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overview My laboratory is focused on the analysis of signaling and gene regulatory pathways, which play a role in cardiac failure. Recently, others and we have demonstrated that protein acetylation, regulated by histone acetyltransferases (HATs) and histone deacetylases (HDACs), plays a significant role in modulating gene expression in cardiac pathologies. Importantly, treatment with HDAC inhibitors preserves ventricular remodeling and cardiac function in models of cardiac hypertrophy, myocardial infarction (MI) and heart failure. We have demonstrated that the acetylation state of specific transcription factors affects their interaction with co-activators and co-repressors. Therefore, HDACs can facilitate gene activation via the direct deacetylation of transcription factors allowing for recruitment of co-activators to the promoter. We utilize both isolated adult cardiac myocytes as well as animal models of hypertrophy, MI and heart failure to determine the signals that regulate HDACs and HATs and how the resulting changes in protein acetylation modulate cardiomyocyte and ventricular function. Our goal is to translate our basic and pre-clinical discoveries into important new therapies for patients with heart disease.
One or more keywords matched the following items that are connected to Menick, Donald
Item TypeName
Academic Article Differential regulation of the cardiac sodium calcium exchanger promoter in adult and neonatal cardiomyocytes by Nkx2.5 and serum response factor.
Academic Article Pathways regulating Na+/Ca2+ exchanger expression in the heart.
Academic Article Regulation of protein synthesis by eIF4E phosphorylation in adult cardiocytes: the consequence of secondary structure in the 5'-untranslated region of mRNA.
Academic Article Regulation of Ncx1 expression. Identification of regulatory elements mediating cardiac-specific expression and up-regulation.
Academic Article Periostin is required for maturation and extracellular matrix stabilization of noncardiomyocyte lineages of the heart.
Academic Article Generation of novel reporter stem cells and their application for molecular imaging of cardiac-differentiated stem cells in vivo.
Academic Article Site-specific microtubule-associated protein 4 dephosphorylation causes microtubule network densification in pressure overload cardiac hypertrophy.
Academic Article Role of MAP kinases in the Na+/Ca2+ exchanger gene expression in feline adult cardiocytes.
Academic Article Phenotypic consequences of beta1-tubulin expression and MAP4 decoration of microtubules in adult cardiocytes.
Academic Article The role of p38 in the regulation of Na+-Ca2+ exchanger expression in adult cardiomyocytes.
Academic Article Microtubule-dependent distribution of mRNA in adult cardiocytes.
Academic Article A direct test of the hypothesis that increased microtubule network density contributes to contractile dysfunction of the hypertrophied heart.
Academic Article Histone deacetylases facilitate sodium/calcium exchanger up-regulation in adult cardiomyocytes.
Academic Article Chronic administration of KB-R7943 induces up-regulation of cardiac NCX1.
Academic Article beta-Adrenergic receptor stimulated Ncx1 upregulation is mediated via a CaMKII/AP-1 signaling pathway in adult cardiomyocytes.
Academic Article Reduced versican cleavage due to Adamts9 haploinsufficiency is associated with cardiac and aortic anomalies.
Concept Myocytes, Cardiac
Concept Muscle Cells
Academic Article Nanowires and Electrical Stimulation Synergistically Improve Functions of hiPSC Cardiac Spheroids.
Academic Article Silicon nanowire-induced maturation of cardiomyocytes derived from human induced pluripotent stem cells.
Academic Article Cell number per spheroid and electrical conductivity of nanowires influence the function of silicon nanowired human cardiac spheroids.
Academic Article HDAC1 localizes to the mitochondria of cardiac myocytes and contributes to early cardiac reperfusion injury.
Academic Article Angiokine Wisp-1 is increased in myocardial infarction and regulates cardiac endothelial signaling.
Academic Article Inspiration from heart development: Biomimetic development of functional human cardiac organoids.
Academic Article Targeting HIF-a for robust prevascularization of human cardiac organoids.
Academic Article Regulation of metabolism by mitochondrial enzyme acetylation in cardiac ischemia-reperfusion injury.
Academic Article Multicellular Human Cardiac Organoids Transcriptomically Model Distinct Tissue-Level Features of Adult Myocardium.
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