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JNK3 signaling pathway activates ceramide synthase leading to mitochondrial dysfunction.
Isc1 regulates sphingolipid metabolism in yeast mitochondria.
Mitochondrially targeted ceramides preferentially promote autophagy, retard cell growth, and induce apoptosis.
Novel pathway of ceramide production in mitochondria: thioesterase and neutral ceramidase produce ceramide from sphingosine and acyl-CoA.
Positively charged ceramide is a potent inducer of mitochondrial permeabilization.
Long-chain ceramide is a potent inhibitor of the mitochondrial permeability transition pore.
Ceramide and mitochondria in ischemia/reperfusion.
Developmentally regulated ceramide synthase 6 increases mitochondrial Ca2+ loading capacity and promotes apoptosis.
Ceramide and mitochondria in ischemic brain injury.
Essential roles of neutral ceramidase and sphingosine in mitochondrial dysfunction due to traumatic brain injury.
SIRT3 Deacetylates Ceramide Synthases: IMPLICATIONS FOR MITOCHONDRIAL DYSFUNCTION AND BRAIN INJURY.
Lactosylceramide contributes to mitochondrial dysfunction in diabetes.
Acid sphingomyelinase promotes mitochondrial dysfunction due to glutamate-induced regulated necrosis.
Acid sphingomyelinase deficiency protects mitochondria and improves function recovery after brain injury.