic Article Evidence for the rate of the final step in the bacteriorhodopsin photocycle being controlled by the proton release group: R134H mutant.
Academic Article Differential regulation of the cardiac sodium calcium exchanger promoter in adult and neonatal cardiomyocytes by Nkx2.5 and serum response factor.
Academic Article The proton release group of bacteriorhodopsin controls the rate of the final step of its photocycle at low pH.
Academic Article Cardiac hypertrophic and developmental regulation of the beta-tubulin multigene family.
Academic Article A beta-tubulin leucine cluster involved in microtubule assembly and paclitaxel resistance.
Academic Article Two groups control light-induced Schiff base deprotonation and the proton affinity of Asp85 in the Arg82 his mutant of bacteriorhodopsin.
Academic Article Pathways regulating Na+/Ca2+ exchanger expression in the heart.
Academic Article Role of sodium-calcium exchanger (Ncx1) in embryonic heart development: a transgenic rescue?
Academic Article Characterization of purified, reconstituted site-directed cysteine mutants of the lactose permease of Escherichia coli.
Academic Article Regulation of protein synthesis by eIF4E phosphorylation in adult cardiocytes: the consequence of secondary structure in the 5'-untranslated region of mRNA.
Academic Article Effect of denervation on the expression of two glucose transporter isoforms in rat hindlimb muscle.
Academic Article Regulation of Ncx1 expression. Identification of regulatory elements mediating cardiac-specific expression and up-regulation.
Academic Article Integrin activation and focal complex formation in cardiac hypertrophy.
Academic Article Regulation of Ncx1 gene expression in the normal and hypertrophic heart.
Academic Article Periostin is required for maturation and extracellular matrix stabilization of noncardiomyocyte lineages of the heart.
Academic Article Exploring the function of Tyr83 in bacteriorhodopsin: features of the Y83F and Y83N mutants.
Academic Article Generation of novel reporter stem cells and their application for molecular imaging of cardiac-differentiated stem cells in vivo.
Academic Article Site-specific microtubule-associated protein 4 dephosphorylation causes microtubule network densification in pressure overload cardiac hypertrophy.
Academic Article NCX1 phosphorylation dilemma: a little closer to resolution. Focus on "Full-length cardiac Na+/Ca2+ exchanger 1 protein is not phosphorylated by protein kinase A".
Academic Article Reduced collagen deposition in infarcted myocardium facilitates induced pluripotent stem cell engraftment and angiomyogenesis for improvement of left ventricular function.
Academic Article Cardiac expression of ms1/STARS, a novel gene involved in cardiac development and disease, is regulated by GATA4.
Academic Article Role of MAP kinases in the Na+/Ca2+ exchanger gene expression in feline adult cardiocytes.
Academic Article Phenotypic consequences of beta1-tubulin expression and MAP4 decoration of microtubules in adult cardiocytes.
Academic Article Site-directed mutagenesis of the lacY gene of Escherichia coli.
Academic Article Probing of the retinal binding site of bacteriorhodopsin by affinity labeling.
Academic Article Characterization of a P-type Ca(2+)-ATPase from Flavobacterium odoratum.
Academic Article Phosphorylation and reaction intermediates of the prokaryotic Ca(2+)-ATPase.
Academic Article Effect of the arginine-82 to alanine mutation in bacteriorhodopsin on dark adaptation, proton release, and the photochemical cycle.
Academic Article Purification and characterization of the Ca2+-ATPase of Flavobacterium odoratum.
Academic Article Initial characterization of the feline sodium-calcium exchanger gene.
Academic Article Arginine-82 regulates the pKa of the group responsible for the light-driven proton release in bacteriorhodopsin.
Academic Article Association of tyrosine-phosphorylated c-Src with the cytoskeleton of hypertrophying myocardium.
Academic Article Cloning of cardiac, kidney, and brain promoters of the feline ncx1 gene.
Academic Article The role of p38 in the regulation of Na+-Ca2+ exchanger expression in adult cardiomyocytes.
Academic Article Mutations at leucine 215 of beta-tubulin affect paclitaxel sensitivity by two distinct mechanisms.
Academic Article Microtubule-dependent distribution of mRNA in adult cardiocytes.
Academic Article A direct test of the hypothesis that increased microtubule network density contributes to contractile dysfunction of the hypertrophied heart.
Academic Article Histone deacetylases facilitate sodium/calcium exchanger up-regulation in adult cardiomyocytes.
Academic Article Chronic administration of KB-R7943 induces up-regulation of cardiac NCX1.
Academic Article beta-Adrenergic receptor stimulated Ncx1 upregulation is mediated via a CaMKII/AP-1 signaling pathway in adult cardiomyocytes.
Academic Article Reduced versican cleavage due to Adamts9 haploinsufficiency is associated with cardiac and aortic anomalies.
Academic Article Inhibition of histone deacetylase protects the retina from ischemic injury.
Academic Article Basis for MAP4 dephosphorylation-related microtubule network densification in pressure overload cardiac hypertrophy.
Academic Article The learning curve for sentinel node biopsy in breast cancer: practical considerations.
Academic Article Purified lac permease and cytochrome o oxidase are functional as monomers.
Academic Article lac permease of Escherichia coli: arginine-302 as a component of the postulated proton relay.
Academic Article cys154 Is important for lac permease activity in Escherichia coli.
Academic Article Site-specific mutagenesis of cysteine 148 to serine in the lac permease of Escherichia coli.
Academic Article Role of cysteine residues in the lac permease of Escherichia coli.
Academic Article Site-directed mutagenesis of cysteine-148 in the lac permease of Escherichia coli: effect on transport, binding, and sulfhydryl inactivation.
Academic Article The two pKa's of aspartate-85 and control of thermal isomerization and proton release in the arginine-82 to lysine mutant of bacteriorhodopsin.
Academic Article Effect of immobilization on glucose transporter expression in rat hindlimb muscles.
Academic Article Rapid expression of the Na(+)-Ca2+ exchanger in response to cardiac pressure overload.
Academic Article Cloning and expression of the unique Ca2+-ATPase from Flavobacterium odoratum.
Academic Article The exchanger and cardiac hypertrophy.
Academic Article Glutamate-194 to cysteine mutation inhibits fast light-induced proton release in bacteriorhodopsin.
Concept Molecular Imaging
Concept Protein-Tyrosine Kinases
Concept Cytokines
Concept Protein Binding
Concept Extracellular Matrix
Concept Age Factors
Concept Disease Models, Animal
Concept Calcium Channel Blockers
Concept Proteolipids
Concept Cations
Concept Sodium-Hydrogen Exchangers
Concept DNA-Binding Proteins
Concept Extracellular Space
Concept Platinum
Concept Transforming Growth Factor beta
Concept Microscopy, Electron
Concept Zymomonas
Concept Silicon
Concept Blood Pressure
Concept Protein Processing, Post-Translational
Concept ADAM Proteins
Concept Adrenergic alpha-Agonists
Concept Animals, Newborn
Concept Anions
Concept Muscle Proteins
Concept Tissue Scaffolds
Concept Multigene Family
Concept Mitochondria
Concept Phosphorus Radioisotopes
Concept Carbon
Concept Costs and Cost Analysis
Concept Endocardium
Concept Biomimetics
Concept Mitogen-Activated Protein Kinases
Concept Spectrophotometry, Atomic
Concept Embryo, Mammalian
Concept Rats, Inbred Strains
Concept Blood Vessels
Concept p38 Mitogen-Activated Protein Kinases
Concept Membrane Transport Modulators
Concept Luciferases, Firefly
Concept Actins
Concept Gene Expression
Concept Matrix Metalloproteinase 1
Concept Membrane Potentials
Concept Mutagenesis, Site-Directed
Concept Cats
Concept Forkhead Transcription Factors
Concept Histone Deacetylase 1
Concept Pyrazoles
Concept DNA, Complementary
Concept Fluorescent Antibody Technique
Concept Sodium-Calcium Exchanger
Concept Electric Conductivity
Concept Cadherins
Concept Ribonucleoproteins
Concept Sensitivity and Specificity
Concept Endothelium, Vascular
Concept Cell Adhesion Molecules
Concept Macrophages
Concept Eukaryotic Initiation Factor-4E
Concept Heterogeneous-Nuclear Ribonucleoprotein Group A-B
Concept Cricetinae
Concept Fibronectins
Concept Tetracycline
Concept Arginine
Concept Protein Kinase Inhibitors
Concept Nitrophenylgalactosides
Concept E1A-Associated p300 Protein
Concept Amino Acid Substitution
Concept Protein Phosphatase 2
Concept Myosin Heavy Chains
Concept Animals
Concept Mitogen-Activated Protein Kinase 1
Concept Versicans
Concept Oncogene Proteins
Concept Carrier Proteins
Concept Genes
Concept Adrenergic beta-Antagonists
Concept Cell Cycle Proteins
Concept Trans-Activators
Concept Adenosine Triphosphate
Concept Protein Biosynthesis
Concept Amino Acid Sequence
Concept Deoxyribonuclease EcoRI
Concept Mice, Knockout
Concept Hydroxamic Acids
Concept Halobacterium salinarum
Concept Lac Operon
Concept Natriuretic Peptide, Brain
Concept Myocytes, Cardiac
Concept Calcium
Concept Adenylyl Cyclases
Concept Coronary Vessels
Concept Recombinant Proteins
Concept Pulmonary Artery
Concept Cyclic AMP-Dependent Protein Kinases
Concept Ethylmaleimide
Concept Color
Concept CHO Cells
Concept Blotting, Western
Concept Neuroprotective Agents
Concept Bacteriorhodopsins
Concept YY1 Transcription Factor
Concept Heart Failure
Concept Myocardial Infarction
Concept Heart Defects, Congenital
Concept Rats, Inbred BN
Concept Luminescent Measurements
Concept Microtubules
Concept Tumor Cells, Cultured
Concept Biopsy
Concept Myocardium
Concept Dithiothreitol
Concept Antineoplastic Agents, Phytogenic
Concept Mutant Proteins
Concept GATA4 Transcription Factor
Concept Mitosis
Concept Shc Signaling Adaptor Proteins
Concept Electron Transport Complex IV
Concept Purple Membrane
Concept Caspase 3
Concept Energy Metabolism
Concept Protein Denaturation
Concept Phenylephrine
Concept Dark Adaptation
Concept Mice
Concept Retinaldehyde
Concept Cardiovascular Agents
Concept Mesoderm
Concept Sodium
Concept DNA Primers
Concept Valproic Acid
Concept Cysteine
Concept Diastole
Concept Models, Biological
Concept Leukocyte Common Antigens
Concept Drug Evaluation, Preclinical
Concept Mitogen-Activated Protein Kinase 3
Concept Hypertrophy, Left Ventricular
Concept Transcription, Genetic
Concept Echocardiography
Concept Microscopy, Confocal
Concept Naphthoquinones
Concept Photochemistry
Concept Histone Deacetylases
Concept Adaptation, Physiological
Concept Leukocytes
Concept Tumor Necrosis Factor-alpha
Concept Repressor Proteins
Concept Xenopus Proteins
Concept Mitral Valve Prolapse
Concept Matrix Metalloproteinase 9
Concept Aspartic Acid
Concept Hypertrophy, Right Ventricular
Concept B7-2 Antigen
Concept Tissue Engineering
Concept Exons
Concept Receptors, Adrenergic, beta
Concept Matrix Metalloproteinase 2
Concept Sarcoplasmic Reticulum
Concept Embryonic and Fetal Development
Concept Mice, Inbred C57BL
Concept Cell Fractionation
Concept Regulatory Sequences, Nucleic Acid
Concept Lysine
Concept Cells, Cultured
Concept Protons
Concept Tyrosine
Concept Mice, Transgenic
Concept CCN Intercellular Signaling Proteins
Concept Isomerism
Concept Light
Concept Mitochondria, Heart
Concept Phosphates
Concept Proteins
Concept Zebrafish Proteins
Concept Oxygen
Concept Organ Culture Techniques
Concept Decision Support Techniques
Concept Cytoplasm
Concept Microtubule-Associated Proteins
Concept Cicatrix
Concept Monocytes
Concept Ventricular Dysfunction, Left
Concept Nucleic Acid Conformation
Concept RNA, Messenger
Concept Cell Proliferation
Concept Survival Rate
Concept MAP Kinase Signaling System
Concept Humans
Concept Heart
Concept Mathematical Computing
Concept Transgenes
Concept Cell Movement
Concept Laminin
Concept Homeodomain Proteins
Concept DNA, Bacterial
Concept Muscle Development
Concept Escherichia coli
Concept Membrane Transport Proteins
Concept Cytoskeletal Proteins
Concept Protein Structure, Tertiary
Concept Adaptor Proteins, Signal Transducing
Concept Glucose Transporter Type 4
Concept Cardiomegaly
Concept Nanowires
Concept Genes, Bacterial
Concept 5' Untranslated Regions
Concept Monosaccharide Transport Proteins
Concept Microscopy, Fluorescence
Concept Genes, Reporter
Concept Cyclic AMP Response Element-Binding Protein
Concept Inflammation
Concept CD11b Antigen
Concept Tantalum
Concept Chromosomes, Human, Pair 11
Concept Transcription Factor AP-1
Concept Myocardial Reperfusion Injury
Concept Aorta
Concept Liposomes
Concept Cell Membrane
Concept Coculture Techniques
Concept Escherichia coli Proteins
Concept Alkaline Phosphatase
Concept Histone Deacetylase Inhibitors
Concept Recombinant Fusion Proteins
Concept Cell Culture Techniques
Concept Vanadates
Concept Clinical Competence
Concept Proto-Oncogene Proteins pp60(c-src)
Concept Cross-Linking Reagents
Concept Protein Stability
Concept Cytoskeleton
Concept Tubulin
Concept Electroretinography
Concept Anti-Arrhythmia Agents
Concept Luciferases
Concept Matrix Metalloproteinase 3
Concept Acetylation
Concept Binding Sites
Concept Calcium Channels, L-Type
Concept Spheroids, Cellular
Concept Denervation
Concept Proto-Oncogene Proteins c-jun
Concept Adenoviridae
Concept Ischemic Preconditioning
Concept Induced Pluripotent Stem Cells
Concept Models, Cardiovascular
Concept Microfilament Proteins
Concept Flavobacterium
Concept Darkness
Concept JNK Mitogen-Activated Protein Kinases
Concept Rats
Concept Calcium-Transporting ATPases
Concept Sequence Homology, Amino Acid
Concept Collagen
Concept Succinate Dehydrogenase
Concept Reperfusion Injury
Concept Autoradiography
Concept Mitral Valve
Concept Muscle Denervation
Concept Focal Adhesion Protein-Tyrosine Kinases
Concept Serum Response Factor
Concept Sequence Homology, Nucleic Acid
Concept Models, Chemical
Concept Models, Molecular
Concept Benzamides
Concept Integrins
Concept Embryonic Stem Cells
Concept Symporters
Concept Fibrosis
Concept Calcium-Calmodulin-Dependent Protein Kinase Type 2
Concept Enzyme Inhibitors
Concept Rats, Wistar
Concept Cell Line
Concept Electrochemistry
Concept DNA Restriction Enzymes
Concept Breast Neoplasms
Concept Heart Ventricles
Concept Point Mutation
Concept Lymphatic Metastasis
Concept Body Patterning
Concept Rats, Sprague-Dawley
Concept beta-Galactosidase
Concept Polymerase Chain Reaction
Concept Adaptor Proteins, Vesicular Transport
Concept Paclitaxel
Concept Protein Isoforms
Concept Heart Valve Diseases
Concept Protein Conformation
Concept Histone Deacetylase 2
Concept Myocardial Contraction
Concept Deuterium Oxide
Concept Gene Deletion
Concept MicroRNAs
Concept Promoter Regions, Genetic
Concept Proton Pumps
Concept Proto-Oncogene Proteins
Concept Fluorescent Antibody Technique, Indirect
Concept Freeze Fracturing
Concept Hydrogen Bonding
Concept Cyclic AMP
Concept Base Sequence
Concept Zebrafish
Concept Muscle, Skeletal
Concept Embryonic Development
Concept Heart Diseases
Concept Immunohistochemistry
Concept Molecular Sequence Data
Concept Hypoxia-Inducible Factor 1, alpha Subunit
Concept Halobacterium
Concept Immunoblotting
Concept RNA-Binding Proteins
Concept Cell Count
Academic Article Selective inhibition of class I but not class IIb histone deacetylases exerts cardiac protection from ischemia reperfusion.
Academic Article Acetylation: a lysine modification with neuroprotective effects in ischemic retinal degeneration.
Academic Article Mutations in DCHS1 cause mitral valve prolapse.
Academic Article Evidence for a non-canonical role of HDAC5 in regulation of the cardiac Ncx1 and Bnp genes.
Academic Article HDACs Regulate miR-133a Expression in Pressure Overload-Induced Cardiac Fibrosis.
Academic Article Histone Deacetylases Exert Class-Specific Roles in Conditioning the Brain and Heart Against Acute Ischemic Injury.
Academic Article Induction and Assessment of Ischemia-reperfusion Injury in Langendorff-perfused Rat Hearts.
Academic Article Nanowires and Electrical Stimulation Synergistically Improve Functions of hiPSC Cardiac Spheroids.
Academic Article A class of their own: exploring the nondeacetylase roles of class IIa HDACs in cardiovascular disease.
Academic Article Silicon nanowire-induced maturation of cardiomyocytes derived from human induced pluripotent stem cells.
Academic Article Inhibition of class I histone deacetylase activity represses matrix metalloproteinase-2 and -9 expression and preserves LV function postmyocardial infarction.
Academic Article Cell number per spheroid and electrical conductivity of nanowires influence the function of silicon nanowired human cardiac spheroids.
Academic Article HDAC1 localizes to the mitochondria of cardiac myocytes and contributes to early cardiac reperfusion injury.
Academic Article Angiokine Wisp-1 is increased in myocardial infarction and regulates cardiac endothelial signaling.
Academic Article Inspiration from heart development: Biomimetic development of functional human cardiac organoids.
Academic Article HDAC inhibition helps post-MI healing by modulating macrophage polarization.
Academic Article Targeting HIF-a for robust prevascularization of human cardiac organoids.
Academic Article Regulation of metabolism by mitochondrial enzyme acetylation in cardiac ischemia-reperfusion injury.
Academic Article Human cardiac organoids for the modelling of myocardial infarction and drug cardiotoxicity.
Academic Article Focusing Heart Failure Research on Myocardial Fibrosis to Prioritize Translation.
Concept Transcriptome
Concept Cadherin Related Proteins
Concept Primary Cell Culture
Concept Human Umbilical Vein Endothelial Cells
Concept Cardiotoxicity
Concept ADAMTS9 Protein
Concept Isolated Heart Preparation
Concept Histone Deacetylase 6
Concept Forkhead Box Protein O3
Concept Homeobox Protein Nkx-2.5
Academic Article Multicellular Human Cardiac Organoids Transcriptomically Model Distinct Tissue-Level Features of Adult Myocardium.
Academic Article Human Cardiac Organoids to Model COVID-19 Cytokine Storm Induced Cardiac Injuries.
Academic Article Human cardiac organoids to model COVID-19 cytokine storm induced cardiac injuries.
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